ATE400359T1 - Kontinuierliches verfahren zur herstellung von kombinatorischen substanzbibliotheken - Google Patents

Kontinuierliches verfahren zur herstellung von kombinatorischen substanzbibliotheken

Info

Publication number
ATE400359T1
ATE400359T1 AT02720782T AT02720782T ATE400359T1 AT E400359 T1 ATE400359 T1 AT E400359T1 AT 02720782 T AT02720782 T AT 02720782T AT 02720782 T AT02720782 T AT 02720782T AT E400359 T1 ATE400359 T1 AT E400359T1
Authority
AT
Austria
Prior art keywords
combinatory
producing
continuous process
substance libraries
plug flow
Prior art date
Application number
AT02720782T
Other languages
English (en)
Inventor
James Nelson
Robert Davidson
Jeffrey Cernohous
Michael Annen
James Mcnerney
Robert Ferguson
Anthony Maistrovich
James Higgins
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of ATE400359T1 publication Critical patent/ATE400359T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/1812—Tubular reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/1812—Tubular reactors
    • B01J19/1818—Tubular reactors in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/1862—Stationary reactors having moving elements inside placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/20—Stationary reactors having moving elements inside in the form of helices, e.g. screw reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/242—Tubular reactors in series
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
    • C08F297/02—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer using a catalyst of the anionic type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00033—Continuous processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00036—Intermittent processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00054—Controlling or regulating the heat exchange system
    • B01J2219/00056—Controlling or regulating the heat exchange system involving measured parameters
    • B01J2219/00058—Temperature measurement
    • B01J2219/00063—Temperature measurement of the reactants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00094—Jackets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B01J2219/00355—Pumps peristaltic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00481—Means for mixing reactants or products in the reaction vessels by the use of moving stirrers within the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00756—Compositions, e.g. coatings, crystals, formulations
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25875—Gaseous sample or with change of physical state

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Polymerisation Methods In General (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Saccharide Compounds (AREA)
  • Inorganic Fibers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
AT02720782T 2001-04-02 2002-01-10 Kontinuierliches verfahren zur herstellung von kombinatorischen substanzbibliotheken ATE400359T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/824,330 US7514263B2 (en) 2001-04-02 2001-04-02 Continuous process for the production of combinatorial libraries of materials

Publications (1)

Publication Number Publication Date
ATE400359T1 true ATE400359T1 (de) 2008-07-15

Family

ID=25241109

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02720782T ATE400359T1 (de) 2001-04-02 2002-01-10 Kontinuierliches verfahren zur herstellung von kombinatorischen substanzbibliotheken

Country Status (8)

Country Link
US (1) US7514263B2 (de)
EP (1) EP1379329B1 (de)
JP (1) JP4559028B2 (de)
KR (1) KR100855142B1 (de)
AT (1) ATE400359T1 (de)
AU (1) AU2002251757A1 (de)
DE (1) DE60227493D1 (de)
WO (1) WO2002081079A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052792B2 (en) 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US7459022B2 (en) 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US7514263B2 (en) 2001-04-02 2009-04-07 3M Innovative Properties Company Continuous process for the production of combinatorial libraries of materials
DE10125571A1 (de) * 2001-05-25 2002-12-05 Ticona Gmbh Mischungen mit hoher Diversität, Verfahren zu ihrer Herstellung und ihre Verwendung
US6881363B2 (en) 2001-12-07 2005-04-19 Symyx Technologies, Inc. High throughput preparation and analysis of materials
US6903173B2 (en) 2002-08-02 2005-06-07 3M Innovative Properties Co. Fluorinated polymers
US7632916B2 (en) 2002-08-02 2009-12-15 3M Innovative Properties Company Process to modify polymeric materials and resulting compositions
US7157283B2 (en) 2002-08-02 2007-01-02 3M Innovative Properties Company Continuous process for the production of combinatorial libraries of modified materials
US6716935B1 (en) * 2002-12-19 2004-04-06 3M Innovative Properties Company Continuous process for the production of controlled architecture materials under high solids loading conditions
US6969490B2 (en) * 2003-06-26 2005-11-29 3M Innovative Properties Company Device for the continuous process for the production of controlled architecture materials
DE10335968A1 (de) * 2003-08-06 2005-02-24 Basf Ag Verfahren zur sequentiellen Herstellung einer Heterogenkatalysator-Bibliothek
US7528089B2 (en) 2003-12-30 2009-05-05 Exxonmobil Research And Engineering Company High solids materials processing
DE102004001599A1 (de) * 2004-01-09 2005-08-04 Röhm GmbH & Co. KG Verfahren zur Herstellung von Schmelzpolymerisaten im Rohrreaktor
US7495051B2 (en) * 2004-09-27 2009-02-24 3M Innovative Properties Company Nanocomposite and method of making the same
US7691932B2 (en) * 2004-09-27 2010-04-06 3M Innovative Properties Company Method of making a composition and nanocomposites therefrom
US7329702B2 (en) * 2004-09-27 2008-02-12 3M Innovative Properties Company Composition and method of making the same
US8193270B2 (en) * 2004-12-14 2012-06-05 3M Innovative Properties Company Method of making composites and nanocomposites
EP1676632A1 (de) 2004-12-28 2006-07-05 Covion Organic Semiconductors GmbH Verfahren zur Herstellung von Polymeren
US7576037B2 (en) * 2005-11-18 2009-08-18 Mei Technologies, Inc. Process and apparatus for combinatorial synthesis
EP2075059A1 (de) * 2007-12-14 2009-07-01 Biotage AB Vorrichtungen und Verfahren zur Ausführung mikrowellenunterstützter chemischer Synthesen
US8394977B2 (en) * 2008-03-28 2013-03-12 3M Innovative Properties Company Process for the surface modification of particles
CN102037066B (zh) * 2008-03-28 2014-11-19 3M创新有限公司 填充树脂及制造填充树脂的方法
BRPI0910662A2 (pt) * 2008-04-25 2015-09-29 3M Innovative Properties Co processo para modificação de superfície de partículas
US8314206B2 (en) 2008-12-02 2012-11-20 Micron Technology, Inc. Block copolymer-comprising compositions and methods of purifying PS-b-PXVP
EP2435178B1 (de) 2009-05-26 2020-08-12 3M Innovative Properties Company Verfahren zur herstellung von gefüllten harzen
PL2534199T3 (pl) 2010-02-11 2019-04-30 3M Innovative Properties Co System żywicy zawierający rozproszone wielomodalne nanocząstki modyfikowane powierzchniowo
JP5809241B2 (ja) 2010-04-20 2015-11-10 スリーエム イノベイティブ プロパティズ カンパニー ポリマー表面修飾ナノ粒子を含有する感圧接着剤
JP5605945B2 (ja) * 2010-09-17 2014-10-15 国立大学法人京都大学 リビングラジカル重合法
GB201209239D0 (en) * 2012-05-25 2012-07-04 Univ Glasgow Methods of evolutionary synthesis including embodied chemical synthesis
WO2022136093A1 (en) 2020-12-21 2022-06-30 Hte Gmbh The High Throughput Experimentation Company System for analyzing material systems
KR102495709B1 (ko) 2021-01-13 2023-02-06 포항공과대학교 산학협력단 화합물 라이브러리의 병렬형 다중 합성 방법 및 이를 이용한 화합물 라이브러리의 병렬형 합성 장치

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3036997A (en) 1956-11-21 1962-05-29 Du Pont Diene-modified polymers and elastomers thereform
US2915554A (en) 1957-07-23 1959-12-01 Minnesota Mining & Mfg Non-ionic surfactant derivatives of perfluoro alkane-sulfonamides
DE2003266A1 (de) 1970-01-26 1971-08-05 Waldhof Zellstoff Fab Verfahren zur Herstellung von Gelen
US3804881A (en) 1972-06-20 1974-04-16 Union Carbide Corp Polymerization using varying monomer concentration
DE2250274A1 (de) * 1972-10-13 1974-04-25 Manfred Dipl Ing Lapczyna Verfahren und vorrichtung zur kontinuierlichen herstellung von faellungs- und traenkungskatalysatoren
US4086151A (en) 1974-02-20 1978-04-25 The Dow Chemical Company Curable mixtures and cured resins made from linear polymers of glycidol
US4346193A (en) 1981-05-04 1982-08-24 Atlantic Richfield Company Continuous process for making star-block copolymers
US4500687A (en) 1981-06-18 1985-02-19 The Dow Chemical Company Elastomeric polyether-containing impact polymer products
DD206387A1 (de) 1981-08-03 1984-01-25 Sprela Werke Spremberg Veb Verfahren zur kontinuierlichen herstellung fluessiger resole
US4415615A (en) 1982-01-15 1983-11-15 Minnesota Mining And Manufacturing Co. Cellular pressure-sensitive adhesive product and method of making
US4371661A (en) 1982-02-17 1983-02-01 Atlantic Richfield Company Semi-continuous process for making star-block copolymers
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4442273A (en) 1983-04-06 1984-04-10 Atlantic Richfield Company Process and apparatus for continuous polymerization of a monovinyl aromatic monomer
IT1164238B (it) 1983-05-25 1987-04-08 Anic Spa Procedimento per la polimerizzazione del butadiene
US4572819A (en) * 1983-08-24 1986-02-25 The Dow Chemical Company Apparatus for anionic polymerization wherein the molecular weight of the polymer is closely controlled
FR2565350B1 (fr) 1984-06-05 1986-10-10 Paris Nord Universite Moyens propres a permettre le support, le traitement, le stockage et l'analyse automatiques en continu d'echantillons biologiques
US4599437A (en) 1984-10-29 1986-07-08 Wacker-Chemie Gmbh Continuous process for varying molecular weight of organopolysiloxanes
DE3519411A1 (de) 1985-05-30 1986-12-04 Wacker-Chemie GmbH, 8000 München Kontinuierliches verfahren zur aenderung des molekulargewichts von organosiliciumverbindungen
JPH0689047B2 (ja) 1987-03-27 1994-11-09 新日鐵化学株式会社 重合反応装置
ES2011993A6 (es) * 1989-04-13 1990-02-16 Consejo Superior Investigacion Unidad computerizada para estudio y evaluacion de catalizadores de fcc
IT1230085B (it) 1989-05-24 1991-10-05 Montedipe Spa Processo per la produzione in massa e in continuo di (co) polimeri vinil aromatici antiurto.
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5047898A (en) 1989-11-13 1991-09-10 International Business Machines Corporation Deflectable contact for providing positive surface contact for shielding electromagnetic interference
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5144069A (en) 1990-12-13 1992-09-01 Minnesota Mining And Manufacturing Company Process for the preparation of fluoroaliphatic aminocarboxylate surfactants
US5227460A (en) 1991-12-30 1993-07-13 Xerox Corporation Cross-linked toner resins
US5521095A (en) 1992-02-10 1996-05-28 Queen's University At Kingston Temperature scanning reactor method
CA2128723A1 (en) * 1992-02-10 1993-08-19 Bohdan W. Wojciechowski Temperature scanning reactor
DE4234601A1 (de) 1992-10-14 1994-04-21 Basf Ag Verfahren zur Herstellung von Blockcopolymeren durch ionische Polymerisation
DE4235786A1 (de) 1992-10-23 1994-04-28 Basf Ag Polystyrol-Formmasse und Verfahren zu ihrer Herstellung
DE4235980A1 (de) 1992-10-24 1994-04-28 Basf Ag Verfahren zur Herstellung einer vinylaromatischen Verbindung
US5345213A (en) 1992-10-26 1994-09-06 The United States Of America, As Represented By The Secretary Of Commerce Temperature-controlled, micromachined arrays for chemical sensor fabrication and operation
US5356756A (en) 1992-10-26 1994-10-18 The United States Of America As Represented By The Secretary Of Commerce Application of microsubstrates for materials processing
DE4313008C1 (de) 1993-04-21 1994-11-10 Beiersdorf Ag Selbstklebemasse auf Acrylathotmelt-Basis, Verfahren zu deren Herstellung und deren Verwendung
DE69327461T2 (de) * 1993-10-06 2000-07-27 Imation Corp., Saint Paul Photographisches Silberhalogenidmaterial mit verbesserten antistatischen Eigenschaften
CA2180526A1 (en) 1994-01-05 1995-07-13 Joseph C. Hogan, Jr. Method of identifying chemical compounds having selected properties for a particular application
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US6004617A (en) 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
JPH08127602A (ja) 1994-10-31 1996-05-21 Mitsui Petrochem Ind Ltd ポリマーの連続重合方法及び装置
GB2295152A (en) 1994-11-18 1996-05-22 Pfizer Ltd Preparation of a library of compounds by solid-phase synthesis
US5571655A (en) 1995-04-17 1996-11-05 Xerox Corporation Toner reactive melt mixing process
FR2735480B1 (fr) 1995-06-15 1997-07-18 Atochem Elf Sa Procede de polymerisation anionique en continu d'au moins un monomere (meth)acrylique pour l'obtention de polymeres a haut taux de solide
US5644007A (en) 1996-04-26 1997-07-01 Minnesota Mining And Manufacturing Company Continuous process for the production of poly(1-alkenes)
US5804625A (en) 1996-05-21 1998-09-08 Minnesota Mining And Manufacturing Company Fluorochemical and hydrocarbon surfactant blends as hydrophilic additives to thermoplastic polymers
US6720186B1 (en) * 1998-04-03 2004-04-13 Symyx Technologies, Inc. Method of research for creating and testing novel catalysts, reactions and polymers
JP3523271B2 (ja) 1997-01-20 2004-04-26 積水化成品工業株式会社 発泡性熱可塑性樹脂粒子およびこれを用いた発泡成形体
NO304355B1 (no) 1997-02-20 1998-12-07 Sinvent As Multi-autoklav for metodisk, automatisert syntese av zeolitter og andre forbindelser
US6224832B1 (en) * 1997-05-30 2001-05-01 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
GB9726983D0 (en) 1997-12-22 1998-02-18 Cambridge Combinatorial Ltd Novel substrate for solid phase combinatorial library generation, apparatus for preparing addressable portions thereof, and a method of preparing a library
US20020006604A1 (en) 1998-02-21 2002-01-17 Alan W Schwabacher One dimensional compound arrays and a method for assaying them
US6175409B1 (en) 1999-04-02 2001-01-16 Symyx Technologies, Inc. Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers
AU761458B2 (en) 1998-04-13 2003-06-05 Rutgers, The State University The construction of copolymer libraries
CA2334390A1 (en) 1998-06-05 2000-01-27 Thomas E. Mallouk Method of screening compositions for electrocatalytic activity
US6149882A (en) 1998-06-09 2000-11-21 Symyx Technologies, Inc. Parallel fixed bed reactor and fluid contacting apparatus
US6160060A (en) 1998-08-04 2000-12-12 Eastman Chemical Company Process for the synthesis of high molecular weight predominantly amorphous polymers with improved color and adhesive properties
US6306658B1 (en) 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
CN1150231C (zh) * 1998-09-03 2004-05-19 西巴特殊化学品控股有限公司 烯属不饱和单体在聚合物上的接枝方法
US6531704B2 (en) * 1998-09-14 2003-03-11 Nanoproducts Corporation Nanotechnology for engineering the performance of substances
GB9820208D0 (en) 1998-09-16 1998-11-11 Central Research Lab Ltd Apparatus for and method of storing a plurality of chemical compounds
US6485692B1 (en) * 1998-12-04 2002-11-26 Symyx Technologies, Inc. Continuous feed parallel reactor
US6749814B1 (en) * 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6693220B2 (en) * 1999-05-07 2004-02-17 General Electric Company Method for screening multiple reactants and catalyst systems using incremental flow reactor methodology
WO2000077085A1 (en) 1999-06-11 2000-12-21 Sydney Hyman Image making medium
DE60042561D1 (de) 1999-10-27 2009-08-27 3M Innovative Properties Co Fluorochemische sulfonamide tenside
US6586541B2 (en) * 2000-02-02 2003-07-01 E. I. Du Pont De Nemours And Company Process for production of polyolefins
US6448353B1 (en) * 2000-02-08 2002-09-10 3M Innovative Properties Company Continuous process for the production of controlled architecture materials
DE10016652A1 (de) 2000-04-04 2001-10-18 Basf Ag Additivarme strahlenhärtbare Bindemittel
DE60118576T2 (de) 2000-08-18 2006-11-02 3M Innovative Properties Co., Saint Paul Fluoro(meth)acrylatecopolymer-beschichtungsmassen
US6593436B2 (en) * 2000-11-29 2003-07-15 Crompton Corporation Continuous manufacture of silicone copolymers via static mixing plug flow reactors
JP3714870B2 (ja) 2000-12-28 2005-11-09 セントラル硝子株式会社 透明性含フッ素共重合体
US7118917B2 (en) * 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
US7514263B2 (en) 2001-04-02 2009-04-07 3M Innovative Properties Company Continuous process for the production of combinatorial libraries of materials
US20030012700A1 (en) * 2001-07-11 2003-01-16 Carnahan James Claude Systems and methods for parallel testing of catalyst performance
GB2378068B (en) 2001-07-27 2005-05-04 Motorola Inc Bipolar differential amplifier
US7157283B2 (en) 2002-08-02 2007-01-02 3M Innovative Properties Company Continuous process for the production of combinatorial libraries of modified materials

Also Published As

Publication number Publication date
JP4559028B2 (ja) 2010-10-06
US20030035756A1 (en) 2003-02-20
EP1379329A2 (de) 2004-01-14
DE60227493D1 (de) 2008-08-21
WO2002081079A3 (en) 2003-03-06
KR20030092043A (ko) 2003-12-03
WO2002081079A2 (en) 2002-10-17
KR100855142B1 (ko) 2008-08-28
EP1379329B1 (de) 2008-07-09
JP2004535274A (ja) 2004-11-25
US7514263B2 (en) 2009-04-07
AU2002251757A1 (en) 2002-10-21

Similar Documents

Publication Publication Date Title
DE60227493D1 (de) Kontinuierliches verfahren zur herstellung von kombinatorischen substanzbibliotheken
DE59803203D1 (de) Formkörper und verfahren zu dessen herstellung
ATE366756T1 (de) Verfahren zur voraktivierung von katalysatoren
ATE241427T1 (de) Parallel-reaktor mit interner fühlung und verfahren zu dessen verwendung
ATE373043T1 (de) Verfahren zur herstellung von syntaktischen polyurethanen
DE69920344D1 (de) Verwendung eines Acrylsäure-Typ Polymeres als Desintegrationsmittel, Vefahren zur Herstellung von Tabletten und hergestellte Tabletten
DE69526791D1 (de) Synthese kombinatorischer bibliotheken
ATE327985T1 (de) Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen
Sibi et al. A convenient method for the conversion of N-acyloxazolidinones to hydroxamic acids
DK1294478T3 (da) Nye emulsioner
DE69627314D1 (de) Kettenabbruchgruppen, ihre verwendung zur sequenzierung und synthese von nukleinsäuren und verfahren zu ihrer herstellung
ATE319747T1 (de) Kontinuierliches verfahren zur herstellung von materialien mit einer kontrollierten struktur
DE69819998D1 (de) Verfahren zur chemischen Synthese von Oligonukleotiden
ATE310242T1 (de) Verfahren zur kombinatorischen materialentwicklung durch den einsatz von wärmedifferenzbildern
EP1282631A4 (de) Verfahren zur herstellung und verwendung von radiomarkierten platin-chemotherapeutischen mitteln
CY1115506T1 (el) Μεθοδος για την επεξεργασια ενος καταλυτη που περιεχεται σε αντιδραστηρα στηλης φυσαλιδων
ATE314337T1 (de) Verfahren zur hydration von olefinen
BR0313158A (pt) Método contìnuo de produzir uma biblioteca combinatória de materiais
DE69724141D1 (de) Verbindungen verwendbar zur perhaloalkylierung, reagenz für ihrer durchführung und verfahren zu ihrer herstellung
ATE188954T1 (de) Verfahren zur herstellung von basischem aluminiumpolychlorid und seine anwendung für die behandlung von wasserhaltigen media
ATE189233T1 (de) Beschichtung gegen wandanlage in polymerisationsreaktoren und verfahren zu ihrer herstellung
ID29144A (id) Proses untuk melakukan reaksi gas-cair dan reaktor aliran terus menerus yang bersesuaian untuk tujuan ini
DE69910455D1 (de) Verfahren zur Herstellung von Nitril Verbindungen und dafür verwendeter Katalysator
ATA5052000A (de) Vorrichtung zur aeroben fermentation von biologischen substanzen
SE9803469D0 (sv) New method

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties