ATE391730T1 - Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung - Google Patents

Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung

Info

Publication number
ATE391730T1
ATE391730T1 AT04770552T AT04770552T ATE391730T1 AT E391730 T1 ATE391730 T1 AT E391730T1 AT 04770552 T AT04770552 T AT 04770552T AT 04770552 T AT04770552 T AT 04770552T AT E391730 T1 ATE391730 T1 AT E391730T1
Authority
AT
Austria
Prior art keywords
months
api
alpha
scale production
proteinase inhibitor
Prior art date
Application number
AT04770552T
Other languages
English (en)
Inventor
Shabtai Bauer
Original Assignee
Kamada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34379546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE391730(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL15805303A external-priority patent/IL158053A0/xx
Application filed by Kamada Ltd filed Critical Kamada Ltd
Application granted granted Critical
Publication of ATE391730T1 publication Critical patent/ATE391730T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04770552T 2003-09-22 2004-09-22 Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung ATE391730T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50390203P 2003-09-22 2003-09-22
IL15805303A IL158053A0 (en) 2003-09-22 2003-09-22 Process for large scale purification of alpha-1 proteinase inhibitor

Publications (1)

Publication Number Publication Date
ATE391730T1 true ATE391730T1 (de) 2008-04-15

Family

ID=34379546

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04770552T ATE391730T1 (de) 2003-09-22 2004-09-22 Herstellung eines alpha-1-proteinaseinhibitors im grossmassstab und dessen verwendung

Country Status (12)

Country Link
US (2) US7879800B2 (de)
EP (1) EP1664123B2 (de)
AT (1) ATE391730T1 (de)
CA (1) CA2538998C (de)
DE (1) DE602004013021T3 (de)
DK (1) DK1664123T4 (de)
ES (1) ES2305845T5 (de)
IL (1) IL174410A0 (de)
PL (1) PL1664123T5 (de)
PT (1) PT1664123E (de)
SI (1) SI1664123T2 (de)
WO (1) WO2005027821A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0524432D0 (en) 2005-11-30 2006-01-11 Nhs Blood & Transplant Method
EP1981572B1 (de) 2006-02-09 2012-11-21 Kamada Ltd. Pulmonale abgabe von alpha-i proteinase-hemmer
CA2694854C (en) 2007-08-17 2016-09-27 Csl Behring Gmbh Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i
EP2321336A1 (de) * 2008-07-18 2011-05-18 Talecris Biotherapeutics, Inc. Verfahren zur herstellung eines alpha-1-proteinaseinhibitors
AU2010315325B2 (en) 2009-11-03 2014-11-27 Grifols Therapeutics Inc. Composition, method, and kit for alpha-1 proteinase inhibitor
PT2503995T (pt) 2009-11-24 2017-11-23 Grifols Therapeutics Inc Métodos de liofilização, composições e kits
JP2014520094A (ja) 2011-05-27 2014-08-21 バクスター・インターナショナル・インコーポレイテッド 増加した半減期を有する治療用タンパク質およびそれを調製する方法
KR20140108516A (ko) 2011-12-30 2014-09-11 그리폴스, 에스.에이. 폐 악화의 발현 또는 진행을 지연시키기 위한 알파1-프로테이나제 억제제
TWI629283B (zh) 2012-02-23 2018-07-11 巴克斯歐塔公司 來自血漿中的免疫球蛋白之ｉ-ｉｖ-１部分沉澱
US9353165B2 (en) 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
WO2018116300A1 (en) * 2016-12-22 2018-06-28 Kamada Ltd. Dry powder formulations of alpha-1 antitrypsin
WO2018154568A1 (en) * 2017-02-21 2018-08-30 Kamada Ltd. Methods and uses of alpha 1-antitrypsin for early intervention in pulmonary diseases
ES2984415T3 (es) 2017-12-12 2024-10-29 Kamada Ltd Métodos para inducir tolerancia inmunitaria y reducir la respuesta de anticuerpos anti-fármaco
IL267923B2 (en) * 2018-08-02 2023-06-01 Grifols Worldwide Operations Ltd The composition containing the most concentrated alpha-1 type protein inhibitor and a method for obtaining it
WO2020157752A1 (en) * 2019-01-29 2020-08-06 Kamada Ltd Pharmaceutical aerosol composition

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379087A (en) * 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4439358A (en) * 1982-06-17 1984-03-27 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
US4697003A (en) * 1985-11-01 1987-09-29 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
US4749783A (en) * 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
US5093316A (en) * 1986-12-24 1992-03-03 John Lezdey Treatment of inflammation
AU655766B2 (en) * 1990-05-01 1995-01-12 Chiron Corporation Interleukin-1 antagonist and uses thereof
US5814225A (en) 1994-06-09 1998-09-29 Shanbrom Technologies Llc Iodinated gel filtration media for disinfecting protein solutions
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
US5610285A (en) * 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
AU6884396A (en) * 1995-09-07 1997-03-27 Ppl Therapeutics (Scotland) Ltd Purification of alpha-1 proteinase inhibitor
US5780440A (en) * 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
TW491855B (en) * 1996-08-07 2002-06-21 Csl Ltd Purification of immunoglobulins
AT407114B (de) * 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
US6093804A (en) * 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US6462180B1 (en) * 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
WO2002048176A1 (en) 2000-12-14 2002-06-20 Bayer Corporation Method of preparing alpha-1 proteinase inhibitor
WO2003102132A2 (en) 2002-04-26 2003-12-11 Genetech, Inc. Non-affinity purification of proteins
US7777006B2 (en) * 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
BRPI0412835A (pt) * 2003-08-12 2006-09-26 Octapharma Ag processo para preparação de uma solução de alfa-1-antitripsina
WO2005121163A2 (en) 2004-06-07 2005-12-22 Upfront Chromatography A/S Isolation of plasma or serum proteins

Also Published As

Publication number Publication date
CA2538998C (en) 2015-11-24
PT1664123E (pt) 2008-07-16
DE602004013021T3 (de) 2012-04-05
ES2305845T5 (es) 2012-04-12
CA2538998A1 (en) 2005-03-31
PL1664123T5 (pl) 2012-04-30
ES2305845T3 (es) 2008-11-01
DK1664123T4 (da) 2012-03-05
AU2004273696A1 (en) 2005-03-31
EP1664123A4 (de) 2006-11-02
DE602004013021D1 (de) 2008-05-21
DE602004013021T2 (de) 2009-06-25
EP1664123A2 (de) 2006-06-07
EP1664123B1 (de) 2008-04-09
PL1664123T3 (pl) 2008-11-28
WO2005027821A3 (en) 2005-08-04
SI1664123T2 (sl) 2012-03-30
US7879800B2 (en) 2011-02-01
DK1664123T3 (da) 2008-07-28
IL174410A0 (en) 2006-08-01
US20080139465A1 (en) 2008-06-12
EP1664123B2 (de) 2011-11-30
SI1664123T1 (sl) 2008-10-31
US20110092444A1 (en) 2011-04-21
WO2005027821A2 (en) 2005-03-31

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