ATE408141T1 - Gen-detektionschip, sensor und nachweisverfahren - Google Patents

Gen-detektionschip, sensor und nachweisverfahren

Info

Publication number
ATE408141T1
ATE408141T1 AT00969958T AT00969958T ATE408141T1 AT E408141 T1 ATE408141 T1 AT E408141T1 AT 00969958 T AT00969958 T AT 00969958T AT 00969958 T AT00969958 T AT 00969958T AT E408141 T1 ATE408141 T1 AT E408141T1
Authority
AT
Austria
Prior art keywords
pin electrodes
sensor
gene
detection
recess
Prior art date
Application number
AT00969958T
Other languages
English (en)
Inventor
Shigeori Takenaka
Kazuhiko Uchida
Takatoshi Miyahara
Original Assignee
Shigeori Takenaka
Kazuhiko Uchida
Toppan Printing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shigeori Takenaka, Kazuhiko Uchida, Toppan Printing Co Ltd filed Critical Shigeori Takenaka
Application granted granted Critical
Publication of ATE408141T1 publication Critical patent/ATE408141T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
AT00969958T 1999-10-20 2000-10-20 Gen-detektionschip, sensor und nachweisverfahren ATE408141T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29891799 1999-10-20

Publications (1)

Publication Number Publication Date
ATE408141T1 true ATE408141T1 (de) 2008-09-15

Family

ID=17865860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00969958T ATE408141T1 (de) 1999-10-20 2000-10-20 Gen-detektionschip, sensor und nachweisverfahren

Country Status (8)

Country Link
US (1) US6916614B1 (de)
EP (1) EP1146331B1 (de)
KR (1) KR20010099859A (de)
CN (1) CN1223851C (de)
AT (1) ATE408141T1 (de)
AU (1) AU7952700A (de)
DE (1) DE60040205D1 (de)
WO (1) WO2001029550A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2002066969A1 (ja) * 2001-02-19 2004-06-24 協和メデックス株式会社 荷電成分検出装置及びその使用方法並びに検出パネル
JP2002372533A (ja) * 2001-06-13 2002-12-26 Kiwamu Akagi 血液の検査方法、検査用チップ、並びに検査装置
DE10208794A1 (de) * 2002-02-28 2003-09-04 Degussa Bioactives Gmbh Verfahren zum Sortieren einsträngiger Nucleinsäuren
US7491492B2 (en) * 2002-07-30 2009-02-17 Toppan Printing Co., Ltd. Method of detecting nucleotide mutations
US7097751B2 (en) 2002-08-23 2006-08-29 Kabushiki Kaisha Toshiba Base sequence detecting electrode, base sequence detecting device and base sequence detecting method
AU2003260662A1 (en) * 2002-12-11 2004-07-14 Centre National De La Recherche Scientifique Method for electronically detecting at least one specific interaction between probe molecules and target biomolecules
JP4380631B2 (ja) * 2003-05-19 2009-12-09 東レ株式会社 選択結合性物質固定化担体
JP4285119B2 (ja) * 2003-07-07 2009-06-24 ソニー株式会社 生化学反応装置、生化学反応用基板、ハイブリダイゼーション用基板の製造方法及びハイブリダイゼーション方法
JP4466074B2 (ja) * 2003-12-26 2010-05-26 株式会社日立製作所 微細金属構造体とその製造方法、並びに微細金型とデバイス
KR101050468B1 (ko) * 2004-02-14 2011-07-19 삼성에스디아이 주식회사 바이오 칩 및 이를 이용한 바이오 분자 검출 시스템
JP4872244B2 (ja) * 2005-06-03 2012-02-08 横河電機株式会社 化学反応用カートリッジ
JP4353958B2 (ja) * 2005-09-15 2009-10-28 株式会社日立製作所 Ｄｎａ計測装置、及びｄｎａ計測方法
EP2137523A1 (de) 2007-04-04 2009-12-30 Network Biosystems, Inc. Kunststoff-mikrofluid-trenn- und -nachweisplattformen
US7871571B2 (en) * 2007-10-25 2011-01-18 Parker John A Biomolecule analyzing system
JP2010011791A (ja) * 2008-07-03 2010-01-21 Toshiba Corp 複数核酸の検出方法
GB0822733D0 (en) * 2008-12-12 2009-01-21 Univ Warwick Nanotube electrochemistry
WO2010147654A2 (en) 2009-06-15 2010-12-23 Netbio Inc. Improved methods for forensic dna quantitation
JP2011232328A (ja) * 2010-04-09 2011-11-17 Hitachi Ltd 生体物質検出アレイ、計測装置および計測方法
CN103917661A (zh) 2011-05-12 2014-07-09 网络百奥有限公司 用于快速多重扩增str基因座的方法和组合物
CN104049011B (zh) * 2014-06-30 2016-10-12 安徽师范大学 一种电化学生物传感器，其制备方法，用途以及检测血小板源生长因子的方法
CN106153940A (zh) * 2014-10-17 2016-11-23 广州瑞博奥生物科技有限公司 一种用于检测血管生成因子的抗体芯片试剂盒
CN106153939A (zh) * 2014-10-17 2016-11-23 广州瑞博奥生物科技有限公司 一种用于检测凋亡因子的抗体芯片试剂盒
US10488365B2 (en) * 2015-06-17 2019-11-26 Qualcomm Incorporated Current sensors using bipolar transistors
CA3021580A1 (en) 2015-06-25 2016-12-29 Barry L. Merriman Biomolecular sensors and methods
CN105296351A (zh) * 2015-12-02 2016-02-03 北京大学 用于聚合酶链式反应的芯片、实时检测装置和系统
CN113985017A (zh) 2016-01-14 2022-01-28 罗斯韦尔生物技术股份有限公司 分子传感器及相关方法
EP3408219B1 (de) 2016-01-28 2022-08-17 Roswell Biotechnologies, Inc Massiv parallele dna-sequenzierungsvorrichtung
JP7280590B2 (ja) 2016-01-28 2023-05-24 ロズウェル バイオテクノロジーズ，インコーポレイテッド 大スケールの分子電子工学センサアレイを使用する被分析物を測定するための方法および装置
KR20240170584A (ko) 2016-02-09 2024-12-03 로스웰 엠이 아이엔씨. 전자 비표지 dna 및 게놈 시퀀싱
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
US9829456B1 (en) * 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
KR102622275B1 (ko) 2017-01-10 2024-01-05 로스웰 바이오테크놀로지스 인코포레이티드 Dna 데이터 저장을 위한 방법들 및 시스템들
CA3052140A1 (en) 2017-01-19 2018-07-26 Roswell Biotechnologies, Inc. Solid state sequencing devices comprising two dimensional layer materials
EP3615685B1 (de) 2017-04-25 2025-02-19 Roswell Biotechnologies, Inc Enzymatische schaltungen für molekulare sensoren
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
EP4023764A3 (de) 2017-05-09 2022-09-21 Roswell Biotechnologies, Inc. Bindungssondenschaltungen für molekulare sensoren
TWI745392B (zh) * 2017-06-29 2021-11-11 瑞禾生物科技股份有限公司 生物感測元件及其製造方法以及生物分子檢測方法
CN111373049A (zh) 2017-08-30 2020-07-03 罗斯威尔生命技术公司 用于dna数据存储的进行性酶分子电子传感器
CN111373051A (zh) 2017-10-10 2020-07-03 罗斯威尔生命技术公司 用于无扩增dna数据存储的方法、装置和系统
CN113994013A (zh) 2019-04-12 2022-01-28 罗斯威尔生命技术公司 用于分子电子学传感器的多环芳族桥
CN110227565B (zh) * 2019-06-25 2021-03-19 京东方科技集团股份有限公司 微流控器件及制作方法、生物分子数量检测方法及系统
US12146852B2 (en) 2019-09-06 2024-11-19 Roswell Biotechnologies, Inc. Methods of fabricating nanoscale structures usable in molecular sensors and other devices
KR102800575B1 (ko) * 2020-01-07 2025-04-28 엘지전자 주식회사 전기장 인가용 커버 및 이를 포함하는 전기장 인가 장치

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56152958A (en) 1980-04-30 1981-11-26 Mitsubishi Electric Corp Electroless gold plating solution
US4343684A (en) 1980-12-19 1982-08-10 Stanley Lechtzin Method of electroforming and product
US4840893A (en) 1983-12-16 1989-06-20 Medisense, Inc. Electrochemical assay for nucleic acids and nucleic acid probes
US4857831A (en) 1986-12-29 1989-08-15 Schlumberger Technology Corporation Borehole casing diagnostic apparatus and method
US5108576A (en) 1988-06-13 1992-04-28 Ohmicron Corporation Pyroelectric thermometric device
US5776672A (en) * 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
GB9201481D0 (en) 1992-01-23 1992-03-11 Scient Generics Ltd Treatment of nucleic acid material
US6071394A (en) 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
JP3331261B2 (ja) 1994-08-19 2002-10-07 日本エレクトロプレイテイング・エンジニヤース株式会社 無電解金めっき液
EP0821745A1 (de) 1995-04-17 1998-02-04 The Board Of Trustees Of The University Of Arkansas Verfahren zum elektrobeschichten von substraten und so hergestellte produkte
JP3671100B2 (ja) 1996-02-23 2005-07-13 日本碍子株式会社 酸化物センサ
JP3764779B2 (ja) 1996-03-30 2006-04-12 株式会社東北テクノアーチ 凸状領域を用いた分析方法
JP3233851B2 (ja) 1996-04-24 2001-12-04 繁織 竹中 遺伝子の電気化学的検出法およびその装置
ZA975891B (en) * 1996-07-05 1998-07-23 Combimatrix Corp Electrochemical solid phase synthesis of polymers
EE9900357A (et) 1997-02-21 2000-02-15 Burstein Laboratories, Inc. Geenisekvenaator ja meetodid
FR2764385B1 (fr) 1997-06-06 1999-07-16 Commissariat Energie Atomique Microsysteme d'analyse de liquides a cuvette integree
US6048692A (en) * 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
US6287776B1 (en) * 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
DE19841337C1 (de) * 1998-05-27 1999-09-23 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle
US6093370A (en) 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
JP3888807B2 (ja) * 1999-08-06 2007-03-07 凸版印刷株式会社 遺伝子を検出する方法、並びに検出装置及び検出用チップ
US6749731B2 (en) 2001-01-31 2004-06-15 Kyocera Corporation Gene detection chip and detection device

Also Published As

Publication number Publication date
EP1146331A1 (de) 2001-10-17
KR20010099859A (ko) 2001-11-09
EP1146331A4 (de) 2006-08-30
CN1341211A (zh) 2002-03-20
US6916614B1 (en) 2005-07-12
EP1146331B1 (de) 2008-09-10
CN1223851C (zh) 2005-10-19
DE60040205D1 (de) 2008-10-23
WO2001029550A1 (fr) 2001-04-26
AU7952700A (en) 2001-04-30

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