ATE401574T1 - Analyse zirkulierender tumorzellen, fragmente und trümmer - Google Patents

Analyse zirkulierender tumorzellen, fragmente und trümmer

Info

Publication number
ATE401574T1
ATE401574T1 AT02761478T AT02761478T ATE401574T1 AT E401574 T1 ATE401574 T1 AT E401574T1 AT 02761478 T AT02761478 T AT 02761478T AT 02761478 T AT02761478 T AT 02761478T AT E401574 T1 ATE401574 T1 AT E401574T1
Authority
AT
Austria
Prior art keywords
analysis
damage
debris
fragments
vitro
Prior art date
Application number
AT02761478T
Other languages
English (en)
Inventor
Galla Rao
Christopher Larson
Madeline Repollet
Herman Rutner
Leon Terstappen
Shawn O'hara
Steven Gross
Original Assignee
Immunivest Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26979228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE401574(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunivest Corp filed Critical Immunivest Corp
Application granted granted Critical
Publication of ATE401574T1 publication Critical patent/ATE401574T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT02761478T 2001-08-23 2002-08-23 Analyse zirkulierender tumorzellen, fragmente und trümmer ATE401574T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31415101P 2001-08-23 2001-08-23
US36962802P 2002-04-03 2002-04-03

Publications (1)

Publication Number Publication Date
ATE401574T1 true ATE401574T1 (de) 2008-08-15

Family

ID=26979228

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02761478T ATE401574T1 (de) 2001-08-23 2002-08-23 Analyse zirkulierender tumorzellen, fragmente und trümmer

Country Status (11)

