ATE405667T1 - Verfahren zur produktion von l-threonin - Google Patents
Verfahren zur produktion von l-threoninInfo
- Publication number
- ATE405667T1 ATE405667T1 AT02253703T AT02253703T ATE405667T1 AT E405667 T1 ATE405667 T1 AT E405667T1 AT 02253703 T AT02253703 T AT 02253703T AT 02253703 T AT02253703 T AT 02253703T AT E405667 T1 ATE405667 T1 AT E405667T1
- Authority
- AT
- Austria
- Prior art keywords
- threonine
- gene
- microorganism
- producing
- tdc
- Prior art date
Links
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 title abstract 7
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000004473 Threonine Substances 0.000 abstract 4
- 229960002898 threonine Drugs 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 3
- 101150067147 TDC gene Proteins 0.000 abstract 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 abstract 1
- 108010006873 Threonine Dehydratase Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000037353 metabolic pathway Effects 0.000 abstract 1
- 238000005215 recombination Methods 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2002-0015380A KR100451299B1 (ko) | 2002-03-21 | 2002-03-21 | L―쓰레오닌의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE405667T1 true ATE405667T1 (de) | 2008-09-15 |
Family
ID=27786040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02253703T ATE405667T1 (de) | 2002-03-21 | 2002-05-27 | Verfahren zur produktion von l-threonin |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1347057B1 (de) |
| JP (1) | JP4034737B2 (de) |
| KR (1) | KR100451299B1 (de) |
| CN (1) | CN1194088C (de) |
| AT (1) | ATE405667T1 (de) |
| AU (1) | AU2002256930A1 (de) |
| DE (1) | DE60228402D1 (de) |
| RU (1) | RU2288265C2 (de) |
| WO (1) | WO2003080843A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100505797B1 (ko) * | 2002-10-11 | 2005-08-04 | 씨제이 주식회사 | 염색체 상의 fadR 유전자가 불활성화된 L-쓰레오닌 생성 변이 미생물과 이를 이용한 L-쓰레오닌의 제조방법 |
| KR100498971B1 (ko) * | 2003-04-04 | 2005-07-04 | 씨제이 주식회사 | 염색체 내 tdcBC 및 pckA 유전자가 불활성화된 미생물 및 이를 이용하여 L-쓰레오닌을 제조하는 방법 |
| JP4380305B2 (ja) * | 2003-11-21 | 2009-12-09 | 味の素株式会社 | 発酵法によるl−アミノ酸の製造法 |
| KR100576342B1 (ko) * | 2004-02-05 | 2006-05-03 | 씨제이 주식회사 | galR 유전자가 불활성화된 L-쓰레오닌 생성 미생물,그를 제조하는 방법 및 상기 미생물을 이용한L-쓰레오닌의 제조방법 |
| KR100608085B1 (ko) * | 2004-02-05 | 2006-08-02 | 씨제이 주식회사 | tyrR 유전자가 불활성화된 L-쓰레오닌 생성 미생물,그를 제조하는 방법 및 상기 미생물을 이용한L-쓰레오닌의 제조방법 |
| KR100596372B1 (ko) * | 2004-12-06 | 2006-07-04 | 씨제이 주식회사 | 염색체 상의 lysR유전자가 불활성화된 L-쓰레오닌생성 미생물, 그를 제조하는 방법 및 상기 미생물을이용한 L-쓰레오닌의 제조방법 |
| KR100837842B1 (ko) | 2006-08-10 | 2008-06-13 | 씨제이제일제당 (주) | 아스파테이트 세미알데히드 디하이드로게나아제 활성이증가된 l-쓰레오닌 생산 미생물 및 이를 이용한l-쓰레오닌 생산 방법 |
| KR101804017B1 (ko) * | 2015-10-23 | 2017-12-04 | 씨제이제일제당 (주) | L-쓰레오닌을 생산하는 재조합 미생물 및 이를 이용하여 l-쓰레오닌을 생산하는 방법 |
| CN109554322B (zh) * | 2018-12-03 | 2020-08-04 | 江南大学 | 一种高产l-苏氨酸的重组大肠杆菌及其构建方法 |
| CN109735478B (zh) * | 2019-01-28 | 2021-03-30 | 江南大学 | 一株高产l-苏氨酸基因工程菌的构建方法及其应用 |
| CN116555131A (zh) * | 2022-01-27 | 2023-08-08 | 廊坊梅花生物技术开发有限公司 | 一种重组微生物及其构建方法和应用 |
| CN116606785A (zh) * | 2022-02-08 | 2023-08-18 | 廊坊梅花生物技术开发有限公司 | 一种修饰的棒状杆菌属微生物及其应用与构建方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3891417C5 (de) * | 1988-10-25 | 2006-01-05 | Ajinomoto Co., Inc. | Verfahren zur Veränderung eines L-Threonin produzierenden Mikroorganismus und Verwendung eines so erhaltenen Mikroorganismus zur Herstellung von L-Threonin |
| ATE203769T1 (de) * | 1992-11-10 | 2001-08-15 | Ajinomoto Kk | Dna, die aspartokinase iii-mutanten kodiert und ihre verwendung zur herstellung von l-threonin durch fermentation |
| DE4400926C1 (de) * | 1994-01-14 | 1995-06-01 | Forschungszentrum Juelich Gmbh | Herstellung von L-Isoleucin mittels rekombinanter Mikroorganismen mit deregulierter Threonindehydratase |
| US5939307A (en) * | 1996-07-30 | 1999-08-17 | The Archer-Daniels-Midland Company | Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production |
| DE19907567B4 (de) * | 1999-02-22 | 2007-08-09 | Forschungszentrum Jülich GmbH | Verfahren zur mikrobiellen Herstellung von L-Valin |
-
2002
- 2002-03-21 KR KR10-2002-0015380A patent/KR100451299B1/ko not_active Expired - Fee Related
- 2002-05-16 RU RU2004127987/13A patent/RU2288265C2/ru not_active IP Right Cessation
- 2002-05-16 AU AU2002256930A patent/AU2002256930A1/en not_active Abandoned
- 2002-05-16 WO PCT/KR2002/000920 patent/WO2003080843A1/en not_active Ceased
- 2002-05-16 JP JP2003578568A patent/JP4034737B2/ja not_active Expired - Fee Related
- 2002-05-27 EP EP02253703A patent/EP1347057B1/de not_active Expired - Lifetime
- 2002-05-27 DE DE60228402T patent/DE60228402D1/de not_active Expired - Lifetime
- 2002-05-27 AT AT02253703T patent/ATE405667T1/de not_active IP Right Cessation
- 2002-06-14 CN CNB021226008A patent/CN1194088C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2288265C2 (ru) | 2006-11-27 |
| KR20030075902A (ko) | 2003-09-26 |
| KR100451299B1 (ko) | 2004-10-06 |
| JP2005520548A (ja) | 2005-07-14 |
| RU2004127987A (ru) | 2005-06-10 |
| AU2002256930A1 (en) | 2003-10-08 |
| CN1194088C (zh) | 2005-03-23 |
| WO2003080843A1 (en) | 2003-10-02 |
| EP1347057A1 (de) | 2003-09-24 |
| EP1347057B1 (de) | 2008-08-20 |
| CN1446914A (zh) | 2003-10-08 |
| DE60228402D1 (de) | 2008-10-02 |
| JP4034737B2 (ja) | 2008-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE405667T1 (de) | Verfahren zur produktion von l-threonin | |
| DE602004014158D1 (de) | Verfahren zur herstellung von l-lysin oder l-threonin unter verwendung von escherichia-bakterien mit abgeschwächter malatenzymaktivität | |
| ATE287961T1 (de) | Verfahren zur herstellung von l - lysin durch fermentation | |
| DE50001708D1 (de) | Verfahren zur mikrobiellen herstellung von l-valin | |
| ATE442453T1 (de) | Verfahren zur herstellung von l-aminosäure oder nucleinsäure unter verwendung von mikroorganismen | |
| WO2010114245A3 (ko) | 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법 | |
| DE60207685D1 (de) | Verfahren zur herstellung von l-threonin | |
| CA2354103A1 (en) | Method for producing threonine and isoleucine | |
| RU96110201A (ru) | Способ получения веществ | |
| DE602007013447D1 (de) | Glutaminsäure in hoher ausbeute produzierender mikroorganismus und verfahren zur produktion von glutaminsäure damit | |
| ATE542886T1 (de) | Verfahren zur herstellung von l-arginin mit corynebacterium glutamicum | |
| ATE553210T1 (de) | Verfahren zur herstellung von l-threonin unter verwendung eines mikroorganismus mit inaktivierten galr gen. | |
| ID26461A (id) | Corynebacteria untuk memproduksi l-lisin dan proses pembuatan lisin | |
| ATE263246T1 (de) | Verfahren zur fermentativen herstellung von l- aminosäuren unter verwendung coryneformer bakterien | |
| BR0010817A (pt) | Processo para a preparação fermentativa de l-aminoácidos com amplificação do gene gnd | |
| ATE474912T1 (de) | Mikroorganismus einer escherichia- oder corynebacterium-spezies mit einem fremdgen für nadp-abhängige glycerinaldehyd-3-phosphat- dehydrogenase und verfahren zur herstellung von l-lysin damit | |
| ATE556145T1 (de) | Verfahren zur herstellung von l-threonin oder l- lysin unter verwendung rekombinanter enterobacteriaceae mit erhöhter enolaseaktivität | |
| ATE423197T1 (de) | Mikroorganismen des genus corynebakteriums mit resistenz gegen kanamycin und erhöhter l-lysin- produktivität und verfahren zur herstellung von l-lysin damit | |
| ATE422211T1 (de) | Verfahren zur fermentativen herstellung von l- valin unter verwendung coryneformer bakterien mit erhöhter transaminase c aktivität | |
| WO2002021418A3 (en) | Method and system for identifying commercially distributed organisms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |