ATE408006T1 - Udp-galaktose: beta-i(n)-acetyl-glukosamin beta1, 3 galaktosyltransferasen, beta3gal-t5 - Google Patents
Udp-galaktose: beta-i(n)-acetyl-glukosamin beta1, 3 galaktosyltransferasen, beta3gal-t5Info
- Publication number
- ATE408006T1 ATE408006T1 AT99958927T AT99958927T ATE408006T1 AT E408006 T1 ATE408006 T1 AT E408006T1 AT 99958927 T AT99958927 T AT 99958927T AT 99958927 T AT99958927 T AT 99958927T AT E408006 T1 ATE408006 T1 AT E408006T1
- Authority
- AT
- Austria
- Prior art keywords
- beta3gal
- dna
- beta1
- beta
- disclosed
- Prior art date
Links
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 title abstract 2
- 102000030902 Galactosyltransferase Human genes 0.000 title 1
- 108060003306 Galactosyltransferase Proteins 0.000 title 1
- HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 title 1
- 229950006780 n-acetylglucosamine Drugs 0.000 title 1
- 102100023993 Beta-1,3-galactosyltransferase 5 Human genes 0.000 abstract 9
- 108020004414 DNA Proteins 0.000 abstract 5
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000002068 Glycopeptides Human genes 0.000 abstract 2
- 108010015899 Glycopeptides Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108700024394 Exon Proteins 0.000 abstract 1
- 102100021700 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Human genes 0.000 abstract 1
- 101000896564 Homo sapiens Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Proteins 0.000 abstract 1
- OVRNDRQMDRJTHS-JAJWTYFOSA-N N-acetyl-beta-D-galactosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-JAJWTYFOSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
- HSCJRCZFDFQWRP-LNYDKVEPSA-N UDP-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)OC1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-LNYDKVEPSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801483 | 1998-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE408006T1 true ATE408006T1 (de) | 2008-09-15 |
Family
ID=8105318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99958927T ATE408006T1 (de) | 1998-11-13 | 1999-11-11 | Udp-galaktose: beta-i(n)-acetyl-glukosamin beta1, 3 galaktosyltransferasen, beta3gal-t5 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7476527B2 (de) |
| EP (1) | EP1129179B1 (de) |
| JP (1) | JP2002530071A (de) |
| AT (1) | ATE408006T1 (de) |
| AU (1) | AU772112B2 (de) |
| CA (1) | CA2350079A1 (de) |
| DE (1) | DE69939549D1 (de) |
| MX (1) | MXPA01004779A (de) |
| WO (1) | WO2000029558A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000245464A (ja) * | 1999-02-25 | 2000-09-12 | Kyowa Hakko Kogyo Co Ltd | 新規ポリペプチド |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| EP1814573B1 (de) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf) |
| CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
| US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US20080255026A1 (en) | 2005-05-25 | 2008-10-16 | Glycopegylated Factor 1X | Glycopegylated Factor Ix |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| CN101516388B (zh) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| EP2144923B1 (de) | 2007-04-03 | 2013-02-13 | BioGeneriX AG | Behandlungsverfahren mit glycopegyliertem g-csf |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| US20130189239A1 (en) | 2008-02-27 | 2013-07-25 | Novo Nordisk A/S | Conjugated Factor VIII Molecules |
| TWI710571B (zh) * | 2015-01-24 | 2020-11-21 | 中央研究院 | 腫瘤標記及其使用方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059520A (en) | 1986-08-27 | 1991-10-22 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibody panel for blood group a antigen |
| US4942224A (en) | 1987-01-12 | 1990-07-17 | The Biomembrane Institute | A-associated H-antigens, monoclonal antibodies specific thereto and methods for employing the same in blood typing |
| US4857639A (en) | 1987-01-12 | 1989-08-15 | The Biomembrane Institute | A-associated H-antigens, monoclonal antibodies specific thereto and methods for employing the same in blood typing |
| US5229289A (en) | 1988-03-11 | 1993-07-20 | The Biomembrane Institute | Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human and with synthetic carbohydrate-carrier conjugates |
| US5660834A (en) | 1988-03-11 | 1997-08-26 | The Biomembrane Institute | Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates |
| US5418129A (en) | 1989-01-30 | 1995-05-23 | The Biomembrane Institute | Blood treatment method |
| US5240833A (en) | 1989-01-30 | 1993-08-31 | The Biomembrane Institute | Method for the production of monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides |
| EP0395217A3 (de) | 1989-04-28 | 1991-01-23 | The Biomembrane Institute | Bio-organische Synthese von dimerem LeX (difucosyl y2; III3FucV3FucnLc6Cer) und Analogen hiervon |
| US5068191A (en) | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| JPH05506565A (ja) | 1990-01-26 | 1993-09-30 | ベイ・デベロップメント・コーポレイション・エスエー | 抗炭水化物抗体および炭水化物抗原を使用する後天性免疫不全症候群（ａｉｄｓ）およびａｉｄｓ関連症候群（ａｒｃ）の処置のための薬剤および方法 |
| JP3170369B2 (ja) | 1992-12-16 | 2001-05-28 | 協和醗酵工業株式会社 | β１，３−ガラクトシルトランスフェラーゼ |
| US5871990A (en) | 1996-05-15 | 1999-02-16 | Clausen; Henrik | UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase, gAlnAc-T3 |
| US5955282A (en) * | 1998-04-03 | 1999-09-21 | Incyte Pharmaceuticals, Inc. | Human galactosyltransferases |
| US6800468B1 (en) * | 1998-11-13 | 2004-10-05 | Henrik Clausen | UDP-galactose: β-N-acetyl-glucosamine β1,3galactosyltransferases, β3Gal-T5 |
| JP2000245464A (ja) * | 1999-02-25 | 2000-09-12 | Kyowa Hakko Kogyo Co Ltd | 新規ポリペプチド |
-
1999
- 1999-11-11 DE DE69939549T patent/DE69939549D1/de not_active Expired - Fee Related
- 1999-11-11 MX MXPA01004779A patent/MXPA01004779A/es not_active IP Right Cessation
- 1999-11-11 EP EP99958927A patent/EP1129179B1/de not_active Expired - Lifetime
- 1999-11-11 CA CA002350079A patent/CA2350079A1/en not_active Abandoned
- 1999-11-11 AU AU16197/00A patent/AU772112B2/en not_active Ceased
- 1999-11-11 JP JP2000582542A patent/JP2002530071A/ja active Pending
- 1999-11-11 WO PCT/US1999/026807 patent/WO2000029558A1/en not_active Ceased
- 1999-11-11 AT AT99958927T patent/ATE408006T1/de not_active IP Right Cessation
-
2005
- 2005-12-16 US US11/305,413 patent/US7476527B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU1619700A (en) | 2000-06-05 |
| DE69939549D1 (de) | 2008-10-23 |
| EP1129179A4 (de) | 2003-07-09 |
| AU772112B2 (en) | 2004-04-08 |
| US20060099699A1 (en) | 2006-05-11 |
| MXPA01004779A (es) | 2002-09-18 |
| EP1129179B1 (de) | 2008-09-10 |
| CA2350079A1 (en) | 2000-05-25 |
| US7476527B2 (en) | 2009-01-13 |
| WO2000029558A1 (en) | 2000-05-25 |
| EP1129179A1 (de) | 2001-09-05 |
| JP2002530071A (ja) | 2002-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |