ATE404691T1 - Pyruvat-kinase als einem neuen zielmolekül - Google Patents
Pyruvat-kinase als einem neuen zielmolekülInfo
- Publication number
- ATE404691T1 ATE404691T1 AT02748716T AT02748716T ATE404691T1 AT E404691 T1 ATE404691 T1 AT E404691T1 AT 02748716 T AT02748716 T AT 02748716T AT 02748716 T AT02748716 T AT 02748716T AT E404691 T1 ATE404691 T1 AT E404691T1
- Authority
- AT
- Austria
- Prior art keywords
- target molecule
- new target
- pyruvate kinase
- pyruvate
- kinase
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112601 | 2001-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE404691T1 true ATE404691T1 (de) | 2008-08-15 |
Family
ID=8177529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02748716T ATE404691T1 (de) | 2001-05-23 | 2002-05-23 | Pyruvat-kinase als einem neuen zielmolekül |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040152648A1 (de) |
| EP (2) | EP1990422A1 (de) |
| AT (1) | ATE404691T1 (de) |
| AU (1) | AU2002319180B2 (de) |
| CA (1) | CA2448165A1 (de) |
| DE (1) | DE60228233D1 (de) |
| DK (1) | DK1390525T3 (de) |
| ES (1) | ES2312595T3 (de) |
| PT (1) | PT1390525E (de) |
| WO (1) | WO2002095063A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004016646A2 (en) * | 2002-08-12 | 2004-02-26 | Amynon Bio Tech Gmbh | Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk) |
| AU2003297318A1 (en) * | 2002-12-20 | 2004-07-22 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476. |
| DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
| WO2006055880A2 (en) * | 2004-11-16 | 2006-05-26 | Genzyme Corporation | Diagnostic pkm2 methods and compositions |
| WO2006065967A2 (en) * | 2004-12-15 | 2006-06-22 | General Atomics | Allosteric enzyme coupled immunoassay (aecia) |
| WO2009025781A1 (en) * | 2007-08-16 | 2009-02-26 | Beth Israel Deaconess Medical Center | Activators of pyruvate kinase m2 and methods of treating disease |
| WO2010042867A2 (en) | 2008-10-09 | 2010-04-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
| CA2758071C (en) | 2009-04-06 | 2018-01-09 | Agios Pharmaceuticals, Inc. | Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use |
| DK2427441T3 (en) | 2009-05-04 | 2017-03-20 | Agios Pharmaceuticals Inc | PKM2 Activators for use in the treatment of cancer |
| TWI598337B (zh) | 2009-06-29 | 2017-09-11 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| ES2618630T3 (es) | 2009-06-29 | 2017-06-21 | Agios Pharmaceuticals, Inc. | Composiciones terapéuticas y métodos de uso relacionados |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| EP2525790B1 (de) | 2009-10-21 | 2020-05-27 | Agios Pharmaceuticals, Inc. | Verfahren und zusammensetzungen für zellproliferationsbedingte erkrankungen |
| EP2542267A4 (de) | 2010-03-05 | 2014-09-17 | Univ Columbia | Die rna-bindeproteine hnrnpa1, hnrnpa2 und ptb hemmende rnas und verwendungen davon |
| US20130109672A1 (en) | 2010-04-29 | 2013-05-02 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Activators of human pyruvate kinase |
| WO2012083246A1 (en) | 2010-12-17 | 2012-06-21 | Agios Pharmaceuticals, Inc. | Novel n- (4- (azetidine - 1 - carbonyl) phenyl) - (hetero - ) arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators |
| ES2569712T3 (es) | 2010-12-21 | 2016-05-12 | Agios Pharmaceuticals, Inc. | Activadores de PKM2 bicíclicos |
| TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| SMT202400081T1 (it) | 2011-05-03 | 2024-03-13 | Agios Pharmaceuticals Inc | Attivatori della piruvato chinasi per uso in terapia |
| CA2989111C (en) | 2015-06-11 | 2023-10-03 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
| LT3483164T (lt) | 2017-03-20 | 2020-05-11 | Forma Therapeutics, Inc. | Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai |
| EP3853206B1 (de) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Behandlung von sichelzellanämie mit einer pyruvatkinase-r-aktivierenden verbindung |
| EP3852791B1 (de) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Aktivierung von pyruvatkinase r |
| HRP20251148T1 (hr) | 2019-09-19 | 2025-11-21 | Novo Nordisk Health Care Ag | Pripravci koji aktiviraju piruvat-kinazu r (pkr) |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821254A (en) * | 1995-02-17 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Uses of 9-cis-retinoic acids and derivatives thereof alone or in combination with antineoplastic agents in the prevention or treatment of cancer |
| AU6333598A (en) * | 1997-02-11 | 1998-08-26 | Regents Of The University Of California, The | Methods of inducing cell cycle stasis |
| US7074895B2 (en) * | 1997-08-21 | 2006-07-11 | Quark Biotech, Inc. | Sequences characteristic of hypoxia-regulated gene transcription |
| US5948628A (en) * | 1997-09-05 | 1999-09-07 | The Board Of Regents Of The University Of Oklahoma | Methods of screening for compounds which mimic galectin-1 |
| US6458538B1 (en) * | 1999-12-14 | 2002-10-01 | Ptc Therapeutics, Inc. | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay |
-
2002
- 2002-05-23 AU AU2002319180A patent/AU2002319180B2/en not_active Ceased
- 2002-05-23 EP EP08014232A patent/EP1990422A1/de not_active Withdrawn
- 2002-05-23 AT AT02748716T patent/ATE404691T1/de not_active IP Right Cessation
- 2002-05-23 ES ES02748716T patent/ES2312595T3/es not_active Expired - Lifetime
- 2002-05-23 EP EP02748716A patent/EP1390525B8/de not_active Expired - Lifetime
- 2002-05-23 DE DE60228233T patent/DE60228233D1/de not_active Expired - Lifetime
- 2002-05-23 WO PCT/EP2002/005684 patent/WO2002095063A1/en not_active Ceased
- 2002-05-23 PT PT02748716T patent/PT1390525E/pt unknown
- 2002-05-23 CA CA002448165A patent/CA2448165A1/en not_active Abandoned
- 2002-05-23 US US10/478,679 patent/US20040152648A1/en not_active Abandoned
- 2002-05-23 DK DK02748716T patent/DK1390525T3/da active
-
2007
- 2007-06-29 US US11/771,462 patent/US20080021116A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040152648A1 (en) | 2004-08-05 |
| DE60228233D1 (de) | 2008-09-25 |
| EP1390525B1 (de) | 2008-08-13 |
| ES2312595T3 (es) | 2009-03-01 |
| EP1390525B8 (de) | 2009-03-04 |
| DK1390525T3 (da) | 2008-12-08 |
| WO2002095063A1 (en) | 2002-11-28 |
| US20080021116A1 (en) | 2008-01-24 |
| CA2448165A1 (en) | 2002-11-28 |
| EP1990422A1 (de) | 2008-11-12 |
| PT1390525E (pt) | 2008-11-25 |
| EP1390525A1 (de) | 2004-02-25 |
| AU2002319180B2 (en) | 2007-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1390525 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |