ATE386105T1 - CHIMERIC HUMAN PAPILLOMAVIRUS (HPV) L1 MOLECULES AND THEIR USES - Google Patents

CHIMERIC HUMAN PAPILLOMAVIRUS (HPV) L1 MOLECULES AND THEIR USES

Info

Publication number
ATE386105T1
ATE386105T1 AT01942170T AT01942170T ATE386105T1 AT E386105 T1 ATE386105 T1 AT E386105T1 AT 01942170 T AT01942170 T AT 01942170T AT 01942170 T AT01942170 T AT 01942170T AT E386105 T1 ATE386105 T1 AT E386105T1
Authority
AT
Austria
Prior art keywords
hpv
molecules
human papillomavirus
chimeric human
proteins
Prior art date
Application number
AT01942170T
Other languages
German (de)
Inventor
Susan Wilson
Wendy White
Joann Suzich
Brian Mullikin
Original Assignee
Medimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Inc filed Critical Medimmune Inc
Application granted granted Critical
Publication of ATE386105T1 publication Critical patent/ATE386105T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/084—Papillomaviridae (F); Polyomaviridae (F), e.g. SV40, BK virus or JC virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.
AT01942170T 2000-06-21 2001-06-12 CHIMERIC HUMAN PAPILLOMAVIRUS (HPV) L1 MOLECULES AND THEIR USES ATE386105T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21283900P 2000-06-21 2000-06-21

Publications (1)

Publication Number Publication Date
ATE386105T1 true ATE386105T1 (en) 2008-03-15

Family

ID=22792617

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01942170T ATE386105T1 (en) 2000-06-21 2001-06-12 CHIMERIC HUMAN PAPILLOMAVIRUS (HPV) L1 MOLECULES AND THEIR USES

Country Status (11)

Country Link
US (2) US6908613B2 (en)
EP (1) EP1292328B1 (en)
AT (1) ATE386105T1 (en)
AU (2) AU2001275458B2 (en)
CA (1) CA2411945C (en)
CY (1) CY1108106T1 (en)
DE (1) DE60132770T2 (en)
DK (1) DK1292328T3 (en)
ES (1) ES2301551T3 (en)
PT (1) PT1292328E (en)
WO (1) WO2001097840A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69935606T9 (en) 1998-10-16 2021-03-11 Glaxosmithkline Biologicals S.A. ADJUVANCE SYSTEMS AND VACCINE
US6908613B2 (en) * 2000-06-21 2005-06-21 Medimmune, Inc. Chimeric human papillomavirus (HPV) L1 molecules and uses therefor
DE10137102A1 (en) 2001-07-30 2003-02-27 Deutsches Krebsforsch Polyvalent vaccine against diseases caused by papillomaviruses, processes for their production and their use
GB0206359D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
GB0206360D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
WO2004056389A1 (en) * 2002-12-20 2004-07-08 Glaxosmithkline Biologicals Sa Hpv-16 and -18 l1 vlp vaccine
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
WO2004062584A2 (en) * 2003-01-10 2004-07-29 Regents Of The University Of Colorado Therapeutic and prophylactic vaccine for the treatment and prevention of papillomavirus infection
US20060029612A1 (en) * 2004-04-15 2006-02-09 Large Scale Biology Corporation Prevention and treatment of recurrent respiratory papillomatosis
PE20060434A1 (en) * 2004-06-16 2006-06-08 Glaxosmithkline Biolog Sa IMMUNOGENIC COMPOSITION INCLUDING PLV OR CAPSOMERS OF HPV 16, HPV 18 AND AT LEAST ANOTHER TYPE OF HPV CANCER
US7758866B2 (en) * 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
ATE474596T1 (en) * 2004-09-10 2010-08-15 Asahi Glass Co Ltd VACCINE AGAINST HUMAN PAPILLOMAVIRUS FOR ORAL ADMINISTRATION
JP4182074B2 (en) * 2005-03-03 2008-11-19 ファナック株式会社 Hand and handling robot
US20060240456A1 (en) * 2005-03-22 2006-10-26 Liaohai Chen Nanosized biological container and manufacture thereof
AR053715A1 (en) * 2005-04-26 2007-05-16 Glaxosmithkline Biolog Sa HPV MULTIVALENT VACCINE
CA2606092A1 (en) * 2005-04-26 2006-11-02 Glaxosmithkline Biologicals S.A. Vaccine
AU2006295040A1 (en) * 2005-09-08 2007-04-05 Kentucky Bioprocessing, Llc Modified tobacco mosaic virus particles as scaffolds for display of protein antigens for vaccine applications
WO2010036400A2 (en) * 2008-05-02 2010-04-01 University Of Rochester Arrayed detector system for measurement of anti-viral immune response
AU2010243489A1 (en) * 2009-05-01 2011-12-22 Redbiotec Ag Recombinant virus-like particles encoded by multi-gene vector
CN114127093B (en) * 2019-07-19 2024-04-12 神州细胞工程有限公司 Chimeric human papillomavirus type 45 L1 protein
WO2021013069A1 (en) * 2019-07-19 2021-01-28 神州细胞工程有限公司 Chimeric human papillomavirus type 11 l1 protein
MY207280A (en) * 2019-07-19 2025-02-13 Sinocelltech Ltd Polyvalent immunogenicity composition for human papillomavirus
WO2021013070A1 (en) * 2019-07-19 2021-01-28 神州细胞工程有限公司 Chimeric human papillomavirus 35 type l1 protein
WO2021013072A1 (en) * 2019-07-19 2021-01-28 神州细胞工程有限公司 Chimeric human papillomavirus type 39 l1 protein
WO2021013073A1 (en) * 2019-07-19 2021-01-28 神州细胞工程有限公司 Chimeric papillomavirus l1 protein
CN114174320B (en) * 2019-07-19 2024-05-24 神州细胞工程有限公司 Chimeric human papillomavirus type 18 L1 protein
CN114127295B (en) * 2019-07-19 2024-05-14 神州细胞工程有限公司 Chimeric human papillomavirus 16-type L1 protein
CN110646612A (en) * 2019-09-30 2020-01-03 源道隆（苏州）医学科技有限公司 Reagent and kit for detecting serum HPV antibody
TWI858159B (en) * 2020-10-13 2024-10-11 大陸商神州細胞工程有限公司 Human papillomavirus polyvalent immunogenic composition
US20240075124A1 (en) * 2021-01-14 2024-03-07 Sinocelltech Ltd Stable formulation of human papillomavirus virus-like particle vaccine
CN117737311B (en) * 2024-02-20 2024-04-19 湖南派智生物科技有限公司 Universal primer pair, reagent and kit for detecting canine papillomavirus and application of universal primer pair

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618536A (en) * 1992-09-03 1997-04-08 The United States Of America As Represented By The Department Of Health And Human Services Chimeric papillomavirus-like particles
WO1996011272A2 (en) * 1994-10-07 1996-04-18 Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh Papilloma virus-like particles, fusion proteins and process for producing the same
ES2258778T3 (en) * 1995-07-19 2006-09-01 MERCK & CO., INC. PARTICLES SIMILAR TO SYNTHETIC VIRUSES HPV11.
AUPO390396A0 (en) * 1996-11-29 1996-12-19 Csl Limited Novel promiscuous T helper cell epitopes
FR2767217B1 (en) * 1997-08-06 1999-11-12 Conception Organisation Logist SYSTEM FOR READING AND AUTHENTICATING A MAGNETIC CODE
US6228368B1 (en) * 1997-10-06 2001-05-08 Loyola University Of Chicago Papilloma virus capsomere formulations and method of use
WO2000035479A1 (en) * 1998-12-17 2000-06-22 Merck & Co., Inc. Synthetic virus-like particles with heterologous epitopes
US6908613B2 (en) * 2000-06-21 2005-06-21 Medimmune, Inc. Chimeric human papillomavirus (HPV) L1 molecules and uses therefor

Also Published As

Publication number Publication date
ES2301551T3 (en) 2008-07-01
US20060127979A1 (en) 2006-06-15
PT1292328E (en) 2008-05-19
EP1292328A1 (en) 2003-03-19
DK1292328T3 (en) 2008-06-16
US7390487B2 (en) 2008-06-24
US20040224305A1 (en) 2004-11-11
CA2411945C (en) 2015-05-26
DE60132770T2 (en) 2009-05-07
DE60132770D1 (en) 2008-03-27
CY1108106T1 (en) 2014-02-12
US6908613B2 (en) 2005-06-21
EP1292328B1 (en) 2008-02-13
WO2001097840A1 (en) 2001-12-27
AU2001275458B2 (en) 2004-08-19
CA2411945A1 (en) 2001-12-27
AU7545801A (en) 2002-01-02
EP1292328A4 (en) 2005-01-26

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