ATE380181T1 - Natriumkanalblocker - Google Patents
NatriumkanalblockerInfo
- Publication number
- ATE380181T1 ATE380181T1 AT03711105T AT03711105T ATE380181T1 AT E380181 T1 ATE380181 T1 AT E380181T1 AT 03711105 T AT03711105 T AT 03711105T AT 03711105 T AT03711105 T AT 03711105T AT E380181 T1 ATE380181 T1 AT E380181T1
- Authority
- AT
- Austria
- Prior art keywords
- sodium channel
- channel blockers
- sup
- formula
- compounds
- Prior art date
Links
- 239000003195 sodium channel blocking agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010052164 Sodium Channels Proteins 0.000 abstract 1
- 102000018674 Sodium Channels Human genes 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/076,551 US6858614B2 (en) | 2002-02-19 | 2002-02-19 | Phenolic guanidine sodium channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE380181T1 true ATE380181T1 (de) | 2007-12-15 |
Family
ID=27752676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03711105T ATE380181T1 (de) | 2002-02-19 | 2003-02-19 | Natriumkanalblocker |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US6858614B2 (de) |
| EP (1) | EP1485359B1 (de) |
| JP (1) | JP2005526726A (de) |
| KR (1) | KR20040091065A (de) |
| AT (1) | ATE380181T1 (de) |
| AU (1) | AU2003215286A1 (de) |
| CA (1) | CA2476837A1 (de) |
| CY (1) | CY1107228T1 (de) |
| DE (1) | DE60317884T8 (de) |
| DK (1) | DK1485359T3 (de) |
| ES (1) | ES2298505T3 (de) |
| PT (1) | PT1485359E (de) |
| WO (1) | WO2003070184A2 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| CA2534568A1 (en) * | 2003-08-18 | 2005-03-24 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers |
| AU2004266704B2 (en) * | 2003-08-18 | 2012-02-23 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| EP1670474A4 (de) * | 2003-08-18 | 2008-08-06 | Parion Sciences Inc | Cyclische pyrazinoylguanidine als natriumkanalblocker |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| WO2005049050A1 (ja) * | 2003-11-19 | 2005-06-02 | Meiji Seika Kaisha, Ltd. | 唾液分泌促進剤並びにこれを配合した口腔用組成物及び食品組成物 |
| CA2575670A1 (en) * | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
| CA2575680A1 (en) | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Cyclic amide & ester pyrazinoylguanidine sodium channel blockers |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US8569367B2 (en) * | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
| US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| GB0520405D0 (en) * | 2005-10-07 | 2005-11-16 | Imp College Innovations Ltd | Biological agents and method |
| US20070149456A1 (en) * | 2005-12-13 | 2007-06-28 | University Of Pittsburgh | Epithelial sodium channel inhibiting agents and uses therefor |
| PT2035004E (pt) * | 2006-06-09 | 2012-11-21 | Parion Sciences Inc | Bloqueadores dos canais de sódio de pirazinoilguanidona substituída com fenilo que possuem actividade agonista beta |
| US20110195973A1 (en) * | 2006-06-09 | 2011-08-11 | Parion Sciences, Inc. | Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity |
| US8324218B2 (en) * | 2006-06-09 | 2012-12-04 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
| WO2008031048A2 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| AU2007294547A1 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| GB2447298A (en) * | 2007-03-09 | 2008-09-10 | Geraldine Carter | Toothpaste containing chromium |
| WO2008124496A1 (en) * | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders |
| US8288391B2 (en) * | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
| WO2009049159A1 (en) | 2007-10-10 | 2009-04-16 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| WO2009139948A1 (en) * | 2008-02-26 | 2009-11-19 | Johnson Michael R | Poly aromatic sodium channel blockers |
| US20100074881A1 (en) * | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
| EP2717855A4 (de) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | Behandlungsverfahren |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| SI2723176T1 (sl) | 2011-06-27 | 2017-09-29 | Parion Sciences, Inc. | Kemijsko in metabolno stabilni dipeptid, ki ima močno aktivnost blokiranja natrijevega kanala |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| WO2013181232A2 (en) | 2012-05-29 | 2013-12-05 | Michael Ross Johnson | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
| HUE032891T2 (hu) | 2012-12-17 | 2017-11-28 | Parion Sciences Inc | Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére |
| RU2671976C2 (ru) | 2012-12-17 | 2018-11-08 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| CA2915633A1 (en) | 2013-07-02 | 2015-01-08 | The California Institute For Biomedical Research | Compounds for treatment of cystic fibrosis |
| SG11201601291QA (en) | 2013-08-23 | 2016-03-30 | Parion Sciences Inc | Dithiol mucolytic agents |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
| CN107405505A (zh) * | 2015-01-07 | 2017-11-28 | 加州生物医学研究所 | 用于治疗囊性纤维化的化合物 |
| BR112017016067A2 (pt) | 2015-01-30 | 2018-04-03 | Parion Sciences Inc | agentes mucolíticos de monotiol |
| EP3244893A4 (de) * | 2015-02-18 | 2019-01-09 | Parion Sciences, Inc. | Natriumkanalblocker für hauterkrankungen |
| JP2018520986A (ja) | 2015-04-30 | 2018-08-02 | パリオン・サイエンシィズ・インコーポレーテッド | ジチオール粘液溶解剤の新規なプロドラッグ |
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
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-
2002
- 2002-02-19 US US10/076,551 patent/US6858614B2/en not_active Expired - Fee Related
-
2003
- 2003-02-19 PT PT03711105T patent/PT1485359E/pt unknown
- 2003-02-19 JP JP2003569144A patent/JP2005526726A/ja active Pending
- 2003-02-19 AT AT03711105T patent/ATE380181T1/de not_active IP Right Cessation
- 2003-02-19 ES ES03711105T patent/ES2298505T3/es not_active Expired - Lifetime
- 2003-02-19 WO PCT/US2003/004823 patent/WO2003070184A2/en not_active Ceased
- 2003-02-19 DE DE60317884T patent/DE60317884T8/de active Active
- 2003-02-19 DK DK03711105T patent/DK1485359T3/da active
- 2003-02-19 EP EP03711105A patent/EP1485359B1/de not_active Expired - Lifetime
- 2003-02-19 KR KR10-2004-7012935A patent/KR20040091065A/ko not_active Ceased
- 2003-02-19 CA CA002476837A patent/CA2476837A1/en not_active Abandoned
- 2003-02-19 AU AU2003215286A patent/AU2003215286A1/en not_active Abandoned
-
2004
- 2004-04-21 US US10/828,353 patent/US7192959B2/en not_active Expired - Fee Related
- 2004-04-21 US US10/828,278 patent/US7241766B2/en not_active Expired - Fee Related
- 2004-04-21 US US10/828,329 patent/US7192958B2/en not_active Expired - Fee Related
- 2004-04-21 US US10/828,235 patent/US7247636B2/en not_active Expired - Fee Related
- 2004-04-21 US US10/828,354 patent/US7368450B2/en not_active Expired - Lifetime
-
2008
- 2008-03-05 CY CY20081100252T patent/CY1107228T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7368450B2 (en) | 2008-05-06 |
| DE60317884D1 (de) | 2008-01-17 |
| DK1485359T3 (da) | 2008-04-14 |
| US7192958B2 (en) | 2007-03-20 |
| WO2003070184A2 (en) | 2003-08-28 |
| US7192959B2 (en) | 2007-03-20 |
| US20040198744A1 (en) | 2004-10-07 |
| US20040204424A1 (en) | 2004-10-14 |
| US20040198745A1 (en) | 2004-10-07 |
| JP2005526726A (ja) | 2005-09-08 |
| DE60317884T8 (de) | 2009-06-04 |
| US20040198746A1 (en) | 2004-10-07 |
| EP1485359B1 (de) | 2007-12-05 |
| HK1068609A1 (en) | 2005-04-29 |
| US20040198747A1 (en) | 2004-10-07 |
| US7241766B2 (en) | 2007-07-10 |
| WO2003070184A3 (en) | 2004-06-17 |
| US6858614B2 (en) | 2005-02-22 |
| CA2476837A1 (en) | 2003-08-28 |
| EP1485359A4 (de) | 2006-03-22 |
| AU2003215286A1 (en) | 2003-09-09 |
| DE60317884T2 (de) | 2009-01-02 |
| US7247636B2 (en) | 2007-07-24 |
| EP1485359A2 (de) | 2004-12-15 |
| CY1107228T1 (el) | 2012-11-21 |
| ES2298505T3 (es) | 2008-05-16 |
| PT1485359E (pt) | 2008-03-17 |
| KR20040091065A (ko) | 2004-10-27 |
| US20030195160A1 (en) | 2003-10-16 |
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