ATE392433T1 - Verfahren zur anwendung eines an lkb1/strad/mo25- komplexes - Google Patents

Verfahren zur anwendung eines an lkb1/strad/mo25- komplexes

Info

Publication number: ATE392433T1
Authority: AT; Austria
Prior art keywords: lkb1; ampk; protein kinase; kinase activity; strad
Prior art date: 2003-07-17

Application number

AT04743435T

Other languages

English (en)

Inventor

David Hardie

Dario Alessi

Jerome Boudeau

Original Assignee

Univ Dundee

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-17

Filing date

2004-07-16

Publication date

2008-05-15

2003-07-17 Priority claimed from GB0316725A external-priority patent/GB0316725D0/en

2003-12-20 Priority claimed from GB0330078A external-priority patent/GB0330078D0/en

2004-07-16 Application filed by Univ Dundee filed Critical Univ Dundee

2008-05-15 Application granted granted Critical

2008-05-15 Publication of ATE392433T1 publication Critical patent/ATE392433T1/de

Links

102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 title abstract 6
101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 title abstract 6
JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 3
102100022533 Calcium-binding protein 39 Human genes 0.000 title 1
101000899411 Homo sapiens Calcium-binding protein 39 Proteins 0.000 title 1
108010011376 AMP-Activated Protein Kinases Proteins 0.000 abstract 8
102000014156 AMP-Activated Protein Kinases Human genes 0.000 abstract 8
230000000694 effects Effects 0.000 abstract 4
102000001253 Protein Kinase Human genes 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
108060006633 protein kinase Proteins 0.000 abstract 3
101001059429 Homo sapiens MAP/microtubule affinity-regulating kinase 3 Proteins 0.000 abstract 1
101001059427 Homo sapiens MAP/microtubule affinity-regulating kinase 4 Proteins 0.000 abstract 1
101000970023 Homo sapiens NUAK family SNF1-like kinase 1 Proteins 0.000 abstract 1
101000970025 Homo sapiens NUAK family SNF1-like kinase 2 Proteins 0.000 abstract 1
101000695043 Homo sapiens Serine/threonine-protein kinase BRSK1 Proteins 0.000 abstract 1
101000794043 Homo sapiens Serine/threonine-protein kinase BRSK2 Proteins 0.000 abstract 1
101001059443 Homo sapiens Serine/threonine-protein kinase MARK1 Proteins 0.000 abstract 1
101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 1
101000709250 Homo sapiens Serine/threonine-protein kinase SIK2 Proteins 0.000 abstract 1
101000654491 Homo sapiens Serine/threonine-protein kinase SIK3 Proteins 0.000 abstract 1
102100028920 MAP/microtubule affinity-regulating kinase 3 Human genes 0.000 abstract 1
102100028913 MAP/microtubule affinity-regulating kinase 4 Human genes 0.000 abstract 1
102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 abstract 1
101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 abstract 1
101100354317 Mus musculus Ptk6 gene Proteins 0.000 abstract 1
102100021732 NUAK family SNF1-like kinase 1 Human genes 0.000 abstract 1
102100021733 NUAK family SNF1-like kinase 2 Human genes 0.000 abstract 1
108091000080 Phosphotransferase Proteins 0.000 abstract 1
101150083487 SIK1 gene Proteins 0.000 abstract 1
102100028623 Serine/threonine-protein kinase BRSK1 Human genes 0.000 abstract 1
102100029891 Serine/threonine-protein kinase BRSK2 Human genes 0.000 abstract 1
102100028921 Serine/threonine-protein kinase MARK1 Human genes 0.000 abstract 1
102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 1
102100032771 Serine/threonine-protein kinase SIK1 Human genes 0.000 abstract 1
102100034377 Serine/threonine-protein kinase SIK2 Human genes 0.000 abstract 1
102100031445 Serine/threonine-protein kinase SIK3 Human genes 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
230000026731 phosphorylation Effects 0.000 abstract 1
238000006366 phosphorylation reaction Methods 0.000 abstract 1
102000020233 phosphotransferase Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Hematology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Steroid Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT04743435T 2003-07-17 2004-07-16 Verfahren zur anwendung eines an lkb1/strad/mo25- komplexes ATE392433T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0316725A GB0316725D0 (en)	2003-07-17	2003-07-17	Methods
GB0330078A GB0330078D0 (en)	2003-12-20	2003-12-20	Methods

Publications (1)

Publication Number	Publication Date
ATE392433T1 true ATE392433T1 (de)	2008-05-15

Family

ID=34105982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04743435T ATE392433T1 (de)	2003-07-17	2004-07-16	Verfahren zur anwendung eines an lkb1/strad/mo25- komplexes

Country Status (8)

