ATE390923T1 - Topoisomerase-giftmittel - Google Patents

Topoisomerase-giftmittel

Info

Publication number
ATE390923T1
ATE390923T1 AT02802569T AT02802569T ATE390923T1 AT E390923 T1 ATE390923 T1 AT E390923T1 AT 02802569 T AT02802569 T AT 02802569T AT 02802569 T AT02802569 T AT 02802569T AT E390923 T1 ATE390923 T1 AT E390923T1
Authority
AT
Austria
Prior art keywords
sub
formula
compounds
toxicants
topoisomerase
Prior art date
Application number
AT02802569T
Other languages
English (en)
Inventor
Edmond Lavoie
Alexander Ruchelman
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Application granted granted Critical
Publication of ATE390923T1 publication Critical patent/ATE390923T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Paper (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
AT02802569T 2001-11-14 2002-11-14 Topoisomerase-giftmittel ATE390923T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33305001P 2001-11-14 2001-11-14

Publications (1)

Publication Number Publication Date
ATE390923T1 true ATE390923T1 (de) 2008-04-15

Family

ID=23301042

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02802569T ATE390923T1 (de) 2001-11-14 2002-11-14 Topoisomerase-giftmittel

Country Status (6)

Country Link
US (1) US6964964B2 (de)
EP (1) EP1453506B1 (de)
AT (1) ATE390923T1 (de)
AU (1) AU2002364953A1 (de)
DE (1) DE60225943T2 (de)
WO (1) WO2003047505A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003047505A2 (en) 2001-11-14 2003-06-12 Rutgers, The State University Topoisomerase poison agents
MXPA04004607A (es) 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
KR20050044491A (ko) 2001-11-14 2005-05-12 루트거스, 더 스테이트 유니버시티 가용화된 토포이소머라제 독
AU2002352708A1 (en) 2001-11-14 2003-05-26 Edmond J. Lavoie Cytotoxic agents
WO2004014918A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
AU2003265405A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted heterocycles as topoisomerase i targeting agents
US6992089B2 (en) 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
WO2004044174A2 (en) * 2002-11-12 2004-05-27 Rutgers, The State University Topoisomerase-targeting agents
EP2403856B1 (de) 2009-03-06 2012-12-19 Rutgers, The State University of New Jersey Zur behandlung von krebs verwendete methylendioxybenzo[i]phenanthridinderivate
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
US20190218226A1 (en) * 2016-02-04 2019-07-18 Purdue Research Foundation Prodrugs of anticancer agents indotecan and indimitecan
US10759795B2 (en) 2016-03-15 2020-09-01 Purdue Research Foundation Aza-A-ring indenoisoquinoline topoisomerase I poisons
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons
WO2018118852A1 (en) 2016-12-22 2018-06-28 Purdue Research Foundation Azaindenoisoquinoline compounds and uses thereof

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US2985661A (en) 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
US2915523A (en) 1956-12-03 1959-12-01 Parke Davis & Co Benzacridine compounds
US3272707A (en) 1964-07-17 1966-09-13 Smith Kline French Lab Pharmaceutical compositions and methods for their use
CH420045A (de) 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Poly-azolen als optische Aufhellmittel für textile organische Materialien
US3267107A (en) 1964-09-17 1966-08-16 American Home Prod 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines
US3849561A (en) 1964-10-20 1974-11-19 S Naruto Anti-peptic ulcer substance from corydalis tubers
DE1670684A1 (de) 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
US3542782A (en) 1967-03-15 1970-11-24 Sandoz Ag 5,6-dihydro-8h-isoquino(1,2-b)quinazolines
JPS4942700A (de) 1972-08-25 1974-04-22
US3912740A (en) 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
PT73763B (fr) 1981-10-01 1983-10-26 Quatrum Empresa Nacional De Qu Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent
US4761417A (en) 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
US5153178A (en) 1982-05-14 1992-10-06 Maroko Peter R Compositions and method of treatment for improving circulatory performance
US4980344A (en) 1982-05-14 1990-12-25 Maroko Peter R Compositions for improving circulatory performance
US4749708A (en) 1982-05-14 1988-06-07 Maroko Peter R Composition for improving circulatory performance
IE55519B1 (en) 1982-05-14 1990-10-10 Maroko Peter R Use of a protoberberine alkaloid and composition containing same
JPS61130289A (ja) 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
FR2595356B1 (fr) 1986-03-05 1991-05-24 Pasteur Strasbourg Universite Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications
US5244903A (en) 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
US5153753A (en) * 1989-04-12 1992-10-06 Ricoh Company, Ltd. Active matrix-type liquid crystal display containing a horizontal MIM device with inter-digital conductors
US5106863A (en) 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5135934A (en) 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5126351A (en) 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
US5223506A (en) 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
US5428040A (en) 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
WO1995009153A1 (en) 1993-09-28 1995-04-06 Kyowa Hakko Kogyo Co., Ltd. Novel tetracyclic compound
US5767142A (en) 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
BR9608476A (pt) 1995-05-17 1999-08-17 Univ Rutgers Composto processo para inibir o crescimento de uma célula tumoral de mam¡fero e composicão terapéutica
US5807874A (en) 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
CZ254498A3 (cs) 1996-02-12 1998-12-16 Rutgers, The State University Of New Jersey Analogy coralynu jako inhibitory topoisomerasy
US5770617A (en) 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
WO1998012181A1 (en) 1996-09-23 1998-03-26 Rutgers, The State University Of New Jersey Substituted heterocycles as anti-tumor agents
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
DE69940523D1 (de) 1998-10-14 2009-04-16 Purdue Research Foundation Neue indenoisoquinoline als antineoplastische mittel
US6740650B2 (en) * 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
WO2001032631A2 (en) 1999-10-29 2001-05-10 Rutgers, The State University Of New Jerey Heterocyclic cytotoxic agents
MXPA04004607A (es) 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
WO2003047505A2 (en) 2001-11-14 2003-06-12 Rutgers, The State University Topoisomerase poison agents
AU2002352708A1 (en) 2001-11-14 2003-05-26 Edmond J. Lavoie Cytotoxic agents
KR20050044491A (ko) 2001-11-14 2005-05-12 루트거스, 더 스테이트 유니버시티 가용화된 토포이소머라제 독
WO2004014918A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents

Also Published As

Publication number Publication date
EP1453506A4 (de) 2005-06-08
EP1453506A2 (de) 2004-09-08
EP1453506B1 (de) 2008-04-02
US20050010046A1 (en) 2005-01-13
DE60225943D1 (de) 2008-05-15
AU2002364953A1 (en) 2003-06-17
US6964964B2 (en) 2005-11-15
WO2003047505A3 (en) 2003-09-04
DE60225943T2 (de) 2009-01-29
AU2002364953A8 (en) 2003-06-17
WO2003047505A2 (en) 2003-06-12

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Legal Events

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