ATE386335T1 - Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie - Google Patents

Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie

Info

Publication number
ATE386335T1
ATE386335T1 AT00972498T AT00972498T ATE386335T1 AT E386335 T1 ATE386335 T1 AT E386335T1 AT 00972498 T AT00972498 T AT 00972498T AT 00972498 T AT00972498 T AT 00972498T AT E386335 T1 ATE386335 T1 AT E386335T1
Authority
AT
Austria
Prior art keywords
atmospheric pressure
analyte
ionization
dopant
spray
Prior art date
Application number
AT00972498T
Other languages
English (en)
Inventor
Damon Robb
Andries Bruins
Original Assignee
Mds Inc Through Its Mds Sciex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Inc Through Its Mds Sciex filed Critical Mds Inc Through Its Mds Sciex
Application granted granted Critical
Publication of ATE386335T1 publication Critical patent/ATE386335T1/de

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/162—Direct photo-ionisation, e.g. single photon or multi-photon ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H01J49/045—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol with means for using a nebulising gas, i.e. pneumatically assisted
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/049—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for applying heat to desorb the sample; Evaporation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Extraction Or Liquid Replacement (AREA)
AT00972498T 1999-10-29 2000-10-26 Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie ATE386335T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16270999P 1999-10-29 1999-10-29

Publications (1)

Publication Number Publication Date
ATE386335T1 true ATE386335T1 (de) 2008-03-15

Family

ID=22586814

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00972498T ATE386335T1 (de) 1999-10-29 2000-10-26 Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie

Country Status (8)

Country Link
US (1) US6534765B1 (de)
EP (1) EP1226602B1 (de)
JP (1) JP4600909B2 (de)
AT (1) ATE386335T1 (de)
AU (1) AU772052B2 (de)
CA (1) CA2386832C (de)
DE (1) DE60038033T2 (de)
WO (1) WO2001033605A2 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653626B2 (en) 1994-07-11 2003-11-25 Agilent Technologies, Inc. Ion sampling for APPI mass spectrometry
US6630664B1 (en) * 1999-02-09 2003-10-07 Syagen Technology Atmospheric pressure photoionizer for mass spectrometry
US7119342B2 (en) * 1999-02-09 2006-10-10 Syagen Technology Interfaces for a photoionization mass spectrometer
US7375319B1 (en) 2000-06-09 2008-05-20 Willoughby Ross C Laser desorption ion source
US6835929B2 (en) 2002-01-25 2004-12-28 Waters Investments Limited Coaxial atmospheric pressure photoionization source for mass spectrometers
US6825462B2 (en) * 2002-02-22 2004-11-30 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
GB2425399B (en) * 2002-05-31 2007-03-14 Waters Investments Ltd A high speed combination multi-mode ionization source for mass spectrometers
US6888132B1 (en) 2002-06-01 2005-05-03 Edward W Sheehan Remote reagent chemical ionization source
US7095019B1 (en) 2003-05-30 2006-08-22 Chem-Space Associates, Inc. Remote reagent chemical ionization source
US6646257B1 (en) * 2002-09-18 2003-11-11 Agilent Technologies, Inc. Multimode ionization source
US20040256550A1 (en) * 2003-01-27 2004-12-23 Finch Jeffrey W. Coaxial atmospheric pressure photoionization source for mass spectrometers
JP3686657B2 (ja) * 2003-02-27 2005-08-24 帝国臓器製薬株式会社 ステロイド性生体内微量物質の測定方法
US7332347B2 (en) 2003-04-14 2008-02-19 Liang Li Apparatus and method for concentrating and collecting analytes from a flowing liquid stream
US7095016B2 (en) * 2003-04-29 2006-08-22 Sri International Direct liquid injection inlet to a laser photoionization apparatus
DE102004025841B4 (de) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Verfahren und Vorrichtung zur massenspektroskopischen Untersuchung von Analyten
JP4782796B2 (ja) * 2004-11-09 2011-09-28 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 質量分析計用イオン源
US20060255261A1 (en) * 2005-04-04 2006-11-16 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
US7138626B1 (en) 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
GB2434250B (en) * 2005-05-24 2010-11-10 Bruker Daltonik Gmbh Method and device for mass spectrometry examination of analytes
US7568401B1 (en) 2005-06-20 2009-08-04 Science Applications International Corporation Sample tube holder
US7946150B2 (en) * 2005-07-20 2011-05-24 Smiths Detection-Watford Limited Detection systems
US7576322B2 (en) 2005-11-08 2009-08-18 Science Applications International Corporation Non-contact detector system with plasma ion source
FR2896585B1 (fr) * 2006-01-20 2008-12-05 Commissariat Energie Atomique Introduction d'additifs pour une interface d'ionisation a pression atmospherique en entree d'un spectrometre
JP4679389B2 (ja) * 2006-02-20 2011-04-27 株式会社日立ハイテクノロジーズ イオン化エネルギーの低い試料を検出する検出器及び分析装置
US7642510B2 (en) * 2006-08-22 2010-01-05 E.I. Du Pont De Nemours And Company Ion source for a mass spectrometer
US7880140B2 (en) * 2007-05-02 2011-02-01 Dh Technologies Development Pte. Ltd Multipole mass filter having improved mass resolution
KR100902946B1 (ko) * 2007-05-15 2009-06-15 (주)에이치시티 소프트 엑스레이 광이온화 하전기
US8123396B1 (en) 2007-05-16 2012-02-28 Science Applications International Corporation Method and means for precision mixing
US8963075B2 (en) * 2007-12-13 2015-02-24 Academia Sinica Bioparticle ionization with pressure controlled discharge for mass spectrometry
US8044346B2 (en) * 2007-12-21 2011-10-25 Licentia Oy Method and system for desorbing and ionizing chemical compounds from surfaces
US8008617B1 (en) 2007-12-28 2011-08-30 Science Applications International Corporation Ion transfer device
US8071957B1 (en) 2009-03-10 2011-12-06 Science Applications International Corporation Soft chemical ionization source
US8642952B2 (en) * 2009-11-10 2014-02-04 Waters Technologies Corporation Apparatus and methods for gas chromatography-mass spectrometry
FR2953927B1 (fr) * 2009-12-14 2012-02-03 Commissariat Energie Atomique Dispositif et procede de fabrication d'echantillon a partir d'un liquide
WO2011127130A1 (en) * 2010-04-09 2011-10-13 Water Technologies Corporation Apparatus for photoionization of an analyte in an eluent of a chromatography column
US8723111B2 (en) * 2011-09-29 2014-05-13 Morpho Detection, Llc Apparatus for chemical sampling and method of assembling the same
WO2013152344A1 (en) 2012-04-06 2013-10-10 Implant Sciences Corporation Selective ionization using high frequency filtering of reactive ions
CA2900105A1 (en) * 2013-01-31 2014-08-07 Smiths Detection Montreal Inc. Surface ionization source
US9018598B2 (en) * 2013-05-18 2015-04-28 Brechtel Manufacturing, Inc. Aerosol ionizer
WO2015132579A1 (en) * 2014-03-04 2015-09-11 Micromass Uk Limited Sample introduction system for spectrometers
KR102599775B1 (ko) * 2015-05-05 2023-11-07 더 리젠츠 오브 더 유니버시티 오브 미시건 마이크로 유체 광이온화 검출기
EP4357784A3 (de) 2016-09-02 2024-07-31 Board of Regents, The University of Texas System Erfassungssonde und verfahren zur verwendung davon
CN110958914A (zh) 2017-08-10 2020-04-03 拉皮斯坎系统股份有限公司 使用热稳定收集装置的物质检测的系统和方法
IT201700115527A1 (it) * 2017-10-13 2019-04-13 Univ Degli Studi Di Urbino Carlo Bo Macchina per analisi chimica comprendente la combinazione della spettrometria di massa a ionizzazione elettronica con la cromatografia liquida
JP2021504703A (ja) 2017-11-27 2021-02-15 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 低侵襲性収集プローブおよびその使用方法
US11609214B2 (en) 2019-07-31 2023-03-21 Rapiscan Systems, Inc. Systems and methods for improving detection accuracy in electronic trace detectors
US12411122B2 (en) 2020-05-12 2025-09-09 Rapiscan Systems, Inc. Sensitivity traps for electronic trace detection having explosives or narcotics embedded in a plasticized polymer matrix
CN117269292A (zh) * 2022-06-15 2023-12-22 中国科学院大连化学物理研究所 一种离子迁移谱检测乳酸的定量分析方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1159412A1 (ru) 1983-01-24 1985-12-23 Revelskij I A Способ масс-спектрометрического анализа газовой смеси
US4814612A (en) * 1983-08-30 1989-03-21 Research Corporation Method and means for vaporizing liquids for detection or analysis
US4804846A (en) 1987-12-04 1989-02-14 O. I. Corporation Photoionization detector for gas chromatography
US4883958A (en) * 1988-12-16 1989-11-28 Vestec Corporation Interface for coupling liquid chromatography to solid or gas phase detectors
JPH0830695B2 (ja) * 1988-12-27 1996-03-27 株式会社島津製作所 液体クロマトグラフ・質量分析装置
JPH04101345A (ja) * 1990-08-20 1992-04-02 Jeol Ltd 液体クロマトグラフ質量分折装置
US5338931A (en) * 1992-04-23 1994-08-16 Environmental Technologies Group, Inc. Photoionization ion mobility spectrometer
US5381006A (en) * 1992-05-29 1995-01-10 Varian Associates, Inc. Methods of using ion trap mass spectrometers
IT1270203B (it) * 1994-06-09 1997-04-29 Fisons Instr Spa Procedimento e dispositivo per l'introduzione di liquidi in spettrometri di massa mediante nebulizzazione elettrostatica
GB9602158D0 (en) * 1996-02-02 1996-04-03 Graseby Dynamics Ltd Corona discharge ion sources for analytical instruments
DE19609582C1 (de) * 1996-03-12 1997-05-28 Bruker Saxonia Analytik Gmbh Photoionisations-Ionenmobilitätsspektrometrie
US5808299A (en) 1996-04-01 1998-09-15 Syagen Technology Real-time multispecies monitoring by photoionization mass spectrometry
US5828062A (en) * 1997-03-03 1998-10-27 Waters Investments Limited Ionization electrospray apparatus for mass spectrometry
JP2002502543A (ja) * 1997-05-23 2002-01-22 ノースイースタン ユニバーシティ マトリクス支援レーザ離脱イオン化−飛翔時間（ｍａｌｄｉ−ｔｏｆ）質量分光用のオンライン液体試料析出インターフェース
US5917185A (en) * 1997-06-26 1999-06-29 Iowa State University Research Foundation, Inc. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry
JP3592494B2 (ja) * 1997-08-22 2004-11-24 日本電子株式会社 大気圧レーザー気化質量分析装置及び方法
US6100522A (en) * 1998-06-15 2000-08-08 Amway Corporation Interface for liquid chromatograph and mass spectrometer
US6211516B1 (en) 1999-02-09 2001-04-03 Syagen Technology Photoionization mass spectrometer

Also Published As

Publication number Publication date
CA2386832C (en) 2009-09-29
JP4600909B2 (ja) 2010-12-22
CA2386832A1 (en) 2001-05-10
EP1226602B1 (de) 2008-02-13
DE60038033D1 (de) 2008-03-27
US6534765B1 (en) 2003-03-18
JP2003515105A (ja) 2003-04-22
DE60038033T2 (de) 2009-04-23
WO2001033605A2 (en) 2001-05-10
EP1226602A2 (de) 2002-07-31
AU772052B2 (en) 2004-04-08
AU1122101A (en) 2001-05-14
WO2001033605A9 (en) 2002-08-29
WO2001033605A3 (en) 2002-01-03

Similar Documents

Publication Publication Date Title
DE60038033D1 (de) Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie-massenspekrometrie
JP7183346B2 (ja) イオン生成と、不連続の大気インターフェースの周期との同期
US20120006983A1 (en) Method of surface ionization with solvent spray and excited-state neutrals
CN105588872B (zh) 一种用于复杂基质中有效成分的快速在线大气压光电离质谱装置
US5877495A (en) Mass spectrometer
WO2008137484A3 (en) Laser desorption - electrospray ion (esi) source for mass spectrometers
US10714323B2 (en) Zero voltage mass spectrometry probes and systems
WO2005094389A3 (en) Method and system for desorption electrospray ionization
Corr et al. Arsenic speciation by liquid chromatography coupled with ionspray tandem mass spectrometry
DE69829398D1 (de) Mehrprobeneinführungs-massenspektrometrie
WO2003052399A3 (en) Method of chemical of ionization at reduced pressures
CN206992048U (zh) 一种纸喷雾电离与质谱的联用装置
Yang et al. Fragmentation study and analysis of benzoylurea insecticides and their analogs by liquid chromatography–electrospray ionization-mass spectrometry
WO2005047848A3 (en) Method and apparatus for mass spectrometric analysis
Zhu et al. Chemical and optical characterization of aqueous secondary organic aerosol generated by reaction of pyruvaldehyde with sodium sulfite
Betowski et al. Evidence for thermal decomposition contributions to the mass spectra of chlorinated phenoxyacid herbicides obtained by particle beam liquid chromatography mass spectrometry
JP2001108656A (ja) 質量分析計用インターフェイスおよび質量分析システム
JP2004294453A (ja) イオン源、質量分析方法及び質量分析計
CN205404478U (zh) 一种用于复杂基质中有效成分的快速在线大气压光电离质谱装置
WO2023178442A1 (en) Self cleaning ionization source
JP2010025714A (ja) イオン化剤の添加方法
Hu et al. Coupling corona discharge for ambient extractive ionization mass spectrometry
Gross Ambient mass spectrometry
CA2937047A1 (en) Method for ionizing laser plumes through atmospheric pressure chemical ionization
Song et al. Non-contact light-radiation thermal desorption-assisted LTP ionization miniature ion trap mass spectrometry for rapid analysis of the flavouring substances in pipe tobacco

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties