ATE401298T1 - Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin - Google Patents
Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diaminInfo
- Publication number
- ATE401298T1 ATE401298T1 AT00990356T AT00990356T ATE401298T1 AT E401298 T1 ATE401298 T1 AT E401298T1 AT 00990356 T AT00990356 T AT 00990356T AT 00990356 T AT00990356 T AT 00990356T AT E401298 T1 ATE401298 T1 AT E401298T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- phenylbutyl
- isobutyl
- amino
- derivatives
- Prior art date
Links
- 230000001976 improved effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 amide hydrochloride Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17204399P | 1999-12-23 | 1999-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE401298T1 true ATE401298T1 (de) | 2008-08-15 |
Family
ID=22626131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00990356T ATE401298T1 (de) | 1999-12-23 | 2000-12-22 | Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin |
Country Status (5)
| Country | Link |
|---|---|
| EP (6) | EP2314563A3 (de) |
| AT (1) | ATE401298T1 (de) |
| AU (1) | AU2739201A (de) |
| DE (1) | DE60039533D1 (de) |
| WO (1) | WO2001046120A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4818124B2 (ja) | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法 |
| HRP20080554B1 (hr) | 2006-03-29 | 2014-11-21 | Gilead Sciences, Inc. | Postupak priprave inhibitora proteaze hiv |
| WO2008132154A1 (en) | 2007-04-27 | 2008-11-06 | Tibotec Pharmaceuticals Ltd. | Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
| ES2881949T3 (es) | 2016-10-27 | 2021-11-30 | Gilead Sciences Inc | Forma cristalina de base libre de darunavir |
| AR110922A1 (es) | 2017-02-06 | 2019-05-15 | Gilead Sciences Inc | Compuestos inhibidores del vih |
| TWI829205B (zh) | 2018-07-30 | 2024-01-11 | 美商基利科學股份有限公司 | 抗hiv化合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE520156C (de) * | 1927-09-01 | 1931-03-09 | Ici Ltd | Verfahren zur Herstellung von Morpholin und seinen Homologen |
| FR2557101B1 (fr) * | 1983-12-21 | 1986-06-27 | Pharmascience Lab | Nouveau procede de preparation de diamine-alcools |
| DE4220758A1 (de) | 1992-06-24 | 1994-01-05 | Inst Genbiologische Forschung | DNA-Sequenz und Plasmide zur Herstellung von Pflanzen mit veränderter Saccharose-Konzentration |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| EP0715618B1 (de) * | 1993-08-24 | 1998-12-16 | G.D. Searle & Co. | Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5767316A (en) * | 1995-11-17 | 1998-06-16 | Ajinomoto Co., Inc. | Process for producing 3-amino-2-oxo-1-halogenopropane derivatives |
| SE9602646D0 (sv) * | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| GB9805898D0 (en) * | 1998-03-20 | 1998-05-13 | Glaxo Group Ltd | Process for the sythesis of hiv protease inhibitors |
| JP4814427B2 (ja) * | 1999-02-12 | 2011-11-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパルチルプロテアーゼのインヒビター |
-
2000
- 2000-12-22 EP EP10185680A patent/EP2314563A3/de not_active Withdrawn
- 2000-12-22 EP EP00990356A patent/EP1244610B1/de not_active Expired - Lifetime
- 2000-12-22 EP EP10185671A patent/EP2314562A3/de not_active Withdrawn
- 2000-12-22 EP EP10185692A patent/EP2314564A3/de not_active Withdrawn
- 2000-12-22 EP EP10185688A patent/EP2319824A3/de not_active Withdrawn
- 2000-12-22 AU AU27392/01A patent/AU2739201A/en not_active Abandoned
- 2000-12-22 AT AT00990356T patent/ATE401298T1/de not_active IP Right Cessation
- 2000-12-22 EP EP08160457A patent/EP2194038A3/de not_active Withdrawn
- 2000-12-22 DE DE60039533T patent/DE60039533D1/de not_active Expired - Lifetime
- 2000-12-22 WO PCT/US2000/035335 patent/WO2001046120A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1244610A1 (de) | 2002-10-02 |
| DE60039533D1 (de) | 2008-08-28 |
| EP2314564A2 (de) | 2011-04-27 |
| EP2314563A3 (de) | 2012-04-04 |
| EP2319824A2 (de) | 2011-05-11 |
| EP1244610B1 (de) | 2008-07-16 |
| EP2194038A2 (de) | 2010-06-09 |
| EP2319824A3 (de) | 2012-04-11 |
| EP2314563A2 (de) | 2011-04-27 |
| EP2314562A2 (de) | 2011-04-27 |
| AU2739201A (en) | 2001-07-03 |
| EP2314562A3 (de) | 2012-03-21 |
| EP2194038A3 (de) | 2010-09-01 |
| WO2001046120A1 (en) | 2001-06-28 |
| EP2314564A3 (de) | 2012-04-04 |
| EP1244610A4 (de) | 2005-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |