ATE386111T1 - Zusammensetzungen, verfahren und kits zum nachweis eines antigens auf einer zelle und in einem biologischen gemisch - Google Patents

Zusammensetzungen, verfahren und kits zum nachweis eines antigens auf einer zelle und in einem biologischen gemisch

Info

Publication number
ATE386111T1
ATE386111T1 AT03754675T AT03754675T ATE386111T1 AT E386111 T1 ATE386111 T1 AT E386111T1 AT 03754675 T AT03754675 T AT 03754675T AT 03754675 T AT03754675 T AT 03754675T AT E386111 T1 ATE386111 T1 AT E386111T1
Authority
AT
Austria
Prior art keywords
detecting
cell
antigen
phage
kits
Prior art date
Application number
AT03754675T
Other languages
English (en)
Inventor
Donald Siegel
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of ATE386111T1 publication Critical patent/ATE386111T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT03754675T 2002-09-18 2003-09-18 Zusammensetzungen, verfahren und kits zum nachweis eines antigens auf einer zelle und in einem biologischen gemisch ATE386111T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41169302P 2002-09-18 2002-09-18

Publications (1)

Publication Number Publication Date
ATE386111T1 true ATE386111T1 (de) 2008-03-15

Family

ID=32030711

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03754675T ATE386111T1 (de) 2002-09-18 2003-09-18 Zusammensetzungen, verfahren und kits zum nachweis eines antigens auf einer zelle und in einem biologischen gemisch

Country Status (10)

Country Link
US (2) US8617805B2 (de)
EP (1) EP1554401B1 (de)
JP (1) JP4601427B2 (de)
AT (1) ATE386111T1 (de)
AU (1) AU2003272491B2 (de)
CA (1) CA2499355C (de)
DE (1) DE60319121T2 (de)
ES (1) ES2301818T3 (de)
MX (1) MXPA05002934A (de)
WO (1) WO2004027028A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004027028A2 (en) * 2002-09-18 2004-04-01 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture
GB0304832D0 (en) * 2003-03-04 2003-04-09 Secr Defence Assay method
US7776553B2 (en) 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
US20070100557A1 (en) * 2005-10-24 2007-05-03 Yi Zhang Selection of genotyped transfusion donors by cross-matching to genotyped recipients
EP1963494B1 (de) * 2005-11-29 2014-10-08 The Trustees of The University of Pennsylvania Diagnostische phagenpartikelreagentien
ES2391906T3 (es) * 2007-09-12 2012-11-30 Institut Pasteur Polinucleótido apto para un ensayo indicador basado en una sola célula para controlar los patrones de expresión génica con una resolución espacio-temporal elevada
CN102944684B (zh) * 2012-11-07 2014-09-10 武汉康莱博生物科技有限公司 抗a、抗b血型定型试剂
US20200333322A1 (en) * 2017-07-31 2020-10-22 Essenlix Corporation Assays with reduced interference
JPWO2019069980A1 (ja) * 2017-10-04 2020-10-22 晋一郎 川本 大腸癌の検出方法
EP3746485B1 (de) * 2018-02-02 2023-11-22 Bloodworks Antikörper-screening mit transgenen antigenen
GB201906331D0 (en) * 2019-05-03 2019-06-19 Governing Council Of The Univ Of Toronto Digital microfluidic agglutination assays

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856092A (en) * 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
AU662148B2 (en) * 1991-04-10 1995-08-24 Scripps Research Institute, The Heterodimeric receptor libraries using phagemids
WO1994005781A1 (en) * 1992-09-04 1994-03-17 The Scripps Research Institute Phagemids coexpressing a surface receptor and a surface heterologous protein
PT744958E (pt) * 1994-01-31 2003-11-28 Univ Boston Bancos de anticorpos policlonais
US5691132A (en) * 1994-11-14 1997-11-25 Cerus Corporation Method for inactivating pathogens in red cell compositions using quinacrine mustard
EP1416280A3 (de) * 1995-09-14 2005-08-10 The Regents of the University of California Antikörper spezifisch für natives PrPsc
JP2744938B2 (ja) * 1996-01-30 1998-04-28 工業技術院長 多孔質高強度低熱伝導窒化ケイ素質セラミックス及びその製造方法
US5716784A (en) * 1996-02-05 1998-02-10 The Perkin-Elmer Corporation Fluorescence detection assay for homogeneous PCR hybridization systems
US6747136B2 (en) * 1996-04-19 2004-06-08 Karolinska Innovations Ab Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen
ATE428801T1 (de) * 1996-06-04 2009-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
US6255455B1 (en) 1996-10-11 2001-07-03 The Trustees Of The University Of Pennsylvania Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
US5876925A (en) 1996-10-11 1999-03-02 The Trustees Of The University Of Pennsylvania Magnetically activated cell sorting for production of proteins
US5985543A (en) * 1996-10-11 1999-11-16 The Trustees Of The University Of Pennsylvania Compositions and methods for detection of antibody binding to cells
US6153411A (en) 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
CA2368875A1 (en) * 1999-04-14 2000-10-19 The Government Of The United States Of America High sensitivity phage display biomolecule detection
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
WO2004027028A2 (en) * 2002-09-18 2004-04-01 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture
EP1963494B1 (de) * 2005-11-29 2014-10-08 The Trustees of The University of Pennsylvania Diagnostische phagenpartikelreagentien

Also Published As

Publication number Publication date
DE60319121D1 (de) 2008-03-27
CA2499355A1 (en) 2004-04-01
US8586293B2 (en) 2013-11-19
JP2006516088A (ja) 2006-06-22
DE60319121T2 (de) 2009-02-05
EP1554401A2 (de) 2005-07-20
HK1077851A1 (en) 2006-02-24
EP1554401B1 (de) 2008-02-13
US20050191622A1 (en) 2005-09-01
AU2003272491A1 (en) 2004-04-08
ES2301818T3 (es) 2008-07-01
JP4601427B2 (ja) 2010-12-22
MXPA05002934A (es) 2006-02-24
WO2004027028A3 (en) 2005-05-26
AU2003272491B2 (en) 2008-10-02
US8617805B2 (en) 2013-12-31
CA2499355C (en) 2012-07-17
WO2004027028A2 (en) 2004-04-01
US20050136399A1 (en) 2005-06-23
EP1554401A4 (de) 2006-04-12

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