ATE382336T1 - Verfahren zur herstellung von partikeln und deren produkte - Google Patents

Verfahren zur herstellung von partikeln und deren produkte

Info

Publication number
ATE382336T1
ATE382336T1 AT01978670T AT01978670T ATE382336T1 AT E382336 T1 ATE382336 T1 AT E382336T1 AT 01978670 T AT01978670 T AT 01978670T AT 01978670 T AT01978670 T AT 01978670T AT E382336 T1 ATE382336 T1 AT E382336T1
Authority
AT
Austria
Prior art keywords
particle
active substance
additive
particle surface
products
Prior art date
Application number
AT01978670T
Other languages
English (en)
Inventor
Mazen Hermiz Hanna
Peter York
Original Assignee
Nektar Therapeutics Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9902848&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE382336(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics Uk Ltd filed Critical Nektar Therapeutics Uk Ltd
Application granted granted Critical
Publication of ATE382336T1 publication Critical patent/ATE382336T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/30—Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Glanulating (AREA)
  • Disintegrating Or Milling (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT01978670T 2000-11-09 2001-11-01 Verfahren zur herstellung von partikeln und deren produkte ATE382336T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0027357A GB0027357D0 (en) 2000-11-09 2000-11-09 Particle formation methods and their products

Publications (1)

Publication Number Publication Date
ATE382336T1 true ATE382336T1 (de) 2008-01-15

Family

ID=9902848

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01978670T ATE382336T1 (de) 2000-11-09 2001-11-01 Verfahren zur herstellung von partikeln und deren produkte

Country Status (13)

Country Link
US (4) US7115280B2 (de)
EP (1) EP1331928B1 (de)
JP (1) JP4880863B2 (de)
KR (1) KR100822098B1 (de)
AT (1) ATE382336T1 (de)
AU (2) AU2002210765B9 (de)
CA (1) CA2426247C (de)
DE (1) DE60132230T2 (de)
ES (1) ES2299519T3 (de)
GB (3) GB0027357D0 (de)
MX (1) MXPA03003846A (de)
TW (1) TWI241198B (de)
WO (1) WO2002038127A2 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
US8268333B2 (en) * 2001-04-24 2012-09-18 Lintec Corporation Orally administered agent and an orally administered agent/supporting substrate complex
JP4993652B2 (ja) * 2004-03-31 2012-08-08 リンテック株式会社 経口投与剤
JP4267926B2 (ja) * 2001-04-24 2009-05-27 リンテック株式会社 経口投与剤及び経口投与剤保持体
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
JP2006516958A (ja) * 2002-12-19 2006-07-13 バクスター・インターナショナル・インコーポレイテッド 超臨界流体を用いた組み合わせ薬学的処方物を調製するためのプロセス
GB0310636D0 (en) * 2003-05-08 2003-06-11 Nektar Therapeutics Uk Ltd Particulate materials
WO2004098561A2 (en) 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
KR100603974B1 (ko) 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
WO2005072710A2 (en) 2004-01-28 2005-08-11 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
JP2005298471A (ja) * 2004-03-17 2005-10-27 Lintec Corp 薬剤の製造方法
JP2005289867A (ja) * 2004-03-31 2005-10-20 Lintec Corp 経口投与剤
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
US7351423B2 (en) * 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
DE602006020642D1 (de) * 2005-01-06 2011-04-21 Cima Labs Inc Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel
