ATE397606T1 - Pyrazino(1',2':1,6)-pyrido(3,4-b) indole-1,4- dionderivate - Google Patents

Pyrazino(1',2':1,6)-pyrido(3,4-b) indole-1,4- dionderivate

Info

Publication number: ATE397606T1
Authority: AT; Austria
Prior art keywords: compounds; pyrazino; pyrido; indole; dione derivatives
Prior art date: 2001-06-05

Application number

AT02733984T

Other languages

English (en)

Inventor

Mark Orme

Jason Sawyer

Lisa Schultze

Original Assignee

Lilly Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-05

Filing date

2002-04-15

Publication date

2008-06-15

2002-04-15 Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc

2008-06-15 Application granted granted Critical

2008-06-15 Publication of ATE397606T1 publication Critical patent/ATE397606T1/de

Links

BQYSXXPIBLDEEG-UHFFFAOYSA-N pyrazino[1,2-b]$b-carboline-1,4-quinone Chemical class C1=CC=CC2=C3C=C4C(=O)N=CC(=O)N4C=C3N=C21 BQYSXXPIBLDEEG-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 abstract 1
208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
101150098694 PDE5A gene Proteins 0.000 abstract 1
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 abstract 1
201000001881 impotence Diseases 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02733984T 2001-06-05 2002-04-15 Pyrazino(1',2':1,6)-pyrido(3,4-b) indole-1,4- dionderivate ATE397606T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US29602301P	2001-06-05	2001-06-05

Publications (1)

Publication Number	Publication Date
ATE397606T1 true ATE397606T1 (de)	2008-06-15

Family

ID=23140266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02733984T ATE397606T1 (de)	2001-06-05	2002-04-15	Pyrazino(1',2':1,6)-pyrido(3,4-b) indole-1,4- dionderivate

Country Status (9)

Country	Link
US (1)	US7098209B2 (de)
EP (1)	EP1392688B1 (de)
JP (1)	JP4217605B2 (de)
AT (1)	ATE397606T1 (de)
CA (1)	CA2445625C (de)
DE (1)	DE60226970D1 (de)
ES (1)	ES2307758T3 (de)
MX (1)	MXPA03011082A (de)
WO (1)	WO2002098877A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100430395C (zh) *	2002-07-31	2008-11-05	利利艾科斯有限公司	改进的皮克特-施彭格勒反应和由该反应制备得到的产物
US20050186289A1 (en) *	2003-04-01	2005-08-25	Medical College Of Georgia Research Institute, Inc.	Regulation of T cell-mediated immunity by D isomers of inhibitors of indoleamine-2,3-dioxygenase
US7598287B2 (en)	2003-04-01	2009-10-06	Medical College Of Georgia Research Institute, Inc.	Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
CA2626547A1 (en) *	2005-10-21	2007-05-03	Medical College Of Georgia Research Institute, Inc.	The induction of indoleamine 2,3-dioxygenase in dendritic cells by tlr ligands and uses thereof
AR073522A1 (es)	2008-09-30	2010-11-10	Biolab Sanus Farmaceutica Ltda	Compuestos derivados de 2-(3-metilenodioxi) - benzoil indol
UY33535A (es) *	2010-08-13	2011-12-01	Biolab Sanus Farmaceutuca Limitada	Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona
WO2015089105A1 (en)	2013-12-09	2015-06-18	Respira Therapeutics, Inc.	Pde5 inhibitor powder formulations and methods relating thereto
AR099523A1 (es) *	2014-02-24	2016-07-27	Biolab Sanus Farmacêutica Ltda	Compuestos derivados de 6,7-dihidro-3h-oxazolo[3,4-a]pirazina-5,8-diona
CA3132620C (en)	2015-07-24	2024-03-05	Lumos Pharma, Inc.	Salts and prodrugs of 1-methyl-d-tryptophan
WO2018071873A2 (en)	2016-10-13	2018-04-19	Juno Therapeutics, Inc.	Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators
MX389626B (es)	2017-11-17	2025-03-20	Cellix Bio Private Ltd	Compuestos de pilocarpina con ácido lipoico para el tratamiento de trastornos oculares.
CN109467555A (zh) *	2018-06-21	2019-03-15	广东蓝堡生物科技有限公司	一种他达那非衍生物及其制备方法和应用
WO2021245192A1 (en)	2020-06-04	2021-12-09	Topadur Pharma Ag	Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5711984A (en) *	1980-06-25	1982-01-21	Sendai Fukusokan Kagaku Kenkyusho	Preparation of brevianamide e compound
GB9401090D0 (en)	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514464D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Medicaments

