ATE398109T1 - 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden - Google Patents
4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methodenInfo
- Publication number
- ATE398109T1 ATE398109T1 AT01959581T AT01959581T ATE398109T1 AT E398109 T1 ATE398109 T1 AT E398109T1 AT 01959581 T AT01959581 T AT 01959581T AT 01959581 T AT01959581 T AT 01959581T AT E398109 T1 ATE398109 T1 AT E398109T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimidinaminine
- derivatives
- pharmaceutical compositions
- related methods
- methods
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22379100P | 2000-08-08 | 2000-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE398109T1 true ATE398109T1 (de) | 2008-07-15 |
Family
ID=22837982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01959581T ATE398109T1 (de) | 2000-08-08 | 2001-08-06 | 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20030008883A1 (de) |
| EP (1) | EP1313713B1 (de) |
| JP (1) | JP2004505952A (de) |
| CN (1) | CN1468225A (de) |
| AR (1) | AR031601A1 (de) |
| AT (1) | ATE398109T1 (de) |
| AU (1) | AU2001281120A1 (de) |
| BR (1) | BR0113165A (de) |
| CA (1) | CA2419030A1 (de) |
| DE (1) | DE60134414D1 (de) |
| HK (1) | HK1054033A1 (de) |
| IL (1) | IL154240A0 (de) |
| MX (1) | MXPA03001226A (de) |
| NZ (1) | NZ524100A (de) |
| WO (1) | WO2002012198A2 (de) |
| ZA (1) | ZA200301868B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL375552A1 (en) * | 2002-05-22 | 2005-11-28 | Amgen Inc. | Vanilloid receptor ligands and their medical applications |
| US7419984B2 (en) * | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
| EP1651619A1 (de) * | 2003-07-15 | 2006-05-03 | Neurogen Corporation | Substituierte pyrimidin-4-ylaminanaloge als vanilloidrezeptorliganden |
| US20070161637A1 (en) * | 2003-07-22 | 2007-07-12 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| BRPI0416853A (pt) * | 2003-11-24 | 2007-02-13 | Hoffmann La Roche | pirazolila e imidazolila pirimidinas |
| JP2007522233A (ja) * | 2004-02-11 | 2007-08-09 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療におけるそれらの使用 |
| AU2005245386B2 (en) * | 2004-05-07 | 2008-11-27 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
| MXPA06014747A (es) | 2004-06-28 | 2007-02-16 | Altana Pharma Ag | Pirimidinas 4,6-disustituidas y su uso como inhibidores de proteina cinasa. |
| EP1807418A2 (de) * | 2004-10-22 | 2007-07-18 | Amgen, Inc | Substituierte stickstoffhaltige heterocyclen als vanilloidrezeptorliganden und ihre verwendung als arzneimittel |
| HU0900798D0 (en) | 2009-12-21 | 2010-03-01 | Vichem Chemie Kutato Kft | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
| CN102917700A (zh) * | 2010-03-26 | 2013-02-06 | 国立大学法人北海道大学 | 神经退行性疾病治疗药物 |
| CN104822380B (zh) * | 2012-08-23 | 2019-01-01 | 维罗斯塔蒂克斯公司 | 新颖的4,6-二取代的氨基嘧啶衍生物 |
| HRP20181109T1 (hr) * | 2013-12-11 | 2018-11-02 | Biogen Ma Inc. | Spojevi biarila korisni za liječenje ljudskih bolesti u onkologiji, neurologiji i imunologiji |
| CA3078583A1 (en) * | 2017-10-17 | 2019-04-25 | Merck Patent Gmbh | Pyrimidine tbk/ikk.epsilon. inhibitor compounds and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5068271A (en) * | 1988-09-21 | 1991-11-26 | Uniroyal Chemical Company, Inc. | Arylenediamine substituted pyrimidines compositions |
| DE3905364A1 (de) * | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
| US5506231A (en) * | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
| CA2174080A1 (en) * | 1993-10-12 | 1995-04-20 | Paul Edward Aldrich | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
| AU751573C (en) * | 1998-03-27 | 2003-10-09 | Janssen Pharmaceutica N.V. | HIV inhibiting pyrimidine derivatives |
| AU762345B2 (en) * | 1998-10-16 | 2003-06-26 | Asubio Pharma Co., Ltd. | Aminophenoxyacetic acid derivatives as neuroprotectants |
| JP2003146987A (ja) * | 1999-05-31 | 2003-05-21 | Dainippon Pharmaceut Co Ltd | ２−アリールプリン−９−アセトアミド誘導体 |
-
2001
- 2001-08-06 NZ NZ524100A patent/NZ524100A/en not_active Application Discontinuation
- 2001-08-06 JP JP2002518176A patent/JP2004505952A/ja active Pending
- 2001-08-06 DE DE60134414T patent/DE60134414D1/de not_active Expired - Lifetime
- 2001-08-06 BR BR0113165-6A patent/BR0113165A/pt not_active IP Right Cessation
- 2001-08-06 AU AU2001281120A patent/AU2001281120A1/en not_active Abandoned
- 2001-08-06 HK HK03106375.9A patent/HK1054033A1/zh unknown
- 2001-08-06 AT AT01959581T patent/ATE398109T1/de not_active IP Right Cessation
- 2001-08-06 EP EP01959581A patent/EP1313713B1/de not_active Expired - Lifetime
- 2001-08-06 MX MXPA03001226A patent/MXPA03001226A/es active IP Right Grant
- 2001-08-06 CA CA002419030A patent/CA2419030A1/en not_active Abandoned
- 2001-08-06 US US09/922,874 patent/US20030008883A1/en not_active Abandoned
- 2001-08-06 IL IL15424001A patent/IL154240A0/xx unknown
- 2001-08-06 CN CNA018166938A patent/CN1468225A/zh active Pending
- 2001-08-06 WO PCT/US2001/024659 patent/WO2002012198A2/en not_active Ceased
- 2001-08-08 AR ARP010103803A patent/AR031601A1/es unknown
-
2003
- 2003-03-06 ZA ZA200301868A patent/ZA200301868B/en unknown
- 2003-03-25 US US10/396,158 patent/US20030212079A1/en not_active Abandoned
- 2003-03-25 US US10/395,971 patent/US20040006094A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HK1054033A1 (zh) | 2003-11-14 |
| WO2002012198A2 (en) | 2002-02-14 |
| WO2002012198A3 (en) | 2002-06-06 |
| US20030008883A1 (en) | 2003-01-09 |
| EP1313713B1 (de) | 2008-06-11 |
| CA2419030A1 (en) | 2002-02-14 |
| DE60134414D1 (de) | 2008-07-24 |
| JP2004505952A (ja) | 2004-02-26 |
| US20030212079A1 (en) | 2003-11-13 |
| AR031601A1 (es) | 2003-09-24 |
| AU2001281120A1 (en) | 2002-02-18 |
| CN1468225A (zh) | 2004-01-14 |
| EP1313713A2 (de) | 2003-05-28 |
| US20040006094A1 (en) | 2004-01-08 |
| ZA200301868B (en) | 2004-06-25 |
| IL154240A0 (en) | 2003-07-31 |
| MXPA03001226A (es) | 2004-09-10 |
| BR0113165A (pt) | 2003-07-15 |
| NZ524100A (en) | 2005-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |