ATE407144T1 - T1r-geschmacksrezeptoren und dafür kodierende gene - Google Patents

T1r-geschmacksrezeptoren und dafür kodierende gene

Info

Publication number
ATE407144T1
ATE407144T1 AT02720756T AT02720756T ATE407144T1 AT E407144 T1 ATE407144 T1 AT E407144T1 AT 02720756 T AT02720756 T AT 02720756T AT 02720756 T AT02720756 T AT 02720756T AT E407144 T1 ATE407144 T1 AT E407144T1
Authority
AT
Austria
Prior art keywords
methods
taste
genes
receptors
mammal
Prior art date
Application number
AT02720756T
Other languages
English (en)
Inventor
Jon Elliott Adler
Xiaodong Li
Lena Staszewski
Shawn O'connell
Sergey Zozulya
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Application granted granted Critical
Publication of ATE407144T1 publication Critical patent/ATE407144T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Evolutionary Biology (AREA)
  • Physiology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT02720756T 2001-01-03 2002-01-03 T1r-geschmacksrezeptoren und dafür kodierende gene ATE407144T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25922701P 2001-01-03 2001-01-03
US28454701P 2001-04-19 2001-04-19

Publications (1)

Publication Number Publication Date
ATE407144T1 true ATE407144T1 (de) 2008-09-15

Family

ID=26947173

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02720756T ATE407144T1 (de) 2001-01-03 2002-01-03 T1r-geschmacksrezeptoren und dafür kodierende gene
AT08153652T ATE554100T1 (de) 2001-01-03 2002-01-03 T1r2 hybrid-geschmacksrezeptor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT08153652T ATE554100T1 (de) 2001-01-03 2002-01-03 T1r2 hybrid-geschmacksrezeptor

Country Status (15)

Country Link
US (16) US7241880B2 (de)
EP (2) EP1430083B1 (de)
JP (2) JP5411400B2 (de)
CN (2) CN102242126A (de)
AT (2) ATE407144T1 (de)
AU (2) AU2002251734B2 (de)
CA (1) CA2433514C (de)
DE (1) DE60228741D1 (de)
DK (2) DK1430083T3 (de)
ES (2) ES2385383T3 (de)
IL (1) IL156380A0 (de)
MX (1) MXPA03005989A (de)
NO (1) NO20033030L (de)
TW (1) TW201022287A (de)
WO (1) WO2002064631A2 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
US20040086877A1 (en) * 2000-06-16 2004-05-06 Lal Preeti G. Multi-mode directi memory access controller and method
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US6955887B2 (en) 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US7309577B2 (en) * 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US20080244761A1 (en) * 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US20040219632A1 (en) * 2001-04-20 2004-11-04 Robert Margolskee T1r3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
EP1412750B1 (de) * 2001-06-26 2012-05-23 Senomyx, Inc. Heterooligomere t1r2-t1r3 Süssegeschmacksrezeptoren und diese exprimierende Zellinien sowie Verwendung davon zur Identifizierung von Süssegeschmacksverbindungen
AU2007203680B8 (en) * 2001-06-26 2010-07-08 Senomyx, Inc. T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
WO2003004992A2 (en) 2001-07-03 2003-01-16 The Regents Of The University Of California Mammalian sweet and amino acid heterodimeric taste receptors
WO2003004611A2 (en) 2001-07-06 2003-01-16 Senomyx, Inc. Human olfactory nucleotide-gated ion channels
WO2003025137A2 (en) 2001-09-18 2003-03-27 Irm, Llc Sweet taste receptors
US7527944B2 (en) 2003-06-27 2009-05-05 Monell Chemical Senses Center Taste receptors of the T1R family from domestic cat
EP1659881B1 (de) 2003-08-06 2019-04-03 Senomyx Inc. Neue geschmacke, geschmacksmodifikatoren, geschmacksstoffe, geschmacksverstärker, geschmacksstoffe für umami oder süss, und/oder verstärker und ihre verwendung
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
WO2005116069A2 (en) 2004-04-14 2005-12-08 Monell Chemical Senses Center Taste receptors of the t1r family from domestic dog
EP1767654A4 (de) * 2004-06-28 2008-05-07 Univ Nihon Neues testverfahren für geschmacksanomalie
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
US20060263476A1 (en) * 2004-08-25 2006-11-23 Cadbury Adams Usa, Llc. Center-filled chewing gum with barrier layer
WO2006068745A1 (en) 2004-12-22 2006-06-29 Cargill, Incorporated Methods for determining cellular response to stimuli
CN101384183B (zh) 2005-02-04 2012-07-04 西诺米克斯公司 包含连接有杂芳基部分的化合物及其作为用于食物组合物的新型鲜味调节剂、促味剂和味觉增强剂的应用
JP2008530017A (ja) * 2005-02-04 2008-08-07 セノミックス インコーポレイテッド 食料用組成物のための風味調整剤として連結された有機部分を含む分子
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US7851006B2 (en) * 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
US7851005B2 (en) * 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
WO2006127934A2 (en) 2005-05-23 2006-11-30 Cadbury Adams Usa, Llc Taste potentiator compositions and edible confectionery and chewing gum products containing same
CN101179943B (zh) 2005-05-23 2013-06-26 卡夫食品环球品牌有限责任公司 填充液体的咀嚼型胶基糖组合物
TW200715993A (en) 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
EP2995950B1 (de) 2006-04-20 2024-01-17 Givaudan SA Verfahren zur verbesserung der süsse
US20110097741A1 (en) * 2006-04-20 2011-04-28 Jay Patrick Slack Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays
US8124360B2 (en) * 2006-04-20 2012-02-28 Givaudan S.A. Use of a T1R2 nucleic acid sequence to identify tastants
DK3235811T3 (en) 2006-04-21 2018-11-12 Senomyx Inc PROCEDURE FOR THE PREPARATION OF OXALAMIDS
EP2024518A4 (de) * 2006-06-08 2010-05-26 Senomyx Inc Rationale, verfahren und anordnungen zur identifizierung von neuartigen geschmackszellengenen und salzgeschmackrezeptor-targets und anordnungen mit diesen identifizierten genen bzw. genprodukten
US7629134B2 (en) * 2006-07-10 2009-12-08 Duke University Sour taste receptor compositions and methods
EP2046829A4 (de) * 2006-07-27 2010-05-12 Coca Cola Co Modellgeschmackszellen und verfahren zur identifizierung von modulatoren der geschmacksempfindung
JP5301464B2 (ja) * 2007-01-18 2013-09-25 ジボダン エス エー キメラうま味受容体、それをコードする核酸およびその利用
US8187822B2 (en) * 2007-03-30 2012-05-29 Givaudan S.A. Methods to identify modulators
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
TW200904981A (en) * 2007-06-08 2009-02-01 Senomyx Inc Identification of TRPML3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release
AU2013202912B2 (en) * 2007-06-08 2016-10-27 Firmenich Incorporated Modulation of chemosensory receptors and ligands associated therewith
GB0713297D0 (en) * 2007-07-10 2007-08-15 Cadbury Schweppes Plc Chocolate compositions having improved flavour characteristics
NZ601353A (en) * 2008-02-01 2014-06-27 Chromocell Corp Cell lines and methods for making and using them
EP2093234A1 (de) 2008-02-08 2009-08-26 Nutrinova Nutrition Specialties & Food Ingredients GmbH Oligopeptide zur Verwendung als Geschmacksmodulatoren
TWI429404B (zh) 2008-03-03 2014-03-11 Senomyx Inc 異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途
JP5588970B2 (ja) 2008-05-27 2014-09-10 ダコ・デンマーク・エー／エス ハイブリダイゼーション組成物及び方法
EP3085699B1 (de) 2008-07-31 2022-03-02 Firmenich Incorporated Verfahren zur herstellung von verstärkern des süssen geschmacks
MX2011001155A (es) 2008-07-31 2011-07-29 Senomyx Inc Composiciones que comprenden mejoradores del dulzor, y métodos para prepararlas.
CN102369275A (zh) * 2009-02-02 2012-03-07 卓莫赛尔公司 新型细胞系和方法
US9303287B2 (en) 2009-02-26 2016-04-05 Dako Denmark A/S Compositions and methods for RNA hybridization applications
WO2011067678A2 (en) * 2009-12-02 2011-06-09 Matthiesen Steen H Compositions and methods for performing hybridizations with no denaturation
ES2753523T3 (es) 2010-04-02 2020-04-13 Firmenich Incorporated Modificador del sabor dulce
US20130115624A1 (en) 2010-05-07 2013-05-09 Givaudan S.A. Methods To Identify Modulators
US20130123135A1 (en) 2010-05-07 2013-05-16 Jay Patrick Slack Methods To Identify Modulators of TAS2R48 Receptors
CN103153096B (zh) 2010-08-12 2016-08-03 赛诺米克斯公司 提高甜味增强剂的稳定性的方法和包含稳定的甜味增强剂的组合物
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
MX365710B (es) 2011-04-29 2019-06-11 Intercontinental Great Brands Llc Acido encapsulado, metodo para la preparacion del mismo y goma de mascar que comprende el mismo.
EP2742350B1 (de) 2011-08-08 2019-10-30 The Coca-Cola Company Zelllinien mit endogenen geschmacksrezptoren und deren verwendungen
PH12014500184A1 (en) 2011-08-12 2014-03-24 Firmenich Incorporated Sweet flavor modifier
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
EP3252173A1 (de) 2011-10-21 2017-12-06 Dako Denmark A/S Hybridisierungszusammensetzungen und -verfahren
WO2013160415A1 (en) 2012-04-25 2013-10-31 B.R.A.I.N. Biotechnology Research And Information Network Ag Human taste cells capable of continuous proliferation
US9456916B2 (en) 2013-03-12 2016-10-04 Medibotics Llc Device for selectively reducing absorption of unhealthy food
US9536449B2 (en) 2013-05-23 2017-01-03 Medibotics Llc Smart watch and food utensil for monitoring food consumption
US9254099B2 (en) 2013-05-23 2016-02-09 Medibotics Llc Smart watch and food-imaging member for monitoring food consumption
US9042596B2 (en) 2012-06-14 2015-05-26 Medibotics Llc Willpower watch (TM)—a wearable food consumption monitor
US10314492B2 (en) 2013-05-23 2019-06-11 Medibotics Llc Wearable spectroscopic sensor to measure food consumption based on interaction between light and the human body
US9442100B2 (en) 2013-12-18 2016-09-13 Medibotics Llc Caloric intake measuring system using spectroscopic and 3D imaging analysis
AU2013299859B2 (en) 2012-08-06 2017-06-15 Firmenich Incorporated Sweet flavor modifier
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
US9011365B2 (en) 2013-03-12 2015-04-21 Medibotics Llc Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food
US9067070B2 (en) 2013-03-12 2015-06-30 Medibotics Llc Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
US9529385B2 (en) 2013-05-23 2016-12-27 Medibotics Llc Smart watch and human-to-computer interface for monitoring food consumption
JP6755640B2 (ja) 2014-03-28 2020-09-16 味の素株式会社 甘味受容体キメラタンパク質及びその利用
JP6339432B2 (ja) * 2014-07-16 2018-06-06 オリンパス株式会社 細胞観察情報処理システム、細胞観察情報処理方法、細胞観察情報処理プログラム
CA2963901A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
JP6383704B2 (ja) * 2015-07-02 2018-08-29 日立オートモティブシステムズ株式会社 電池制御装置
WO2017030862A1 (en) * 2015-08-20 2017-02-23 Monell Chemical Senses Center Method of modulating fat taste perception
CN107513505A (zh) * 2017-10-17 2017-12-26 北京理工大学 一种高效检测甜味强度的工程化酵母生物系统及其应用
CN108611324A (zh) * 2018-05-07 2018-10-02 云南中烟工业有限责任公司 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法
WO2020033420A1 (en) 2018-08-07 2020-02-13 Firmenich Incorporated 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof
WO2021150686A1 (en) 2020-01-22 2021-07-29 Firmenich Incorporated High-sensitivity detection of gpcr activity and uses thereof
US20240344126A1 (en) * 2020-10-15 2024-10-17 Phenomune, LLC Compositions, systems, and methods for determination of t2r and/or t1r phenotype in individuals to predict wine tasting preferences, characterization of wine in relation to individual tasting preferences, and selection of wine
US20240410893A1 (en) * 2020-10-15 2024-12-12 Phenomune, LLC Compositions, systems, and methods for determination of t2r and/or t1r phenotype in individuals to predict cannabis tasting preferences, characterization of cannabis in relation to individual tasting preferences, and selection of cannabis
CN119403928A (zh) * 2022-06-16 2025-02-07 花王株式会社 G蛋白偶联受体的解析方法

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US243770A (en) 1881-07-05 Holder for grinding tools
JPS5825980B2 (ja) 1976-02-12 1983-05-31 ヤマサ醤油株式会社 サイクリックヌクレオチドの定量法
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
DE779362T1 (de) 1989-12-22 2001-04-05 Applied Research Systems Ars Holding N.V., Curacao DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen
WO1991012650A1 (fr) 1990-02-09 1991-08-22 Asulab S.A. Micromoteur electrostatique a champ radial realise par microfabrication photolithographique et procede de realisation d'un tel micromoteur
WO1991018005A1 (en) * 1990-05-14 1991-11-28 Duke University Cloned genes encoding the d1 dopamine receptor
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
JPH06509702A (ja) 1991-04-05 1994-11-02 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 匂い物質受容体およびその使用
US6008011A (en) * 1991-10-31 1999-12-28 Whitehead Institute For Biomedical Research TGF-β type II receptor cDNAs
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5968817A (en) * 1993-03-15 1999-10-19 The Scripps Research Institute DNA encoding serotonin receptors
US6664107B1 (en) 1993-05-26 2003-12-16 Ontario Cancer Institute, University Health Network CD45 disrupted nucleic acid
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
FI961251L (fi) * 1993-09-20 1996-03-18 Ciba Geigy Ihmisten metabotrooppiset glutamaattireseptorialatyypit(HMR4, HMR6, HMR7)ja niihin liittyvät DNA-yhdisteet
IL108205A0 (en) 1993-12-28 1994-04-12 Yeda Res & Dev Olfactory genes and receptors
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5716835A (en) * 1994-05-05 1998-02-10 Allergan, Inc. Nucleic acid encoding a novel human EP prostaglandin receptor
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
AU698739B2 (en) 1995-06-06 1998-11-05 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
WO1997000271A1 (en) 1995-06-14 1997-01-03 The Regents Of The University Of California Novel high affinity human antibodies to tumor antigens
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
AU1118197A (en) 1995-11-09 1997-05-29 Johns Hopkins University School Of Medicine, The Novel sperm receptors
US5874243A (en) 1997-03-28 1999-02-23 Smithkline Beecham Corporation OLRCC15 receptor
US5993778A (en) * 1997-05-07 1999-11-30 Firestein; Stuart J. Functional expression of, and assay for, functional cellular receptors in vivo
US20020061522A1 (en) 2000-02-29 2002-05-23 Glucksmann Maria Alexandra 1983, 52881, 2398, 45449, 50289, and 52872 novel G protein-coupled receptors and uses therefor
FR2780405B1 (fr) 1998-06-25 2001-12-28 Centre Nat Rech Scient Nouveaux recepteurs olfactifs et leurs utilisations
US7402400B2 (en) 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
WO2000006593A1 (en) 1998-07-28 2000-02-10 The Regents Of The University Of California Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction
WO2000006592A1 (en) 1998-07-28 2000-02-10 The Regents Of The University Of California Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction
CN1317044A (zh) 1998-07-28 2001-10-10 加利福尼亚大学董事会 编码与感觉转导有关的蛋白质的核酸
DE19839359C2 (de) * 1998-08-28 2000-07-27 Jost Werke Ag Stützvorrichtung
KR100616583B1 (ko) 1998-10-29 2006-08-28 가부시키가이샤 에바라 세이사꾸쇼 Ｐｆｃ계 가스회수방법 및 장치
US6106555A (en) 1998-12-15 2000-08-22 Av Healing Llc Method for tissue fixation
AU2378600A (en) * 1998-12-23 2000-07-31 Mount Sinai School Of Medicine Of The City University Of New York, The Inhibitors of the bitter taste response
WO2000065921A1 (en) * 1999-05-02 2000-11-09 Hitec Co., Ltd. Method and device for manufacturing chain food such as sausage
EP1214343A2 (de) 1999-09-10 2002-06-19 The Regents Of The University Of California T2r geschmacksrezeptorfamilie
US6558910B2 (en) * 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
US20030036089A1 (en) * 1999-12-20 2003-02-20 Applera Corporation Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
TW201006846A (en) * 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
US6608176B2 (en) * 2000-03-31 2003-08-19 University Of Miami Taste receptor for umami (monosodium glutamate) taste
CN100447156C (zh) 2000-04-07 2008-12-31 塞诺米克斯公司 T2r味觉受体及其编码基因
JP2003531614A (ja) * 2000-04-28 2003-10-28 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異
US20040086877A1 (en) 2000-06-16 2004-05-06 Lal Preeti G. Multi-mode directi memory access controller and method
AU2002213409A1 (en) 2000-10-30 2002-05-15 Senomyx, Inc. Galphaqproetin variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US20080244761A1 (en) 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US6955887B2 (en) * 2001-03-30 2005-10-18 Senomyx, Inc. Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7309577B2 (en) 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
EP1412750B1 (de) 2001-06-26 2012-05-23 Senomyx, Inc. Heterooligomere t1r2-t1r3 Süssegeschmacksrezeptoren und diese exprimierende Zellinien sowie Verwendung davon zur Identifizierung von Süssegeschmacksverbindungen
DK2327985T3 (en) * 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
WO2003004992A2 (en) 2001-07-03 2003-01-16 The Regents Of The University Of California Mammalian sweet and amino acid heterodimeric taste receptors
US7022488B2 (en) 2003-02-03 2006-04-04 Senomyx, Inc. Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators
WO2003025137A2 (en) 2001-09-18 2003-03-27 Irm, Llc Sweet taste receptors
US7208290B2 (en) 2001-12-14 2007-04-24 Senomyx, Inc. Methods of co-expressing umami taste receptors and chimeric Gα15 variants
FR2852463B1 (fr) * 2003-03-11 2005-05-06 Convertisseur tension/tension
EP1659881B1 (de) 2003-08-06 2019-04-03 Senomyx Inc. Neue geschmacke, geschmacksmodifikatoren, geschmacksstoffe, geschmacksverstärker, geschmacksstoffe für umami oder süss, und/oder verstärker und ihre verwendung
US7906627B2 (en) 2003-08-06 2011-03-15 Senomyx, Inc. Chimeric human sweet-umami and umami-sweet taste receptors
US20050106571A1 (en) 2003-10-02 2005-05-19 The Regents Of The University Of California Mammalian T1R3 sweet taste receptors
US20060045953A1 (en) 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
US7303866B2 (en) * 2004-10-19 2007-12-04 Thanos D. Halazonetis Methods of identifying an agent that modulates an interaction between 53BP1 and histone H3, and uses thereof
US7435522B2 (en) 2005-03-31 2008-10-14 Xerox Corporation Carrier compositions

Also Published As

Publication number Publication date
US8067539B2 (en) 2011-11-29
US20030054448A1 (en) 2003-03-20
WO2002064631A2 (en) 2002-08-22
CN1525981A (zh) 2004-09-01
NO20033030D0 (no) 2003-07-02
EP1985630B1 (de) 2012-04-18
JP5612276B2 (ja) 2014-10-22
US8436143B2 (en) 2013-05-07
AU2007203177B2 (en) 2009-12-10
EP1985630A2 (de) 2008-10-29
US20070292944A1 (en) 2007-12-20
CA2433514A1 (en) 2002-08-22
EP1430083A2 (de) 2004-06-23
US8138322B2 (en) 2012-03-20
US7786263B2 (en) 2010-08-31
US20120271035A1 (en) 2012-10-25
EP1985630A3 (de) 2009-02-18
US8450457B2 (en) 2013-05-28
US20100075412A1 (en) 2010-03-25
US7588916B2 (en) 2009-09-15
JP2009225805A (ja) 2009-10-08
IL156380A0 (en) 2004-01-04
NO20033030L (no) 2003-08-14
CN1525981B (zh) 2012-07-04
US10597437B2 (en) 2020-03-24
US20090275125A1 (en) 2009-11-05
US20080220451A1 (en) 2008-09-11
US20120164664A1 (en) 2012-06-28
US7655422B2 (en) 2010-02-02
US20130345092A1 (en) 2013-12-26
US20090047736A1 (en) 2009-02-19
US20150322132A1 (en) 2015-11-12
ES2385383T3 (es) 2012-07-24
MXPA03005989A (es) 2004-05-04
US9481722B2 (en) 2016-11-01
US7241880B2 (en) 2007-07-10
US7435552B2 (en) 2008-10-14
JP2005500817A (ja) 2005-01-13
JP5411400B2 (ja) 2014-02-12
US8361729B2 (en) 2013-01-29
DE60228741D1 (de) 2008-10-16
US7534577B2 (en) 2009-05-19
CN102242126A (zh) 2011-11-16
DK1430083T3 (da) 2008-12-15
US7781181B2 (en) 2010-08-24
US20180086815A1 (en) 2018-03-29
CA2433514C (en) 2012-07-17
US20120171674A1 (en) 2012-07-05
US20040209286A1 (en) 2004-10-21
US20080214784A1 (en) 2008-09-04
WO2002064631A3 (en) 2004-04-01
ES2312560T3 (es) 2009-03-01
DK1985630T3 (da) 2012-07-30
US8153774B2 (en) 2012-04-10
US20050032158A1 (en) 2005-02-10
US9790265B2 (en) 2017-10-17
AU2002251734B2 (en) 2007-08-16
TW201022287A (en) 2010-06-16
AU2007203177A1 (en) 2007-07-26
EP1430083B1 (de) 2008-09-03
ATE554100T1 (de) 2012-05-15
US20090098579A1 (en) 2009-04-16

Similar Documents

Publication Publication Date Title
DE60228741D1 (de) T1r-geschmacksrezeptoren und dafür kodierende gene
ATE403669T1 (de) T1r-geschmacksrezeptoren und ihre kodierenden gene
WO2001068805A3 (en) Human olfactory receptors and genes encoding same
IL226717A (en) Isolated nucleic acids encoded by anti-beta human antibodies 7
DE60322426D1 (de)
EP2123675A3 (de) Menschliche EPO nachahmende Hinge-Core-Mimetikörper, Zusammensetzungen, Verfahren und Verwendungen
TW200602491A (en) Human GLP-1 mimetibodies, compositions, methods and uses
YU9404A (sh) Multimerna, usmerena kontrastna sredstva na bazi peptida
ATE429645T1 (de) Verwendung von eph-rezeptor-inhibitoren zur behandlung neurodegenerativer krankheiten
WO2003068944A3 (en) METHODS AND COMPOSITION FOR MODULATING TYPE I MUSCLE FORMATION USING PGC-1α-
ATE527378T1 (de) Antisense-modulation von p38-mitogen-aktivierter proteinkinase-expression
ATE363531T1 (de) Claudin polypeptide
DE60115878D1 (de) Schmerz signalisierende moleküle
ATE387497T1 (de) Samenspezifische 7s-alpha-promoter zur expression von genen in pflanzen
DE60325194D1 (de) Methoden zur verwendung von lamellaren körpern für therapeutische zwecke
WO2004089982A3 (en) April variants and methods thereof
DE60232318D1 (de) Gen-targeting-tiermodell für die wechselwirkung der apolipoprotein e4-domäne und verwendungen davon
WO2005060375A3 (en) Methods of therapy and diagnosis using targeting of cells that express killer cell immunoglobulin-like receptor-like protein
DK1644505T3 (da) Gærmodel for amyloidogen proteintoksicitet
ATE324906T1 (de) Verwendung von chimäres il6-il6r in huntingtonskrankheit
ATE537835T1 (de) Kontinuierliches dosierschema mit abt-751

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1430083

Country of ref document: EP