EP1904219A4 (de) * 2005-07-15 2011-07-27 Map Pharmaceuticals Inc Teilchenbildungsverfahren
GB0602637D0 (en) * 2006-02-09 2006-03-22 Glaxo Group Ltd Novel process
TWI407959B (zh) * 2006-05-23 2013-09-11 Takeda Pharmaceutical 口服製劑
WO2008030557A2 (en) * 2006-09-08 2008-03-13 Johns Hopkins University Compositions and methods for enhancing transport through mucus
JP4705691B2 (ja) * 2006-10-11 2011-06-22 クリティテック・インコーポレイテッド 使用のための容器に小さい医薬粒子を沈殿させるための方法
US20080132560A1 (en) * 2006-11-21 2008-06-05 San-Laung Chow Solid dispersion composition
DK2425820T3 (en) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
WO2009085828A2 (en) * 2007-12-20 2009-07-09 Mutual Pharmaceutical Company, Inc. Quinine sulfate polymorphs, processes of preparing, compositions and uses thereof
US20090197963A1 (en) * 2008-02-01 2009-08-06 Dan Llewellyn Method and compositions for suppressing appetite or treating obesity
US8258155B2 (en) * 2008-06-30 2012-09-04 Mutual Pharmaceutical Company, Inc. Quinine sulfate/bisulfate solid complex; methods of making; and methods of use thereof
CN102170871B (zh) * 2008-07-31 2013-04-17 费伊肯有限公司 微胶囊化物及其制备方法
CA2791278C (en) 2010-02-25 2015-11-24 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
CN102858682B (zh) 2010-03-22 2014-07-16 株式会社Bio-Synectics 纳米颗粒制备方法
WO2012109363A2 (en) 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
EP2825207B1 (de) 2012-03-16 2020-08-19 The Johns Hopkins University Nichtlineare multiblock-copolymer-arzneimittelkonjugate zur verabreichung von wirkstoffen
AU2013232297B2 (en) 2012-03-16 2016-01-14 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
HK1208162A1 (en) 2012-05-03 2016-02-26 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
WO2013166408A1 (en) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US9533068B2 (en) 2012-05-04 2017-01-03 The Johns Hopkins University Drug loaded microfiber sutures for ophthalmic application
HK1214736A1 (zh) * 2012-11-14 2016-08-05 Pepsico, Inc. 改善低水溶性材料的分散性的方法
WO2014124006A1 (en) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
CA2900652C (en) 2013-02-15 2021-05-04 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
CN107915751A (zh) 2013-02-20 2018-04-17 卡拉制药公司 治疗性化合物和其用途
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CA2907765C (en) 2013-03-21 2021-07-06 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
WO2015066482A1 (en) 2013-11-01 2015-05-07 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2015317339A1 (en) * 2014-09-19 2017-04-27 Eupraxia Pharmaceuticals Inc. Injectable microparticles for hyper-localized release of therapeutic agents
CA2974715C (en) 2015-01-27 2020-05-05 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
TW201720427A (zh) 2015-10-27 2017-06-16 優普順藥物股份有限公司 局部麻醉劑之持續釋放調配物
HK1257499A1 (zh) 2015-11-12 2019-10-25 Graybug Vision, Inc. 用於治疗的聚集性微粒
AU2017324716B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
MX2019002629A (es) 2016-09-08 2019-10-07 Kala Pharmaceuticals Inc Formas cristalinas de compuestos terapéuticos y usos de los mismos.
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2018240462C1 (en) 2017-03-23 2022-12-08 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
CN111201040A (zh) 2017-05-10 2020-05-26 灰色视觉公司 用于医学疗法的缓释微粒及其悬浮液
US12496279B2 (en) 2019-04-11 2025-12-16 The Johns Hopkins University Nanoparticles for drug delivery to brain

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1122284A (en) 1965-03-19 1968-08-07 Fisons Pharmaceuticals Ltd Inhalation device
JPS5254709A (en) * 1975-10-31 1977-05-04 Lion Corp Multi-stage spray drying method
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
FI54093C (fi) * 1976-12-20 1978-10-10 Outokumpu Oy Saett att framstaella pulverformigt selen fraon raoselen
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
JPS6034925B2 (ja) * 1979-07-31 1985-08-12 帝人株式会社 持続性鼻腔用製剤およびその製造法
WO1981002975A1 (en) 1980-04-21 1981-10-29 Univ California Prolonged action drug formulation
US4423099A (en) * 1980-07-28 1983-12-27 Ciba-Geigy Corporation Membrane modified hydrogels
US4397907A (en) * 1981-06-22 1983-08-09 Hughes Aircraft Company Multi-purpose air permeable composites
US5260306A (en) * 1981-07-24 1993-11-09 Fisons Plc Inhalation pharmaceuticals
EP0072046B1 (de) 1981-07-24 1986-01-15 FISONS plc Inhalierbare Arzneimittel, Verfahren zu deren Herstellung und pharmazeutische Formulierungen diese enthaltend
GB2105189B (en) 1981-07-24 1985-03-20 Fisons Plc Inhalation drugs
CH656077A5 (de) * 1982-01-29 1986-06-13 Glatt Maschinen & Apparatebau Verfahren zum ueberziehen von teilchen, insbesondere arzneimittel-teilchen, und vorrichtung zur durchfuehrung des verfahrens.
JPS59163313A (ja) 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
US4486435A (en) 1983-05-16 1984-12-04 Basf Wyandotte Corporation Spray-dried vitamin powders using hydrophobic silica
US4582731A (en) * 1983-09-01 1986-04-15 Battelle Memorial Institute Supercritical fluid molecular spray film deposition and powder formation
US4514574A (en) * 1984-01-09 1985-04-30 The Dow Chemical Company Process for separating isomeric mixtures
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4624848A (en) * 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
US4749576A (en) * 1984-05-10 1988-06-07 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
PT85521B (pt) * 1986-08-11 1990-06-29 Innovata Biomed Ltd Processo para a preparacao de composicoes farmaceuticas que consistem em microcapsulas
US4760093A (en) 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
JP2562624B2 (ja) * 1986-11-07 1996-12-11 昭和電工株式会社 水溶性マイクロカプセルおよび液体洗剤組成物
NZ222907A (en) 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
US4784878A (en) * 1987-04-06 1988-11-15 Damrow Company, Inc. Spray drying method and apparatus for concurrent particle coating
SE8701479L (sv) 1987-04-09 1988-10-10 Carbomatrix Ab Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
GB8712176D0 (en) 1987-05-22 1987-06-24 Cosmas Damian Ltd Drug delivery system
US4835187A (en) 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US5219575A (en) * 1987-06-26 1993-06-15 Duphar International Research B.V. Compositions with controlled zero-order delivery rate and method of preparing these compositions
ATE94782T1 (de) * 1987-12-21 1993-10-15 Union Carbide Corp Verwendung von superkritischen fluessigkeiten als verduenner beim aufspruehen von ueberzuegen.
DE3744329A1 (de) 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
JPH01176437A (ja) 1987-12-29 1989-07-12 Ono Pharmaceut Co Ltd 有機物質の微粒化方法
US4919853A (en) * 1988-01-21 1990-04-24 The United States Of America As Represented By The United States Department Of Energy Apparatus and method for spraying liquid materials
ATE98094T1 (de) 1988-06-03 1993-12-15 Niro Sterner Inc Spruehtrocknungsverfahren und vorrichtung zum gleichzeitigen beschichten von teilchen.
US5066522A (en) * 1988-07-14 1991-11-19 Union Carbide Chemicals And Plastics Technology Corporation Supercritical fluids as diluents in liquid spray applications of adhesives
EP0360340A1 (de) 1988-09-19 1990-03-28 Akzo N.V. Peptidenthaltende Zubereitung zur intranasalen Verabreichung
AU624421B2 (en) 1988-10-05 1992-06-11 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US4999189A (en) * 1988-11-14 1991-03-12 Schering Corporation Sustained release oral suspensions
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US5009367A (en) * 1989-03-22 1991-04-23 Union Carbide Chemicals And Plastics Technology Corporation Methods and apparatus for obtaining wider sprays when spraying liquids by airless techniques
US5232707A (en) * 1989-07-10 1993-08-03 Syntex (U.S.A.) Inc. Solvent extraction process
US5238920A (en) * 1989-08-22 1993-08-24 Abbott Laboratories Pulmonary surfactant protein fragments
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5376386A (en) 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
US5000888A (en) * 1990-05-23 1991-03-19 Basf Corporation Process for spray drying riboflavin to produce a granulate product having low binder content
DE69112917T2 (de) 1990-06-15 1996-05-15 Merck & Co Inc Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse.
GB9017155D0 (en) 1990-08-03 1990-09-19 Ici Plc Spray drying
JP3080983B2 (ja) 1990-11-21 2000-08-28 東芝タンガロイ株式会社 傾斜組成組織の硬質焼結合金及びその製造方法
DE4118230A1 (de) * 1990-12-20 1992-06-25 Bayer Ag Verfahren zur isolierung von polymeren aus ihren loesungsmitteln mit kohlendioxid-haltigen fluessigkeiten
DE4041563A1 (de) * 1990-12-22 1992-06-25 Sanol Arznei Schwarz Gmbh Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
DE4117751A1 (de) * 1991-05-30 1992-12-03 Bayer Ag Verfahren zur isolierung von polycarbonaten
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5269980A (en) 1991-08-05 1993-12-14 Northeastern University Production of polymer particles in powder form using an atomization technique
DE69220317T2 (de) * 1991-10-01 1997-10-16 Takeda Chemical Industries Ltd Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
US6063910A (en) 1991-11-14 2000-05-16 The Trustees Of Princeton University Preparation of protein microparticles by supercritical fluid precipitation
JPH07503154A (ja) * 1992-01-21 1995-04-06 エス・アール・アイ・インターナシヨナル 微細化ポリペプチド薬剤の改良調製方法
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
EP0611567B1 (de) 1992-06-12 2002-08-28 Teijin Limited Ultrafeines pulver zur inhalation und dessen herstellung
AU4198793A (en) * 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
WO1994009913A1 (en) * 1992-11-02 1994-05-11 Ferro Corporation Method of preparing coating materials
NZ248813A (en) * 1992-11-25 1995-06-27 Eastman Kodak Co Polymeric grinding media used in grinding pharmaceutical substances
KR950703935A (ko) * 1992-11-30 1995-11-17 밋첼 아이, 커시너 맛을 차단하는 약제학적 조성물
GB9226474D0 (en) 1992-12-18 1993-02-10 Ici Plc Production of particulate materials
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
IL105658A (en) 1993-05-11 1995-10-31 Ultrasonic Dryer Ltd Spray drying system
US5554382A (en) * 1993-05-28 1996-09-10 Aphios Corporation Methods and apparatus for making liposomes
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9313650D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
KR960011238B1 (ko) * 1993-07-05 1996-08-21 주식회사 코오롱 산에서 불안정한 화합물의 경구 제형 및 그 제조방법
JPH09508055A (ja) * 1993-11-08 1997-08-19 ザ、ジレット、カンパニー 超臨界流体を用いる粒子の形成法、これによって形成されるエーロゲル粒子、およびエーロゲル粒子を含む制汗剤
IT1265473B1 (it) 1993-12-30 1996-11-22 Otefal Srl Procedimento per la produzione di polveri a granulometria controllata e prodotto in polvere cosi' ottenuto
US5595761A (en) * 1994-01-27 1997-01-21 The Board Of Regents Of The University Of Oklahoma Particulate support matrix for making a rapidly dissolving tablet
US5635210A (en) * 1994-02-03 1997-06-03 The Board Of Regents Of The University Of Oklahoma Method of making a rapidly dissolving tablet
CA2182988A1 (en) * 1994-02-09 1995-08-17 Kinerton Limited Process for drying a material from solution
SI9400079B (sl) 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
JPH081882A (ja) 1994-06-20 1996-01-09 Chisso Corp ポリオレフィン系樹脂製積層フィルム
JP3883588B2 (ja) 1994-06-22 2007-02-21 大日本印刷株式会社 化粧材
JP3175482B2 (ja) 1994-06-23 2001-06-11 凸版印刷株式会社 化粧シート及びその製造方法
JP3093103B2 (ja) 1994-06-24 2000-10-03 住友ベークライト株式会社 多層フィルム
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5499848A (en) 1994-09-26 1996-03-19 Bundy Corporation Connection verifier for a quick connector coupling
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US5716558A (en) * 1994-11-14 1998-02-10 Union Carbide Chemicals & Plastics Technology Corporation Method for producing coating powders catalysts and drier water-borne coatings by spraying compositions with compressed fluids
MX9504934A (es) * 1994-12-12 1997-01-31 Morton Int Inc Revestimientos en polvo de pelicula delgada lisa.
US5639475A (en) * 1995-02-03 1997-06-17 Eurand America, Incorporated Effervescent microcapsules
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US6258341B1 (en) * 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
US5495681A (en) 1995-05-24 1996-03-05 Paradis; Andr´E Pivotable panel for clothes dryer drum
US5667806A (en) * 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
JP3541090B2 (ja) * 1995-09-08 2004-07-07 三洋電機株式会社 アルカリ蓄電池用正極活物質及びその製造方法
CA2234957C (en) 1995-10-17 2006-12-19 Inge B. Henriksen Insoluble drug delivery
US5807578A (en) * 1995-11-22 1998-09-15 Lab Pharmaceutical Research International Inc. Fast-melt tablet and method of making same
AU709384B2 (en) 1996-03-01 1999-08-26 University Of Kansas, The Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
DE19617487A1 (de) * 1996-05-02 1997-11-06 Merck Patent Gmbh Geschmacksverbesserung von Arzneimittelwirkstoffen
US6116516A (en) * 1996-05-13 2000-09-12 Universidad De Sevilla Stabilized capillary microjet and devices and methods for producing same
ES2140998B1 (es) * 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
JP4036233B2 (ja) 1996-08-09 2008-01-23 ヤマハ株式会社 楽音発生装置および楽音発生方法、並びに該方法に係るプログラムを記憶した記憶媒体
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
AU4219897A (en) * 1996-09-18 1998-04-14 Daiso Co. Ltd. Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
FR2753639B1 (fr) * 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
GB9622173D0 (en) 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
AU5806998A (en) 1996-12-31 1998-07-31 Inhale Therapeutic Systems Processes for spray drying solutions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
GB9703673D0 (en) 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
US6051257A (en) * 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
GB9800936D0 (en) * 1997-05-10 1998-03-11 Univ Nottingham Biofunctional polymers
WO1998053940A1 (de) * 1997-05-28 1998-12-03 Siemens Aktiengesellschaft Metall-keramik-gradientenwerkstoff, erzeugnis daraus und verfahren zur herstellung eines metall-keramik-gradientenwerkstoffes
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
EP1027036A2 (de) 1997-10-03 2000-08-16 ELAN CORPORATION, Plc Geschmacksmaskierte formulierungen
US5904937A (en) 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
ATE453460T1 (de) 1997-10-15 2010-01-15 Univ South Florida Beschichtung von partikelmaterial mittels superkritischer flüssigkeit
CA2314918A1 (en) 1997-12-17 1999-06-24 Universidad De Sevilla Device and method for creating dry particles
JPH11197494A (ja) * 1998-01-13 1999-07-27 Kenji Mishima 超臨界流体を用いた微小粒子コーティング
GB9804379D0 (en) 1998-03-02 1998-04-22 Bradford Particle Design Ltd Method of particle formation
SE9801288D0 (sv) 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and metod of production
GB9810559D0 (en) 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US6387410B1 (en) * 1998-09-10 2002-05-14 Norton Healthcare Ltd Anti-inflammatory pharmaceutical formulations
SE9804003D0 (sv) 1998-11-23 1998-11-23 Astra Ab A method of producing drug particles
SE9804001D0 (sv) 1998-11-23 1998-11-23 Astra Ab New process
EP2260836B1 (de) 1998-11-25 2016-08-10 Cima Labs Inc. Schnellfreisetzende Tablette mit beschichtetem, wirkstoffhaltigem Kern und umgebender Schicht als Geschmacksbarriere
GB9825883D0 (en) 1998-11-27 1999-01-20 Aea Technology Plc Formation of monodisperse particles
ATE404178T1 (de) * 1999-02-10 2008-08-15 Pfizer Prod Inc Vorrichtung mit matrixgesteuerter wirkstofffreisetzung
SE9901667D0 (sv) 1999-05-07 1999-05-07 Astra Ab Method and device for forming particles
GB9915975D0 (en) * 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
FR2795962B1 (fr) 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
US20020081266A1 (en) * 1999-08-20 2002-06-27 Norton Healthcare Ltd. Spray dried powders for pulmonary or nasal administration
GB9920558D0 (en) 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
EP1242112A4 (de) * 1999-12-21 2005-02-09 Rxkinetix Inc Partikel-enthaltende medikamente und methode zu deren herstellung
PE20011227A1 (es) * 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
US6551617B1 (en) * 2000-04-20 2003-04-22 Bristol-Myers Squibb Company Taste masking coating composition
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6620351B2 (en) * 2000-05-24 2003-09-16 Auburn University Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer
US6656492B2 (en) 2000-06-30 2003-12-02 Yamanouchi Pharmaceutical Co., Ltd. Quick disintegrating tablet in buccal cavity and manufacturing method thereof
WO2002009669A2 (en) * 2000-08-01 2002-02-07 Inhale Therapeutic Systems, Inc. Apparatus and process to produce particles having a narrow size distribution and particles made thereby
FR2815540B1 (fr) * 2000-10-19 2005-06-10 Separex Sa Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
GB0102075D0 (en) 2001-01-26 2001-03-14 Astrazeneca Ab Process
TW586963B (en) 2001-07-20 2004-05-11 Nektar Therapeutics Uk Ltd Method and apparatus for preparing target substance in particulate form and fluid inlet assembly for said apparatus
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
TW200300696A (en) * 2001-11-01 2003-06-16 Inhale Therapeutic Syst Spray drying methods and related compositions
AU2003209673B2 (en) * 2002-03-08 2007-10-18 M/S. Ind-Swift Limited Tasteless directly compressible fast-dissolving complexes and pharmaceutical formulations thereof
WO2004098561A2 (en) 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
JP4187739B2 (ja) 2005-10-17 2008-11-26 電気化学工業株式会社 アルミニウム合金−炭化珪素窒化珪素質複合体
JP5057166B2 (ja) 2008-10-30 2012-10-24 アイシン・エィ・ダブリュ株式会社 安全運転評価システム及び安全運転評価プログラム

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