ATE384529T1 - Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen - Google Patents

Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen

Info

Publication number: ATE384529T1
Authority: AT; Austria
Prior art keywords: treatment; respiratory diseases; active ingredients; synergistic combination; ingredients selected
Prior art date: 2003-03-28

Application number

AT04723608T

Other languages

English (en)

Inventor

Daniela Bundschuh

Stefan-Lutz Wollin

Christian Weimar

Original Assignee

Nycomed Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-28

Filing date

2004-03-26

Publication date

2008-02-15

2004-03-26 Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE384529T1 publication Critical patent/ATE384529T1/de

Links

MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title abstract 2
229960002586 roflumilast Drugs 0.000 title abstract 2
LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title 1
230000001078 anti-cholinergic effect Effects 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000000241 respiratory effect Effects 0.000 title 1
239000011885 synergistic combination Substances 0.000 title 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
239000000812 cholinergic antagonist Substances 0.000 abstract 1
OEXHQOGQTVQTAT-JRNQLAHRSA-N ipratropium Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-JRNQLAHRSA-N 0.000 abstract 1
229960001888 ipratropium Drugs 0.000 abstract 1
NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 abstract 1
229960000797 oxitropium Drugs 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT04723608T 2003-03-28 2004-03-26 Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen ATE384529T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03007104		2003-03-28

Publications (1)

Publication Number	Publication Date
ATE384529T1 true ATE384529T1 (de)	2008-02-15

Family

ID=33040925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04723608T ATE384529T1 (de)	2003-03-28	2004-03-26	Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen

Country Status (13)

Country	Link
US (1)	US20060147382A1 (de)
EP (1)	EP1610787B1 (de)
AT (1)	ATE384529T1 (de)
CA (1)	CA2519679C (de)
CY (1)	CY1110373T1 (de)
DE (1)	DE602004011494T2 (de)
DK (1)	DK1610787T3 (de)
ES (1)	ES2300755T3 (de)
MX (1)	MXPA05010160A (de)
PL (1)	PL1610787T3 (de)
PT (1)	PT1610787E (de)
SI (1)	SI1610787T1 (de)
WO (1)	WO2004084896A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2165768B1 (es)	1999-07-14	2003-04-01	Almirall Prodesfarma Sa	Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
MY140561A (en)	2002-02-20	2009-12-31	Nycomed Gmbh	Dosage form containing pde 4 inhibitor as active ingredient
DK1606261T3 (da)	2003-03-10	2010-01-18	Nycomed Gmbh	Hidtil ukendt fremgangsmåde til fremstilling af roflumilast
US20050026887A1 (en) *	2003-07-29	2005-02-03	Boehringer Ingelheim International Gmbh	Medicaments for inhalation comprising an anticholinergic and a steroid
AU2005210085B2 (en) *	2004-02-06	2010-06-24	Meda Pharma Gmbh & Co. Kg	The combination of anticholinergics and glucocorticoids for the long-term treatment of asthma and COPD
PL1713471T3 (pl) *	2004-02-06	2012-06-29	Meda Pharma Gmbh & Co Kg	Kombinacja środków antycholinergicznych i inhibitorów fosfodiesterazy typu 4 do leczenia chorób oddechowych
NZ551669A (en) *	2004-05-31	2010-07-30	Almirall Lab	Combinations comprising antimuscarinic agents and PDE4 inhibitors
ES2257152B1 (es) *	2004-05-31	2007-07-01	Laboratorios Almirall S.A.	Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
AU2006224619B2 (en) *	2005-03-16	2012-06-07	Takeda Gmbh	Taste masked dosage form containing roflumilast
MX2007011273A (es) *	2005-03-16	2007-11-08	Meda Pharma Gmbh & Co Kg	La combinacion de anticolinergicos y antagonistas del receptor de leucotrieno para el tratamiento de enfermedades respiratorias.
US20060219242A1 (en) *	2005-03-30	2006-10-05	Boehringer Ingelheim International	Method for the Administration of an Anticholinergic by Inhalation
JP2009509980A (ja) *	2005-09-28	2009-03-12	メルクフロストカナダリミテツド	篩分けされたラクトースを含むエアゾール粉末製剤
WO2007071313A2 (en)	2005-12-21	2007-06-28	Meda Pharma Gmbh & Co Kg	Combination of anticholinergics, glucocorticoids, beta2-ag0nists, pde4 inhibitor and antileukotriene for the treatment of inflammatory diseases
EP2100599A1 (de)	2008-03-13	2009-09-16	Laboratorios Almirall, S.A.	Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
EP2100598A1 (de)	2008-03-13	2009-09-16	Laboratorios Almirall, S.A.	Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
EP2510928A1 (de)	2011-04-15	2012-10-17	Almirall, S.A.	Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE283033T1 (de) *	1998-07-24	2004-12-15	Jago Res Ag	Medizinische aerosolformulierungen
US20020052312A1 (en) *	2000-05-30	2002-05-02	Reiss Theodore F.	Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists
DE10110772A1 (de) *	2001-03-07	2002-09-12	Boehringer Ingelheim Pharma	Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren
US20020193393A1 (en) *	2001-03-07	2002-12-19	Michel Pairet	Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
ES2276942T3 (es) *	2001-05-25	2007-07-01	BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG	Combinacion de un inhibidor de pde4 y tiotropio o un derivado del mismo para tratar vias respiratorias obstructivas y otras enfermedades inflamatorias.
CA2446613A1 (en) *	2001-05-25	2002-12-05	Pfizer Inc.	A pde 4 inhibitor and an anti-cholinergic agent in combination for treating obstructive airways diseases
GB0118373D0 (en) *	2001-07-27	2001-09-19	Glaxo Group Ltd	Novel therapeutic method
US20050107420A1 (en) *	2002-05-23	2005-05-19	Boehringe Ingelheim Pharma Gmbh & Co. Kg	Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases

2004
- 2004-03-26 AT AT04723608T patent/ATE384529T1/de active
- 2004-03-26 CA CA2519679A patent/CA2519679C/en not_active Expired - Fee Related
- 2004-03-26 US US10/550,192 patent/US20060147382A1/en not_active Abandoned
- 2004-03-26 DE DE602004011494T patent/DE602004011494T2/de not_active Expired - Lifetime
- 2004-03-26 MX MXPA05010160A patent/MXPA05010160A/es active IP Right Grant
- 2004-03-26 EP EP04723608A patent/EP1610787B1/de not_active Expired - Lifetime
- 2004-03-26 PT PT04723608T patent/PT1610787E/pt unknown
- 2004-03-26 DK DK04723608T patent/DK1610787T3/da active
- 2004-03-26 PL PL04723608T patent/PL1610787T3/pl unknown
- 2004-03-26 SI SI200430665T patent/SI1610787T1/sl unknown
- 2004-03-26 WO PCT/EP2004/050376 patent/WO2004084896A1/en not_active Ceased
- 2004-03-26 ES ES04723608T patent/ES2300755T3/es not_active Expired - Lifetime
2008
- 2008-03-27 CY CY20081100350T patent/CY1110373T1/el unknown

Also Published As

Publication number	Publication date
PL1610787T3 (pl)	2008-07-31
CY1110373T1 (el)	2015-04-29
EP1610787B1 (de)	2008-01-23
PT1610787E (pt)	2008-04-23
CA2519679C (en)	2012-08-28
SI1610787T1 (sl)	2008-06-30
WO2004084896A1 (en)	2004-10-07
DK1610787T3 (da)	2008-06-02
US20060147382A1 (en)	2006-07-06
CA2519679A1 (en)	2004-10-07
MXPA05010160A (es)	2005-11-16
EP1610787A1 (de)	2006-01-04
DE602004011494T2 (de)	2009-01-22
DE602004011494D1 (de)	2008-03-13
ES2300755T3 (es)	2008-06-16

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