ATE384076T1 - Regulierte aktivierung von zellmembranrezeptoren durch metallchelatisierende agonisten - Google Patents

Regulierte aktivierung von zellmembranrezeptoren durch metallchelatisierende agonisten

Info

Publication number
ATE384076T1
ATE384076T1 AT01988426T AT01988426T ATE384076T1 AT E384076 T1 ATE384076 T1 AT E384076T1 AT 01988426 T AT01988426 T AT 01988426T AT 01988426 T AT01988426 T AT 01988426T AT E384076 T1 ATE384076 T1 AT E384076T1
Authority
AT
Austria
Prior art keywords
agonists
membrane receptors
cell membrane
metal chelating
activation
Prior art date
Application number
AT01988426T
Other languages
English (en)
Inventor
Evelyn Delorme
Kevin Duffy
Peter Lamb
Juan Luengo
Shin-Shay Tian
Original Assignee
Smithkline Beecham Corp
Ligand Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Ligand Pharmaceuticals filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE384076T1 publication Critical patent/ATE384076T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7153—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for colony-stimulating factors [CSF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01988426T 2000-12-21 2001-12-19 Regulierte aktivierung von zellmembranrezeptoren durch metallchelatisierende agonisten ATE384076T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25700200P 2000-12-21 2000-12-21

Publications (1)

Publication Number Publication Date
ATE384076T1 true ATE384076T1 (de) 2008-02-15

Family

ID=22974480

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01988426T ATE384076T1 (de) 2000-12-21 2001-12-19 Regulierte aktivierung von zellmembranrezeptoren durch metallchelatisierende agonisten

Country Status (8)

Country Link
US (1) US20040053299A1 (de)
EP (1) EP1351979B1 (de)
JP (1) JP2004532614A (de)
AT (1) ATE384076T1 (de)
AU (1) AU2002241734B2 (de)
CA (1) CA2432800A1 (de)
DE (1) DE60132488D1 (de)
WO (1) WO2002057300A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
MY142390A (en) 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US20090298179A1 (en) * 2003-04-29 2009-12-03 Connie Erickson-Miller Methods For Treating Degenerative Diseases/Injuries
EP1622609A4 (de) * 2003-04-29 2008-09-03 Smithkline Beecham Corp Verfahren zur behandlung von degenerativen erkrankungen/verletzungen
US20100004302A1 (en) * 2003-04-29 2010-01-07 Connie Erickson-Miller Methods for Treating Degenerative Diseases/Injuries
US20090048318A1 (en) * 2003-04-29 2009-02-19 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
US20090143453A1 (en) * 2003-04-29 2009-06-04 Connie Erickson-Miller Methods for treating degenerative diseases/injuries
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
WO2005118551A2 (en) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
CA2583764C (en) * 2004-10-25 2009-06-09 Ligand Pharmaceuticals, Inc. Thrombopoietin activity modulating compounds and methods
JP5344732B2 (ja) * 2006-04-28 2013-11-20 塩野義製薬株式会社 ヒトｔｐｏ受容体の膜貫通部位を有するキメラｔｐｏ受容体導入ノックイン非ヒト哺乳動物
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
SG176088A1 (en) 2009-05-29 2011-12-29 Glaxosmithkline Llc Methods of administration of thrombopoietin agonist compounds
WO2013074459A1 (en) * 2011-11-14 2013-05-23 Ligand Pharmaceuticals, Inc. Methods and compositions associated with the granulocyte colony-stimulating factor receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140120A (en) * 1993-02-12 2000-10-31 Board Of Trustees Of Leland Stanford Jr. University Regulated transcription of targeted genes and other biological events

Also Published As

Publication number Publication date
EP1351979B1 (de) 2008-01-16
WO2002057300A1 (en) 2002-07-25
DE60132488D1 (de) 2008-03-06
JP2004532614A (ja) 2004-10-28
CA2432800A1 (en) 2002-07-25
EP1351979A4 (de) 2005-04-27
AU2002241734B2 (en) 2006-02-23
US20040053299A1 (en) 2004-03-18
EP1351979A1 (de) 2003-10-15

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties