ATE400179T1 - Verwendung von pyrimidinetrion-derivaten als acetylcholinesterase-hemmer, diese enthaltende zusammensetzungen und deren verwendungen - Google Patents
Verwendung von pyrimidinetrion-derivaten als acetylcholinesterase-hemmer, diese enthaltende zusammensetzungen und deren verwendungenInfo
- Publication number
- ATE400179T1 ATE400179T1 AT06755417T AT06755417T ATE400179T1 AT E400179 T1 ATE400179 T1 AT E400179T1 AT 06755417 T AT06755417 T AT 06755417T AT 06755417 T AT06755417 T AT 06755417T AT E400179 T1 ATE400179 T1 AT E400179T1
- Authority
- AT
- Austria
- Prior art keywords
- acetylcholinesterase
- optionally substituted
- acetylcholinesterase inhibitors
- derivatives
- pyrimidinetrion
- Prior art date
Links
- 239000000544 cholinesterase inhibitor Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- SOFSSZFBVOGIKD-UHFFFAOYSA-N pyrimidine-2,4,5-trione Chemical class O=C1NC(=O)C(=O)C=N1 SOFSSZFBVOGIKD-UHFFFAOYSA-N 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 102000012440 Acetylcholinesterase Human genes 0.000 abstract 2
- 108010022752 Acetylcholinesterase Proteins 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 230000000749 insecticidal effect Effects 0.000 abstract 2
- 239000002917 insecticide Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 2
- 150000003230 pyrimidines Chemical class 0.000 abstract 2
- DAIAJSOQDQWBAR-UHFFFAOYSA-N 5-[(5-methylfuran-2-yl)methylidene]-1-phenyl-1,3-diazinane-2,4,6-trione Chemical compound O1C(C)=CC=C1C=C1C(=O)N(C=2C=CC=CC=2)C(=O)NC1=O DAIAJSOQDQWBAR-UHFFFAOYSA-N 0.000 abstract 1
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 abstract 1
- 229940022698 acetylcholinesterase Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Agronomy & Crop Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Plant Pathology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0501328A FR2881618B1 (fr) | 2005-02-10 | 2005-02-10 | Utilisation de composes derives de pyrimidinetrione en tant qu'inhibiteurs de l'acetylcholinesterase, compositions contenant ces derives et leurs utilisations en tant qu'insecticides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE400179T1 true ATE400179T1 (de) | 2008-07-15 |
Family
ID=35406144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06755417T ATE400179T1 (de) | 2005-02-10 | 2006-02-10 | Verwendung von pyrimidinetrion-derivaten als acetylcholinesterase-hemmer, diese enthaltende zusammensetzungen und deren verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8309556B2 (de) |
| EP (1) | EP1845781B1 (de) |
| AT (1) | ATE400179T1 (de) |
| CA (1) | CA2597349C (de) |
| DE (1) | DE602006001731D1 (de) |
| ES (1) | ES2312134T3 (de) |
| FR (1) | FR2881618B1 (de) |
| WO (1) | WO2006097588A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011215870B2 (en) | 2010-02-09 | 2016-01-28 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| JP6433482B2 (ja) | 2013-03-15 | 2018-12-05 | エージンバイオ, インコーポレイテッド | 認知機能を改善するための方法および組成物 |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2016191288A1 (en) | 2015-05-22 | 2016-12-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR382112A (fr) | 1907-09-20 | 1908-01-30 | Juan Puig Y Marco | Appareil indiquant à tout instant la longueur de tissu fabriqué par un métier |
| FR455300A (fr) | 1913-03-08 | 1913-07-26 | Deutsche Maschf Ag | Chariot de coulée |
| DE3903404A1 (de) * | 1989-02-06 | 1990-08-09 | Hoechst Ag | Pyrimidintrionderivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schaedlingsbekaempfungsmittel |
| NL9001075A (de) * | 1990-05-04 | 1991-12-02 | Duphar Int Res | |
| US20050049267A1 (en) * | 2002-03-01 | 2005-03-03 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
-
2005
- 2005-02-10 FR FR0501328A patent/FR2881618B1/fr not_active Expired - Fee Related
-
2006
- 2006-02-10 US US11/816,032 patent/US8309556B2/en not_active Expired - Fee Related
- 2006-02-10 CA CA2597349A patent/CA2597349C/fr not_active Expired - Fee Related
- 2006-02-10 AT AT06755417T patent/ATE400179T1/de not_active IP Right Cessation
- 2006-02-10 WO PCT/FR2006/000307 patent/WO2006097588A1/fr not_active Ceased
- 2006-02-10 EP EP06755417A patent/EP1845781B1/de not_active Expired - Lifetime
- 2006-02-10 DE DE602006001731T patent/DE602006001731D1/de not_active Expired - Lifetime
- 2006-02-10 ES ES06755417T patent/ES2312134T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006097588A1 (fr) | 2006-09-21 |
| EP1845781A1 (de) | 2007-10-24 |
| CA2597349C (fr) | 2015-05-26 |
| EP1845781B1 (de) | 2008-07-09 |
| US8309556B2 (en) | 2012-11-13 |
| ES2312134T3 (es) | 2009-02-16 |
| FR2881618A1 (fr) | 2006-08-11 |
| FR2881618B1 (fr) | 2007-04-13 |
| CA2597349A1 (fr) | 2006-09-21 |
| DE602006001731D1 (de) | 2008-08-21 |
| US20080269252A1 (en) | 2008-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |