ATE404210T1 - Zusammensetzungen von polysäuren, nichtionischen polymeren von alkylenoxid-monomeren und mehrwertigen kationen, und deren verwendung zur reduzierung der gewebeadhäsion - Google Patents

Zusammensetzungen von polysäuren, nichtionischen polymeren von alkylenoxid-monomeren und mehrwertigen kationen, und deren verwendung zur reduzierung der gewebeadhäsion

Info

Publication number: ATE404210T1
Authority: AT; Austria
Prior art keywords: membranes; compositions; bioadhesive; adhesion; polyacids
Prior art date: 1999-04-02

Application number

AT00921450T

Other languages

English (en)

Inventor

Herbert Schwartz

John Blackmore

Stephanie Cortese

William Oppelt

Original Assignee

Fziomed Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-02

Filing date

2000-03-23

Publication date

2008-08-15

1999-12-27 Priority claimed from US09/472,110 external-priority patent/US6869938B1/en

2000-03-23 Application filed by Fziomed Inc filed Critical Fziomed Inc

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE404210T1 publication Critical patent/ATE404210T1/de

Links

239000000203 mixture Substances 0.000 title abstract 7
150000001768 cations Chemical class 0.000 title abstract 3
208000031737 Tissue Adhesions Diseases 0.000 title abstract 2
229920000831 ionic polymer Polymers 0.000 title 1
239000000178 monomer Substances 0.000 title 1
239000012528 membrane Substances 0.000 abstract 7
239000000227 bioadhesive Substances 0.000 abstract 3
230000003750 conditioning effect Effects 0.000 abstract 2
239000000499 gel Substances 0.000 abstract 2
230000000704 physical effect Effects 0.000 abstract 2
229920000233 poly(alkylene oxides) Polymers 0.000 abstract 2
229920000642 polymer Polymers 0.000 abstract 2
238000001356 surgical procedure Methods 0.000 abstract 2
230000002965 anti-thrombogenic effect Effects 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
238000005266 casting Methods 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000004005 microsphere Substances 0.000 abstract 1
-1 polyacids Polymers 0.000 abstract 1
229920000570 polyether Polymers 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/062—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Surgery (AREA)
General Chemical & Material Sciences (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Materials Engineering (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Materials For Medical Uses (AREA)
Adhesives Or Adhesive Processes (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

AT00921450T 1999-04-02 2000-03-23 Zusammensetzungen von polysäuren, nichtionischen polymeren von alkylenoxid-monomeren und mehrwertigen kationen, und deren verwendung zur reduzierung der gewebeadhäsion ATE404210T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12757199P	1999-04-02	1999-04-02
US09/472,110 US6869938B1 (en)	1997-06-17	1999-12-27	Compositions of polyacids and polyethers and methods for their use in reducing adhesions

Publications (1)

Publication Number	Publication Date
ATE404210T1 true ATE404210T1 (de)	2008-08-15

Family

ID=26825748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00921450T ATE404210T1 (de)	1999-04-02	2000-03-23	Zusammensetzungen von polysäuren, nichtionischen polymeren von alkylenoxid-monomeren und mehrwertigen kationen, und deren verwendung zur reduzierung der gewebeadhäsion

Country Status (8)

Country	Link
EP (1)	EP1181023B1 (de)
JP (1)	JP2003530136A (de)
AT (1)	ATE404210T1 (de)
AU (1)	AU778853B2 (de)
CA (1)	CA2366880C (de)
DE (1)	DE60039868D1 (de)
ES (1)	ES2311455T3 (de)
WO (1)	WO2000059516A1 (de)

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US6566345B2 (en)	2000-04-28	2003-05-20	Fziomed, Inc.	Polyacid/polyalkylene oxide foams and gels and methods for their delivery
ATE425776T1 (de) *	2000-04-28	2009-04-15	Fziomed Inc	Haemostatische zusammenstellung von polysauren und polyalkylenoxyden und deren verwendungsmethoden
JP4794057B2 (ja) *	2001-02-28	2011-10-12	京セラ株式会社	骨修復材の製造方法および骨修復材
FR2823119B1 (fr) *	2001-04-05	2004-02-20	Seppic Sa	Adjuvant d'immunite contenant un cation metallique complexe et vaccin le contenant
WO2005000374A1 (ja) *	2003-06-30	2005-01-06	Denki Kagaku Kogyo Kabushiki Kaisha	脊椎・脊髄手術用癒着防止材
US7914805B2 (en)	2003-07-31	2011-03-29	Boston Scientific Scimed, Inc.	Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent
CN1220528C (zh) *	2003-08-19	2005-09-28	大连永兴医用材料有限公司	羧甲基壳聚糖/羧甲基纤维素防手术粘连膜及其制备方法
DE10350481A1 (de)	2003-10-29	2005-06-16	Henkel Kgaa	Festigkeitsoptimierte Polymere mit gemischten Oxyalkyleneinheiten
SE0401182D0 (sv) *	2004-05-05	2004-05-05	Q Med Ab	Novel use of a viscoelastic composition
WO2005110439A2 (en) *	2004-05-07	2005-11-24	S.K. Pharmaceuticals, Inc.	Stabilized hyaluronan preparations and related methods
US8288362B2 (en)	2004-05-07	2012-10-16	S.K. Pharmaceuticals, Inc.	Stabilized glycosaminoglycan preparations and related methods
KR101125934B1 (ko) *	2008-11-19	2012-03-21	한남대학교 산학협력단	열감응성 조직 유착 방지 조성물 및 이의 제조 방법
US9445795B2 (en)	2009-10-16	2016-09-20	Confluent Surgical, Inc.	Prevention of premature gelling of delivery devices for pH dependent forming materials
KR101142234B1 (ko) *	2009-12-28	2012-07-09	한남대학교 산학협력단	주사 주입이 용이한 다공성 미세입자 필러 시스템
CA2730598C (en) *	2010-03-16	2018-03-13	Confluent Surgical, Inc.	Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
CA2731187A1 (en) *	2010-03-16	2011-09-16	Confluent Surgical, Inc.	Mitigating thrombus formation on medical devices by influencing ph microenvironment near the surface
US20130052236A1 (en) *	2011-08-30	2013-02-28	Mast Biosurgery	Composite polylactic acid/alginate surgical barrier
DE102012222365A1 (de) *	2012-12-05	2014-06-05	Aesculap Ag	Zusammensetzung zur Anwendung bei der Prophylaxe von post-chirurgischen Adhäsionen
EP2774953B1 (de) *	2013-03-08	2018-06-27	Fluoron Gmbh	Gelierbare Zusammensetzungen
KR101627787B1 (ko) *	2014-07-24	2016-06-07	주식회사 메디톡스	열감응성 유착 방지용 조성물 및 그의 용도
US20180169295A1 (en) *	2016-12-21	2018-06-21	Industrial Technology Research Institute	Film, manufacturing method thereof, and use thereof
US12383700B2 (en)	2019-06-13	2025-08-12	Hollister Incorporated	Reusable urinary catheter products
EP4628107A3 (de)	2019-06-25	2025-12-17	Hollister Incorporated	Wiederverwendbare harnkatheterprodukte
CN113069598B (zh) *	2020-01-06	2022-05-17	中国科学院宁波材料技术与工程研究所	血液透析器的抗凝改性方法
JP7619544B2 (ja) *	2020-07-22	2025-01-22	国立大学法人東京大学	腱又は靭帯の治療用ゲル材料
CN113842358B (zh) *	2021-10-29	2023-05-09	佛山市南海东方澳龙制药有限公司	一种兽用子宫注入剂及其制备方法和应用

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2000
- 2000-03-23 AU AU41770/00A patent/AU778853B2/en not_active Expired
- 2000-03-23 CA CA2366880A patent/CA2366880C/en not_active Expired - Lifetime
- 2000-03-23 EP EP00921450A patent/EP1181023B1/de not_active Expired - Lifetime
- 2000-03-23 WO PCT/US2000/007963 patent/WO2000059516A1/en not_active Ceased
- 2000-03-23 AT AT00921450T patent/ATE404210T1/de not_active IP Right Cessation
- 2000-03-23 JP JP2000609079A patent/JP2003530136A/ja active Pending
- 2000-03-23 DE DE60039868T patent/DE60039868D1/de not_active Expired - Lifetime
- 2000-03-23 ES ES00921450T patent/ES2311455T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1181023A1 (de)	2002-02-27
JP2003530136A (ja)	2003-10-14
EP1181023B1 (de)	2008-08-13
AU778853B2 (en)	2004-12-23
CA2366880C (en)	2013-02-12
EP1181023A4 (de)	2004-03-31
CA2366880A1 (en)	2000-10-12
WO2000059516A1 (en)	2000-10-12
ES2311455T3 (es)	2009-02-16
DE60039868D1 (de)	2008-09-25
AU4177000A (en)	2000-10-23

Legal Events

Date	Code	Title	Description
2009-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE404210T1 (de)	2008-08-15	Zusammensetzungen von polysäuren, nichtionischen polymeren von alkylenoxid-monomeren und mehrwertigen kationen, und deren verwendung zur reduzierung der gewebeadhäsion
ATE425776T1 (de)	2009-04-15	Haemostatische zusammenstellung von polysauren und polyalkylenoxyden und deren verwendungsmethoden
JP7263459B2 (ja)	2023-04-24	癒着予防のためのハイドロゲル膜
ATE376567T1 (de)	2007-11-15	Antiadhäsivbioresorbierbarkomplexe von polyethern und carboxypolysacchariden und verfahren zu ihrer verwendung für die verminderung postchirurgischer verklebung
WO2005027852A3 (en)	2005-10-27	Compositions of polyacids and polyethers and methods for their use in reducing pain
JP5604440B2 (ja)	2014-10-08	熱感応性組織癒着防止用組成物およびその製造方法
EP1228771A1 (de)	2002-08-07	Verwendung löslicher cellulosederivate, die schwer löslich in wasser gemacht wurden und das verfahren zu ihrer herstellung
KR101627787B1 (ko)	2016-06-07	열감응성 유착 방지용 조성물 및 그의 용도
BR112014010192B1 (pt)	2019-05-14	Composição biocompatível, uso de uma Composição biocompatível, e, método de fabricação de uma composição biocompatível
AU2021312621B2 (en)	2024-11-14	Anti-adhesion polymer composition
KR101668349B1 (ko)	2016-10-21	유착 방지제
CN118718114A (zh)	2024-10-01	促骨再生骨蜡及其制备方法与应用
Padalhin et al.	2024	Evaluation of sodium hyaluronate-based composite hydrogels for prevention of nasal adhesions
KR101799534B1 (ko)	2017-11-20	조직 유착 방지용 조성물 및 이의 제조 방법
ES2387032T3 (es)	2012-09-12	Producto médico-técnico, procedimiento para su fabricación y puesta a disposición para la cirugía