ATE407677T1 - Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung - Google Patents

Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung

Info

Publication number: ATE407677T1
Authority: AT; Austria
Prior art keywords: propargyl; tumors; 10dam; deazaaminopterin; human
Prior art date: 1996-07-17

Application number

AT97934905T

Other languages

English (en)

Inventor

Francis M Sirotnak

James Piper

Joseph Degraw

William Colwell

Original Assignee

Sloan Kettering Inst Cancer

Stanford Res Inst Int

Southern Res Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-17

Filing date

1997-07-16

Publication date

2008-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21806781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE407677(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-07-16 Application filed by Sloan Kettering Inst Cancer, Stanford Res Inst Int, Southern Res Inst filed Critical Sloan Kettering Inst Cancer

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE407677T1 publication Critical patent/ATE407677T1/de

Links

206010028980 Neoplasm Diseases 0.000 title abstract 4
OGSBUKJUDHAQEA-WMCAAGNKSA-N pralatrexate Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CC(CC#C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OGSBUKJUDHAQEA-WMCAAGNKSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
FSIRXIHZBIXHKT-MHTVFEQDSA-N edatrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CC(CC)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FSIRXIHZBIXHKT-MHTVFEQDSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
206010006187 Breast cancer Diseases 0.000 abstract 1
206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
229950006700 edatrexate Drugs 0.000 abstract 1
201000005202 lung cancer Diseases 0.000 abstract 1
208000020816 lung neoplasm Diseases 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
230000004614 tumor growth Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT97934905T 1996-07-17 1997-07-16 Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung ATE407677T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2190896P	1996-07-17	1996-07-17

Publications (1)

Publication Number	Publication Date
ATE407677T1 true ATE407677T1 (de)	2008-09-15

Family

ID=21806781

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97934905T ATE407677T1 (de)	1996-07-17	1997-07-16	Gereinigte zubereitungen von 10-propargyl-10- deazaaminopterin und verfahren zu ihrer verwendung in der tumorbehandlung

Country Status (10)

Country	Link
US (1)	US6028071A (de)
EP (2)	EP2258702A3 (de)
JP (2)	JP2001505537A (de)
AT (1)	ATE407677T1 (de)
CA (1)	CA2260266C (de)
DE (1)	DE69738981D1 (de)
DK (1)	DK0944389T3 (de)
ES (1)	ES2313737T3 (de)
PT (1)	PT944389E (de)
WO (1)	WO1998002163A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2780808B1 (fr) *	1998-07-03	2001-08-10	Thomson Csf	Dispositif a emission de champ et procedes de fabrication
US20040053836A1 (en) *	2002-04-22	2004-03-18	Philipp Mayer-Kuckuk	Method for modulating the production of a selected protein in vivo
US8263354B2 (en)	2004-05-30	2012-09-11	Sloan-Kettering Institute For Cancer Research	Methods for assessing cancer for increased sensitivity to 10-propargyl-10-deazaaminopterin
US20080188479A1 (en)	2004-05-30	2008-08-07	Sloan-Kettering Institute For Cancer Research	Methods to Treat Cancer with 10-propargyl-10-deazaaminopterin and Methods for Assessing Cancer for Increased Sensitivity to 10-propargyl-10-deazaaminopterin
NZ576849A (en) *	2004-05-30	2011-03-31	Sloan Kettering Inst Cancer	Treatment of T-cell lymphoma using 10-propargyl-10-deazaaminopterin salts
US20100248249A1 (en) *	2007-08-17	2010-09-30	Allos Therapeutics, Inc.	Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels
US9901578B2 (en)	2007-08-17	2018-02-27	Allos Therapeutics, Inc.	Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
AU2010345065B2 (en)	2010-02-02	2014-06-05	Allos Therapeutics, Inc.	Optically pure diastereomers of 10-propargyl-10-deazaaminopterin and methods of using same
BR112012030764A2 (pt) *	2010-06-02	2015-09-29	Allos Therapeutics Inc	métodos para tratamento de distúrbios metotrexato-resistentes com 10-propargil-10-deazaanibopterin
WO2012061469A2 (en)	2010-11-02	2012-05-10	Sicor Inc.	Crystalline forms of pralatrexate
EP2794610B1 (de)	2011-12-21	2016-03-09	Plus Chemicals SA	Verfahren und zwischenprodukte zur herstellung von pralatrexat
WO2013164856A1 (en) *	2012-05-04	2013-11-07	Avra Laboratories Private Limited	A process for preparing intermediates of 10-propargyl-10-deazaaminopterin (pralatrexate) synthesis and the intermediates thereof
WO2013177713A1 (en) *	2012-05-31	2013-12-05	Alphora Research Inc.	Process for preparation of an antifolate agent
US9440979B2 (en)	2012-07-23	2016-09-13	Fresenius Kabi Oncology Limited	Process for the preparation of pralatrexate
WO2014020553A1 (en)	2012-08-03	2014-02-06	Fresenius Kabi Oncology Ltd.	Salts of pralatrexate
WO2014068599A2 (en) *	2012-11-02	2014-05-08	Hetero Research Foundation	Process for pralatrexate
WO2014187274A1 (zh) *	2013-05-24	2014-11-27	苏州明锐医药科技有限公司	普拉曲沙及其中间体的制备方法
CN103588775B (zh) *	2013-11-12	2016-08-17	连云港恒运医药科技有限公司	普拉曲沙降解杂质及其制备方法
JP2018517788A (ja)	2015-06-16	2018-07-05	スペクトラム・ファーマシューティカルズ，インコーポレイテッド	リンパ腫を治療するためにベリノスタットおよびプララトレキサートを使用する組合せ療法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4393064A (en) *	1976-03-05	1983-07-12	Sri International	Process and composition for treatment of leukemia and process for preparing the same
US5354751A (en) *	1992-03-03	1994-10-11	Sri International	Heteroaroyl 10-deazaamino-pterine compounds and use for rheumatoid arthritis

1997
- 1997-07-16 DE DE69738981T patent/DE69738981D1/de not_active Expired - Lifetime
- 1997-07-16 ES ES97934905T patent/ES2313737T3/es not_active Expired - Lifetime
- 1997-07-16 EP EP10179892A patent/EP2258702A3/de not_active Withdrawn
- 1997-07-16 DK DK97934905T patent/DK0944389T3/da active
- 1997-07-16 WO PCT/US1997/011982 patent/WO1998002163A1/en not_active Ceased
- 1997-07-16 CA CA2260266A patent/CA2260266C/en not_active Expired - Lifetime
- 1997-07-16 EP EP97934905A patent/EP0944389B1/de not_active Expired - Lifetime
- 1997-07-16 JP JP50613398A patent/JP2001505537A/ja not_active Withdrawn
- 1997-07-16 US US09/214,984 patent/US6028071A/en not_active Expired - Lifetime
- 1997-07-16 PT PT97934905T patent/PT944389E/pt unknown
- 1997-07-16 AT AT97934905T patent/ATE407677T1/de active
2008
- 2008-11-19 JP JP2008295509A patent/JP5271677B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP2258702A3 (de)	2011-11-30
JP5271677B2 (ja)	2013-08-21
WO1998002163A1 (en)	1998-01-22
ES2313737T3 (es)	2009-03-01
JP2009091361A (ja)	2009-04-30
CA2260266C (en)	2011-01-18
JP2001505537A (ja)	2001-04-24
DE69738981D1 (de)	2008-10-23
EP0944389A1 (de)	1999-09-29
PT944389E (pt)	2008-12-03
EP0944389B1 (de)	2008-09-10
DK0944389T3 (da)	2008-11-17
CA2260266A1 (en)	1998-01-22
US6028071A (en)	2000-02-22
EP2258702A2 (de)	2010-12-08
EP0944389A4 (de)	2001-04-04

Legal Events

Date

Code

Title

Description

2009-04-15

UEP

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