ATE396996T1 - Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen - Google Patents

Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen

Info

Publication number: ATE396996T1
Authority: AT; Austria
Prior art keywords: sub; obesity; receptor antagonists; selective; treatment
Prior art date: 2002-08-29

Application number

AT03791865T

Other languages

English (en)

Inventor

Wen-Lian Wu

Duane Burnett

William Greenlee

Thavalakulam Sasikumar

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-29

Filing date

2003-08-27

Publication date

2008-06-15

2003-08-27 Application filed by Schering Corp filed Critical Schering Corp

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE396996T1 publication Critical patent/ATE396996T1/de

Links

208000008589 Obesity Diseases 0.000 title abstract 2
235000020824 obesity Nutrition 0.000 title abstract 2
239000002464 receptor antagonist Substances 0.000 title abstract 2
229940044551 receptor antagonist Drugs 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
206010020710 Hyperphagia Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Nutrition Science (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Child & Adolescent Psychology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT03791865T 2002-08-29 2003-08-27 Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen ATE396996T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40685602P	2002-08-29	2002-08-29

Publications (1)

Publication Number	Publication Date
ATE396996T1 true ATE396996T1 (de)	2008-06-15

Family

ID=31978370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03791865T ATE396996T1 (de)	2002-08-29	2003-08-27	Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen

Country Status (11)

Country	Link
US (1)	US7211574B2 (de)
EP (1)	EP1537115B1 (de)
JP (1)	JP4555685B2 (de)
CN (1)	CN1688584A (de)
AT (1)	ATE396996T1 (de)
AU (1)	AU2003262926A1 (de)
CA (1)	CA2495879C (de)
DE (1)	DE60321354D1 (de)
ES (1)	ES2308016T3 (de)
MX (1)	MXPA05002249A (de)
WO (1)	WO2004020442A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1646623A2 (de) *	2003-05-22	2006-04-19	Schering Corporation	5-h-benzo[d]naphth[2,1-b]azepinderivate als selektive d1/d5-rezeptorantagonisten zur behandlung von obesitas und zns-erkrankungen
WO2025194153A1 (en)	2024-03-15	2025-09-18	Emalex Biosciences, Inc.	Pharmaceutical dosage forms and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4973586A (en) *	1986-01-16	1990-11-27	Schering Corporation	Fused benzazepines, compositions of, and medical use thereof
EP0254737B1 (de) *	1986-01-16	1990-07-25	Schering Corporation	Kondensierte benzazepine
AU617651B2 (en) *	1987-07-15	1991-12-05	Schering Corporation	Fused benzazepines
DK325188D0 (da) *	1988-06-15	1988-06-15	Novo Industri As	Hidtil ukendte benzazepinderivater
BR0211140A (pt) *	2001-07-13	2005-10-25	Upjohn Co	Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht

2003
- 2003-08-27 JP JP2004531584A patent/JP4555685B2/ja not_active Expired - Fee Related
- 2003-08-27 CN CNA038243857A patent/CN1688584A/zh active Pending
- 2003-08-27 US US10/649,495 patent/US7211574B2/en not_active Expired - Fee Related
- 2003-08-27 WO PCT/US2003/026878 patent/WO2004020442A1/en not_active Ceased
- 2003-08-27 MX MXPA05002249A patent/MXPA05002249A/es active IP Right Grant
- 2003-08-27 AT AT03791865T patent/ATE396996T1/de not_active IP Right Cessation
- 2003-08-27 CA CA2495879A patent/CA2495879C/en not_active Expired - Fee Related
- 2003-08-27 AU AU2003262926A patent/AU2003262926A1/en not_active Abandoned
- 2003-08-27 ES ES03791865T patent/ES2308016T3/es not_active Expired - Lifetime
- 2003-08-27 DE DE60321354T patent/DE60321354D1/de not_active Expired - Lifetime
- 2003-08-27 EP EP03791865A patent/EP1537115B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1688584A (zh)	2005-10-26
MXPA05002249A (es)	2005-06-08
DE60321354D1 (de)	2008-07-10
US7211574B2 (en)	2007-05-01
AU2003262926A1 (en)	2004-03-19
CA2495879A1 (en)	2004-03-11
WO2004020442A1 (en)	2004-03-11
US20040058906A1 (en)	2004-03-25
JP2006501244A (ja)	2006-01-12
JP4555685B2 (ja)	2010-10-06
CA2495879C (en)	2011-04-26
ES2308016T3 (es)	2008-12-01
EP1537115B1 (de)	2008-05-28
EP1537115A1 (de)	2005-06-08

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Legal Events

Date	Code	Title	Description
2008-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties