ATE402937T1 - Hydromorphinone and hydrocodeinone compositions and methods for their synthesis - Google Patents

Hydromorphinone and hydrocodeinone compositions and methods for their synthesis

Info

Publication number: ATE402937T1
Authority: AT; Austria
Prior art keywords: hydromorphone; methods; compositions; hydroxy; dihydromorphone
Prior art date: 1999-11-09

Application number

AT00978498T

Other languages

English (en)

Inventor

William Harclerode

Robert Gault

Mark Sandison

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-09

Filing date

2000-11-09

Publication date

2008-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE402937(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-11-09 Application filed by Abbott Lab filed Critical Abbott Lab

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE402937T1 publication Critical patent/ATE402937T1/de

Links

238000000034 method Methods 0.000 title abstract 6
239000000203 mixture Substances 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical class O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 abstract 4
HKUBHNBSWVSAAH-IPHHTLHHSA-N (4r,4ar,7ar,12bs)-5,9-dihydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O([C@H]1C(CC(O)[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O HKUBHNBSWVSAAH-IPHHTLHHSA-N 0.000 abstract 3
229960001410 hydromorphone Drugs 0.000 abstract 3
229930013930 alkaloid Natural products 0.000 abstract 2
150000003797 alkaloid derivatives Chemical class 0.000 abstract 2
230000003533 narcotic effect Effects 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000004808 allyl alcohols Chemical group 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 abstract 1
229960000240 hydrocodone Drugs 0.000 abstract 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
External Artificial Organs (AREA)
Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)

AT00978498T 1999-11-09 2000-11-09 Hydromorphinone and hydrocodeinone compositions and methods for their synthesis ATE402937T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US16453699P	1999-11-09	1999-11-09
US16436499P	1999-11-09	1999-11-09
US16450599P	1999-11-09	1999-11-09

Publications (1)

Publication Number	Publication Date
ATE402937T1 true ATE402937T1 (de)	2008-08-15

Family

ID=27389009

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT08157739T ATE500257T1 (de)	1999-11-09	2000-11-09	Hydromorphinonzusammensetzungen
AT00978498T ATE402937T1 (de)	1999-11-09	2000-11-09	Hydromorphinone and hydrocodeinone compositions and methods for their synthesis

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT08157739T ATE500257T1 (de)	1999-11-09	2000-11-09	Hydromorphinonzusammensetzungen

Country Status (10)

Country	Link
US (2)	US6512117B1 (de)
EP (3)	EP2338891A3 (de)
JP (1)	JP4886953B2 (de)
AT (2)	ATE500257T1 (de)
AU (1)	AU1595701A (de)
CA (3)	CA2854796A1 (de)
DE (2)	DE60039711D1 (de)
ES (1)	ES2309001T5 (de)
MX (1)	MXPA02004678A (de)
WO (1)	WO2001034608A1 (de)

