ATE390923T1 - Topoisomerase-giftmittel - Google Patents

Topoisomerase-giftmittel

Info

Publication number
ATE390923T1
ATE390923T1 AT02802569T AT02802569T ATE390923T1 AT E390923 T1 ATE390923 T1 AT E390923T1 AT 02802569 T AT02802569 T AT 02802569T AT 02802569 T AT02802569 T AT 02802569T AT E390923 T1 ATE390923 T1 AT E390923T1
Authority
AT
Austria
Prior art keywords
sub
formula
compounds
toxicants
topoisomerase
Prior art date
Application number
AT02802569T
Other languages
English (en)
Inventor
Edmond Lavoie
Alexander Ruchelman
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Application granted granted Critical
Publication of ATE390923T1 publication Critical patent/ATE390923T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Paper (AREA)
AT02802569T 2001-11-14 2002-11-14 Topoisomerase-giftmittel ATE390923T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33305001P 2001-11-14 2001-11-14

Publications (1)

Publication Number Publication Date
ATE390923T1 true ATE390923T1 (de) 2008-04-15

Family

ID=23301042

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02802569T ATE390923T1 (de) 2001-11-14 2002-11-14 Topoisomerase-giftmittel

Country Status (6)

Country Link
US (1) US6964964B2 (de)
EP (1) EP1453506B1 (de)
AT (1) ATE390923T1 (de)
AU (1) AU2002364953A1 (de)
DE (1) DE60225943T2 (de)
WO (1) WO2003047505A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2311639T3 (es) 2001-11-14 2009-02-16 Rutgers, The State University Agentes citotoxicos.
WO2003041660A2 (en) 2001-11-14 2003-05-22 Rutgers, The State University Solubilized topoisomerase poisons
ATE390923T1 (de) 2001-11-14 2008-04-15 Univ Rutgers Topoisomerase-giftmittel
JP4789414B2 (ja) * 2001-11-14 2011-10-12 ラトガーズ，ザ ステイト ユニバーシティ 可溶化トポイソメラーゼ毒性剤
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
US6992089B2 (en) 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
WO2004014918A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
AU2003290818A1 (en) * 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
EP3411377A4 (de) * 2016-02-04 2019-07-17 Purdue Research Foundation Prodrugs der krebsbekämpfungsmittel indotecan und indimitecan
US10759795B2 (en) 2016-03-15 2020-09-01 Purdue Research Foundation Aza-A-ring indenoisoquinoline topoisomerase I poisons
JP2019515025A (ja) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー トポイソメラーゼ毒
CN110167936A (zh) 2016-12-22 2019-08-23 珀杜研究基金会 氮杂茚并异喹啉化合物及其用途

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CH420044A (de) * 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien
US3267107A (en) * 1964-09-17 1966-08-16 American Home Prod 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines
US3849561A (en) * 1964-10-20 1974-11-19 S Naruto Anti-peptic ulcer substance from corydalis tubers
DE1670684A1 (de) * 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
US3542782A (en) * 1967-03-15 1970-11-24 Sandoz Ag 5,6-dihydro-8h-isoquino(1,2-b)quinazolines
JPS4942700A (de) * 1972-08-25 1974-04-22
US3912740A (en) * 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
PT73763B (fr) 1981-10-01 1983-10-26 Quatrum Empresa Nacional De Qu Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent
US4761417A (en) * 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
US4749708A (en) * 1982-05-14 1988-06-07 Maroko Peter R Composition for improving circulatory performance
US5153178A (en) 1982-05-14 1992-10-06 Maroko Peter R Compositions and method of treatment for improving circulatory performance
IE55519B1 (en) 1982-05-14 1990-10-10 Maroko Peter R Use of a protoberberine alkaloid and composition containing same
US4980344A (en) * 1982-05-14 1990-12-25 Maroko Peter R Compositions for improving circulatory performance
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
FR2595356B1 (fr) * 1986-03-05 1991-05-24 Pasteur Strasbourg Universite Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
US5153753A (en) * 1989-04-12 1992-10-06 Ricoh Company, Ltd. Active matrix-type liquid crystal display containing a horizontal MIM device with inter-digital conductors
US5106863A (en) * 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5126351A (en) 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
US5223506A (en) 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
CA2150235A1 (en) * 1993-09-28 1995-04-06 Fumio Suzuki A novel tetracyclic compound
US5807874A (en) * 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
CA2221248A1 (en) 1995-05-17 1996-11-21 Leroy Fong Liu Tribenzimidazoles useful as topoisomerase i inhibitors
US5767142A (en) * 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
CA2241551A1 (en) 1996-02-12 1997-08-14 Rutgers, The State University Of New Jersey Coralyne analogs as topoisomerase inhibitors
US5770617A (en) * 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
US5981541A (en) 1996-09-23 1999-11-09 Rutgers, The State University Of New Jersey Substituted heterocycles as anti-tumor agents
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU765135B2 (en) * 1998-10-14 2003-09-11 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Novel indenoisoquinolines as antineoplastic agents
US6740650B2 (en) * 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU1236401A (en) 1999-10-29 2001-05-14 Rutgers, The State University Of New Jerey Heterocyclic cytotoxic agents
ATE390923T1 (de) 2001-11-14 2008-04-15 Univ Rutgers Topoisomerase-giftmittel
ES2311639T3 (es) * 2001-11-14 2009-02-16 Rutgers, The State University Agentes citotoxicos.
JP4789414B2 (ja) * 2001-11-14 2011-10-12 ラトガーズ，ザ ステイト ユニバーシティ 可溶化トポイソメラーゼ毒性剤
WO2003041660A2 (en) * 2001-11-14 2003-05-22 Rutgers, The State University Solubilized topoisomerase poisons
WO2004014918A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents

Also Published As

Publication number Publication date
AU2002364953A8 (en) 2003-06-17
US6964964B2 (en) 2005-11-15
US20050010046A1 (en) 2005-01-13
EP1453506A4 (de) 2005-06-08
WO2003047505A3 (en) 2003-09-04
WO2003047505A2 (en) 2003-06-12
DE60225943T2 (de) 2009-01-29
EP1453506B1 (de) 2008-04-02
AU2002364953A1 (en) 2003-06-17
DE60225943D1 (de) 2008-05-15
EP1453506A2 (de) 2004-09-08

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Legal Events

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