ATE399022T1 - Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen - Google Patents

Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen

Info

Publication number
ATE399022T1
ATE399022T1 AT96936768T AT96936768T ATE399022T1 AT E399022 T1 ATE399022 T1 AT E399022T1 AT 96936768 T AT96936768 T AT 96936768T AT 96936768 T AT96936768 T AT 96936768T AT E399022 T1 ATE399022 T1 AT E399022T1
Authority
AT
Austria
Prior art keywords
immune response
enhancing
presenting cells
antigen
composition
Prior art date
Application number
AT96936768T
Other languages
English (en)
Inventor
Sam Sanderson
Michael Hollingsworth
Richard Tempero
Original Assignee
Univ Nebraska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nebraska filed Critical Univ Nebraska
Application granted granted Critical
Publication of ATE399022T1 publication Critical patent/ATE399022T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT96936768T 1995-10-20 1996-10-18 Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen ATE399022T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US572795P 1995-10-20 1995-10-20

Publications (1)

Publication Number Publication Date
ATE399022T1 true ATE399022T1 (de) 2008-07-15

Family

ID=21717413

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96936768T ATE399022T1 (de) 1995-10-20 1996-10-18 Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen

Country Status (9)

Country Link
US (5) US6821517B1 (de)
EP (1) EP0859625B1 (de)
JP (1) JP4125784B2 (de)
AT (1) ATE399022T1 (de)
AU (1) AU703120B2 (de)
CA (1) CA2232344C (de)
DE (1) DE69637571D1 (de)
ES (1) ES2309992T3 (de)
WO (1) WO1997014426A1 (de)

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US20080286228A1 (en) * 1995-10-20 2008-11-20 Tarantolo Stefano R Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
DE69637571D1 (de) 1995-10-20 2008-08-07 Univ Nebraska Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen
GB9930591D0 (en) * 1999-12-23 2000-02-16 Univ London Component for vaccine
US20030138434A1 (en) * 2001-08-13 2003-07-24 Campbell Robert L. Agents for enhancing the immune response
GB0208817D0 (en) * 2002-04-17 2002-05-29 European Molecular Biology Lab Embl Method for producing monoclonal antibodies
KR20050090390A (ko) * 2002-12-02 2005-09-13 레지스턴시아 파마슈티컬스 아베 자기 ｃ５ 아미노산 단편 및 비자기 아미노산 단편을포함하는 폴리펩티드를 이용하여 염증성 질환을 치료하기위한 방법 및 물질
WO2008039432A1 (en) * 2006-09-26 2008-04-03 Alexion Pharmaceuticals, Inc. Compositions and methods for enhancing an adjuvant
EP2173374A2 (de) * 2007-07-24 2010-04-14 Stichting Katholieke Universiteit, Radboud University Nijmegen Medical Centre Zusammensetzungen und verfahren zur erzeugung einer immunantwort in einer person
KR20100075483A (ko) * 2007-09-20 2010-07-02 더 제이. 데이비드 글래드스톤 인스티튜트 장산재 핵 요소 폴리펩티드 조성물 및 그것의 사용방법
JP2011514160A (ja) * 2008-02-21 2011-05-06 バーナム インスティテュート フォー メディカル リサーチ Ｃ末端エレメントを有するペプチドおよびタンパク質に関する方法および組成物
WO2011005540A1 (en) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Methods and compositions using peptides and proteins with c-terminal elements
FR2955773B1 (fr) 2010-02-01 2017-05-26 Commissariat Energie Atomique Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination
WO2012006149A2 (en) * 2010-06-29 2012-01-12 Board Of Regents Of The University Of Nebraska Analogs of c5a and methods of using same
US10220002B2 (en) 2011-12-02 2019-03-05 Board Of Regents Of The University Of Nebraska Controlled-release peptide compositions and uses thereof
US12156912B2 (en) * 2012-05-18 2024-12-03 Board Of Regents Of The University Of Nebraska Methods and compositions for inhibiting diseases of the central nervous system
CN107847452A (zh) 2015-03-11 2018-03-27 内布拉斯加大学董事会 应答选择性C5a激动剂EP67的构象稳定类似物
CA3065552A1 (en) 2017-06-12 2018-12-20 Board Of Regents Of The University Of Nebraska Hydrochloride salts of c5a receptor agonist peptides
CA3154373A1 (en) 2018-09-14 2020-03-19 Prommune, Inc. Anti-parasitic immunological compositions
CN111544585B (zh) * 2019-02-11 2024-12-27 北京卡替医疗技术有限公司 一种可助推免疫细胞在体内扩增的佐剂
CN116438191A (zh) * 2020-09-18 2023-07-14 欧萨尔普罗席纳有限公司 治疗阿尔茨海默病之多表位疫苗
EP4460507A4 (de) * 2022-01-06 2026-03-25 Washington University St Louis Verfahren und zusammensetzungen zur verbesserung der tumorimmunogenität und zur stimulation der antitumorimmunantworten in einem tier
CN120168630B (zh) * 2025-05-23 2025-09-02 中国医学科学院医学生物学研究所 一种细胞器靶向的分子原位组装嵌合体及其应用

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Also Published As

Publication number Publication date
CA2232344C (en) 2005-04-05
JP4125784B2 (ja) 2008-07-30
US20020091234A1 (en) 2002-07-11
EP0859625A4 (de) 2004-03-03
US20070031445A1 (en) 2007-02-08
US20050025784A1 (en) 2005-02-03
EP0859625A1 (de) 1998-08-26
CA2232344A1 (en) 1997-04-24
DE69637571D1 (de) 2008-08-07
ES2309992T3 (es) 2008-12-16
WO1997014426A1 (en) 1997-04-24
EP0859625B1 (de) 2008-06-25
US6821517B1 (en) 2004-11-23
AU703120B2 (en) 1999-03-18
JPH11515005A (ja) 1999-12-21
US7358087B2 (en) 2008-04-15
US7063847B1 (en) 2006-06-20
US7291336B2 (en) 2007-11-06
AU7460896A (en) 1997-05-07

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