ATE406575T1 - Verfahren zur erkennung von medikamentenempfindlichkeit in patienten mit entzündungskrankheiten - Google Patents
Verfahren zur erkennung von medikamentenempfindlichkeit in patienten mit entzündungskrankheitenInfo
- Publication number
- ATE406575T1 ATE406575T1 AT02762680T AT02762680T ATE406575T1 AT E406575 T1 ATE406575 T1 AT E406575T1 AT 02762680 T AT02762680 T AT 02762680T AT 02762680 T AT02762680 T AT 02762680T AT E406575 T1 ATE406575 T1 AT E406575T1
- Authority
- AT
- Austria
- Prior art keywords
- expression profile
- sample
- patients
- inflammatory diseases
- drug sensitivity
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 208000027866 inflammatory disease Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000035945 sensitivity Effects 0.000 title 1
- 230000014509 gene expression Effects 0.000 abstract 5
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/947,991 US7384736B2 (en) | 2001-09-06 | 2001-09-06 | Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE406575T1 true ATE406575T1 (de) | 2008-09-15 |
Family
ID=25487094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02762680T ATE406575T1 (de) | 2001-09-06 | 2002-09-02 | Verfahren zur erkennung von medikamentenempfindlichkeit in patienten mit entzündungskrankheiten |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7384736B2 (de) |
| EP (1) | EP1428023B1 (de) |
| JP (1) | JP2005502345A (de) |
| AT (1) | ATE406575T1 (de) |
| AU (1) | AU2002328110B2 (de) |
| CA (1) | CA2457476A1 (de) |
| DE (1) | DE60228592D1 (de) |
| DK (1) | DK1428023T3 (de) |
| WO (1) | WO2003021261A2 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1233651A1 (de) * | 2000-04-07 | 2002-08-21 | Ibiden Co., Ltd. | Keramisches heizelement |
| US7198895B2 (en) * | 2000-11-14 | 2007-04-03 | Mohanlal Ramon W | In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals |
| US7384736B2 (en) * | 2001-09-06 | 2008-06-10 | Decode Genetics Ehf. | Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease |
| US6893828B2 (en) * | 2001-09-06 | 2005-05-17 | Decode Genetics Ehf. | Methods for producing ex vivo models for inflammatory disease and uses thereof |
| CN102402650A (zh) * | 2001-11-09 | 2012-04-04 | 生命技术公司 | 利用基因表达分布图识别、监控和治疗疾病以及鉴定生物学状态 |
| US20050036943A1 (en) * | 2001-12-07 | 2005-02-17 | Broughton Kenneth Shane | Methods and compositions for the diagnosis of asthma |
| US7655397B2 (en) * | 2002-04-25 | 2010-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers |
| US7774143B2 (en) * | 2002-04-25 | 2010-08-10 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states |
| EP1573054A4 (de) * | 2002-11-12 | 2005-12-28 | Becton Dickinson Co | Sepsis- oder sirs-diagnose mittels biomarkerprofilen |
| AU2003900639A0 (en) * | 2003-02-12 | 2003-02-27 | G2 Therapies Ltd | Novel method of treating inflammatory diseases |
| AU2003304165A1 (en) * | 2003-05-30 | 2005-01-21 | Reinhard Guthke | Method for assessing the response behavior of an individual to antirheumatics |
| WO2004108960A2 (en) * | 2003-06-09 | 2004-12-16 | Decode Genetics Ehf. | Methods for predicting drug efficacy in patients afflicted with hypertension |
| CA2546111A1 (en) * | 2003-11-25 | 2005-06-16 | Novartis Ag | Biomarkers for the efficacy of calcitonin and parathyroid hormone treatment |
| DE602006005333D1 (de) * | 2006-03-06 | 2009-04-09 | Gen Electric | Automatische Kalibrierung der Sensibilität einer Person gegenüber einem Arzneimittel |
| JP5168513B2 (ja) * | 2007-03-30 | 2013-03-21 | 王子ホールディングス株式会社 | 遺伝子発現情報を用いた植物の形質を判定もしくは予測する方法 |
| CA2699376C (en) | 2007-09-14 | 2018-10-23 | University Of South Florida | Gene signature for the prediction of radiation therapy response |
| US8574834B2 (en) | 2007-12-14 | 2013-11-05 | Index Pharmaceuticals Ab | Method for predicting the response to a therapy |
| US8577620B2 (en) * | 2008-03-27 | 2013-11-05 | Gus J. Slotman | Methods for assessing drug efficacy and response of patient to therapy |
| JP6161233B2 (ja) * | 2008-03-31 | 2017-07-12 | ジェネンテック， インコーポレイテッド | 喘息の治療及び診断のための組成物及び方法 |
| EP2652498B1 (de) | 2010-12-16 | 2018-04-18 | F.Hoffmann-La Roche Ag | Diagnose und behandlungen im zusammenhang mit th2-hemmung |
| US20150292012A1 (en) * | 2012-10-26 | 2015-10-15 | Case Western Reserve University | Biomarkers for nod2 and/or rip2 activity related application |
| CN105308460A (zh) * | 2013-05-02 | 2016-02-03 | 天主教大学基金会 | 个性化药物 |
| CL2015001420A1 (es) * | 2015-05-26 | 2015-10-02 | Univ Chile | Método ex vivo y kit predictor de respuesta a tratamiento con glucocorticoides (gc) en pacientes portadores de enfermedades inflamatorias, basado en la cuantificación de la razón de cambio de los niveles de las isoformas del receptor de gc. |
| EP3676402B1 (de) * | 2017-08-30 | 2023-12-27 | Bristol-Myers Squibb Company | Verfahren zur überwachung von pharmakodynamischen reaktionen, die durch in-vivo-verabreichung von glukokortikoiden vermittelt werden |
| US12191023B1 (en) | 2018-03-30 | 2025-01-07 | Flagship Pioneering Innovations Vi, Llc | Systems and methods for patient targeted therapy development |
| CN108830040B (zh) * | 2018-06-07 | 2021-06-15 | 中南大学 | 一种基于细胞系和药物相似性网络的药物敏感性预测方法 |
| US20230407397A1 (en) * | 2020-11-04 | 2023-12-21 | Massachusetts Institute Of Technology | Methods for identifying drivers of immune responses using molecular expression signatures of immunomodulating agents |
| US12512218B2 (en) * | 2021-03-12 | 2025-12-30 | PulManage, Inc. | Spirometry data systems, methods, and apparatuses |
| WO2025125356A1 (en) * | 2023-12-11 | 2025-06-19 | King Faisal Specialist Hospital & Research Centre | A method for determining the activity of a drug or drug candidate under conditions of microgravity |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6801859B1 (en) | 1998-12-23 | 2004-10-05 | Rosetta Inpharmatics Llc | Methods of characterizing drug activities using consensus profiles |
| US6692916B2 (en) * | 1999-06-28 | 2004-02-17 | Source Precision Medicine, Inc. | Systems and methods for characterizing a biological condition or agent using precision gene expression profiles |
| US7198895B2 (en) * | 2000-11-14 | 2007-04-03 | Mohanlal Ramon W | In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals |
| WO2002059367A2 (en) * | 2000-11-30 | 2002-08-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis |
| AU2002230997A1 (en) * | 2000-12-15 | 2002-06-24 | Genetics Institute, Llc | Methods and compositions for diagnosing and treating rheumatoid arthritis |
| JP2004519439A (ja) * | 2000-12-20 | 2004-07-02 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | グルココルチコイド関連副作用の治療用の解離したグルココルチコイドレセプターアンタゴニスト |
| US6893828B2 (en) * | 2001-09-06 | 2005-05-17 | Decode Genetics Ehf. | Methods for producing ex vivo models for inflammatory disease and uses thereof |
| US7384736B2 (en) * | 2001-09-06 | 2008-06-10 | Decode Genetics Ehf. | Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease |
| US20040116462A1 (en) * | 2002-12-12 | 2004-06-17 | Mitsunori Ono | Indolizine compounds |
| WO2004108960A2 (en) * | 2003-06-09 | 2004-12-16 | Decode Genetics Ehf. | Methods for predicting drug efficacy in patients afflicted with hypertension |
-
2001
- 2001-09-06 US US09/947,991 patent/US7384736B2/en not_active Expired - Fee Related
-
2002
- 2002-09-02 AT AT02762680T patent/ATE406575T1/de not_active IP Right Cessation
- 2002-09-02 JP JP2003525293A patent/JP2005502345A/ja active Pending
- 2002-09-02 DK DK02762680T patent/DK1428023T3/da active
- 2002-09-02 CA CA002457476A patent/CA2457476A1/en not_active Abandoned
- 2002-09-02 WO PCT/IB2002/003613 patent/WO2003021261A2/en not_active Ceased
- 2002-09-02 EP EP02762680A patent/EP1428023B1/de not_active Expired - Lifetime
- 2002-09-02 AU AU2002328110A patent/AU2002328110B2/en not_active Ceased
- 2002-09-02 DE DE60228592T patent/DE60228592D1/de not_active Expired - Lifetime
- 2002-09-03 US US10/234,652 patent/US7148008B2/en not_active Expired - Fee Related
-
2006
- 2006-11-03 US US11/592,699 patent/US20070054309A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002328110B2 (en) | 2007-01-25 |
| US20030113831A1 (en) | 2003-06-19 |
| WO2003021261A3 (en) | 2003-11-20 |
| US20070054309A1 (en) | 2007-03-08 |
| WO2003021261A2 (en) | 2003-03-13 |
| US20030134776A1 (en) | 2003-07-17 |
| US7148008B2 (en) | 2006-12-12 |
| DK1428023T3 (da) | 2009-01-19 |
| EP1428023A2 (de) | 2004-06-16 |
| DE60228592D1 (de) | 2008-10-09 |
| US7384736B2 (en) | 2008-06-10 |
| CA2457476A1 (en) | 2003-03-13 |
| EP1428023B1 (de) | 2008-08-27 |
| JP2005502345A (ja) | 2005-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |