ATE404558T1 - Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen - Google Patents

Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen

Info

Publication number: ATE404558T1
Authority: AT; Austria
Prior art keywords: halo; oxocinolicine; antimicrobial; compounds; oxoquinolizine
Prior art date: 2001-09-28

Application number

AT02775254T

Other languages

English (en)

Inventor

Ryoichi Fukumoto

Yoshimi Niwano

Hiroyuki Kusakabe

Chong Chu

Hiroaki Kimura

Koh Nagasawa

Satoshi Yanagihara

Chisato Hirosawa

Seiji Ishiduka

Original Assignee

Sato Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-28

Filing date

2002-09-27

Publication date

2008-08-15

2002-09-27 Application filed by Sato Pharma filed Critical Sato Pharma

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE404558T1 publication Critical patent/ATE404558T1/de

Links

230000000845 anti-microbial effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
125000001475 halogen functional group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
ZUVKZCTUVRLOAQ-UHFFFAOYSA-N quinolizin-4-one Chemical class C1=CC=CN2C(=O)C=CC=C21 ZUVKZCTUVRLOAQ-UHFFFAOYSA-N 0.000 abstract 2
BHJNYJBPBFSPNP-UHFFFAOYSA-N 8-(4-aminophenyl)-1-cyclopropyl-9-methyl-4-oxoquinolizine-3-carboxylic acid Chemical compound CC1=C(C=2C=CC(N)=CC=2)C=CN(C(C(C(O)=O)=C2)=O)C1=C2C1CC1 BHJNYJBPBFSPNP-UHFFFAOYSA-N 0.000 abstract 1
241000588724 Escherichia coli Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT02775254T 2001-09-28 2002-09-27 Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen ATE404558T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001299088		2001-09-28
JP2001326133		2001-10-24

Publications (1)

Publication Number	Publication Date
ATE404558T1 true ATE404558T1 (de)	2008-08-15

Family

ID=26623198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02775254T ATE404558T1 (de)	2001-09-28	2002-09-27	Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen

Country Status (6)

Country	Link
US (1)	US7223773B2 (de)
EP (1)	EP1437354B1 (de)
JP (1)	JP4101754B2 (de)
AT (1)	ATE404558T1 (de)
DE (1)	DE60228297D1 (de)
WO (1)	WO2003029253A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7745459B2 (en)	2004-09-21	2010-06-29	Japan Tobacco Inc.	Quinolizinone compound and use thereof as HIV integrase inhibitor
WO2011031745A1 (en)	2009-09-09	2011-03-17	Achaogen, Inc.	Antibacterial fluoroquinolone analogs
EP3034078A1 (de) *	2010-09-27	2016-06-22	Emergent Product Development Gaithersburg Inc.	Antimikrobielle 2-pyridon-zusammensetzungen
EP3312176A1 (de) *	2011-02-01	2018-04-25	Emergent Product Development Gaithersburg Inc.	Antimikrobielle 4-oxochinolizine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE217309T1 (de) *	1993-10-14	2002-05-15	Abbott Lab	Verbindungen des chinolizinon-typs
KR19990022524A (ko) *	1995-06-06	1999-03-25	웨인스톡 스티븐 에프.	퀴놀리지논형화합물
EP1227096B1 (de) *	1999-10-19	2004-09-22	Sato Pharmaceutical Co. Ltd.	Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur
AU2001286191A1 (en) *	2000-09-12	2002-03-26	Sankyo Company, Limited	Quinolizine derivatives

2002
- 2002-09-27 WO PCT/JP2002/010103 patent/WO2003029253A1/ja not_active Ceased
- 2002-09-27 AT AT02775254T patent/ATE404558T1/de not_active IP Right Cessation
- 2002-09-27 EP EP02775254A patent/EP1437354B1/de not_active Expired - Lifetime
- 2002-09-27 JP JP2003532501A patent/JP4101754B2/ja not_active Expired - Fee Related
- 2002-09-27 DE DE60228297T patent/DE60228297D1/de not_active Expired - Fee Related
2004
- 2004-03-26 US US10/809,874 patent/US7223773B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1437354A1 (de)	2004-07-14
US20040229903A1 (en)	2004-11-18
WO2003029253A1 (en)	2003-04-10
DE60228297D1 (de)	2008-09-25
JPWO2003029253A1 (ja)	2005-01-13
JP4101754B2 (ja)	2008-06-18
EP1437354B1 (de)	2008-08-13
EP1437354A4 (de)	2005-10-12
US7223773B2 (en)	2007-05-29

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Legal Events

Date	Code	Title	Description
2009-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties