ATE383424T1 - Polypeptide, deren herstellung und verwendung - Google Patents

Polypeptide, deren herstellung und verwendung

Info

Publication number
ATE383424T1
ATE383424T1 AT98961474T AT98961474T ATE383424T1 AT E383424 T1 ATE383424 T1 AT E383424T1 AT 98961474 T AT98961474 T AT 98961474T AT 98961474 T AT98961474 T AT 98961474T AT E383424 T1 ATE383424 T1 AT E383424T1
Authority
AT
Austria
Prior art keywords
function
polypeptides
production
aids
diseases
Prior art date
Application number
AT98961474T
Other languages
English (en)
Inventor
Shuji Hinuma
Kazuhiko Tatemoto
Masaki Hosoya
Yugo Habata
Ryo Fujii
Chieko Kitada
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE383424T1 publication Critical patent/ATE383424T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98961474T 1997-12-24 1998-12-22 Polypeptide, deren herstellung und verwendung ATE383424T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP35395597 1997-12-24
JP3257798 1998-02-16
JP22085398 1998-08-04
JP27164598 1998-09-25

Publications (1)

Publication Number Publication Date
ATE383424T1 true ATE383424T1 (de) 2008-01-15

Family

ID=27459639

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961474T ATE383424T1 (de) 1997-12-24 1998-12-22 Polypeptide, deren herstellung und verwendung

Country Status (9)

Country Link
US (3) US6492324B1 (de)
EP (1) EP1040189B1 (de)
KR (1) KR20010033601A (de)
CN (1) CN1283228A (de)
AT (1) ATE383424T1 (de)
AU (1) AU1685499A (de)
CA (1) CA2313246A1 (de)
DE (1) DE69838986T2 (de)
WO (1) WO1999033976A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU770018B2 (en) * 1998-03-13 2004-02-12 Brown University Research Foundation Human N-type calcium channel isoform and uses thereof
AU5759399A (en) * 1998-09-25 2000-04-17 Takeda Chemical Industries Ltd. Peptide derivative
EP1138772A4 (de) * 1998-12-11 2005-04-06 Takeda Chemical Industries Ltd Verfahren zur herstellung von apelin
AU2001242749A1 (en) * 2000-03-23 2001-10-03 Takeda Chemical Industries Ltd. Peptide derivative
DE10138569A1 (de) * 2001-08-06 2003-04-30 Bayer Ag Regulation des APJ-Rezeptors
WO2003063892A1 (en) * 2002-01-29 2003-08-07 Takeda Chemical Industries, Ltd. Use of apelin
WO2004061085A2 (en) 2002-12-30 2004-07-22 The Regents Of The University Of California Methods and apparatus for pathogen detection and analysis
EP1598369B1 (de) * 2003-02-28 2010-12-08 Takeda Pharmaceutical Company Limited Anti tgr23-2 ligand antikörper und deren verwendungen
EP1613348B1 (de) * 2003-03-12 2010-06-23 The Arizona Board of Regents on Behalf of the University of Arizona Verfahren zur regulierung von angiogenese mit apelin-zusammensetzungen
US7947280B2 (en) * 2003-05-22 2011-05-24 The Board Of Trustees Of The Leland Stanford Junior University Apelin and uses thereof
WO2006019193A1 (ja) * 2004-08-20 2006-02-23 Takeda Pharmaceutical Company Limited 阻害剤・促進剤の用途
US20060045880A1 (en) * 2004-08-23 2006-03-02 Krieg Paul A Methods for modulating angiogenesis and apoptosis with apelin compositions
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
US20090233854A1 (en) 2005-12-20 2009-09-17 Takeda Pharmaceutical Company Limited Novel application of apelin
US20090324610A1 (en) * 2006-04-25 2009-12-31 Kyushu Univeristy, National University Corporation Gene associated with arteriosclerotic disease, and use thereof
WO2009043478A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
US8946382B2 (en) * 2009-02-27 2015-02-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Apelin peptides and methods of use
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
WO2013050441A1 (en) 2011-10-05 2013-04-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation
WO2013079487A1 (en) 2011-11-28 2013-06-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical composition for use in the treatment of dysfunction associated with aging
US8921307B2 (en) 2012-11-20 2014-12-30 Novartis Ag Synthetic linear apelin mimetics for the treatment of heart failure
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
WO2014152955A1 (en) 2013-03-14 2014-09-25 Regeneron Pharmaceuticals, Inc. Apelin fusion proteins and uses thereof
US9266925B2 (en) 2013-07-25 2016-02-23 Novartis Ag Cyclic polypeptides for the treatment of heart failure
BR112016001376A2 (pt) * 2013-07-25 2017-10-24 Novartis Ag bioconjugados de polipeptídeos de apelin sintéticos
WO2015077491A1 (en) 2013-11-20 2015-05-28 Regeneron Pharmaceuticals, Inc. Aplnr modulators and uses thereof
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
SG11201609706VA (en) 2014-06-23 2017-01-27 Novartis Ag Site specific protein modifications
WO2016061141A1 (en) 2014-10-13 2016-04-21 University Of Maryland, Baltimore Methods for treating cardiovascular dysfunction and improving fluid homeostasis with a peptide hormone
CA2972871A1 (en) 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
WO2016151018A1 (en) 2015-03-24 2016-09-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and pharmaceutical composition for use in the treatment of diabetes
US11484577B2 (en) 2016-02-15 2022-11-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction
EP3228630A1 (de) 2016-04-07 2017-10-11 IMBA-Institut für Molekulare Biotechnologie GmbH Kombination eines apelin-antagonisten und angiogeneseinhibitor zur behandlung von krebs
CN108376608B (zh) * 2018-02-10 2020-11-06 青岛大学 一种磁性纳米粒子及其制备磁性固相载体的用途
CN119613548A (zh) 2018-06-13 2025-03-14 鸿运华宁（杭州）生物医药有限公司 APJ抗体及其与Elabela的融合蛋白质，以及其药物组合物和应用
CN109575117B (zh) * 2018-12-14 2021-09-21 昆明积大制药股份有限公司 [Pyr1]-apelin-13的制备方法
AU2023316015A1 (en) 2022-07-25 2025-02-13 Centre Hospitalier Universitaire De Toulouse Use of apelin for the treatment of lymphedema
CN115920057B (zh) * 2023-01-03 2026-04-21 中国科学院合肥物质科学研究院 靶向aplnr蛋白棕榈酰化修饰的多肽及其在癌痛治疗中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE164884T1 (de) * 1992-11-17 1998-04-15 Icos Corp Neue sieben-transmembran-rezeptor v28
AU7115896A (en) * 1995-09-20 1997-04-09 Molecular Geriatrics Corporation Yeast receptor and g-protein fusion protein

Also Published As

Publication number Publication date
EP1040189B1 (de) 2008-01-09
DE69838986T2 (de) 2009-01-08
US20090075334A1 (en) 2009-03-19
DE69838986D1 (de) 2008-02-21
EP1040189A1 (de) 2000-10-04
US7410776B2 (en) 2008-08-12
US7799533B2 (en) 2010-09-21
WO1999033976A1 (en) 1999-07-08
US20030092618A1 (en) 2003-05-15
US6492324B1 (en) 2002-12-10
AU1685499A (en) 1999-07-19
CA2313246A1 (en) 1999-07-08
CN1283228A (zh) 2001-02-07
KR20010033601A (ko) 2001-04-25

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