ATE393150T1 - 2-imino-1,3-thiazin-derivate - Google Patents
2-imino-1,3-thiazin-derivateInfo
- Publication number
- ATE393150T1 ATE393150T1 AT00957083T AT00957083T ATE393150T1 AT E393150 T1 ATE393150 T1 AT E393150T1 AT 00957083 T AT00957083 T AT 00957083T AT 00957083 T AT00957083 T AT 00957083T AT E393150 T1 ATE393150 T1 AT E393150T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- formula
- imino
- cb2r
- optionally substituted
- Prior art date
Links
- FZPINHOWPABQQM-UHFFFAOYSA-N 1,3-thiazin-2-imine Chemical class N=C1N=CC=CS1 FZPINHOWPABQQM-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229930003827 cannabinoid Natural products 0.000 abstract 1
- 239000003557 cannabinoid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26078099 | 1999-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE393150T1 true ATE393150T1 (de) | 2008-05-15 |
Family
ID=17352635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00957083T ATE393150T1 (de) | 1999-09-14 | 2000-09-11 | 2-imino-1,3-thiazin-derivate |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6818640B1 (de) |
| EP (1) | EP1219612B1 (de) |
| JP (1) | JP3936189B2 (de) |
| KR (1) | KR100509401B1 (de) |
| CN (1) | CN1247553C (de) |
| AT (1) | ATE393150T1 (de) |
| AU (1) | AU6877300A (de) |
| CA (1) | CA2384757A1 (de) |
| DE (1) | DE60038687T2 (de) |
| TW (1) | TWI285199B (de) |
| WO (1) | WO2001019807A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| US7067539B2 (en) | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
| ATE405555T1 (de) * | 2001-03-08 | 2008-09-15 | Shionogi & Co | Medizinische zusammensetzung, die ein 1,3- thiazinderivat enthält |
| EP2130820A1 (de) | 2002-02-19 | 2009-12-09 | Shionogi & Co., Ltd. | Antipruriginosa |
| CA2478338A1 (en) | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| US6825209B2 (en) | 2002-04-15 | 2004-11-30 | Research Triangle Institute | Compounds having unique CB1 receptor binding selectivity and methods for their production and use |
| EP1661572A1 (de) * | 2003-08-18 | 2006-05-31 | Shionogi & Co., Ltd. | Neue verwendung von cannabinoid-rezeptor-agonisten |
| TW200508211A (en) * | 2003-08-26 | 2005-03-01 | Shionogi & Co | 2-naphthylimino-1,3-thiazine derivatives |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| US7435828B2 (en) | 2003-11-21 | 2008-10-14 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| JPWO2006080287A1 (ja) * | 2005-01-25 | 2008-06-19 | 塩野義製薬株式会社 | ２−アゾリルイミノ−１，３−チアジン誘導体 |
| EP2038266A2 (de) | 2006-05-31 | 2009-03-25 | Abbott Laboratories | Verbindungen als cannabinoid-rezeptorliganden und ihre verwendung |
| CN101448800A (zh) | 2006-05-31 | 2009-06-03 | 艾博特公司 | 作为大麻素受体配体的新型化合物及其用途 |
| US8841334B2 (en) | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
| US7868038B2 (en) | 2006-08-31 | 2011-01-11 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| WO2008028094A1 (en) | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Compounds as cb2 cannabinoid receptor ligands |
| US8481574B2 (en) | 2006-10-12 | 2013-07-09 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| MX2009005048A (es) | 2006-11-23 | 2009-05-25 | Actelion Pharmaceuticals Ltd | Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona. |
| US8158663B2 (en) | 2006-12-22 | 2012-04-17 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
| EP2127673A4 (de) | 2007-03-09 | 2010-05-05 | Univ Kyoto | Pharmazeutisches mittel zur prävention und behandlung von hauterkrankungen durch beschleunigte keratinisierung |
| CN101765594A (zh) | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物 |
| US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| CN101711253A (zh) | 2007-05-18 | 2010-05-19 | 雅培制药有限公司 | 用作大麻素受体配体的新化合物 |
| US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| TW200942535A (en) | 2008-03-11 | 2009-10-16 | Abbott Lab | Novel compounds as cannabinoid receptor ligands |
| US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| TW201016692A (en) | 2008-09-16 | 2010-05-01 | Abbott Lab | Novel compounds as cannabinoid receptor ligands |
| PA8854001A1 (es) | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
| SMT202000298T1 (it) | 2012-08-17 | 2020-07-08 | Actelion Pharmaceuticals Ltd | Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1604530A (de) | 1967-06-06 | 1971-11-29 | ||
| JPS4823793B1 (de) | 1968-06-17 | 1973-07-16 | ||
| BE788743A (fr) * | 1971-09-14 | 1973-03-13 | Bayer Ag | Nouveaux 2-(aminophenylimino)-3- aza-1-thia-cycloalcanes, leur procede de preparation et leur application comme |
| FR2201080A1 (en) * | 1972-09-22 | 1974-04-26 | Basf Ag | 2-imino-5-methylene-thiazolidine derivs - antiinflammatory antibacterial, antifungal and hypotensive |
| HU167761B (de) * | 1973-07-12 | 1975-12-25 | ||
| DE2436263C2 (de) * | 1974-07-27 | 1983-02-17 | Hoechst Ag, 6000 Frankfurt | Thiazolidinderivate und Verfahren zu ihrer Herstellung |
| DE2533821A1 (de) * | 1975-07-29 | 1977-02-17 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| DE2546165A1 (de) * | 1975-10-15 | 1977-04-28 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| US4195092A (en) | 1977-12-27 | 1980-03-25 | Eli Lilly And Company | 2-(Substituted amino)-N-(3-substituted phenyl)-2-imidazoline-1-carbothioamides |
| DE2926771A1 (de) * | 1979-07-03 | 1981-01-15 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| DE3049460A1 (de) * | 1980-12-30 | 1982-07-29 | Hoechst Ag, 6000 Frankfurt | "thiazolinderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| SU1209689A1 (ru) * | 1984-06-25 | 1986-02-07 | Предприятие П/Я В-2343 | Способ получени производных 2-имино-3-тиокарбамоилтиазолидина |
| JPS62212378A (ja) * | 1986-03-08 | 1987-09-18 | バイエル・アクチエンゲゼルシヤフト | ジアリ−ルスルフイド誘導体 |
| JPS6341471A (ja) * | 1986-08-08 | 1988-02-22 | Nippon Soda Co Ltd | オキサ（チア）ゾリジン誘導体、その製造法及び殺ダニ剤 |
| CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
| JPH0720943B2 (ja) * | 1988-08-19 | 1995-03-08 | 宇部興産株式会社 | アミノピリミジン誘導体、その製法及び殺虫・殺菌剤 |
| JP2879395B2 (ja) | 1992-10-26 | 1999-04-05 | 富士写真フイルム株式会社 | ロダシアニン化合物及びシクロデキストリンを含有する抗癌性組成物 |
| JPH06220053A (ja) * | 1992-11-17 | 1994-08-09 | Fuji Photo Film Co Ltd | 水溶性メチン化合物 |
| JPH1180124A (ja) | 1997-07-11 | 1999-03-26 | Japan Tobacco Inc | キノリン化合物及びその医薬用途 |
| DE19756303C1 (de) | 1997-12-09 | 1999-07-08 | Mannesmann Ag | Verteilförderer zum Übergeben von Stückgut |
| JP4165669B2 (ja) | 1998-02-09 | 2008-10-15 | 日本エヌエスシー株式会社 | 化粧品用樹脂組成物およびその製法 |
| BR9916999A (pt) * | 1999-01-14 | 2001-10-30 | Bayer Ag | Heterociclos de 2-arilimino substituìdos ecomposições contendo-os, para uso como agentesde ligação do receptor de progesterona |
| US6353006B1 (en) * | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| KR20020015389A (ko) * | 1999-07-26 | 2002-02-27 | 모리타 다카카즈 | 신규 티아진 또는 피라진 유도체 |
| JP2001261652A (ja) | 2000-03-21 | 2001-09-26 | Suntory Ltd | 二置換イミノヘテロサイクリック化合物 |
| US6762200B2 (en) * | 2000-03-28 | 2004-07-13 | Nippon Soda Co. Ltd. | Oxa(thia)zolidine derivative and anti-inflammatory drug |
| ATE405555T1 (de) * | 2001-03-08 | 2008-09-15 | Shionogi & Co | Medizinische zusammensetzung, die ein 1,3- thiazinderivat enthält |
| KR100441681B1 (ko) * | 2001-03-12 | 2004-07-27 | 삼성전자주식회사 | 금속 게이트 형성 방법 |
| DE50203896D1 (de) * | 2001-05-21 | 2005-09-15 | Basf Ag | Oxazin(thi)onverbindungen als fungizide |
| DE10130706A1 (de) * | 2001-06-26 | 2003-01-02 | Bayer Ag | Thiazine und Thiazole als Materialschutzmittel |
| TW200508211A (en) * | 2003-08-26 | 2005-03-01 | Shionogi & Co | 2-naphthylimino-1,3-thiazine derivatives |
-
2000
- 2000-09-11 CN CNB008154368A patent/CN1247553C/zh not_active Expired - Fee Related
- 2000-09-11 US US10/069,421 patent/US6818640B1/en not_active Expired - Fee Related
- 2000-09-11 WO PCT/JP2000/006185 patent/WO2001019807A1/ja not_active Ceased
- 2000-09-11 KR KR10-2002-7003364A patent/KR100509401B1/ko not_active Expired - Fee Related
- 2000-09-11 EP EP00957083A patent/EP1219612B1/de not_active Expired - Lifetime
- 2000-09-11 CA CA002384757A patent/CA2384757A1/en not_active Abandoned
- 2000-09-11 JP JP2001523386A patent/JP3936189B2/ja not_active Expired - Fee Related
- 2000-09-11 AU AU68773/00A patent/AU6877300A/en not_active Abandoned
- 2000-09-11 AT AT00957083T patent/ATE393150T1/de not_active IP Right Cessation
- 2000-09-11 DE DE60038687T patent/DE60038687T2/de not_active Expired - Lifetime
- 2000-09-13 TW TW089118689A patent/TWI285199B/zh active
-
2004
- 2004-10-26 US US10/972,414 patent/US7183275B2/en not_active Expired - Fee Related
-
2006
- 2006-11-29 US US11/605,434 patent/US7420053B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TWI285199B (en) | 2007-08-11 |
| US7420053B2 (en) | 2008-09-02 |
| CA2384757A1 (en) | 2001-03-22 |
| KR100509401B1 (ko) | 2005-08-22 |
| JP3936189B2 (ja) | 2007-06-27 |
| EP1219612B1 (de) | 2008-04-23 |
| WO2001019807A1 (en) | 2001-03-22 |
| DE60038687D1 (de) | 2008-06-05 |
| EP1219612A1 (de) | 2002-07-03 |
| CN1247553C (zh) | 2006-03-29 |
| DE60038687T2 (de) | 2009-05-28 |
| US7183275B2 (en) | 2007-02-27 |
| US20050124617A1 (en) | 2005-06-09 |
| AU6877300A (en) | 2001-04-17 |
| KR20020027646A (ko) | 2002-04-13 |
| EP1219612A4 (de) | 2002-10-16 |
| CN1387519A (zh) | 2002-12-25 |
| US6818640B1 (en) | 2004-11-16 |
| US20070088020A1 (en) | 2007-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |