ATE404558T1 - Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen - Google Patents
Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisenInfo
- Publication number
- ATE404558T1 ATE404558T1 AT02775254T AT02775254T ATE404558T1 AT E404558 T1 ATE404558 T1 AT E404558T1 AT 02775254 T AT02775254 T AT 02775254T AT 02775254 T AT02775254 T AT 02775254T AT E404558 T1 ATE404558 T1 AT E404558T1
- Authority
- AT
- Austria
- Prior art keywords
- halo
- oxocinolicine
- antimicrobial
- compounds
- oxoquinolizine
- Prior art date
Links
- 230000000845 anti-microbial effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- ZUVKZCTUVRLOAQ-UHFFFAOYSA-N quinolizin-4-one Chemical class C1=CC=CN2C(=O)C=CC=C21 ZUVKZCTUVRLOAQ-UHFFFAOYSA-N 0.000 abstract 2
- BHJNYJBPBFSPNP-UHFFFAOYSA-N 8-(4-aminophenyl)-1-cyclopropyl-9-methyl-4-oxoquinolizine-3-carboxylic acid Chemical compound CC1=C(C=2C=CC(N)=CC=2)C=CN(C(C(C(O)=O)=C2)=O)C1=C2C1CC1 BHJNYJBPBFSPNP-UHFFFAOYSA-N 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001299088 | 2001-09-28 | ||
| JP2001326133 | 2001-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE404558T1 true ATE404558T1 (de) | 2008-08-15 |
Family
ID=26623198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02775254T ATE404558T1 (de) | 2001-09-28 | 2002-09-27 | Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7223773B2 (de) |
| EP (1) | EP1437354B1 (de) |
| JP (1) | JP4101754B2 (de) |
| AT (1) | ATE404558T1 (de) |
| DE (1) | DE60228297D1 (de) |
| WO (1) | WO2003029253A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745459B2 (en) | 2004-09-21 | 2010-06-29 | Japan Tobacco Inc. | Quinolizinone compound and use thereof as HIV integrase inhibitor |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| WO2012047487A1 (en) * | 2010-09-27 | 2012-04-12 | Evolva Sa | 2-pyridone antimicrobial compositions |
| ES2658346T3 (es) | 2011-02-01 | 2018-03-09 | Emergent Product Development Gaithersburg Inc. | 4-Oxoquinolizinas antimicrobianas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0723545B1 (de) * | 1993-10-14 | 2002-05-08 | Abbott Laboratories | Verbindungen des chinolizinon-typs |
| KR19990022524A (ko) * | 1995-06-06 | 1999-03-25 | 웨인스톡 스티븐 에프. | 퀴놀리지논형화합물 |
| EP1227096B1 (de) * | 1999-10-19 | 2004-09-22 | Sato Pharmaceutical Co. Ltd. | Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur |
| AU2001286191A1 (en) * | 2000-09-12 | 2002-03-26 | Sankyo Company, Limited | Quinolizine derivatives |
-
2002
- 2002-09-27 EP EP02775254A patent/EP1437354B1/de not_active Expired - Lifetime
- 2002-09-27 DE DE60228297T patent/DE60228297D1/de not_active Expired - Fee Related
- 2002-09-27 JP JP2003532501A patent/JP4101754B2/ja not_active Expired - Fee Related
- 2002-09-27 AT AT02775254T patent/ATE404558T1/de not_active IP Right Cessation
- 2002-09-27 WO PCT/JP2002/010103 patent/WO2003029253A1/ja not_active Ceased
-
2004
- 2004-03-26 US US10/809,874 patent/US7223773B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2003029253A1 (ja) | 2005-01-13 |
| US7223773B2 (en) | 2007-05-29 |
| EP1437354A4 (de) | 2005-10-12 |
| JP4101754B2 (ja) | 2008-06-18 |
| US20040229903A1 (en) | 2004-11-18 |
| EP1437354B1 (de) | 2008-08-13 |
| EP1437354A1 (de) | 2004-07-14 |
| WO2003029253A1 (en) | 2003-04-10 |
| DE60228297D1 (de) | 2008-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |