ATE39483T1 - Kondensierte pyrrolinon-derivate, und ihre herstellung. - Google Patents
Kondensierte pyrrolinon-derivate, und ihre herstellung.Info
- Publication number
- ATE39483T1 ATE39483T1 AT83301656T AT83301656T ATE39483T1 AT E39483 T1 ATE39483 T1 AT E39483T1 AT 83301656 T AT83301656 T AT 83301656T AT 83301656 T AT83301656 T AT 83301656T AT E39483 T1 ATE39483 T1 AT E39483T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- integer
- optionally
- condensed
- preparation
- Prior art date
Links
- HMXQIFUGFZEJEO-UHFFFAOYSA-N 1,2-dihydropyrrol-3-one Chemical class O=C1CNC=C1 HMXQIFUGFZEJEO-UHFFFAOYSA-N 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000000049 anti-anxiety effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1982/000096 WO1983003410A1 (fr) | 1982-04-02 | 1982-04-02 | Derives d'isoindoline |
| PCT/JP1982/000401 WO1984001576A1 (fr) | 1982-10-07 | 1982-10-07 | Derives de pyrrolidone fondus |
| PCT/JP1983/000032 WO1984003089A1 (fr) | 1983-02-05 | 1983-02-05 | Derives condenses de pyrrolinone |
| EP83301656A EP0091241B1 (de) | 1982-04-02 | 1983-03-24 | Kondensierte Pyrrolinon-Derivate, und ihre Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE39483T1 true ATE39483T1 (de) | 1989-01-15 |
Family
ID=27303767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83301656T ATE39483T1 (de) | 1982-04-02 | 1983-03-24 | Kondensierte pyrrolinon-derivate, und ihre herstellung. |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US4590189A (de) |
| EP (1) | EP0091241B1 (de) |
| KR (1) | KR900007780B1 (de) |
| AT (1) | ATE39483T1 (de) |
| CA (1) | CA1196330A (de) |
| DE (1) | DE3378763D1 (de) |
| HK (1) | HK104190A (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0091241B1 (de) * | 1982-04-02 | 1988-12-28 | Takeda Chemical Industries, Ltd. | Kondensierte Pyrrolinon-Derivate, und ihre Herstellung |
| JPS6169773A (ja) * | 1984-09-14 | 1986-04-10 | Takeda Chem Ind Ltd | イソインドリノン誘導体 |
| US5264436A (en) * | 1986-11-27 | 1993-11-23 | Beecham Group P.L.C. | Heterocyclic compounds which have useful pharmaceutical utility |
| FR2607504B1 (fr) * | 1986-12-02 | 1989-01-27 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2607503B1 (fr) * | 1986-12-02 | 1989-02-24 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US4959374A (en) * | 1989-07-06 | 1990-09-25 | Beecham Group P.L.C. | Novel compounds |
| FR2654726B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
| US5273978A (en) * | 1991-07-10 | 1993-12-28 | Takeda Chemical Industries, Ltd. | Optically active isoindoline derivatives, their production and use |
| US5798368A (en) * | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| TR200101502T2 (tr) * | 1998-03-16 | 2002-06-21 | Celgene Corporation | 2-(2,6-dioksopiperidin-3-il) izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı |
| US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
| US7064135B2 (en) | 2001-10-12 | 2006-06-20 | Novo Nordisk Inc. | Substituted piperidines |
| WO2003031432A1 (en) * | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
| WO2004048332A1 (ja) * | 2002-11-26 | 2004-06-10 | Maruishi Pharmaceutical Co., Ltd. | イソインドリン誘導体 |
| GB0308025D0 (en) * | 2003-04-07 | 2003-05-14 | Glaxo Group Ltd | Compounds |
| EP1749817A4 (de) * | 2004-05-24 | 2007-12-26 | Maruishi Pharma | Zusammesetzung von mitteln für die bekämpfung neurogener schmerzen |
