ATE385257T1 - Oligonukleotid-unterstützte koaleszenz - Google Patents

Oligonukleotid-unterstützte koaleszenz

Info

Publication number: ATE385257T1
Authority: AT; Austria
Prior art keywords: oligonucleotide; coalescence; assisted; cells; outwardly projecting
Prior art date: 2000-10-12

Application number

AT01987791T

Other languages

English (en)

Inventor

Sanjay Tyagi

Fred Kramer

Osama Alsmadi

Original Assignee

Univ New Jersey Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2001-10-11

Publication date

2008-02-15

2001-10-11 Application filed by Univ New Jersey Med filed Critical Univ New Jersey Med

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE385257T1 publication Critical patent/ATE385257T1/de

Links

238000004581 coalescence Methods 0.000 title abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 3
238000004873 anchoring Methods 0.000 abstract 2
230000000295 complement effect Effects 0.000 abstract 2
239000003298 DNA probe Substances 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT01987791T 2000-10-12 2001-10-11 Oligonukleotid-unterstützte koaleszenz ATE385257T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23969800P	2000-10-12	2000-10-12

Publications (1)

Publication Number	Publication Date
ATE385257T1 true ATE385257T1 (de)	2008-02-15

Family

ID=22903339

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01987791T ATE385257T1 (de)	2000-10-12	2001-10-11	Oligonukleotid-unterstützte koaleszenz

Country Status (10)

Country	Link
US (1)	US7129087B2 (de)
EP (1)	EP1332220B1 (de)
JP (1)	JP4115833B2 (de)
CN (1)	CN1240842C (de)
AT (1)	ATE385257T1 (de)
AU (2)	AU3237902A (de)
BR (1)	BR0114618B1 (de)
CA (1)	CA2425193C (de)
DE (1)	DE60132670T2 (de)
WO (1)	WO2002033045A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0301038D0 (sv) *	2003-04-07	2003-04-07	Pro Forma Xi Ab	Surface immobilised multilayer structure of vesicles
NZ549643A (en) *	2004-02-26	2009-07-31	Layerlab Aktiebolag	Methods of forming lipid membrane attached linkers comprising contacting membrane with an oligonucleotide having two or more hydrophobic anchoring moieties
US9650407B2 (en)	2011-11-02	2017-05-16	The Regents Of The University Of California	Reprogramming of cellular adhesion
JP6607936B2 (ja) *	2015-06-08	2019-11-20	国立研究開発法人科学技術振興機構	高密度微小チャンバーアレイおよびこれを用いた測定方法
EP3440090B1 (de) *	2016-04-06	2022-09-28	Ohio State Innovation Foundation	Rna ligand-anzeigende exosomen zur spezifischen abgabe von therapeutika an zellen durch rna-nanotechnologie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925517A (en) *	1993-11-12	1999-07-20	The Public Health Research Institute Of The City Of New York, Inc.	Detectably labeled dual conformation oligonucleotide probes, assays and kits
GB9404709D0 (en)	1994-03-11	1994-04-27	Multilyte Ltd	Binding assay
US5908635A (en) *	1994-08-05	1999-06-01	The United States Of America As Represented By The Department Of Health And Human Services	Method for the liposomal delivery of nucleic acids
US5756352A (en) *	1995-06-07	1998-05-26	Gen-Probe Incorporated	Thiocationic lipid-nucleic acid conjugates
US5908777A (en) *	1995-06-23	1999-06-01	University Of Pittsburgh	Lipidic vector for nucleic acid delivery
US5821354A (en) *	1996-11-26	1998-10-13	Angiogene Inc.	Radiolabeled DNA oligonucleotide and method of preparation
US6506559B1 (en) *	1997-12-23	2003-01-14	Carnegie Institute Of Washington	Genetic inhibition by double-stranded RNA
GB9819417D0 (en)	1998-09-07	1998-10-28	Secr Defence	Reaction method
ES2251134T3 (es)	1999-06-08	2006-04-16	Gentium S.P.A.	Uso de complejos entre liposomas cationicos y polidesoxirribonucleotidos como medicamentos.

2001
- 2001-10-11 WO PCT/US2001/042658 patent/WO2002033045A2/en not_active Ceased
- 2001-10-11 BR BRPI0114618-1A patent/BR0114618B1/pt not_active IP Right Cessation
- 2001-10-11 CN CNB018200036A patent/CN1240842C/zh not_active Expired - Fee Related
- 2001-10-11 AU AU3237902A patent/AU3237902A/xx active Pending
- 2001-10-11 AU AU2002232379A patent/AU2002232379B2/en not_active Ceased
- 2001-10-11 JP JP2002536415A patent/JP4115833B2/ja not_active Expired - Fee Related
- 2001-10-11 DE DE60132670T patent/DE60132670T2/de not_active Expired - Lifetime
- 2001-10-11 US US10/398,833 patent/US7129087B2/en not_active Expired - Lifetime
- 2001-10-11 EP EP01987791A patent/EP1332220B1/de not_active Expired - Lifetime
- 2001-10-11 CA CA2425193A patent/CA2425193C/en not_active Expired - Fee Related
- 2001-10-11 AT AT01987791T patent/ATE385257T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2425193C (en)	2011-09-20
EP1332220B1 (de)	2008-01-30
CN1240842C (zh)	2006-02-08
WO2002033045A2 (en)	2002-04-25
CA2425193A1 (en)	2002-04-25
WO2002033045A3 (en)	2002-10-10
CN1505683A (zh)	2004-06-16
AU3237902A (en)	2002-04-29
JP4115833B2 (ja)	2008-07-09
JP2004520816A (ja)	2004-07-15
US7129087B2 (en)	2006-10-31
EP1332220A2 (de)	2003-08-06
DE60132670T2 (de)	2009-02-05
DE60132670D1 (de)	2008-03-20
BR0114618B1 (pt)	2014-06-10
US20040013654A1 (en)	2004-01-22
EP1332220A4 (de)	2004-07-14
BR0114618A (pt)	2005-12-13
AU2002232379B2 (en)	2006-07-13

Legal Events

Date	Code	Title	Description
2008-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
WO2001012862A3 (en)	2002-05-02	Compositions and methods for preparing oligonucleotide solutions
BR9812785A (pt)	2000-10-10	"imidazotriazinonas 2-fenil-substituìdas como inibidores de fosfodiesterase"
EP1765417A4 (de)	2009-03-25	Immunstimulatorische oligonucleotid-multimere
PL366039A1 (en)	2005-01-24	Antisense oligonucleotides against vr1
DE602006016941D1 (de)	2010-10-28	Verfahren und system zur absoluten bestimmung einer prozentualen plättchenhäufung
DE69621953D1 (de)	2002-07-25	Vehikel zum einbringen von nukleinsäuren in zellen
WO2001091727A3 (de)	2002-05-10	Selbstemulgierende wirkstofformulierung und verwendung dieser formulierung
EP1236043A4 (de)	2003-01-15	Elektrochemisches verfahren zur anreicherung eines mikroorganismus sowie ein biosensor zur analyse organischer substanzen und des bsb
WO2003074731A3 (en)	2004-01-08	Nucleic acid probes, their synthesis and use
WO1999037806A3 (en)	1999-09-30	Modified nucleic acid probes and uses thereof
DE69942459D1 (de)	2010-07-15	Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
EP1546327A4 (de)	2005-11-09	Selektion und isolierung lebender zellen unter verwendung rna-bindender sonden
TW200700725A (en)	2007-01-01	Detection of nucleic acid associated with disease
BRPI0512480A (pt)	2008-03-11	aperfeiçoamentos em aparelho de teste de microorganismos e relacionados com o mesmo e métodos de utilização do mesmo
DE69609725D1 (de)	2000-09-14	Neue polymerträger zur nukleinsäuresynthese
BR0013012A (pt)	2002-04-30	Composição contendo substância ativa, sua produção e seu uso
WO2001075157A1 (en)	2001-10-11	Probe for constructing probe polymer, method of constructing probe polymer and utilization thereof
DE69937689D1 (de)	2008-01-17	Stabiele transfizierte zellen zum auffinden von wirkstoffen, die die mrna stabilität beeinflussen
ATE385257T1 (de)	2008-02-15	Oligonukleotid-unterstützte koaleszenz
WO2000070945A3 (en)	2001-02-15	Fatty acid elongation genes and uses thereof
WO2003035702A3 (de)	2003-12-18	Invertormischungen für polymerdispersionen mit verbesserter umweltverträglichkeit
ID27760A (id)	2001-04-26	Poliketida-poliketida, pembuatannya, dan bahan-bahan untuk penggunaannya
DE602004016363D1 (de)	2008-10-16	Universaladaptorclip
WO2002029085A3 (en)	2004-06-24	Nucleotide detection method
DE602005022714D1 (de)	2010-09-16	Hybridisierung von pna-sonden in alkohollösungen