ATE383337T1 - 1-(1h-indol-1-yl)-3-(4-methylpiperazin-1-yl)-1- phenylpropan-2-olderivate und verwandte verbindungen als modulatoren der norepinephrin- (ne-) und der serotonin-(5-ht-) aktivität und der monoaminwiederaufnahme zur behandlung von vasomotorischen symptomen (vms) - Google Patents

1-(1h-indol-1-yl)-3-(4-methylpiperazin-1-yl)-1- phenylpropan-2-olderivate und verwandte verbindungen als modulatoren der norepinephrin- (ne-) und der serotonin-(5-ht-) aktivität und der monoaminwiederaufnahme zur behandlung von vasomotorischen symptomen (vms)

Info

Publication number: ATE383337T1
Authority: AT; Austria
Prior art keywords: resubstitution; phenylpropane; vms; norepinephrine; methylpiperazine
Prior art date: 2004-03-30

Application number

AT05730271T

Other languages

English (en)

Inventor

Callain Kim

Paige Mahaney

Eugene Trybulski

Puwen Zhang

Eugene Terefenko

Casey Mccomas

Michael Marella

Richard Coghlan

Gavin Heffernan

Stephen Cohn

An Vu

Joseph Sabatucci

Fei Ye

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-30

Filing date

2005-03-29

Publication date

2008-01-15

2005-03-29 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE383337T1 publication Critical patent/ATE383337T1/de

Links

SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 title 1
WNNACCODSWYYDZ-UHFFFAOYSA-N 1-indol-1-yl-3-(4-methylpiperazin-1-yl)-1-phenylpropan-2-ol Chemical class C1CN(C)CCN1CC(O)C(N1C2=CC=CC=C2C=C1)C1=CC=CC=C1 WNNACCODSWYYDZ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
230000000694 effects Effects 0.000 title 1
229960002748 norepinephrine Drugs 0.000 title 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 title 1
230000001457 vasomotor Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT05730271T 2004-03-30 2005-03-29 1-(1h-indol-1-yl)-3-(4-methylpiperazin-1-yl)-1- phenylpropan-2-olderivate und verwandte verbindungen als modulatoren der norepinephrin- (ne-) und der serotonin-(5-ht-) aktivität und der monoaminwiederaufnahme zur behandlung von vasomotorischen symptomen (vms) ATE383337T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US55765104P	2004-03-30	2004-03-30
US56986304P	2004-05-11	2004-05-11
US11/091,885 US7517899B2 (en)	2004-03-30	2005-03-28	Phenylaminopropanol derivatives and methods of their use

Publications (1)

Publication Number	Publication Date
ATE383337T1 true ATE383337T1 (de)	2008-01-15

Family

ID=34964018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05730271T ATE383337T1 (de)	2004-03-30	2005-03-29	1-(1h-indol-1-yl)-3-(4-methylpiperazin-1-yl)-1- phenylpropan-2-olderivate und verwandte verbindungen als modulatoren der norepinephrin- (ne-) und der serotonin-(5-ht-) aktivität und der monoaminwiederaufnahme zur behandlung von vasomotorischen symptomen (vms)

Country Status (20)

Country	Link
US (3)	US7517899B2 (de)
EP (1)	EP1732887B1 (de)
JP (1)	JP2007531751A (de)
KR (1)	KR20060134186A (de)
AR (1)	AR048675A1 (de)
AT (1)	ATE383337T1 (de)
AU (1)	AU2005230900A1 (de)
BR (1)	BRPI0509390A (de)
CA (1)	CA2560967A1 (de)
CR (1)	CR8639A (de)
DE (1)	DE602005004268T2 (de)
DK (1)	DK1732887T3 (de)
EC (1)	ECSP066899A (de)
ES (1)	ES2299025T3 (de)
IL (1)	IL178185A0 (de)
NO (1)	NO20064892L (de)
PE (1)	PE20060288A1 (de)
PL (1)	PL1732887T3 (de)
TW (1)	TW200536532A (de)
WO (1)	WO2005097744A1 (de)

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2005
- 2005-03-28 US US11/091,885 patent/US7517899B2/en not_active Expired - Fee Related
- 2005-03-29 AT AT05730271T patent/ATE383337T1/de not_active IP Right Cessation
- 2005-03-29 DE DE602005004268T patent/DE602005004268T2/de not_active Expired - Fee Related
- 2005-03-29 BR BRPI0509390-2A patent/BRPI0509390A/pt not_active IP Right Cessation
- 2005-03-29 AU AU2005230900A patent/AU2005230900A1/en not_active Withdrawn
- 2005-03-29 WO PCT/US2005/010511 patent/WO2005097744A1/en not_active Ceased
- 2005-03-29 EP EP05730271A patent/EP1732887B1/de not_active Expired - Lifetime
- 2005-03-29 TW TW094109747A patent/TW200536532A/zh unknown
- 2005-03-29 DK DK05730271T patent/DK1732887T3/da active
- 2005-03-29 KR KR1020067022665A patent/KR20060134186A/ko not_active Withdrawn
- 2005-03-29 CA CA002560967A patent/CA2560967A1/en not_active Abandoned
- 2005-03-29 ES ES05730271T patent/ES2299025T3/es not_active Expired - Lifetime
- 2005-03-29 JP JP2007506469A patent/JP2007531751A/ja not_active Withdrawn
- 2005-03-29 PL PL05730271T patent/PL1732887T3/pl unknown
- 2005-03-30 AR ARP050101217A patent/AR048675A1/es unknown
- 2005-03-30 PE PE2005000365A patent/PE20060288A1/es not_active Application Discontinuation
2006
- 2006-09-19 IL IL178185A patent/IL178185A0/en unknown
- 2006-09-20 CR CR8639A patent/CR8639A/es not_active Application Discontinuation
- 2006-09-29 EC EC2006006899A patent/ECSP066899A/es unknown
- 2006-10-26 NO NO20064892A patent/NO20064892L/no not_active Application Discontinuation
2008
- 2008-12-15 US US12/335,245 patent/US20090093469A1/en not_active Abandoned
- 2008-12-15 US US12/335,144 patent/US20090099164A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1732887B1 (de)	2008-01-09
JP2007531751A (ja)	2007-11-08
PE20060288A1 (es)	2006-05-23
DK1732887T3 (da)	2008-04-28
ES2299025T3 (es)	2008-05-16
EP1732887A1 (de)	2006-12-20
KR20060134186A (ko)	2006-12-27
ECSP066899A (es)	2006-11-24
CA2560967A1 (en)	2005-10-20
IL178185A0 (en)	2006-12-31
NO20064892L (no)	2006-12-13
AU2005230900A1 (en)	2005-10-20
BRPI0509390A (pt)	2007-09-18
US20090093469A1 (en)	2009-04-09
TW200536532A (en)	2005-11-16
DE602005004268T2 (de)	2009-01-02
DE602005004268D1 (de)	2008-02-21
PL1732887T3 (pl)	2008-05-30
AR048675A1 (es)	2006-05-17
US20050222148A1 (en)	2005-10-06
WO2005097744A1 (en)	2005-10-20
US7517899B2 (en)	2009-04-14
CR8639A (es)	2007-06-08
US20090099164A1 (en)	2009-04-16

Legal Events

Date	Code	Title	Description
2008-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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