| EP2527328A1 (de) | 2008-04-01 | 2012-11-28 | Abbott GmbH & Co. KG | Tetrahydroisochinoline, pharmazeutische Zusammensetzungen damit und deren therapeutische Verwendung |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8853196B2 (en) | 2011-08-05 | 2014-10-07 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CN104011028A (zh) | 2011-11-18 | 2014-08-27 | 艾伯维德国有限责任两合公司 | N-取代的氨基苯并环庚烯、氨基四氢化萘、氨基茚满和苯烷基胺衍生物、包含所述衍生物的药物组合物及其在治疗中的用途 |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| SG11201602935PA (en) | 2013-10-17 | 2016-05-30 | Abbvie Deutschland | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2015055770A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2017214442A1 (en) | 2016-06-08 | 2017-12-14 | President And Fellows Of Harvard College | Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, rett syndrome, and fragile x syndrome |
| US12252457B2 (en) | 2018-05-22 | 2025-03-18 | President And Fellows Of Harvard College | Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment |
| EP3801512A4 (de) | 2018-05-29 | 2022-01-19 | President and Fellows of Harvard College | Zusammensetzungen und verfahren zur verminderung von taktiler dysfunktion, angst und sozialer beeinträchtigung |
| US12077512B2 (en) | 2019-03-25 | 2024-09-03 | President And Fellows Of Harvard College | Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment |
| CN117263909A (zh) * | 2023-09-21 | 2023-12-22 | 常州大学 | 一种由亚砜叶立德制备异吲哚啉-1-酮的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2957872A (en) * | 1957-10-21 | 1960-10-25 | Ciba Pharm Prod Inc | Phthalimidines and process for manufacturing same |
| US3579524A (en) * | 1968-06-05 | 1971-05-18 | Miles Lab | 2-aminoalkyl derivatives of phthalimidines |
| FR2101081B1 (de) * | 1970-08-19 | 1974-01-11 | Rhone Poulenc Sa | |
| FR2117740B1 (de) * | 1970-12-14 | 1974-04-12 | Rhone Poulenc Sa | |
| BE790408A (fr) * | 1971-10-22 | 1973-04-20 | Rhone Poulenc Sa | Nouveaux derives de la pyrrolo (3,4-b) pyridine, leur preparation et les compositions medicinales qui les |
| OA04285A (fr) * | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. |
| AR203996A1 (es) * | 1972-03-16 | 1975-11-12 | Rhone Poulenc Sa | Procedimiento para preparar derivados de(hidroxi-2-amino-3-propoxi)-3-isoindolinona-1 |
| US4038391A (en) * | 1973-05-15 | 1977-07-26 | Rhone-Poulenc S.A. | 6-(1,8-Naphthyridin-2-yl)-5-piperazino carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazines and related pyridines |
| US4016274A (en) * | 1973-05-15 | 1977-04-05 | Rhone-Poulenc S.A. | Naphthyridine derivatives |
| US4164404A (en) * | 1973-06-25 | 1979-08-14 | American Cyanamid Company | Dithiindicarboximide, dithiolanedicarboximide, thiapyrandicarboximide and pyrandicarboximide derivatives as plant growth regulants |
| JPS5046830A (de) * | 1973-08-28 | 1975-04-25 | ||
| CA1072557A (fr) * | 1976-02-20 | 1980-02-26 | Rhone-Poulenc Industries | Derives du dithiepinno (1,4)(2,3-c) pyrrole, leur preparation et les compositions qui les contiennent |
| FR2451380A1 (fr) * | 1979-03-15 | 1980-10-10 | Rhone Poulenc Ind | Nouveaux derives du dithiepinno (1,4) (2,3-c) pyrrole, leur preparation et les medicaments qui les contiennent |
| US4355031A (en) * | 1981-05-11 | 1982-10-19 | American Home Products Corp. | 2,3-Dihydro-3-[4-(substituted)-1-piperazinyl]-1H-isoindol-1-ones |
| EP0091241B1 (de) * | 1982-04-02 | 1988-12-28 | Takeda Chemical Industries, Ltd. | Kondensierte Pyrrolinon-Derivate, und ihre Herstellung |
-
1983
- 1983-03-24 EP EP83301656A patent/EP0091241B1/de not_active Expired
- 1983-03-24 AT AT83301656T patent/ATE39483T1/de not_active IP Right Cessation
- 1983-03-24 US US06/478,478 patent/US4590189A/en not_active Expired - Fee Related
- 1983-03-24 DE DE8383301656T patent/DE3378763D1/de not_active Expired
- 1983-03-31 CA CA000424994A patent/CA1196330A/en not_active Expired
- 1983-04-01 KR KR1019830001350A patent/KR900007780B1/ko not_active Expired
-
1986
- 1986-04-23 US US06/832,138 patent/US4788191A/en not_active Expired - Fee Related
-
1988
- 1988-09-08 US US07/241,851 patent/US4879293A/en not_active Expired - Fee Related
-
1990
- 1990-12-13 HK HK1041/90A patent/HK104190A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1196330A (en) | 1985-11-05 |
| US4788191A (en) | 1988-11-29 |
| EP0091241A3 (en) | 1984-07-11 |
| US4879293A (en) | 1989-11-07 |
| DE3378763D1 (en) | 1989-02-02 |
| US4590189A (en) | 1986-05-20 |
| HK104190A (en) | 1990-12-21 |
| EP0091241B1 (de) | 1988-12-28 |
| KR900007780B1 (ko) | 1990-10-20 |
| EP0091241A2 (de) | 1983-10-12 |
| KR840004405A (ko) | 1984-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE39483T1 (de) | Kondensierte pyrrolinon-derivate, und ihre herstellung. | |
| NO900306L (no) | Fremgangsmaate for fremstilling av nye pyrazolopyridin-forbindelser. | |
| DE3784624D1 (de) | Benzimidazolderivate mit einer wirkung als ulkusmittel. | |
| GB2306958B (en) | Oximesulfonic acid esters and the use thereof as latent sulfonic acids | |
| SE8307119L (sv) | Karboxylsyraamider och derivat derav | |
| AU560436B2 (en) | 5-substituted 1,2,4,-oxadiazole derivatives | |
| ES492116A0 (es) | Un procedimiento para la preparacion de imidazol-cianoguani-dinas. | |
| FI895046A0 (fi) | 4-amino-3-acylkinolinderivat samt deras anvaendning saosom inhibitorer av sekretion av matsmaeltningsvaetskor. | |
| SE8601852L (sv) | Cyklopentyletrar och deras framstellning och farmaceutiska beredning | |
| ATE92469T1 (de) | Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung. | |
| ES517995A0 (es) | Un procedimiento para la preparacion de un compuesto de hidroxibencilaminobenceno, dotado de propiedades antiinflamatorias. | |
| NO903430D0 (no) | Fremgangsmaate for fremstilling av aminoketonderivater. | |
| SE7907159L (sv) | 3,7-disubstituerade 3-cefem-4-karboxylsyraforeningar och forfarande for deras framstelllning | |
| PT90302A (pt) | Processo para a preparacao de derivados de lactamas hetero-tetraciclicas | |
| DE3887102D1 (de) | Substituierte Derivate von 20,21-Dinoreburnamenin, Verfahren zur Herstellung und so hergestellte Zwischenprodukte, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammenstellungen. | |
| LV5491A3 (lv) | 2-tiazolidinona atvasinajumu iegusanas panemiens | |
| ATE22289T1 (de) | N-(3-trifluormethylphenyl)-n'-propargylpiperazi , seine herstellung und verwendung. | |
| SE7902724L (sv) | Substituerade n-iminometylpiperidiner | |
| JPS5640678A (en) | Bisbenzofuranone derivative | |
| ATE225T1 (de) | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben. | |
| JPS5495533A (en) | Preparation of derivative of anthranylaldehyde | |
| JPS54119455A (en) | Novel thiourea derivative | |
| NO924701L (no) | Amid-bundete pyridyl-benzosyrederivater for behandling avleukotrien-relaterte sykdommer | |
| JPS52136189A (en) | Preparation of unsaturated polyimides having cyanuric ring | |
| JPS5515419A (en) | Novel oxabicyclo(3,2,1)-octane derivative and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |