ATE407122T1 - Azadecalinmodulatoren des glucocorticoidrezeptors - Google Patents

Azadecalinmodulatoren des glucocorticoidrezeptors

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Publication number
ATE407122T1
ATE407122T1 AT05711316T AT05711316T ATE407122T1 AT E407122 T1 ATE407122 T1 AT E407122T1 AT 05711316 T AT05711316 T AT 05711316T AT 05711316 T AT05711316 T AT 05711316T AT E407122 T1 ATE407122 T1 AT E407122T1
Authority
AT
Austria
Prior art keywords
azadecalin
glucocorticoid receptor
modulators
compounds
methods
Prior art date
Application number
AT05711316T
Other languages
English (en)
Inventor
Robin D Clark
Nicholas C Ray
Paul Blaney
Christopher Hurley
Karen Williams
Hazel Hunt
David Clark
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Application granted granted Critical
Publication of ATE407122T1 publication Critical patent/ATE407122T1/de

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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D491/10—Spiro-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
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AT05711316T 2004-01-09 2005-01-10 Azadecalinmodulatoren des glucocorticoidrezeptors ATE407122T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53546004P 2004-01-09 2004-01-09

Publications (1)

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ATE407122T1 true ATE407122T1 (de) 2008-09-15

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AT05711316T ATE407122T1 (de) 2004-01-09 2005-01-10 Azadecalinmodulatoren des glucocorticoidrezeptors

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US (2) US7678813B2 (de)
EP (1) EP1761497B1 (de)
JP (1) JP4851345B2 (de)
KR (1) KR101135885B1 (de)
CN (1) CN101119970A (de)
AT (1) ATE407122T1 (de)
AU (1) AU2005206497B2 (de)
CA (1) CA2552419C (de)
CY (1) CY1110491T1 (de)
DE (1) DE602005009530D1 (de)
DK (1) DK1761497T3 (de)
ES (1) ES2313296T3 (de)
IL (1) IL176706A (de)
NO (1) NO20063456L (de)
NZ (1) NZ548374A (de)
PT (1) PT1761497E (de)
WO (1) WO2005070893A2 (de)
ZA (1) ZA200605634B (de)

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ES2332529T3 (es) * 2005-01-26 2010-02-08 F. Hoffmann-La Roche Ag Derivados de fenil-metanona y su empleo como inhibidores del transportador 1 de glicina.
TW200820977A (en) * 2006-08-08 2008-05-16 Organon Nv Use of glucocorticoid receptor antagonists for treatment of infectious conditions
DE602008002644D1 (de) * 2007-06-25 2010-11-04 Terumo Corp Medizinische Vorrichtung
EP2211845B1 (de) * 2007-10-17 2017-02-22 Laboratoire HRA Pharma Glucocorticoid-rezeptor-antagonisten wie mifepriston zur behandlung des cushing-syndroms
AU2009267016B2 (en) * 2008-07-01 2014-07-03 Corcept Therapeutics, Inc. Use of mifepristone for the treatment of Amyotrophic Lateral Sclerosis
WO2012027702A1 (en) 2010-08-27 2012-03-01 Corcept Therapeutics, Inc. Pyridyl-amine fused azadecalin modulators
CA2821524A1 (en) 2011-01-07 2012-07-12 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
PH12013501906A1 (en) * 2011-03-18 2013-12-16 Corcept Therapeutics Inc Pyrimidine cyclohexyl glucocorticoid receptor modulators
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
MX368167B (es) 2013-11-25 2019-09-23 Corcept Therapeutics Inc Moduladores de receptores de glucocorticoides de azadecalina octahidro fusionada.
MX383318B (es) 2015-08-13 2025-03-13 Corcept Therapeutics Inc Metodo para diagnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina.
KR102197526B1 (ko) 2016-01-19 2020-12-31 코어셉트 쎄라퓨틱스 인코포레이티드 이소성 쿠싱 증후군의 감별 진단
JP6847120B2 (ja) 2016-03-01 2021-03-24 コーセプト セラピューティクス， インコーポレイテッド チェックポイントインヒビターを強化するためのグルココルチコイドレセプターモジュレーターの使用
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US8324203B2 (en) 2012-12-04
IL176706A (en) 2012-06-28
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WO2005070893A3 (en) 2007-01-18
AU2005206497A1 (en) 2005-08-04
PT1761497E (pt) 2008-09-25
DK1761497T3 (da) 2008-11-03
ES2313296T3 (es) 2009-03-01
DE602005009530D1 (de) 2008-10-16
KR101135885B1 (ko) 2012-04-16
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US7678813B2 (en) 2010-03-16
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AU2005206497B2 (en) 2011-02-10
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WO2005070893A2 (en) 2005-08-04
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