ATE399563T1 - Extrazelluläre, gdf-5 enthaltende matrix zur induktion oder verstärkung der chondrogenese - Google Patents

Extrazelluläre, gdf-5 enthaltende matrix zur induktion oder verstärkung der chondrogenese

Info

Publication number: ATE399563T1
Authority: AT; Austria
Prior art keywords: inducing; chondrogenesis; extracellular matrix; enhancement; matrix containing
Prior art date: 1998-10-14

Application number

AT99954943T

Other languages

English (en)

Inventor

Mohammad Heidaran

Robert Spiro

Robin Daverman

Linshu Liu

Original Assignee

Depuy Spine Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-14

Filing date

1999-10-14

Publication date

2008-07-15

1999-10-14 Application filed by Depuy Spine Inc filed Critical Depuy Spine Inc

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE399563T1 publication Critical patent/ATE399563T1/de

Links

102000010834 Extracellular Matrix Proteins Human genes 0.000 title abstract 2
108010037362 Extracellular Matrix Proteins Proteins 0.000 title abstract 2
102000012966 Growth Differentiation Factor 5 Human genes 0.000 title abstract 2
108010090254 Growth Differentiation Factor 5 Proteins 0.000 title abstract 2
230000022159 cartilage development Effects 0.000 title abstract 2
210000002744 extracellular matrix Anatomy 0.000 title abstract 2
230000001939 inductive effect Effects 0.000 title abstract 2
102000012422 Collagen Type I Human genes 0.000 abstract 2
108010022452 Collagen Type I Proteins 0.000 abstract 2
102000000503 Collagen Type II Human genes 0.000 abstract 2
108010041390 Collagen Type II Proteins 0.000 abstract 2
238000000338 in vitro Methods 0.000 abstract 2
238000001727 in vivo Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
229940014041 hyaluronate Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/19—Growth and differentiation factors [GDF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT99954943T 1998-10-14 1999-10-14 Extrazelluläre, gdf-5 enthaltende matrix zur induktion oder verstärkung der chondrogenese ATE399563T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10422098P	1998-10-14	1998-10-14

Publications (1)

Publication Number	Publication Date
ATE399563T1 true ATE399563T1 (de)	2008-07-15

Family

ID=22299290

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99954943T ATE399563T1 (de)	1998-10-14	1999-10-14	Extrazelluläre, gdf-5 enthaltende matrix zur induktion oder verstärkung der chondrogenese

Country Status (8)

Country	Link
US (3)	US6586406B2 (de)
EP (1)	EP1128838B1 (de)
JP (2)	JP2002527402A (de)
AT (1)	ATE399563T1 (de)
AU (1)	AU1116400A (de)
CA (1)	CA2346119C (de)
DE (1)	DE69939025D1 (de)
WO (1)	WO2000021549A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6586388B2 (en)	1988-04-08	2003-07-01	Stryker Corporation	Method of using recombinant osteogenic protein to repair bone or cartilage defects
US6025475A (en) *	1998-09-15	2000-02-15	The Johns Hopkins University School Of Medicine	Growth differentiation factor-3
DE69939025D1 (de) *	1998-10-14	2008-08-14	Depuy Spine Inc	Extrazelluläre, gdf-5 enthaltende matrix zur induktion oder verstärkung der chondrogenese
US6932977B2 (en) *	2000-04-14	2005-08-23	Depuy Spine, Inc.	Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
CA2365376C (en)	2000-12-21	2006-03-28	Ethicon, Inc.	Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2472239A1 (en) *	2002-01-22	2003-07-31	Pfizer Inc.	3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases
US20040078090A1 (en)	2002-10-18	2004-04-22	Francois Binette	Biocompatible scaffolds with tissue fragments
US8197837B2 (en)	2003-03-07	2012-06-12	Depuy Mitek, Inc.	Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US7067123B2 (en)	2003-04-29	2006-06-27	Musculoskeletal Transplant Foundation	Glue for cartilage repair
US7901457B2 (en)	2003-05-16	2011-03-08	Musculoskeletal Transplant Foundation	Cartilage allograft plug
US7488348B2 (en)	2003-05-16	2009-02-10	Musculoskeletal Transplant Foundation	Cartilage allograft plug
US8226715B2 (en)	2003-06-30	2012-07-24	Depuy Mitek, Inc.	Scaffold for connective tissue repair
US10583220B2 (en)	2003-08-11	2020-03-10	DePuy Synthes Products, Inc.	Method and apparatus for resurfacing an articular surface
US7316822B2 (en)	2003-11-26	2008-01-08	Ethicon, Inc.	Conformable tissue repair implant capable of injection delivery
US7901461B2 (en)	2003-12-05	2011-03-08	Ethicon, Inc.	Viable tissue repair implants and methods of use
US11395865B2 (en)	2004-02-09	2022-07-26	DePuy Synthes Products, Inc.	Scaffolds with viable tissue
US8221780B2 (en) *	2004-04-20	2012-07-17	Depuy Mitek, Inc.	Nonwoven tissue scaffold
US7837740B2 (en)	2007-01-24	2010-11-23	Musculoskeletal Transplant Foundation	Two piece cancellous construct for cartilage repair
US20090319045A1 (en)	2004-10-12	2009-12-24	Truncale Katherine G	Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20060286144A1 (en) *	2005-06-17	2006-12-21	Chunlin Yang	Reinforced collagen scaffold
US7815926B2 (en)	2005-07-11	2010-10-19	Musculoskeletal Transplant Foundation	Implant for articular cartilage repair
CA2623106C (en)	2005-09-19	2013-12-24	Histogenics Corporation	Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US8435551B2 (en)	2007-03-06	2013-05-07	Musculoskeletal Transplant Foundation	Cancellous construct with support ring for repair of osteochondral defects
US8455436B2 (en)	2010-12-28	2013-06-04	Depuy Mitek, Llc	Compositions and methods for treating joints
US8524662B2 (en)	2010-12-28	2013-09-03	Depuy Mitek, Llc	Compositions and methods for treating joints
US8398611B2 (en)	2010-12-28	2013-03-19	Depuy Mitek, Inc.	Compositions and methods for treating joints
US8623839B2 (en)	2011-06-30	2014-01-07	Depuy Mitek, Llc	Compositions and methods for stabilized polysaccharide formulations
US10077420B2 (en)	2014-12-02	2018-09-18	Histogenics Corporation	Cell and tissue culture container
US9682099B2 (en)	2015-01-20	2017-06-20	DePuy Synthes Products, Inc.	Compositions and methods for treating joints

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL74715A0 (en)	1984-03-27	1985-06-30	Univ New Jersey Med	Biodegradable matrix and methods for producing same
US5055298A (en) *	1987-12-01	1991-10-08	Chemisches Laboratorium Dr. Kurt Richter Gmbh	Cosmetic composition comprising an extracellular connective tissue matrix
US4975526A (en)	1989-02-23	1990-12-04	Creative Biomolecules, Inc.	Bone collagen matrix for zenogenic implants
US5204325A (en) *	1988-12-15	1993-04-20	Lindstrom Richard L	Viscoelastic solution
US5208219A (en) *	1991-02-14	1993-05-04	Celtrix Pharmaceuticals Inc.	Method for inducing bone growth
US5118667A (en) *	1991-05-03	1992-06-02	Celtrix Pharmaceuticals, Inc.	Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5356629A (en)	1991-07-12	1994-10-18	United States Surgical Corporation	Composition for effecting bone repair
EP0690871A4 (de) *	1993-01-12	1999-10-20	Univ Johns Hopkins Med	Wachstums-differenzierungsfaktor-5
JPH07116240A (ja) *	1993-10-23	1995-05-09	Nippon Ham Kk	骨形成材料
GB9503492D0 (en) *	1995-02-22	1995-04-12	Ed Geistlich S Hne A G F R Che	Chemical product
US5866165A (en) *	1997-01-15	1999-02-02	Orquest, Inc.	Collagen-polysaccharide matrix for bone and cartilage repair
US6303585B1 (en) *	1997-07-03	2001-10-16	Orquest, Inc.	Cross-linked polysaccharide drug carrier
DE69939025D1 (de) *	1998-10-14	2008-08-14	Depuy Spine Inc	Extrazelluläre, gdf-5 enthaltende matrix zur induktion oder verstärkung der chondrogenese

1999
- 1999-10-14 DE DE69939025T patent/DE69939025D1/de not_active Expired - Lifetime
- 1999-10-14 JP JP2000575523A patent/JP2002527402A/ja active Pending
- 1999-10-14 EP EP99954943A patent/EP1128838B1/de not_active Expired - Lifetime
- 1999-10-14 WO PCT/US1999/024130 patent/WO2000021549A1/en not_active Ceased
- 1999-10-14 US US09/418,689 patent/US6586406B2/en not_active Expired - Lifetime
- 1999-10-14 AU AU11164/00A patent/AU1116400A/en not_active Abandoned
- 1999-10-14 CA CA2346119A patent/CA2346119C/en not_active Expired - Fee Related
- 1999-10-14 AT AT99954943T patent/ATE399563T1/de not_active IP Right Cessation
2003
- 2003-05-22 US US10/444,640 patent/US6849606B2/en not_active Expired - Fee Related
2004
- 2004-11-05 US US10/982,258 patent/US7070942B2/en not_active Expired - Fee Related
2010
- 2010-08-05 JP JP2010176401A patent/JP2010248267A/ja active Pending

Also Published As

Publication number	Publication date
US20020173448A1 (en)	2002-11-21
US7070942B2 (en)	2006-07-04
US20030207816A1 (en)	2003-11-06
EP1128838A4 (de)	2004-12-15
JP2002527402A (ja)	2002-08-27
US20050095234A1 (en)	2005-05-05
US6849606B2 (en)	2005-02-01
CA2346119A1 (en)	2000-04-20
EP1128838B1 (de)	2008-07-02
CA2346119C (en)	2011-04-05
WO2000021549A8 (en)	2001-02-22
JP2010248267A (ja)	2010-11-04
EP1128838A1 (de)	2001-09-05
US6586406B2 (en)	2003-07-01
WO2000021549A1 (en)	2000-04-20
DE69939025D1 (de)	2008-08-14
AU1116400A (en)	2000-05-01

Legal Events

Date	Code	Title	Description
2009-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69939025D1 (de)	2008-08-14	Extrazelluläre, gdf-5 enthaltende matrix zur induktion oder verstärkung der chondrogenese
ES2196502T3 (es)	2003-12-16	Composicion y metodo para inhibir el desarrollo de microorganismos que incluye hipobromito sodico estabilizado e isotiazolonas.
NO972171L (no)	1997-07-07	Regulering av neural stamcelleproliferasjon
DE69530403D1 (de)	2003-05-22	Analogen des keratinozytenwachstumfaktors
ES8105360A1 (es)	1981-05-16	Metodo de tratamiento de fibras de vidrio
DE69734605D1 (de)	2005-12-15	Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung
BR9810851A (pt)	2000-07-25	Analgésico de ação rápida, e, processo para produção do mesmo
ATE393831T1 (de)	2008-05-15	Zusammensetzung zur in vivo erzeugung von therapeutischen produkten
DE60232234D1 (de)	2009-06-18	Verfahren zur kultivierung von circovirus
ATE254405T1 (de)	2003-12-15	Stoff zur erhöhung der effizienz der vermehrung und der produktion von säugetieren
BR0014503A (pt)	2002-06-11	Matrizes hìbridas e misturas de matriz hìbrida
DE69525151D1 (de)	2002-03-14	Methoden zur krankheitsbehandlung unter verwendung von sertoli-zellen und allotransplantat oder xenotransplantat
DE69635924D1 (de)	2006-05-11	Isolierung und züchtung von schwannzellen
AR022583A1 (es)	2002-09-04	Secuencias antitumorales anti-sentido dirigidas contra los componentes r1 y r2 de la reductasa de los ribonucleotidos
BR9611571A (pt)	1999-03-30	Composição farmacêutica estável composição farmacêutica kit para administração de ngf e método de aumento da estabilidade de ngf
EP0057942A3 (en)	1982-10-27	Cysteine delivery system
ATE279524T1 (de)	2004-10-15	Künstliche matrix-anheftungsregion zur erhöhung der expression von in pflanzen eingeführten genen
DE69528473D1 (de)	2002-11-07	Verwendung von hepatozyten-wachstumsfaktor zur induzierung der proliferation und differenzierung von hämatopoietischen zellen
BR9609446A (pt)	1999-12-14	Processo para reduzir colesterol de gema de ovo
TR199802706T2 (xx)	1999-05-21	Bir bitki hastal��n�n iyile�tirilmesi i�in y�ntem.
AR018230A1 (es)	2001-10-31	Utilizacion de la vitamina c o analogos para aumentar el procentaje de diferenciacion y/o de proliferacion de las celulas de la piel
DE60028750D1 (de)	2006-07-27	Verwendung von tagatose zur verbesserung wichtiger blutfaktoren
ES2026966T3 (es)	1992-05-16	Procedimiento para la obtencion de 4-metil-4-fenil-1-penta--nales y su empleo como perfumantes.
ES2031552T3 (es)	1992-12-16	2-selenometil-1,4-dihidropiridinas, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
DK0795008T3 (da)	2003-12-15	Humane hypertrofe chondrocyt-cellelinjer