Country Link
EP (2) EP1425294B2 (de)
JP (3) JP2005501236A (de)
KR (2) KR20040053115A (de)
CN (2) CN1596265A (de)
AT (1) ATE401574T1 (de)
AU (2) AU2008288601B2 (de)
BR (2) BR0212125A (de)
CA (2) CA2457894C (de)
DE (1) DE60227678D1 (de)
IL (2) IL160209A0 (de)
WO (2) WO2003019141A2 (de)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003019141A2 (en) * 2001-08-23 2003-03-06 Immunivest Corporation Analysis of circulating tumor cells, fragments, and debris
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
CN1662307A (zh) 2002-05-13 2005-08-31 贝克顿·迪金森公司 蛋白酶抑制剂样品采集系统
AU2003277153A1 (en) 2002-09-27 2004-04-19 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
CA2445204C (en) 2002-10-16 2014-08-12 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
EP1597353B1 (de) 2003-02-27 2010-11-24 Veridex, LLC ZIRKULIERENDE TUMORZELLEN (CTC's): FRÜHE BEURTEILUNG VON TIME-TO-PROGRESSION, ÜBERLEBEN UND ANSPRECHEN AUF THERAPIE BEI PATIENTEN MIT METASTASIERTEM KREBS
JP4629675B2 (ja) * 2003-09-18 2011-02-09 ベリデックス・リミテッド・ライアビリティ・カンパニー オペレーター不要のプログラム可能な試料調製および分析システム
PL1861509T3 (pl) * 2005-03-14 2016-01-29 Janssen Diagnostics Llc Sposób predykcji przeżywalności bez progresji i przeżywalności całkowitej przy wizytach kontrolnych w trakcie terapii u pacjentów z rozsianym rakiem piersi wykorzystujący krążące komórki nowotworowe
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
WO2007002006A2 (en) 2005-06-20 2007-01-04 Panomics, Inc. Multiplex detection of nucleic acids
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8337755B2 (en) 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
MX2008015425A (es) * 2006-06-02 2008-12-12 Pfizer Prod Inc Ensayo de celulas tumorales circulantes.
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
CN101583722A (zh) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
DK2472264T3 (en) * 2007-02-27 2016-02-29 Sentoclone Internat Ab Multiplekspåvisning of tumor cells using a panel of agents which bind to extracellular markers
US20120202189A1 (en) * 2007-04-16 2012-08-09 Diagnostic Hybrids, Inc. Rapid, semi-automated method to detect respiratory virus infected cells in direct specimens
US8003314B2 (en) 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
US8110101B2 (en) 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US7828968B2 (en) 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
EP2229441B1 (de) 2007-12-12 2014-10-01 The Board of Trustees of The Leland Stanford Junior University Verfahren und vorrichtung zur magnetischen trennung von zellen
ES2620012T3 (es) 2008-09-20 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DK2398912T3 (en) 2009-02-18 2017-10-30 Streck Inc Conservation of cell-free nucleic acids
US20130023433A1 (en) 2009-09-28 2013-01-24 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
CN115060882A (zh) * 2009-10-21 2022-09-16 斯克里普斯研究所 用非稀有细胞检测稀有细胞的方法
US20130171621A1 (en) 2010-01-29 2013-07-04 Advanced Cell Diagnostics Inc. Methods of in situ detection of nucleic acids
JPWO2011099565A1 (ja) * 2010-02-10 2013-06-17 シスメックス株式会社 血液中癌細胞の検出方法及びそれに用いるプログラム
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US12545960B2 (en) 2010-05-18 2026-02-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
DE102010020785A1 (de) * 2010-05-18 2011-11-24 Siemens Aktiengesellschaft Vorrichtung und Verfahren zum Erkennen von magnetisch markierten Mikroobjekten
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
CA3037126C (en) 2010-05-18 2023-09-12 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
BR112013016193B1 (pt) 2010-12-22 2019-10-22 Natera, Inc. método ex vivo para determinar se um suposto pai é o pai biológico de um feto que está em gestação em uma gestante e relatório
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
US9956281B2 (en) 2011-05-04 2018-05-01 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
US20140295426A1 (en) * 2011-07-28 2014-10-02 Veridex Llc Methods for Diagnosing Cancer by Characterization of Tumor Cells Associated with Pleural or Serous Fluids
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
WO2013045457A1 (en) 2011-09-26 2013-04-04 Qiagen Gmbh Stabilisation and isolation of extracellular nucleic acids
ES2574956T3 (es) 2011-09-26 2016-06-23 Preanalytix Gmbh Estabilización y aislamiento de ácidos nucleicos extracelulares
KR102037891B1 (ko) * 2012-03-09 2019-10-30 한국전자통신연구원 다중 분리 장치 및 혈중 암세포 분리 방법
JP6179508B2 (ja) * 2012-05-10 2017-08-16 コニカミノルタ株式会社 希少細胞の検出方法
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
JP6608280B2 (ja) 2012-09-25 2019-11-20 キアゲン ゲーエムベーハー 生物学的試料の安定化
CN105264127B (zh) 2013-03-15 2019-04-09 Gpb科学有限责任公司 颗粒的片上微流体处理
US10324011B2 (en) 2013-03-15 2019-06-18 The Trustees Of Princeton University Methods and devices for high throughput purification
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
US11525155B2 (en) 2013-03-18 2022-12-13 Qiagen Gmbh Stabilisation of biological samples
JP6407248B2 (ja) * 2013-03-18 2018-10-17 キアゲン ゲーエムベーハー 細胞外核酸の安定化および単離
ES2938048T3 (es) 2013-07-24 2023-04-04 Streck Llc Composiciones y procedimientos para estabilizar las células tumorales circulantes
US10053692B2 (en) 2013-10-21 2018-08-21 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
EP3100047B1 (de) 2014-01-27 2021-08-11 Epic Sciences, Inc. Diagnose zirkulierender tumorzellen für prostatakrebsbiomarker
EA201691682A1 (ru) 2014-02-21 2017-02-28 Эпик Сайенсиз, Инк. Способы анализирования редких циркулирующих в крови клеток
AU2015233500B2 (en) * 2014-03-18 2018-11-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
CN103940997B (zh) * 2014-03-21 2017-01-04 上海柏慧康生物科技有限公司 一种乳腺癌循环肿瘤细胞检测系统及试剂盒
CA2945962C (en) 2014-04-21 2023-08-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
CN103980365A (zh) * 2014-06-03 2014-08-13 国家纳米科学中心 一种表面固载炭疽致死因子的磁性纳米粒子、其制备方法及用途
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
WO2016004308A1 (en) * 2014-07-02 2016-01-07 Siemens Healthcare Diagnostics Inc. Selective nucleic acid separation
WO2016137915A1 (en) 2015-02-24 2016-09-01 Siemens Healthcare Diagnostics Inc. Prefixation for increased rare cell recovery
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
US20170097361A1 (en) * 2015-07-15 2017-04-06 Streck, Inc. Method and device for stabilizing of proteins
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
JP6617495B2 (ja) * 2015-09-18 2019-12-11 東ソー株式会社 腫瘍細胞の検出方法
US20180328848A1 (en) * 2015-11-04 2018-11-15 Axon Dx, Llc Cell detection, capture, analysis, aggregation, and output methods and apparatus
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
CN114457068B (zh) 2015-11-20 2025-03-14 普瑞阿那利提克斯有限公司 用于稳定细胞外核酸的已灭菌组合物的制备方法
CN105372109A (zh) * 2015-12-15 2016-03-02 苏州药明康德新药开发股份有限公司 添加稳定剂的生物基质的制备方法
PL3422848T3 (pl) 2016-03-04 2025-05-26 Menarini Silicon Biosystems S.P.A. Konserwowanie składników komórkowych z komórek za pomocą środka konserwującego
CA3283226A1 (en) * 2016-03-07 2025-11-29 Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital Noninvasive molecular controls
ES2913468T3 (es) 2016-04-15 2022-06-02 Natera Inc Métodos para la detección del cáncer de pulmón.
JP2017219479A (ja) 2016-06-09 2017-12-14 住友電気工業株式会社 微小粒子計測装置及び分析方法
WO2018022991A1 (en) 2016-07-29 2018-02-01 Streck, Inc. Suspension composition for hematology analysis control
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
KR102476709B1 (ko) 2016-11-21 2022-12-09 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CN110997933B (zh) * 2017-08-02 2024-01-09 萨斯特德特股份有限两合公司 用于稳定无细胞核酸和细胞的方法和组合物
US10844353B2 (en) 2017-09-01 2020-11-24 Gpb Scientific, Inc. Methods for preparing therapeutically active cells using microfluidics
US12378543B2 (en) 2017-10-19 2025-08-05 Streck Llc Compositions for hemolysis and coagulation regulation and stabilization of extracellular vesicles
CA3085933A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
EP3781714B1 (de) 2018-04-14 2026-01-07 Natera, Inc. Verfahren zur krebserkennung und -überwachung durch personalisierte detektion zirkulierender tumor-dna
KR102893736B1 (ko) 2018-05-14 2025-11-28 브루커 스페이셜 바이올로지, 인크. 화학 조성물 및 이의 사용 방법
JP7334468B2 (ja) * 2018-05-29 2023-08-29 東ソー株式会社 血液試料保存剤
JP7036670B2 (ja) 2018-05-31 2022-03-15 アークレイ株式会社 血液中の稀少細胞検査、該検査ための血液処理方法及び採血管
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN108865976B (zh) * 2018-07-19 2022-06-28 复旦大学附属中山医院 一种离散汲取收集外泌体(exosome)的方法及试剂
CN110250159A (zh) * 2019-05-28 2019-09-20 天津中科生物科技有限公司 一种细胞保护液及其制备方法和应用
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
US20250197810A1 (en) * 2022-03-25 2025-06-19 Sekisui Medical Co., Ltd. Kit for isolating circulating tumor cells, container for isolating circulating tumor cells, and method for isolating circulating tumor cells
WO2024238350A1 (en) * 2023-05-12 2024-11-21 The Children's Medical Center Corporation Single-cell regulatory multi-omics with deep mitochondrial mutation profiling (redeem)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4040785A (en) * 1976-10-18 1977-08-09 Technicon Instruments Corporation Lysable blood preservative composition
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
FR2475737A1 (fr) * 1980-02-07 1981-08-14 Pasteur Institut Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede
US4404181A (en) * 1981-10-15 1983-09-13 Cambridge Chemical Products, Inc. Extended-life tissue fixative composition and method of using the same
FR2523810B1 (fr) * 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
EP0156537A3 (de) * 1984-03-02 1987-05-13 Board Of Regents University Of Texas System Biologische magnetische Flüssigkeiten
US4654312A (en) * 1984-05-14 1987-03-31 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
US4788139A (en) * 1987-08-06 1988-11-29 Streck Laboratories, Inc. Platelet aggregation reagent, reagent container and method of determining platelet aggregation in EDTA-anticoagulated blood
US5385707A (en) * 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5849517A (en) * 1991-05-08 1998-12-15 Streck Laboratories, Inc. Method and composition for preserving antigens and nucleic acids and process for utilizing cytological material produced by same
CA2119554C (en) * 1991-09-20 2003-05-06 Gerald W. Camiener Method and compositions with aldehyde stabilizing solution
EP0685994B1 (de) * 1993-02-25 2007-03-21 Abbott Laboratories Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben
US6190870B1 (en) * 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
GB2313288B (en) * 1996-05-24 2000-07-12 North Gen Hospital Nhs Trust Specimen collection fluid
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
US6670197B2 (en) * 1997-11-24 2003-12-30 David L. Rimm Method for assaying whole blood for the presence or absence of circulating cancer or other target cell fragments
JP2002503814A (ja) * 1998-02-12 2002-02-05 イムニベスト・コーポレイション 循環ガン細胞の迅速かつ効率的な単離のための方法および試薬
AU2876900A (en) * 1999-02-10 2000-08-29 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids andmethods of use
EP1221053A4 (de) * 1999-09-13 2004-12-22 Neil H Bander Verfahren zur isolierung von prostatischen epithelzellen aus sperma
WO2003019141A2 (en) * 2001-08-23 2003-03-06 Immunivest Corporation Analysis of circulating tumor cells, fragments, and debris

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EP1425294B2 (de) 2012-12-12
EP1425383A4 (de) 2005-11-09
JP2005501236A (ja) 2005-01-13
CN1571634A (zh) 2005-01-26
EP1425383A2 (de) 2004-06-09
IL160209A0 (en) 2004-07-25
BR0212124A (pt) 2004-07-20
KR20040030984A (ko) 2004-04-09
KR20040053115A (ko) 2004-06-23
EP1425294A2 (de) 2004-06-09
CA2457894C (en) 2014-07-08
JP2009109514A (ja) 2009-05-21
IL160210A0 (en) 2004-07-25
DE60227678D1 (de) 2008-08-28
EP1425294A4 (de) 2005-11-16
AU2009200013A1 (en) 2009-02-05
WO2003018757A2 (en) 2003-03-06
EP1425294B1 (de) 2008-07-16
BR0212125A (pt) 2005-06-28
AU2008288601B2 (en) 2012-05-31
CA2457891C (en) 2019-10-01
AU2009200013B2 (en) 2012-03-08
AU2008288601A1 (en) 2009-04-02
JP2005502863A (ja) 2005-01-27
CN1596265A (zh) 2005-03-16
WO2003018757A3 (en) 2003-09-12
WO2003019141A2 (en) 2003-03-06
CA2457894A1 (en) 2003-03-06
WO2003019141A3 (en) 2004-04-01
CA2457891A1 (en) 2003-03-06

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