ATE408006T1 - Udp-galaktose: beta-i(n)-acetyl-glukosamin beta1, 3 galaktosyltransferasen, beta3gal-t5 - Google Patents
Udp-galaktose: beta-i(n)-acetyl-glukosamin beta1, 3 galaktosyltransferasen, beta3gal-t5Info
- Publication number
- ATE408006T1 ATE408006T1 AT99958927T AT99958927T ATE408006T1 AT E408006 T1 ATE408006 T1 AT E408006T1 AT 99958927 T AT99958927 T AT 99958927T AT 99958927 T AT99958927 T AT 99958927T AT E408006 T1 ATE408006 T1 AT E408006T1
- Authority
- AT
- Austria
- Prior art keywords
- beta3gal
- dna
- beta1
- beta
- disclosed
- Prior art date
Links
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 title abstract 2
- 102000030902 Galactosyltransferase Human genes 0.000 title 1
- 108060003306 Galactosyltransferase Proteins 0.000 title 1
- HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 title 1
- 229950006780 n-acetylglucosamine Drugs 0.000 title 1
- 102100023993 Beta-1,3-galactosyltransferase 5 Human genes 0.000 abstract 9
- 108020004414 DNA Proteins 0.000 abstract 5
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000002068 Glycopeptides Human genes 0.000 abstract 2
- 108010015899 Glycopeptides Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108700024394 Exon Proteins 0.000 abstract 1
- 102100021700 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Human genes 0.000 abstract 1
- 101000896564 Homo sapiens Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Proteins 0.000 abstract 1
- OVRNDRQMDRJTHS-JAJWTYFOSA-N N-acetyl-beta-D-galactosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-JAJWTYFOSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
- HSCJRCZFDFQWRP-LNYDKVEPSA-N UDP-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)OC1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-LNYDKVEPSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801483 | 1998-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE408006T1 true ATE408006T1 (de) | 2008-09-15 |
Family
ID=8105318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99958927T ATE408006T1 (de) | 1998-11-13 | 1999-11-11 | Udp-galaktose: beta-i(n)-acetyl-glukosamin beta1, 3 galaktosyltransferasen, beta3gal-t5 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7476527B2 (de) |
| EP (1) | EP1129179B1 (de) |
| JP (1) | JP2002530071A (de) |
| AT (1) | ATE408006T1 (de) |
| AU (1) | AU772112B2 (de) |
| CA (1) | CA2350079A1 (de) |
| DE (1) | DE69939549D1 (de) |
| MX (1) | MXPA01004779A (de) |
| WO (1) | WO2000029558A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000245464A (ja) | 1999-02-25 | 2000-09-12 | Kyowa Hakko Kogyo Co Ltd | 新規ポリペプチド |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP2975135A1 (de) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glykopegylierter Faktor IX |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP2049144B8 (de) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen |
| EP2054521A4 (de) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Verfahren zur reinigung von polypeptid-konjugate |
| HRP20130382T1 (hr) | 2007-04-03 | 2013-05-31 | Biogenerix Ag | Postupci lijeäśenja pomoä†u glikopegiliranog g-csf |
| CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
| PL2257311T3 (pl) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
| AU2016209056B2 (en) * | 2015-01-24 | 2021-01-28 | Academia Sinica | Cancer markers and methods of use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059520A (en) | 1986-08-27 | 1991-10-22 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibody panel for blood group a antigen |
| US4942224A (en) | 1987-01-12 | 1990-07-17 | The Biomembrane Institute | A-associated H-antigens, monoclonal antibodies specific thereto and methods for employing the same in blood typing |
| US4857639A (en) | 1987-01-12 | 1989-08-15 | The Biomembrane Institute | A-associated H-antigens, monoclonal antibodies specific thereto and methods for employing the same in blood typing |
| US5229289A (en) | 1988-03-11 | 1993-07-20 | The Biomembrane Institute | Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human and with synthetic carbohydrate-carrier conjugates |
| US5660834A (en) | 1988-03-11 | 1997-08-26 | The Biomembrane Institute | Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates |
| US5418129A (en) | 1989-01-30 | 1995-05-23 | The Biomembrane Institute | Blood treatment method |
| US5240833A (en) | 1989-01-30 | 1993-08-31 | The Biomembrane Institute | Method for the production of monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides |
| EP0395217A3 (de) | 1989-04-28 | 1991-01-23 | The Biomembrane Institute | Bio-organische Synthese von dimerem LeX (difucosyl y2; III3FucV3FucnLc6Cer) und Analogen hiervon |
| US5068191A (en) | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| DE69025629T2 (de) | 1990-01-26 | 1996-07-04 | Bay Dev Corp Sa | Arzneimittel und verfahren zur behandlung von erworbenem immundefizienzsyndrom (aids) und aids-verwandtem komplex unter verwendung von karbohydratspezifischen antikörpern |
| JP3170369B2 (ja) | 1992-12-16 | 2001-05-28 | 協和醗酵工業株式会社 | β１，３−ガラクトシルトランスフェラーゼ |
| US5871990A (en) | 1996-05-15 | 1999-02-16 | Clausen; Henrik | UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase, gAlnAc-T3 |
| US5955282A (en) * | 1998-04-03 | 1999-09-21 | Incyte Pharmaceuticals, Inc. | Human galactosyltransferases |
| US6800468B1 (en) * | 1998-11-13 | 2004-10-05 | Henrik Clausen | UDP-galactose: β-N-acetyl-glucosamine β1,3galactosyltransferases, β3Gal-T5 |
| JP2000245464A (ja) * | 1999-02-25 | 2000-09-12 | Kyowa Hakko Kogyo Co Ltd | 新規ポリペプチド |
-
1999
- 1999-11-11 WO PCT/US1999/026807 patent/WO2000029558A1/en not_active Ceased
- 1999-11-11 MX MXPA01004779A patent/MXPA01004779A/es not_active IP Right Cessation
- 1999-11-11 AT AT99958927T patent/ATE408006T1/de not_active IP Right Cessation
- 1999-11-11 DE DE69939549T patent/DE69939549D1/de not_active Expired - Fee Related
- 1999-11-11 CA CA002350079A patent/CA2350079A1/en not_active Abandoned
- 1999-11-11 AU AU16197/00A patent/AU772112B2/en not_active Ceased
- 1999-11-11 EP EP99958927A patent/EP1129179B1/de not_active Expired - Lifetime
- 1999-11-11 JP JP2000582542A patent/JP2002530071A/ja active Pending
-
2005
- 2005-12-16 US US11/305,413 patent/US7476527B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7476527B2 (en) | 2009-01-13 |
| EP1129179B1 (de) | 2008-09-10 |
| WO2000029558A1 (en) | 2000-05-25 |
| EP1129179A1 (de) | 2001-09-05 |
| EP1129179A4 (de) | 2003-07-09 |
| AU772112B2 (en) | 2004-04-08 |
| CA2350079A1 (en) | 2000-05-25 |
| MXPA01004779A (es) | 2002-09-18 |
| AU1619700A (en) | 2000-06-05 |
| DE69939549D1 (de) | 2008-10-23 |
| JP2002530071A (ja) | 2002-09-17 |
| US20060099699A1 (en) | 2006-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |