ATE383430T1 - Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren - Google Patents
Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumorenInfo
- Publication number
- ATE383430T1 ATE383430T1 AT98912977T AT98912977T ATE383430T1 AT E383430 T1 ATE383430 T1 AT E383430T1 AT 98912977 T AT98912977 T AT 98912977T AT 98912977 T AT98912977 T AT 98912977T AT E383430 T1 ATE383430 T1 AT E383430T1
- Authority
- AT
- Austria
- Prior art keywords
- tumors
- recombinant antibodies
- bearing cells
- immune conjugates
- conjugates targeted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4143797P | 1997-03-20 | 1997-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE383430T1 true ATE383430T1 (de) | 2008-01-15 |
Family
ID=21916511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98912977T ATE383430T1 (de) | 1997-03-20 | 1998-03-19 | Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7541034B1 (de) |
| EP (1) | EP0970227B1 (de) |
| JP (3) | JP2002501488A (de) |
| AT (1) | ATE383430T1 (de) |
| AU (1) | AU740904B2 (de) |
| CA (1) | CA2284665C (de) |
| DE (1) | DE69838979T2 (de) |
| ES (1) | ES2300122T3 (de) |
| WO (1) | WO1998041641A1 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7541034B1 (en) * | 1997-03-20 | 2009-06-02 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors |
| US6183744B1 (en) * | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| JP3835827B2 (ja) | 1997-05-02 | 2006-10-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 悪性細胞に対する、ｏｎｃタンパク質を含む、免疫毒素 |
| US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
| JP2004512262A (ja) | 2000-06-20 | 2004-04-22 | アイデック ファーマスーティカルズ コーポレイション | 非放射性抗ｃｄ２０抗体／放射標識抗ｃｄ２２抗体の組合せ |
| US8034903B2 (en) | 2000-10-20 | 2011-10-11 | Chugai Seiyaku Kabushiki Kaisha | Degraded TPO agonist antibody |
| US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| US7355012B2 (en) * | 2001-09-26 | 2008-04-08 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mutated anti-CD22 antibodies with increased affinity to CD22-expressing leukemia cells |
| GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| SG187991A1 (en) | 2002-05-02 | 2013-03-28 | Wyeth Corp | Calicheamicin derivative-carrier conjugates |
| JP2004279086A (ja) | 2003-03-13 | 2004-10-07 | Konica Minolta Holdings Inc | 放射線画像変換パネル及び放射線画像変換パネルの製造方法 |
| US7982011B2 (en) | 2003-11-25 | 2011-07-19 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mutated anti-cd22 antibodies and immunoconjugates |
| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| JP5057967B2 (ja) | 2005-03-31 | 2012-10-24 | 中外製薬株式会社 | ｓｃ（Ｆｖ）２構造異性体 |
| AU2006242154B2 (en) | 2005-05-02 | 2011-11-03 | Cold Spring Harbor Laboratory | Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster |
| KR101367544B1 (ko) | 2005-06-10 | 2014-02-26 | 추가이 세이야쿠 가부시키가이샤 | 메글루민을 함유하는 단백질 제제의 안정화제, 및 그의이용 |
| CA2611726C (en) | 2005-06-10 | 2017-07-11 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(fv)2 |
| CA2646508A1 (en) * | 2006-03-17 | 2007-09-27 | Biogen Idec Ma Inc. | Stabilized polypeptide compositions |
| EP2009101B1 (de) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antikörpermodifikationsverfahren für die aufreinigung eines bispezifischen antikörpers |
| WO2009124109A1 (en) | 2008-04-04 | 2009-10-08 | The Government Of The U.S. A. As Represented By The Secretary Of The Dept. Of Health &Human Services | Human monoclonal antibodies specific for cd22 |
| WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| WO2011031441A1 (en) * | 2009-08-28 | 2011-03-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Therapy with a chimeric molecule and a pro-apoptotic agent |