2002
- 2002-04-15 DE DE60226970T patent/DE60226970D1/de not_active Expired - Lifetime
- 2002-04-15 CA CA2445625A patent/CA2445625C/en not_active Expired - Fee Related
- 2002-04-15 AT AT02733984T patent/ATE397606T1/de not_active IP Right Cessation
- 2002-04-15 EP EP02733984A patent/EP1392688B1/de not_active Expired - Lifetime
- 2002-04-15 US US10/479,099 patent/US7098209B2/en not_active Expired - Fee Related
- 2002-04-15 WO PCT/US2002/011791 patent/WO2002098877A1/en not_active Ceased
- 2002-04-15 ES ES02733984T patent/ES2307758T3/es not_active Expired - Lifetime
- 2002-04-15 JP JP2003501998A patent/JP4217605B2/ja not_active Expired - Fee Related
- 2002-04-15 MX MXPA03011082A patent/MXPA03011082A/es active IP Right Grant

Also Published As

Publication number	Publication date
US20040152705A1 (en)	2004-08-05
JP4217605B2 (ja)	2009-02-04
DE60226970D1 (de)	2008-07-17
JP2004532889A (ja)	2004-10-28
EP1392688A1 (de)	2004-03-03
MXPA03011082A (es)	2004-07-08
CA2445625C (en)	2010-07-27
WO2002098877A1 (en)	2002-12-12
CA2445625A1 (en)	2002-12-12
ES2307758T3 (es)	2008-12-01
EP1392688B1 (de)	2008-06-04
US7098209B2 (en)	2006-08-29

Legal Events

Date	Code	Title	Description
2008-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
WO2002064590A3 (en)	2003-02-27	Carboline derivatives
WO2002064591A3 (en)	2002-12-12	Carboline derivatives
WO2002028865A3 (en)	2003-02-27	Condensed pyridoindole derivatives
CA2413510A1 (en)	2002-01-03	Condensed pyrazindione derivatives
BR0014698A (pt)	2002-06-18	Derivados de pirazolo [4,3-d] pirimidina
DE69925970D1 (de)	2005-08-04	Pyrazolopyrimidinone cGMP PDE5 Inhibitoren zur Behandlung der sexuellen Dysfunktion
CA2287552A1 (en)	2000-04-23	Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
DE60204760D1 (de)	2005-07-28	Pyrazolo[4,3-d]pyrimidinon-verbindungen als cgmp pde-inhibitoren
IS1888B (is)	2003-09-01	Pýrazínó[2',1':6,1]pýridó[3,4-b]indól-1,4-díón, aðferð við framleiðslu og notkun
CA2347950A1 (en)	2000-05-04	Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
ATE397606T1 (de)	2008-06-15	Pyrazino(1',2':1,6)-pyrido(3,4-b) indole-1,4- dionderivate
CA2253948A1 (en)	1997-11-20	Carboline derivatives
WO2001087038A3 (en)	2002-05-16	β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE
MXPA03005937A (es)	2003-09-10	Compuestos farmaceuticamente activos.
TR200003039T2 (tr)	2001-01-22	Seksüel fonksiyon bozukluklarının tedavisi için pirazolopirimidinon cGMP PDE5 inhibitörleri
WO2002028859A3 (en)	2002-09-12	Condensed pyridoindole derivatives
WO2008070313A3 (en)	2008-11-20	3-(dihydro-1h-pyrazolo [4,3-d] pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use
DE60216745D1 (de)	2007-01-25	Carbolin Derivate als Hemmstoffe von Phospphodiesterase 5 (PDE5) zur Behandlung kardiovaskulärer Erkrankungen und der erektilen Dysfunktion
SE0001518L (sv)	2000-10-31	Farmacentisk komposition
NO20013334L (no)	2001-07-05	Anvendelse av imidazo [1,5-A]-pyrido[3,2-E]-pyrazinoner som legemidler
WO2002000656A3 (en)	2003-10-02	Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives
WO2002079203A8 (en)	2002-11-21	Imidazo-triazine derivatives as pde 5 inhibitors
EP1241170A3 (de)	2003-03-12	Pyrazolopyrimidinderivate