ATE382624T1 - Kristalle von taxanderivaten und verfahren zu deren herstellung - Google Patents
Kristalle von taxanderivaten und verfahren zu deren herstellungInfo
- Publication number
- ATE382624T1 ATE382624T1 AT02785977T AT02785977T ATE382624T1 AT E382624 T1 ATE382624 T1 AT E382624T1 AT 02785977 T AT02785977 T AT 02785977T AT 02785977 T AT02785977 T AT 02785977T AT E382624 T1 ATE382624 T1 AT E382624T1
- Authority
- AT
- Austria
- Prior art keywords
- taxand
- crystals
- derivatives
- production
- mixture
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- WCMBUDUPBVQEDN-VHSXEESVSA-N (2r,3s)-3-(3-fluoropyridin-2-yl)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H]([C@@H](O)C(O)=O)C1=NC=CC=C1F WCMBUDUPBVQEDN-VHSXEESVSA-N 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001363681 | 2001-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE382624T1 true ATE382624T1 (de) | 2008-01-15 |
Family
ID=19173983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02785977T ATE382624T1 (de) | 2001-11-29 | 2002-11-29 | Kristalle von taxanderivaten und verfahren zu deren herstellung |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7410980B2 (de) |
| EP (1) | EP1457492B1 (de) |
| JP (1) | JP4310191B2 (de) |
| KR (1) | KR100886805B1 (de) |
| CN (1) | CN1295229C (de) |
| AT (1) | ATE382624T1 (de) |
| AU (1) | AU2002354126A1 (de) |
| CA (1) | CA2468953C (de) |
| DE (1) | DE60224440T2 (de) |
| DK (1) | DK1457492T3 (de) |
| ES (1) | ES2299612T3 (de) |
| MX (1) | MXPA04005192A (de) |
| NO (1) | NO328559B1 (de) |
| PT (1) | PT1457492E (de) |
| RU (1) | RU2284328C2 (de) |
| TW (1) | TWI333856B (de) |
| WO (1) | WO2003045953A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2859996B1 (fr) * | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| DK1741716T3 (da) | 2004-04-30 | 2011-11-28 | Daiichi Sankyo Co Ltd | Fremgangsmåde til fremstilling af pentacyklisk taxan |
| US20070005911A1 (en) * | 2005-07-01 | 2007-01-04 | Nec Laboratories America, Inc. | Operating System-Based Memory Compression for Embedded Systems |
| US8785669B2 (en) | 2010-06-30 | 2014-07-22 | Gfv, Llc | Taxane compounds, compositions and methods |
| US8697892B2 (en) | 2010-06-30 | 2014-04-15 | Gfv, Llc | Taxane compounds, compositions and methods |
| EP2447268A1 (de) * | 2010-10-29 | 2012-05-02 | INDENA S.p.A. | Kristalline Form von 13-[(N-tert-butoxycarbonyl)-2'-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III |
| JP5909089B2 (ja) * | 2011-02-01 | 2016-04-26 | アークレイ株式会社 | 光学結晶、テラヘルツ波発生装置及び方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1254515B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | Tassani di interesse oncologico, loro metodo di preparazione ed uso |
| US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| BR9608040B1 (pt) * | 1995-04-28 | 2010-02-23 | composto taxàide pentacÍclico. | |
| JP2000159757A (ja) * | 1998-12-01 | 2000-06-13 | Dai Ichi Seiyaku Co Ltd | ７−デオキシタキソール誘導体の製造方法 |
| HK1042302B (en) * | 1999-05-17 | 2004-10-08 | Bristol-Myers Squibb Company | Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol) and paclitaxel analogues |
| MXPA02003797A (es) | 1999-10-15 | 2002-12-13 | Daiichi Seiyaku Co | Compuestos de taxano pentaciclico. |
| US6677456B2 (en) | 1999-10-15 | 2004-01-13 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic taxan compound |
| WO2002070512A1 (en) * | 2001-03-07 | 2002-09-12 | Daiichi Pharmaceutical Co, Ltd. | Method for producing 2-azetidinone derivative |
-
2002
- 2002-11-29 US US10/495,437 patent/US7410980B2/en not_active Expired - Lifetime
- 2002-11-29 PT PT02785977T patent/PT1457492E/pt unknown
- 2002-11-29 RU RU2004119547/04A patent/RU2284328C2/ru active IP Right Revival
- 2002-11-29 WO PCT/JP2002/012506 patent/WO2003045953A1/ja not_active Ceased
- 2002-11-29 DK DK02785977T patent/DK1457492T3/da active
- 2002-11-29 MX MXPA04005192A patent/MXPA04005192A/es active IP Right Grant
- 2002-11-29 ES ES02785977T patent/ES2299612T3/es not_active Expired - Lifetime
- 2002-11-29 CA CA2468953A patent/CA2468953C/en not_active Expired - Lifetime
- 2002-11-29 AT AT02785977T patent/ATE382624T1/de active
- 2002-11-29 JP JP2003547403A patent/JP4310191B2/ja not_active Expired - Fee Related
- 2002-11-29 KR KR1020047008200A patent/KR100886805B1/ko not_active Expired - Fee Related
- 2002-11-29 TW TW091134817A patent/TWI333856B/zh not_active IP Right Cessation
- 2002-11-29 DE DE60224440T patent/DE60224440T2/de not_active Expired - Lifetime
- 2002-11-29 EP EP02785977A patent/EP1457492B1/de not_active Expired - Lifetime
- 2002-11-29 AU AU2002354126A patent/AU2002354126A1/en not_active Abandoned
- 2002-11-29 CN CNB02823815XA patent/CN1295229C/zh not_active Expired - Fee Related
-
2004
- 2004-06-28 NO NO20042723A patent/NO328559B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2468953C (en) | 2010-05-11 |
| ES2299612T3 (es) | 2008-06-01 |
| CN1295229C (zh) | 2007-01-17 |
| RU2284328C2 (ru) | 2006-09-27 |
| AU2002354126A1 (en) | 2003-06-10 |
| CN1596259A (zh) | 2005-03-16 |
| JPWO2003045953A1 (ja) | 2005-04-07 |
| EP1457492A4 (de) | 2005-03-23 |
| NO328559B1 (no) | 2010-03-22 |
| US7410980B2 (en) | 2008-08-12 |
| RU2004119547A (ru) | 2005-03-27 |
| DK1457492T3 (da) | 2008-05-13 |
| KR20040081426A (ko) | 2004-09-21 |
| TWI333856B (en) | 2010-12-01 |
| NO20042723L (no) | 2004-06-28 |
| US20050070579A1 (en) | 2005-03-31 |
| MXPA04005192A (es) | 2005-02-22 |
| DE60224440D1 (de) | 2008-02-14 |
| EP1457492A1 (de) | 2004-09-15 |
| HK1065547A1 (en) | 2005-02-25 |
| DE60224440T2 (de) | 2009-01-02 |
| PT1457492E (pt) | 2008-02-28 |
| CA2468953A1 (en) | 2003-06-05 |
| KR100886805B1 (ko) | 2009-03-05 |
| TW200301114A (en) | 2003-07-01 |
| WO2003045953A1 (en) | 2003-06-05 |
| JP4310191B2 (ja) | 2009-08-05 |
| EP1457492B1 (de) | 2008-01-02 |
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