| ES2544805T3 (es) | 2009-09-11 | 2015-09-04 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Exotoxina A de Pseudomonas mejorada con inmunogenicidad reducida |
| WO2012015912A1 (en) | 2010-07-30 | 2012-02-02 | Medimmune, Llc | Method for purifying active polypeptides or immunocojugates |
| WO2012097333A2 (en) | 2011-01-14 | 2012-07-19 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and method of use thereof |
| CN103561771B (zh) | 2011-03-17 | 2019-01-04 | 伯明翰大学 | 重新定向的免疫治疗 |
| KR20140033391A (ko) | 2011-06-09 | 2014-03-18 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 면역원성이 보다 낮은 t 세포 및/또는 b 세포 에피토프를 갖는 슈도모나스 외독소 a |
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| AU2012308591B2 (en) | 2011-09-16 | 2017-02-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Pseudomonas exotoxin a with less immunogenic B cell epitopes |
| ES2654060T3 (es) | 2011-10-20 | 2018-02-12 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Receptores de antígenos quiméricos anti-CD22 |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
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| US10441649B2 (en) | 2015-02-02 | 2019-10-15 | The University Of Birmingham | Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes |
| WO2016146833A1 (en) | 2015-03-19 | 2016-09-22 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance |
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| JP2024501971A (ja) | 2020-12-31 | 2024-01-17 | サナ バイオテクノロジー，インコーポレイテッド | Ｃａｒ－ｔ活性を調節するための方法及び組成物 |
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| US5476659A (en) | 1982-11-09 | 1995-12-19 | The Scripps Research Institute | Cancerous B cell treatment using substituted nucleoside derivatives |
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| US7541034B1 (en) * | 1997-03-20 | 2009-06-02 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors |
-
1998
- 1998-03-19 US US09/381,497 patent/US7541034B1/en not_active Expired - Fee Related
- 1998-03-19 WO PCT/US1998/005453 patent/WO1998041641A1/en not_active Ceased
- 1998-03-19 AU AU67646/98A patent/AU740904B2/en not_active Expired
- 1998-03-19 AT AT98912977T patent/ATE383430T1/de active
- 1998-03-19 EP EP98912977A patent/EP0970227B1/de not_active Expired - Lifetime
- 1998-03-19 CA CA2284665A patent/CA2284665C/en not_active Expired - Lifetime
- 1998-03-19 JP JP54081298A patent/JP2002501488A/ja not_active Withdrawn
- 1998-03-19 DE DE69838979T patent/DE69838979T2/de not_active Expired - Lifetime
- 1998-03-19 ES ES98912977T patent/ES2300122T3/es not_active Expired - Lifetime
-
2008
- 2008-03-18 JP JP2008070484A patent/JP2008208131A/ja active Pending
-
2009
- 2009-04-30 US US12/433,737 patent/US9592304B2/en not_active Expired - Fee Related
-
2010
- 2010-03-31 JP JP2010084519A patent/JP2010200752A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU740904B2 (en) | 2001-11-15 |
| EP0970227B1 (de) | 2008-01-09 |
| DE69838979D1 (de) | 2008-02-21 |
| US9592304B2 (en) | 2017-03-14 |
| DE69838979T2 (de) | 2008-12-24 |
| JP2010200752A (ja) | 2010-09-16 |
| WO1998041641A1 (en) | 1998-09-24 |
| AU6764698A (en) | 1998-10-12 |
| ES2300122T3 (es) | 2008-06-01 |
| JP2002501488A (ja) | 2002-01-15 |
| EP0970227A1 (de) | 2000-01-12 |
| US7541034B1 (en) | 2009-06-02 |
| JP2008208131A (ja) | 2008-09-11 |
| CA2284665C (en) | 2010-08-17 |
| CA2284665A1 (en) | 1998-09-24 |
| US20090305411A1 (en) | 2009-12-10 |
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