ATE382370T1 - Antikörper-serumprotein hybride - Google Patents
Antikörper-serumprotein hybrideInfo
- Publication number
- ATE382370T1 ATE382370T1 AT99954209T AT99954209T ATE382370T1 AT E382370 T1 ATE382370 T1 AT E382370T1 AT 99954209 T AT99954209 T AT 99954209T AT 99954209 T AT99954209 T AT 99954209T AT E382370 T1 ATE382370 T1 AT E382370T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- serum protein
- protein hybrid
- hybrid
- proteins
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9824632.5A GB9824632D0 (en) | 1998-11-10 | 1998-11-10 | Biological compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE382370T1 true ATE382370T1 (de) | 2008-01-15 |
Family
ID=10842195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99954209T ATE382370T1 (de) | 1998-11-10 | 1999-11-10 | Antikörper-serumprotein hybride |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7105160B1 (de) |
| EP (2) | EP1128847B1 (de) |
| AT (1) | ATE382370T1 (de) |
| AU (1) | AU1062700A (de) |
| DE (1) | DE69937899T2 (de) |
| ES (1) | ES2299268T3 (de) |
| GB (1) | GB9824632D0 (de) |
| WO (1) | WO2000027435A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19926475A1 (de) * | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
| JP2005510483A (ja) * | 2001-10-17 | 2005-04-21 | ページ ダブル フォーク | 選択された細胞を標的化してそれに作用する方法及び物質 |
| EP2284192A3 (de) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Antikörper aus Camelidae zur sublingualen Verabreichung |
| GB0411186D0 (en) * | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
| AU2006249144B2 (en) | 2005-05-18 | 2011-11-17 | Ablynx Nv | Improved NanobodiesTM against Tumor Necrosis Factor-alpha |
| AU2007336243B2 (en) | 2006-12-19 | 2012-07-26 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
| CA2673331A1 (en) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders |
| AU2009235467A1 (en) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Single variable domains against the Notch pathways |
| WO2010010119A1 (en) | 2008-07-22 | 2010-01-28 | Ablynx Nv | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
| US8748581B2 (en) | 2009-04-10 | 2014-06-10 | Ablynx N.V. | Anti-IL-6R polypeptides and pharmaceutical compositions thereof |
| KR101852204B1 (ko) | 2009-06-05 | 2018-04-26 | 아블린쓰 엔.브이. | 기도 감염의 예방 및/또는 치료를 위한 일가, 이가 및 삼가 항 인간 호흡기 세포융합 바이러스 (ｈｒｓｖ) 나노바디 구조물 |
| WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| HRP20251657T1 (hr) | 2009-12-14 | 2026-02-13 | Ablynx N.V. | Imunoglobulinska protutijela s jednostrukom varijabilnom domenom protiv ox40l, konstrukti i njihova terapijska upotreba |
| WO2011083141A2 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Method for generation of immunoglobulin sequences by using lipoprotein particles |
| US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| CA2798432A1 (en) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies |
| EA201291181A1 (ru) | 2010-05-06 | 2013-05-30 | Новартис Аг | Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) |
| MX2012013490A (es) | 2010-05-20 | 2013-01-29 | Ablynx Nv | Materiales biologicos relacionados con her3. |
| EA037063B1 (ru) | 2010-11-08 | 2021-02-01 | Аблинкс Н.В. | Cxcr2-связывающие полипептиды |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| JP2014525736A (ja) | 2011-06-23 | 2014-10-02 | アブリンクス エン．ヴェー． | ＩｇＥに対する免疫グロブリン単一可変ドメイン |
| KR20140091031A (ko) | 2011-11-04 | 2014-07-18 | 노파르티스 아게 | 저밀도 지단백질-관련 단백질 6 (lrp6) - 반감기 연장제 구축물 |
| US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
| WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
| IL317416A (en) | 2016-11-16 | 2025-02-01 | Ablynx Nv | T cell-recruiting polypeptides capable of binding CD123 and TCR alpha/beta |
| US20200087390A1 (en) | 2016-12-21 | 2020-03-19 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| MX2019014504A (es) | 2017-06-02 | 2020-07-20 | Merck Patent Gmbh | Inmunoglobulinas de union a agrecano. |
| TW201930358A (zh) | 2017-12-28 | 2019-08-01 | 大陸商南京傳奇生物科技有限公司 | 針對ｔｉｇｉｔ之單域抗體及其變異體 |
| KR102839330B1 (ko) | 2018-01-15 | 2025-07-30 | 난징 레전드 바이오테크 씨오., 엘티디. | Pd-1에 대한 단일-도메인 항체 및 이의 변이체 |
| JP7346790B2 (ja) | 2018-03-30 | 2023-09-20 | ナンジン レジェンド バイオテック カンパニー，リミテッド | Ｌａｇ‐３に対する単一ドメイン抗体およびその使用 |
| CN117321076A (zh) | 2021-02-19 | 2023-12-29 | 美国卫生及公众服务部代表 | 中和SARS-CoV-2的单结构域抗体 |
| WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| WO2025034806A1 (en) | 2023-08-08 | 2025-02-13 | Wisconsin Alumni Research Foundation | Single-domain antibodies and variants thereof against fibroblast activation protein |
| WO2025099632A1 (en) | 2023-11-08 | 2025-05-15 | Sanofi | Cd25 based lysosomal degrader and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4749570A (en) * | 1981-12-31 | 1988-06-07 | The Governors Of The University Of Alberta | Targeting conjugates of albumin and therapeutic agents |
| US4751286A (en) * | 1985-11-19 | 1988-06-14 | The Johns Hopkins University | Protein label and drug delivery system |
| JPH05507924A (ja) * | 1990-07-03 | 1993-11-11 | アクゾ・エヌ・ヴエー | 免疫反応性化合物 |
| CA2074945A1 (en) * | 1990-11-30 | 1992-05-31 | Atsushi Isoai | Tumor cell invasion-inhibiting peptides, peptide complexes and cancer metastasis inhibitors |
| GB9112536D0 (en) | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| EP0602290B1 (de) * | 1992-12-04 | 1999-08-25 | ConjuChem, Inc. | Antikörper-konjugiertes-Hepatitis B-Oberflächenantigen und dessen Verwendung |
| CA2184002A1 (en) * | 1994-02-23 | 1995-08-31 | Jeffrey M. Blaney | Method and compositions for increasing the serum half-life of pharmacologically active agents |
| WO1995033492A1 (en) * | 1994-06-09 | 1995-12-14 | Houston Biotechnology Incorporated | Methods and compositions for modulation of wound healing |
| US5670132A (en) * | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
| ATE279947T1 (de) * | 1996-03-18 | 2004-11-15 | Univ Texas | Immunglobulinähnliche domäne mit erhöhten halbwertszeiten |
| US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| DE69820867T2 (de) * | 1997-04-29 | 2004-11-18 | Amersham Health As | Lichtbilderzeugungskontrastmitteln |
-
1998
- 1998-11-10 GB GBGB9824632.5A patent/GB9824632D0/en not_active Ceased
-
1999
- 1999-11-10 ES ES99954209T patent/ES2299268T3/es not_active Expired - Lifetime
- 1999-11-10 US US09/831,534 patent/US7105160B1/en not_active Expired - Fee Related
- 1999-11-10 DE DE69937899T patent/DE69937899T2/de not_active Expired - Fee Related
- 1999-11-10 EP EP99954209A patent/EP1128847B1/de not_active Expired - Lifetime
- 1999-11-10 AT AT99954209T patent/ATE382370T1/de not_active IP Right Cessation
- 1999-11-10 WO PCT/GB1999/003747 patent/WO2000027435A1/en not_active Ceased
- 1999-11-10 AU AU10627/00A patent/AU1062700A/en not_active Abandoned
- 1999-11-10 EP EP07075275A patent/EP1808155A3/de not_active Withdrawn
-
2006
- 2006-07-24 US US11/492,187 patent/US20060263375A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69937899D1 (de) | 2008-02-14 |
| GB9824632D0 (en) | 1999-01-06 |
| EP1128847A1 (de) | 2001-09-05 |
| US20060263375A1 (en) | 2006-11-23 |
| WO2000027435A1 (en) | 2000-05-18 |
| AU1062700A (en) | 2000-05-29 |
| EP1808155A2 (de) | 2007-07-18 |
| EP1128847B1 (de) | 2008-01-02 |
| EP1808155A3 (de) | 2007-10-31 |
| ES2299268T3 (es) | 2008-05-16 |
| DE69937899T2 (de) | 2008-12-24 |
| US7105160B1 (en) | 2006-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |