ATE394494T1 - Isolierte polynucleotide mit einem verminderten anteil an 5'cpg3' epigenetischen kontrollmotiven, und verwendungen davon - Google Patents

Isolierte polynucleotide mit einem verminderten anteil an 5'cpg3' epigenetischen kontrollmotiven, und verwendungen davon

Info

Publication number
ATE394494T1
ATE394494T1 AT00991199T AT00991199T ATE394494T1 AT E394494 T1 ATE394494 T1 AT E394494T1 AT 00991199 T AT00991199 T AT 00991199T AT 00991199 T AT00991199 T AT 00991199T AT E394494 T1 ATE394494 T1 AT E394494T1
Authority
AT
Austria
Prior art keywords
cpg3
motives
epigenetic control
isolated polynucleotides
reduced proportion
Prior art date
Application number
AT00991199T
Other languages
English (en)
Inventor
Jean-Francois Nicolas
Isabelle Henry
Andre Choulika
Original Assignee
Pasteur Institut
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Centre Nat Rech Scient filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE394494T1 publication Critical patent/ATE394494T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
    • C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00991199T 1999-12-06 2000-12-06 Isolierte polynucleotide mit einem verminderten anteil an 5'cpg3' epigenetischen kontrollmotiven, und verwendungen davon ATE394494T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002291367A CA2291367A1 (en) 1999-12-06 1999-12-06 Genetic constructions having a reduced or an increased number of epigenetic control regions and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE394494T1 true ATE394494T1 (de) 2008-05-15

Family

ID=4164770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00991199T ATE394494T1 (de) 1999-12-06 2000-12-06 Isolierte polynucleotide mit einem verminderten anteil an 5'cpg3' epigenetischen kontrollmotiven, und verwendungen davon

Country Status (12)

Country Link
US (1) US20040097439A9 (de)
EP (2) EP1235916B1 (de)
JP (1) JP2003515344A (de)
AT (1) ATE394494T1 (de)
AU (1) AU3159501A (de)
CA (1) CA2291367A1 (de)
CY (1) CY1108240T1 (de)
DE (1) DE60038813D1 (de)
DK (1) DK1235916T3 (de)
ES (1) ES2304998T3 (de)
PT (1) PT1235916E (de)
WO (1) WO2001040478A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2821855B1 (fr) 2001-03-09 2004-04-02 Cayla Genes synthetiques et plasmides bacteriens depourvus de cpg
AU2002317771A1 (en) * 2001-06-05 2002-12-16 Cellectis Methods for modifying the cpg content of polynucleotides
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7375228B2 (en) 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7642275B2 (en) 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2006114834A1 (ja) * 2005-03-31 2006-11-02 Hokkaido Technology Licensing Office Co., Ltd. 点特異的な官能基導入ベクターの構築方法
JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
CA2615105A1 (en) * 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors
PL2139515T5 (pl) * 2007-03-30 2024-04-08 The Research Foundation Of The State University Of New York Atenuowane wirusy przydatne w szczepionkach
US9734283B2 (en) * 2011-12-30 2017-08-15 Washington State University Genomic features associated with epigenetic control regions and transgenerational inheritance of epimutations
WO2022046682A1 (en) * 2020-08-26 2022-03-03 Mdi Biological Laboratory Bromodomain and extra terminal domain (bet) inhibitor compositions and methods thereof for use as anti-aging agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583009A (en) * 1992-12-08 1996-12-10 University Of Washington Method of preparing recombinant proteins in transgenic animals containing metallothionein gene elements that bestow tissue-independent copy number-dependent, position-indepedent gene expression
DE69417918T2 (de) * 1993-11-30 2000-01-05 Mcgill University, Montreal Dna methyltransferase inhibierung
WO1997011972A1 (en) * 1995-09-28 1997-04-03 The Trustees Of Columbia University In The City Of New York Chimeric dna-binding/dna methyltransferase nucleic acid and polypeptide and uses thereof
US5856462A (en) * 1996-09-10 1999-01-05 Hybridon Incorporated Oligonucleotides having modified CpG dinucleosides
EP1003531B1 (de) * 1997-05-20 2007-08-22 Ottawa Health Research Institute Verfahren zur Herstellung von Nukleinsäurekonstrukten
WO2001032857A1 (en) * 1999-10-29 2001-05-10 The Hospital For Sick Children Methylation of unstable sequences

Also Published As

Publication number Publication date
EP2053127A2 (de) 2009-04-29
CY1108240T1 (el) 2014-02-12
WO2001040478A3 (en) 2002-05-10
EP1235916B1 (de) 2008-05-07
US20030100528A1 (en) 2003-05-29
CA2291367A1 (en) 2001-06-06
DE60038813D1 (de) 2008-06-19
JP2003515344A (ja) 2003-05-07
EP1235916A2 (de) 2002-09-04
ES2304998T3 (es) 2008-11-01
EP2053127A3 (de) 2009-11-11
PT1235916E (pt) 2008-08-12
WO2001040478A2 (en) 2001-06-07
AU3159501A (en) 2001-06-12
US20040097439A9 (en) 2004-05-20
DK1235916T3 (da) 2008-08-25

Similar Documents

Publication Publication Date Title
CY1108240T1 (el) ΑΠΟΜΟΝΩΜΕΝΑ ΠΟΛΥΝΟΥΚΛΕΟΤΙΔΙΑ ΤΑ ΟΠΟΙΑ ΕΧΟΥΝ ΕΝΑ ΜΕΙΩΜΕΝΟ ΠΕΡΙΕΧΟΜΕΝΟ ΜΟΤΙΒΩΝ 5΄CpG3΄ ΕΠΙΓΕΝΕΤΙΚΟΥ ΕΛΕΓΧΟΥ ΚΑΙ ΟΙ ΧΡΗΣΕΙΣ ΤΟΥΣ
ATE232880T1 (de) Neue nucleotidanaloga
EP1013661A4 (de) Bicyclonukleosid- und oligonukleotid-analoga
NO990025D0 (no) Hamster-EF-1<alfa> transkripsjonsregulatorisk DNA
FI875082A0 (fi) Dna-sekvensser deriverade fraon genom av papillomavirus, deras anvaendning foer in vitro diagnostiska aendamaol; samt framstaellning av antigeniska kompositioner.
KR900018376A (ko) 리보핵산(rna)의 합성방법
EP1034302A4 (de) De novo oder "universaler" sequenzierungs-array
DE69838449D1 (de) Aminooxy-modifizierte oligonukleotide
RU94046425A (ru) Самостабилизированный олигонуклеотид и способ ингибирования генной экспрессии
ATE557084T1 (de) Modifizierte dna-polymerasen zur verbesserten inkorporation von nukleotidanaloga
DE69828193D1 (de) Hyaluronan synthase gen und seine verwendung
ATE318273T1 (de) Zuckermodifizierte oligonukleotide zum erkennen und steuern der genexpression
IL158261A0 (en) New polynucleotides and polypeptides of the erythropoietin gene
EP0449972A4 (en) Triple stranded nucleic acid and methods of use
AU2299999A (en) Dnas or genes participating in parkinson's disease
NZ508439A (en) Novel endometriosis-associated gene
ATE242261T1 (de) Fluoreszend-konjugaten von nukleosiden und von nukleotiden, ihrer verfahren zur herstellung und ihrer verwendungen
EP3040423A3 (de) Mikro-rna und verwendung davon
WO1999028439A3 (fr) Erythrovirus et ses applications
TR200003272T2 (tr) Protein üretimi verilmesi için G-CSF geninin genomik sekanslar.
ES2112062T3 (es) Oligonucleotidos con actividad anti-citomegalovirus.
DE69836484D1 (de) Endogene retrovirale sequenzen, verwandten mit auto-immune krankheiten oder mit schwangerschaftsstörungen
JPH11178A5 (de)
ATE317123T1 (de) Reaktiver träger zur bestimmung von dna fragmenten
WO2003054181A3 (en) Nucleic acid labeling by thermoanaerobacter thermohydrosulfuricus dna polymerase i variants

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1235916

Country of ref document: EP