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KR100889069B1 (ko)	1999-10-29	2009-03-17	유로-셀티크 소시에떼 아노뉨	서방성 하이드로코돈 제형
US10179130B2 (en)	1999-10-29	2019-01-15	Purdue Pharma L.P.	Controlled release hydrocodone formulations
AU2738302A (en)	2000-10-30	2002-05-15	Euro Celtique Sa	Controlled release hydrocodone formulations
US7321038B2 (en)	2002-11-11	2008-01-22	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone and hydromorphone
US7323565B2 (en)	2002-11-11	2008-01-29	Mallinckrodt Inc.	Method for the catalytic production of hydrocodone and hydromorphone
WO2005016930A2 (en) *	2003-08-08	2005-02-24	Euro-Celtique, S.A.	Methods for detecting morphinone
SK286047B6 (sk) *	2004-04-13	2008-01-07	Zentiva, A. S.	Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) *	2004-05-21	2005-09-20	Acura Pharmaceuticals, Inc.	Preparation of opioid analgesics by a one-pot process
US7348430B2 (en)	2005-01-21	2008-03-25	Acura Pharmaceuticals, Inc.	Production of opioid analgesics
EP1871774A1 (de) *	2005-03-28	2008-01-02	Mallinckrodt, Inc.	Verfahren zur katalytischen herstellung von hydrocodon, hydromorphon und derivaten davon
KR20080014767A (ko) *	2005-04-18	2008-02-14	노람코 인코퍼레이티드	하이드로모르폰 다형태
US20100073766A1 (en) *	2005-10-26	2010-03-25	Angros Lee H	Microscope slide testing and identification assembly
US20080069891A1 (en)	2006-09-15	2008-03-20	Cima Labs, Inc.	Abuse resistant drug formulation
US8445018B2 (en)	2006-09-15	2013-05-21	Cima Labs Inc.	Abuse resistant drug formulation
US7399859B1 (en)	2007-02-06	2008-07-15	Cody Laboratories Inc.	Method for catalytic preparation of hydromorphone and hydrocodone
US20080206883A1 (en) *	2007-02-26	2008-08-28	Cody Laboratories, Inc.	Hplc method for separation and detection of hydromorphone and related opioid pharmacophores
US7999104B2 (en)	2007-06-29	2011-08-16	Brock University	Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US8962841B2 (en)	2007-06-29	2015-02-24	Brock University	Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US9226907B2 (en)	2008-02-01	2016-01-05	Abbvie Inc.	Extended release hydrocodone acetaminophen and related methods and uses thereof
GB0802351D0 (en) *	2008-02-08	2008-03-12	Owen Mumford Ltd	Injection devices
US8293907B2 (en) *	2009-04-09	2012-10-23	Mallinckrodt Inc.	Preparation of saturated ketone morphinan compounds by catalytic isomerization
US20100261906A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of 6-Keto, 3-Alkoxy Morphinans
WO2010118275A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of saturated ketone morphinan compounds
US8383815B2 (en)	2009-09-21	2013-02-26	Mallinckrodt Llc	Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof
CA2798702A1 (en)	2010-05-11	2011-11-17	Cima Labs Inc.	Alcoholresistant metoprolol-containing extended-release oral dosage forms
CN103619847A (zh)	2011-05-06	2014-03-05	布鲁克大学	通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法
TWI560170B (en) *	2011-12-06	2016-12-01	Lundbeck & Co As H	Process for recovery of nalmefene hydrochloride
US9155734B2 (en)	2012-03-07	2015-10-13	Mallinckrodt Llc	Stability of hydromorphone hydrochloride solutions
CN103408553B (zh) *	2013-08-20	2016-02-03	宜昌人福药业有限责任公司	一种氢吗啡酮酸式盐的精制工艺
AU2015210833B2 (en)	2014-02-03	2019-01-03	Vitae Pharmaceuticals, Llc	Dihydropyrrolopyridine inhibitors of ROR-gamma
JP6564029B2 (ja)	2014-10-14	2019-08-21	ヴァイティーファーマシューティカルズ，エルエルシー	Ｒｏｒ−ガンマのジヒドロピロロピリジン阻害剤
US9845308B2 (en)	2014-11-05	2017-12-19	Vitae Pharmaceuticals, Inc.	Isoindoline inhibitors of ROR-gamma
US9663515B2 (en)	2014-11-05	2017-05-30	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
DK3331876T3 (da)	2015-08-05	2021-01-11	Vitae Pharmaceuticals Llc	Modulators of ror-gamma
MA53943A (fr)	2015-11-20	2021-08-25	Vitae Pharmaceuticals Llc	Modulateurs de ror-gamma
TWI757266B (zh)	2016-01-29	2022-03-11	美商維它藥物有限責任公司	ＲＯＲ－γ調節劑
US9481674B1 (en)	2016-06-10	2016-11-01	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
US10081636B2 (en)	2016-07-08	2018-09-25	Cody Laboratories, Inc.	Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
CN115650976A (zh)	2017-07-24	2023-01-31	生命医药有限责任公司	RORγ的抑制剂
WO2019018975A1 (en)	2017-07-24	2019-01-31	Vitae Pharmaceuticals, Inc.	INHIBITORS OF ROR GAMMA
CN108164540B (zh) *	2017-12-14	2019-08-13	宜昌人福药业有限责任公司	一种合成氢吗啡酮的方法
CA3196369A1 (en) *	2020-11-02	2022-05-05	C. Frederick M. Huntley	Process for purifying noroxymorphone
WO2022101408A1 (en)	2020-11-13	2022-05-19	Ferrer Internacional, S.A.	Synthesis of hydromorphone base

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DE260233C (de)
GB285404A (de) *
DE365683C (de)	1921-03-22	1922-12-22	Knoll & Co Chem Fab	Verfahren zur Darstellung von Ketoderivaten der Morphinreihe
DE607931C (de) *	1934-01-26	1935-01-11	Chemische Fabriken	Verfahren zur Darstellung von Dihydromorphinonen
US2544291A (en)	1949-04-05	1951-03-06	New York Quinine And Chemical	Alkaloid manufacture
US2628962A (en)	1949-10-20	1953-02-17	Mallinckrodt Chemical Works	Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2654756A (en) *	1949-10-20	1953-10-06	Mallinckrodt Chemical Works	Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2649454A (en)	1951-08-20	1953-08-18	Univ California	Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
GB9616253D0 (en) *	1996-08-01	1996-09-11	Johnson Matthey Plc	Preparation of narcotic analgesics

2000
- 2000-11-09 MX MXPA02004678A patent/MXPA02004678A/es active IP Right Grant
- 2000-11-09 DE DE60039711T patent/DE60039711D1/de not_active Expired - Lifetime
- 2000-11-09 AU AU15957/01A patent/AU1595701A/en not_active Abandoned
- 2000-11-09 US US09/711,003 patent/US6512117B1/en not_active Expired - Lifetime
- 2000-11-09 AT AT08157739T patent/ATE500257T1/de not_active IP Right Cessation
- 2000-11-09 DE DE60045695T patent/DE60045695D1/de not_active Expired - Lifetime
- 2000-11-09 CA CA2854796A patent/CA2854796A1/en not_active Abandoned
- 2000-11-09 CA CA2674424A patent/CA2674424C/en not_active Expired - Lifetime
- 2000-11-09 WO PCT/US2000/030931 patent/WO2001034608A1/en not_active Ceased
- 2000-11-09 EP EP10171268A patent/EP2338891A3/de not_active Withdrawn
- 2000-11-09 CA CA002389193A patent/CA2389193A1/en not_active Withdrawn
- 2000-11-09 JP JP2001537321A patent/JP4886953B2/ja not_active Expired - Fee Related
- 2000-11-09 ES ES00978498T patent/ES2309001T5/es not_active Expired - Lifetime
- 2000-11-09 EP EP00978498A patent/EP1233966B2/de not_active Expired - Lifetime
- 2000-11-09 EP EP08157739A patent/EP2003134B1/de not_active Revoked
- 2000-11-09 AT AT00978498T patent/ATE402937T1/de not_active IP Right Cessation
2002
- 2002-09-27 US US10/256,996 patent/US6589960B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP4886953B2 (ja)	2012-02-29
CA2674424C (en)	2012-10-02
ES2309001T3 (es)	2008-12-16
EP1233966B2 (de)	2011-10-19
CA2389193A1 (en)	2001-05-17
ATE500257T1 (de)	2011-03-15
EP2338891A3 (de)	2011-10-26
EP2003134B1 (de)	2011-03-02
EP1233966B1 (de)	2008-07-30
EP2003134A3 (de)	2009-02-25
DE60045695D1 (de)	2011-04-14
ES2309001T5 (es)	2011-12-28
US6512117B1 (en)	2003-01-28
MXPA02004678A (es)	2005-10-05
EP2003134A2 (de)	2008-12-17
CA2674424A1 (en)	2001-05-17
DE60039711D1 (en)	2008-09-11
CA2854796A1 (en)	2001-05-17
EP2338891A2 (de)	2011-06-29
EP1233966A1 (de)	2002-08-28
WO2001034608A1 (en)	2001-05-17
AU1595701A (en)	2001-06-06
JP2003513980A (ja)	2003-04-15
US20030045720A1 (en)	2003-03-06
US6589960B2 (en)	2003-07-08

Legal Events

Date	Code	Title	Description
2009-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE402937T1 (de)	2008-08-15	Hydromorphinone and hydrocodeinone compositions and methods for their synthesis
PH24199A (en)	1990-04-10	Derivatives of quinoline carboxylic acid,pharmaceutical composition containing same and process of preparing same
HUP0102084A2 (hu)	2001-11-28	Kinolinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
ATE302786T1 (de)	2005-09-15	Verfahren zur herstllung von clarithromycin polymorphen und polymorph iv
ATE100440T1 (de)	1994-02-15	Verfahren zur herstellung von n-methyl-3-(ptrifluoromethyl-phenoxy)-3-phenyl-propylamin und ihre salze.
IL152348A0 (en)	2003-05-29	Oxidation process for preparing the intermediate 6.alpha.-difluoro-11.beta., 17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid
HUT60458A (en)	1992-09-28	Process for producing benzyloxyphenyl derivatives and pharmaceutical compositions comprising same
DE69429570D1 (de)	2002-02-07	Galanthamin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente
ATA278988A (de)	1990-05-15	Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
EP0393494A3 (de)	1992-05-20	Gallensäure-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen daraus
CA2067200A1 (en)	1991-04-17	Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates
ATE66913T1 (de)	1991-09-15	Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.
EP0168921A3 (de)	1986-11-05	Chemische Verbindungen
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KR910004563A (ko)	1991-03-28	4,4-이중 치환된 피페리딘 유도체들과 그 화합물을 함유하는 약제학적 조성물 및 그것들의 제조 방법
DE59709792D1 (de)	2003-05-15	Ringannelierte dihydropyrane, verfahren zur herstellung sowie deren verwendung
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DE60014103D1 (de)	2004-10-28	Verfahren zur herstellung von debromohymenialdisin und deren analogen
Shamma et al.	1977	New facets of protoberbinoid chemistry: the 8, 13-dioxoberbines
HUT34478A (en)	1985-03-28	Process for producing hexahydro-pyrrolo/2.1-a/isoquinoline derivatives and pharmaceutical compositions containing them
ATE117977T1 (de)	1995-02-15	Verfahren zur herstellung von alpha-beta- ungesättigten ketonen.
DE59304476D1 (de)	1996-12-19	Lagerstabile Lösungen von carbonisiertem Magnesiumethylat in Ethanol sowie deren Herstellung und Verwendung
KR890009896A (ko)	1989-08-04	디옥사조신 유도체, 그의 제법 및 그를 함유하는 조성물
GR880100409A (en)	1990-05-11	Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids