ATE402937T1 - Hydromorphinone and hydrocodeinone compositions and methods for their synthesis - Google Patents

Hydromorphinone and hydrocodeinone compositions and methods for their synthesis

Info

Publication number
ATE402937T1
ATE402937T1 AT00978498T AT00978498T ATE402937T1 AT E402937 T1 ATE402937 T1 AT E402937T1 AT 00978498 T AT00978498 T AT 00978498T AT 00978498 T AT00978498 T AT 00978498T AT E402937 T1 ATE402937 T1 AT E402937T1
Authority
AT
Austria
Prior art keywords
hydromorphone
methods
compositions
hydroxy
dihydromorphone
Prior art date
Application number
AT00978498T
Other languages
English (en)
Inventor
William Harclerode
Robert Gault
Mark Sandison
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE402937(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE402937T1 publication Critical patent/ATE402937T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
AT00978498T 1999-11-09 2000-11-09 Hydromorphinone and hydrocodeinone compositions and methods for their synthesis ATE402937T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16436499P 1999-11-09 1999-11-09
US16450599P 1999-11-09 1999-11-09
US16453699P 1999-11-09 1999-11-09

Publications (1)

Publication Number Publication Date
ATE402937T1 true ATE402937T1 (de) 2008-08-15

Family

ID=27389009

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08157739T ATE500257T1 (de) 1999-11-09 2000-11-09 Hydromorphinonzusammensetzungen
AT00978498T ATE402937T1 (de) 1999-11-09 2000-11-09 Hydromorphinone and hydrocodeinone compositions and methods for their synthesis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT08157739T ATE500257T1 (de) 1999-11-09 2000-11-09 Hydromorphinonzusammensetzungen

Country Status (10)

Country Link
US (2) US6512117B1 (de)
EP (3) EP2003134B1 (de)
JP (1) JP4886953B2 (de)
AT (2) ATE500257T1 (de)
AU (1) AU1595701A (de)
CA (3) CA2854796A1 (de)
DE (2) DE60045695D1 (de)
ES (1) ES2309001T5 (de)
MX (1) MXPA02004678A (de)
WO (1) WO2001034608A1 (de)

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KR20020059653A (ko) 1999-10-29 2002-07-13 그린 마틴, 브라이언 쥐 테슬리 서방성 하이드로코돈 제형
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
EP1337244A4 (de) 2000-10-30 2006-01-11 Euro Celtique Sa Hydrocodon-formulierungen mit kontrollierter freisetzung
US7323565B2 (en) 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 (en) 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
WO2005016930A2 (en) * 2003-08-08 2005-02-24 Euro-Celtique, S.A. Methods for detecting morphinone
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
US7348430B2 (en) 2005-01-21 2008-03-25 Acura Pharmaceuticals, Inc. Production of opioid analgesics
MX2007011752A (es) * 2005-03-28 2007-11-21 Mallinckrodt Inc Metodo para la produccion catalitica de hidrocodona, hidromorfona y derivados de las mismas.
AU2006236379A1 (en) 2005-04-18 2006-10-26 Noramaco Inc. Hydromorphone polymorphs
US20100073766A1 (en) * 2005-10-26 2010-03-25 Angros Lee H Microscope slide testing and identification assembly
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US7399859B1 (en) 2007-02-06 2008-07-15 Cody Laboratories Inc. Method for catalytic preparation of hydromorphone and hydrocodone
US20080206883A1 (en) * 2007-02-26 2008-08-28 Cody Laboratories, Inc. Hplc method for separation and detection of hydromorphone and related opioid pharmacophores
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en) 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
GB0802351D0 (en) * 2008-02-08 2008-03-12 Owen Mumford Ltd Injection devices
WO2010118275A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of saturated ketone morphinan compounds
WO2010118274A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of 6-keto, 3-alkoxy morphinans
WO2010118271A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of saturated ketone morphinan compounds by catalytic isomerization
US8383815B2 (en) 2009-09-21 2013-02-26 Mallinckrodt Llc Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof
EP2568977A1 (de) 2010-05-11 2013-03-20 Cima Labs Inc. Alkoholresistente metoprololhaltige orale retard-dosierformen
CN103619847A (zh) 2011-05-06 2014-03-05 布鲁克大学 通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
US9155734B2 (en) * 2012-03-07 2015-10-13 Mallinckrodt Llc Stability of hydromorphone hydrochloride solutions
CN103408553B (zh) * 2013-08-20 2016-02-03 宜昌人福药业有限责任公司 一种氢吗啡酮酸式盐的精制工艺
PE20161372A1 (es) 2014-02-03 2017-01-08 Vitae Pharmaceuticals Inc Inhibidores de dihidropirrolopiridina de ror-gamma
EA031967B1 (ru) 2014-10-14 2019-03-29 Вайтаи Фармасьютиклз, Инк. ДИГИДРОПИРРОЛОПИРИДИНОВЫЕ ИНГИБИТОРЫ ROR-γ
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2017024018A1 (en) 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
JP6914257B2 (ja) 2015-11-20 2021-08-04 ヴァイティー ファーマシューティカルズ，エルエルシー Ｒｏｒ−ガンマのモジュレーター
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US10081636B2 (en) 2016-07-08 2018-09-25 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
MX2020000887A (es) 2017-07-24 2020-07-22 Vitae Pharmaceuticals Llc Inhibidores de ror?.
CN108164540B (zh) * 2017-12-14 2019-08-13 宜昌人福药业有限责任公司 一种合成氢吗啡酮的方法
JP2023548356A (ja) * 2020-11-02 2023-11-16 ローズ テクノロジーズ ノルオキシモルホンを精製するための方法
WO2022101408A1 (en) 2020-11-13 2022-05-19 Ferrer Internacional, S.A. Synthesis of hydromorphone base

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB285404A (de) *
DE260233C (de)
DE365683C (de) 1921-03-22 1922-12-22 Knoll & Co Chem Fab Verfahren zur Darstellung von Ketoderivaten der Morphinreihe
DE607931C (de) 1934-01-26 1935-01-11 Chemische Fabriken Verfahren zur Darstellung von Dihydromorphinonen
US2544291A (en) 1949-04-05 1951-03-06 New York Quinine And Chemical Alkaloid manufacture
US2654756A (en) * 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2649454A (en) 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
GB9616253D0 (en) * 1996-08-01 1996-09-11 Johnson Matthey Plc Preparation of narcotic analgesics

Also Published As

Publication number Publication date
EP2003134B1 (de) 2011-03-02
EP2338891A3 (de) 2011-10-26
ES2309001T3 (es) 2008-12-16
CA2389193A1 (en) 2001-05-17
CA2854796A1 (en) 2001-05-17
WO2001034608A1 (en) 2001-05-17
CA2674424A1 (en) 2001-05-17
EP1233966B1 (de) 2008-07-30
EP1233966B2 (de) 2011-10-19
MXPA02004678A (es) 2005-10-05
US20030045720A1 (en) 2003-03-06
ATE500257T1 (de) 2011-03-15
AU1595701A (en) 2001-06-06
ES2309001T5 (es) 2011-12-28
EP1233966A1 (de) 2002-08-28
EP2338891A2 (de) 2011-06-29
EP2003134A2 (de) 2008-12-17
DE60045695D1 (de) 2011-04-14
JP4886953B2 (ja) 2012-02-29
JP2003513980A (ja) 2003-04-15
US6589960B2 (en) 2003-07-08
CA2674424C (en) 2012-10-02
US6512117B1 (en) 2003-01-28
EP2003134A3 (de) 2009-02-25
DE60039711D1 (en) 2008-09-11

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