ATE384711T1 - Substituierte benzimidazol-2-one als vasopressin receptor antagonisten und neuropeptide y modulatoren - Google Patents

Substituierte benzimidazol-2-one als vasopressin receptor antagonisten und neuropeptide y modulatoren

Info

Publication number: ATE384711T1
Authority: AT; Austria
Prior art keywords: neuropeptide; modulators; receptor antagonists; vasopressin receptor; ischemia
Prior art date: 2000-10-27

Application number

AT01989314T

Other languages

English (en)

Inventor

Maud Urbanski

Joseph Gunnet

Keith Demarest

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-27

Filing date

2001-10-23

Publication date

2008-02-15

2001-10-23 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE384711T1 publication Critical patent/ATE384711T1/de

Links

101710151321 Melanostatin Proteins 0.000 title abstract 2
MYONAGGJKCJOBT-UHFFFAOYSA-N benzimidazol-2-one Chemical class C1=CC=CC2=NC(=O)N=C21 MYONAGGJKCJOBT-UHFFFAOYSA-N 0.000 title abstract 2
URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 title abstract 2
239000002536 vasopressin receptor antagonist Substances 0.000 title abstract 2
102100028427 Pro-neuropeptide Y Human genes 0.000 title 1
206010019280 Heart failures Diseases 0.000 abstract 2
208000000044 Amnesia Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010003225 Arteriospasm coronary Diseases 0.000 abstract 1
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
208000003890 Coronary Vasospasm Diseases 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
206010016807 Fluid retention Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
102400000064 Neuropeptide Y Human genes 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
206010030113 Oedema Diseases 0.000 abstract 1
208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 abstract 1
208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 abstract 1
208000001647 Renal Insufficiency Diseases 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
206010047163 Vasospasm Diseases 0.000 abstract 1
208000027418 Wounds and injury Diseases 0.000 abstract 1
230000016571 aggressive behavior Effects 0.000 abstract 1
208000022531 anorexia Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000027288 circadian rhythm Effects 0.000 abstract 1
208000019425 cirrhosis of liver Diseases 0.000 abstract 1
201000011634 coronary artery vasospasm Diseases 0.000 abstract 1
230000006378 damage Effects 0.000 abstract 1
206010061428 decreased appetite Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
201000001421 hyperglycemia Diseases 0.000 abstract 1
208000014674 injury Diseases 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
201000006370 kidney failure Diseases 0.000 abstract 1
230000006984 memory degeneration Effects 0.000 abstract 1
208000023060 memory loss Diseases 0.000 abstract 1
208000031225 myocardial ischemia Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT01989314T 2000-10-27 2001-10-23 Substituierte benzimidazol-2-one als vasopressin receptor antagonisten und neuropeptide y modulatoren ATE384711T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24381700P	2000-10-27	2000-10-27

Publications (1)

Publication Number	Publication Date
ATE384711T1 true ATE384711T1 (de)	2008-02-15

Family

ID=22920251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01989314T ATE384711T1 (de)	2000-10-27	2001-10-23	Substituierte benzimidazol-2-one als vasopressin receptor antagonisten und neuropeptide y modulatoren

Country Status (9)

Country	Link
EP (1)	EP1330451B1 (de)
JP (1)	JP2004517872A (de)
AT (1)	ATE384711T1 (de)
AU (1)	AU2002243419A1 (de)
DE (1)	DE60132611T2 (de)
DK (1)	DK1330451T3 (de)
ES (1)	ES2300376T3 (de)
PT (1)	PT1330451E (de)
WO (1)	WO2002055514A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL1912976T3 (pl) *	2005-07-21	2009-04-30	Hoffmann La Roche	Pochodne indol-3-ilokarbonylopiperydynobenzoimidazolu jako antagoniści receptora V1a
US8119676B2 (en)	2006-08-26	2012-02-21	Abbott GmbH & Co. HG	Substituted benzimidazolone derivatives, medicaments comprising them and their use
WO2013085957A1 (en)	2011-12-06	2013-06-13	Janssen Pharmaceutica Nv	Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors
WO2013085954A1 (en)	2011-12-06	2013-06-13	Janssen Pharmaceutica Nv	Substituted piperidinyl-carboxamide derivatives useful as scd 1 inhibitors
CN105492010B (zh) *	2013-08-19	2020-01-03	豪夫迈·罗氏有限公司	用于治疗相移睡眠障碍的V1a拮抗剂
CA3091951A1 (en)	2018-03-01	2019-09-06	Thomas Helledays Stiftelse For Medicinsk Forskning	Substituted benzodiazoles and use thereof in therapy
JPWO2022250108A1 (de) *	2021-05-26	2022-12-01

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3318900A (en) *	1964-05-06	1967-05-09	Janssen Pharmaceutica Nv	Derivatives of benzimidazolinyl piperidine
AU691829B2 (en) *	1993-07-16	1998-05-28	Merck & Co., Inc.	Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
US6057338A (en) *	1997-04-04	2000-05-02	Merck & Co., Inc.	Somatostatin agonists
US6329389B1 (en) *	1998-04-08	2001-12-11	Takeda Chemical Industries, Ltd.	Amine compounds, their production and use
JP2002525371A (ja) *	1998-09-30	2002-08-13	メルクシャープエンドドームリミテッド	Ｃｇｒｐリガンドとしてのベンゾイミダゾリニルピペリジン
GB9823873D0 (en) *	1998-10-30	1998-12-30	Pharmacia & Upjohn Spa	2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents

2001
- 2001-10-23 EP EP01989314A patent/EP1330451B1/de not_active Expired - Lifetime
- 2001-10-23 ES ES01989314T patent/ES2300376T3/es not_active Expired - Lifetime
- 2001-10-23 DE DE60132611T patent/DE60132611T2/de not_active Expired - Fee Related
- 2001-10-23 DK DK01989314T patent/DK1330451T3/da active
- 2001-10-23 WO PCT/US2001/051108 patent/WO2002055514A2/en not_active Ceased
- 2001-10-23 JP JP2002556183A patent/JP2004517872A/ja active Pending
- 2001-10-23 AT AT01989314T patent/ATE384711T1/de not_active IP Right Cessation
- 2001-10-23 PT PT01989314T patent/PT1330451E/pt unknown
- 2001-10-23 AU AU2002243419A patent/AU2002243419A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PT1330451E (pt)	2008-03-13
ES2300376T3 (es)	2008-06-16
DE60132611T2 (de)	2009-02-19
DK1330451T3 (da)	2008-11-10
EP1330451B1 (de)	2008-01-23
EP1330451A2 (de)	2003-07-30
WO2002055514A2 (en)	2002-07-18
AU2002243419A1 (en)	2002-07-24
JP2004517872A (ja)	2004-06-17
WO2002055514A3 (en)	2002-11-21
DE60132611D1 (de)	2008-03-13

Legal Events

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2008-08-15

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2010-07-15

REN

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MY135688A (en)	2008-06-30	Novel substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide y modulators
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