Country	Link
US (1)	US20070036793A1 (de)
EP (1)	EP1651673B1 (de)
JP (1)	JP2007530000A (de)
AT (1)	ATE392433T1 (de)
DE (1)	DE602004013160T2 (de)
DK (1)	DK1651673T3 (de)
ES (1)	ES2308198T3 (de)
WO (1)	WO2005010174A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2402938B (en) *	2003-06-17	2005-11-09	Medical Res Council	Kinase assay
AU2006215385B2 (en) *	2005-02-17	2010-12-02	Integragen	Uses of human autism susceptibility gene encoding a kinase
BRPI0609040B1 (pt)	2005-03-18	2018-07-31	Microbia, Inc.	Fungo recombinante do gênero yarrowia, método de produção de um carotenóide e método de preparo de um aditivo alimentício ou ração contendo um carotenóide
EP2078092A2 (de)	2006-09-28	2009-07-15	Microbia, Inc.	Herstellung von carotenoiden in öliger hefe und pilzen
WO2008116032A1 (en) *	2007-03-21	2008-09-25	Effat Emamian	Compositions and methods for inhibiting tumor cell growth
EP2377952A1 (de) *	2007-04-26	2011-10-19	Ludwig Institute For Cancer Research	Verfahren zur Diagnostizierung und Behandlung von Astrozytoma
WO2008147881A2 (en) *	2007-05-22	2008-12-04	The Penn State Research Foundation	Methods and compositions relating to pbk1
JP2010280598A (ja) *	2009-06-03	2010-12-16	Kao Corp	Ｌｋｂ１活性化剤
PH12012501581A1 (en)	2010-02-03	2012-10-22	Signal Pharm Llc	Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors
CN102305863B (zh) *	2011-07-18	2013-11-20	厦门大学	以Nur77-LKB1相互作用为靶点的抗糖尿病药物筛选方法
AU2013203714B2 (en)	2012-10-18	2015-12-03	Signal Pharmaceuticals, Llc	Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
HK1221150A1 (zh)	2013-04-17	2017-05-26	西格诺药品有限公司	用二氢吡嗪并-吡嗪类对癌症的治疗
MX368286B (es)	2013-04-17	2019-09-27	Signal Pharm Llc	Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer.
BR112015026257B1 (pt)	2013-04-17	2022-12-20	Signal Pharmaceuticals, Llc	Uso de um composto dihidropirazino-pirazina e enzalutamida, composição farmacêutica que os compreende, e kit
JP6382945B2 (ja)	2013-04-17	2018-08-29	シグナルファーマシューティカルズ，エルエルシー	ジヒドロピラジノ−ピラジンによる癌治療
EP2986321A1 (de)	2013-04-17	2016-02-24	Signal Pharmaceuticals, LLC	Kombinationstherapie mit einem torkinaseinhibitor und einem cytidinanalogon zur behandlung von krebs
CN105339008A (zh)	2013-04-17	2016-02-17	西格诺药品有限公司	用于治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯酰胺的组合疗法
MX393164B (es)	2013-04-17	2025-03-21	Signal Pharm Llc	Formulaciones farmacéuticas, proceso, formas sólidas y métodos de uso relacionados con 1-etil-7-(2-metil-6-(1h-1,2,4-triazol-3-ii)piridin-3-ii)-3,4-dihidropirazino[2,3-b]pirazin-2(1h)-ona.
NZ629486A (en)	2013-05-29	2017-11-24	Signal Pharm Llc	Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
EP3501531A1 (de) *	2014-01-29	2019-06-26	Université de Strasbourg	Neues target zur diabetesbehandlung und -vorbeugung
EP3131551A4 (de)	2014-04-16	2017-09-20	Signal Pharmaceuticals, LLC	Feste formen mit 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-on und co-former, zusammensetzungen und verfahren zu deren verwendung
NZ714742A (en)	2014-04-16	2017-04-28	Signal Pharm Llc	Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
US10745439B2 (en) *	2017-03-20	2020-08-18	Regents Of The University Of Minnesota	Kinase substrates and methods of use thereof
IL271491B2 (en)	2017-06-22	2023-09-01	Celgene Corp	Treatment of carcinoma of the liver characterized by hepatitis b virus infection
EP3421485A1 (de) *	2017-06-30	2019-01-02	Université de Strasbourg	Peptide zur behandlung und prävention von hyperglykämie
CN112980859B (zh) *	2019-12-12	2022-07-05	中国科学院大连化学物理研究所	降低LKB1-STRAD-Mo25蛋白复合体稳定性的方法
CA3169649A1 (en)	2020-01-30	2021-08-05	The Regents Of The University Of California	Strad-binding agents and uses thereof
CN115590017B (zh) *	2022-11-04	2023-09-12	中国农业大学	一种通过降低线粒体温度提高卵母细胞冷冻效果的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6071721A (en) *	1998-11-13	2000-06-06	Incyte Pharmaceuticals, Inc.	Calcium binding protein
AU2001271067A1 (en) *	2000-07-19	2002-01-30	Chugai Seiyaku Kabushiki Kaisha	Method of screening compound controlling mek/erk signal transduction and medicinal use of the compound
ATE408023T1 (de) *	2003-06-17	2008-09-15	Medical Res Council	Verfahren zum testen der lkb1- phosphorylierungsaktivität

2004
- 2004-07-16 AT AT04743435T patent/ATE392433T1/de not_active IP Right Cessation
- 2004-07-16 US US10/565,058 patent/US20070036793A1/en not_active Abandoned
- 2004-07-16 DK DK04743435T patent/DK1651673T3/da active
- 2004-07-16 EP EP04743435A patent/EP1651673B1/de not_active Expired - Lifetime
- 2004-07-16 ES ES04743435T patent/ES2308198T3/es not_active Expired - Lifetime
- 2004-07-16 JP JP2006520011A patent/JP2007530000A/ja active Pending
- 2004-07-16 WO PCT/GB2004/003096 patent/WO2005010174A2/en not_active Ceased
- 2004-07-16 DE DE602004013160T patent/DE602004013160T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2007530000A (ja)	2007-11-01
WO2005010174A2 (en)	2005-02-03
US20070036793A1 (en)	2007-02-15
DK1651673T3 (da)	2008-08-18
WO2005010174A3 (en)	2005-06-30
ES2308198T3 (es)	2008-12-01
DE602004013160T2 (de)	2009-07-02
EP1651673A2 (de)	2006-05-03
EP1651673B1 (de)	2008-04-16
DE602004013160D1 (de)	2008-05-29

Legal Events

Date

Code

Title

Description

2008-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1651673

Country of ref document: EP

2012-04-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE392433T1 (de)	2008-05-15	Verfahren zur anwendung eines an lkb1/strad/mo25- komplexes
DE602005012856D1 (de)	2009-04-02	Verfahren, Computerprogramm und System zur regulieren von E-mail
WO2008122789A3 (en)	2008-12-04	Methods for modulating lrrk2
WO2009081368A3 (en)	2010-04-29	Cosmetic use desmoglein i-type proteins
GB0618651D0 (en)	2006-11-01	Methods and apparatus for estimating physical parameters of reservoirs using pressure transient fracture injection/falloff test analysis
SE0401400D0 (sv)	2004-06-01	Ledprotes, användning av sådan samt förfarande för applicering av en ledprotes
DE60233574D1 (de)	2009-10-15	Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen
WO2009060824A1 (ja)	2009-05-14	血中成分の濃度を精度よく測定する装置および方法
DE602004015732D1 (de)	2008-09-25	Testpackungen für sterilisationsindikator
Blatz et al.	2004	In vitro durability of the resin bond to feldspathic ceramics.
DE60045586D1 (de)	2011-03-10	Testverfahren zur messung der phosphorylierung
WO2003047428A3 (en)	2003-08-14	Apparatus and methods for testing pain sensitivity
Roos et al.	2012	Evaluation of bond strength of resin cements using different general-purpose statistical software packages for two-parameter Weibull statistics
WO2007053634A3 (en)	2007-09-07	Functional testing and verification of software application
EP2662453A3 (de)	2014-02-26	Nachweis und Behandlung von Schizophrenie
ATE405211T1 (de)	2008-09-15	Verfahren zur überprüfung von einem diabetischen fuss
Camatta et al.	2021	Mechanical behavior and fracture loads of screw‐retained and cement‐retained lithium disilicate implant‐supported crowns
Hussein et al.	2019	Effect of chlorhexidine and/or ethanol pre-bonding treatment on the shear bond strength of resin composite to dentin
Sathish et al.	2019	Effect of thermocycling on the micro-tensile bond strength between self-adhesive resin cement and nonphosphate monomer cements on zirconium-oxide ceramics
ATE415153T1 (de)	2008-12-15	Pharmazeutische zusammensetzung zur perkutane absorption unter verwendung von einem metalchlorid, vorzugsweise natriumchlorid, zur vorbeugung von kohäsionsschwäche
Madan et al.	2012	Evaluation of tensile bond strength of heat cure and autopolymerizing silicone-based resilient denture liners before and after thermocycling
DE602006015727D1 (de)	2010-09-02	Verfahren zur messung von plasmaspiegeln von pentraxin ptx3
WO2013033366A3 (en)	2013-04-25	Methods and compositions for promoting glucose homeostasis
Kohorst et al.	2010	Influence of Preliminary Damage on the Load‐Bearing Capacity of Zirconia Fixed Dental Prostheses
Gantier‐Takano et al.	2025	Microgap Formation in Conical Implant‐Abutment Connections Under Oblique Loading: Influence of Cone Angle Mismatch Through Finite Element Analysis