ATE410225T1 - Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze - Google Patents
Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salzeInfo
- Publication number
- ATE410225T1 ATE410225T1 AT02755123T AT02755123T ATE410225T1 AT E410225 T1 ATE410225 T1 AT E410225T1 AT 02755123 T AT02755123 T AT 02755123T AT 02755123 T AT02755123 T AT 02755123T AT E410225 T1 ATE410225 T1 AT E410225T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- sub
- formula
- production
- provides
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- ZRCVYEYHRGVLOC-HYARGMPZSA-N gemifloxacin Chemical compound C1C(CN)C(=N/OC)/CN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1CC1 ZRCVYEYHRGVLOC-HYARGMPZSA-N 0.000 title abstract 2
- 229960003170 gemifloxacin Drugs 0.000 title abstract 2
- -1 AMINO-PROTECTED 4-AMINOMETHYLENE-PYRROLIDINE-3-ONE Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003068 static effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
- B01F25/4314—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles
- B01F25/43141—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor with helical baffles composed of consecutive sections of helical formed elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/242—Tubular reactors in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/32—Packing elements in the form of grids or built-up elements for forming a unit or module inside the apparatus for mass or heat transfer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00164—Controlling or regulating processes controlling the flow
- B01J2219/00166—Controlling or regulating processes controlling the flow controlling the residence time inside the reactor vessel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/32—Details relating to packing elements in the form of grids or built-up elements for forming a unit of module inside the apparatus for mass or heat transfer
- B01J2219/322—Basic shape of the elements
- B01J2219/32203—Sheets
- B01J2219/3221—Corrugated sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/32—Details relating to packing elements in the form of grids or built-up elements for forming a unit of module inside the apparatus for mass or heat transfer
- B01J2219/322—Basic shape of the elements
- B01J2219/32203—Sheets
- B01J2219/32213—Plurality of essentially parallel sheets
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0118938A GB0118938D0 (en) | 2001-08-02 | 2001-08-02 | Novel process |
| GB0217637A GB0217637D0 (en) | 2002-07-30 | 2002-07-30 | Novel processes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE410225T1 true ATE410225T1 (de) | 2008-10-15 |
Family
ID=26246399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02755123T ATE410225T1 (de) | 2001-08-02 | 2002-08-02 | Verfahren zur herstellung von amino-geschützten 4-aminomethylene-pyrrolidin-3-on-derivaten, gemifloxacin und deren salze |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7199242B2 (de) |
| EP (1) | EP1412078B1 (de) |
| JP (1) | JP2005500350A (de) |
| KR (1) | KR100892864B1 (de) |
| AT (1) | ATE410225T1 (de) |
| CY (1) | CY1108812T1 (de) |
| DE (1) | DE60229255D1 (de) |
| DK (1) | DK1412078T3 (de) |
| ES (1) | ES2314082T3 (de) |
| PT (1) | PT1412078E (de) |
| SI (1) | SI1412078T1 (de) |
| WO (1) | WO2003011450A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100653334B1 (ko) * | 2003-03-07 | 2006-12-04 | 주식회사 엘지생명과학 | 4-아미노메틸-3-알콕시이미노피롤리딘 메탄설폰산염의 신규한 제조 방법 |
| JPWO2006030952A1 (ja) * | 2004-09-17 | 2008-05-15 | 株式会社荏原製作所 | 流体混合器 |
| US7834027B2 (en) * | 2005-06-15 | 2010-11-16 | Hetero Drugs Limited | Gemifloxacin process and polymorphs |
| US7902227B2 (en) | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
| KR100894889B1 (ko) * | 2007-12-17 | 2009-04-30 | 삼성전기주식회사 | 교반 기능을 갖는 토출 장치 |
| JP5604038B2 (ja) | 2008-08-25 | 2014-10-08 | 株式会社日立製作所 | 反応装置及び反応プラント |
| CN104693088B (zh) * | 2013-12-06 | 2018-01-05 | 常州市勇毅生物药业有限公司 | 一种吉米沙星侧链的制备方法 |
| US10159953B2 (en) | 2015-11-12 | 2018-12-25 | Uop Llc | Reactor for use with an ionic liquid catalyst |
| CN112584920B (zh) * | 2019-04-25 | 2023-11-21 | 日挥株式会社 | 流体混合单元及流体混合方法 |
| WO2021119717A1 (en) * | 2019-12-19 | 2021-06-24 | Commonwealth Scientific And Industrial Research Organisation | Preparation of halogenated alkoxyethane |
| CN113773240B (zh) * | 2021-10-12 | 2022-05-31 | 北京阳光诺和药物研究股份有限公司 | 吉米沙星侧链化合物的制备方法 |
| CN114349676B (zh) * | 2022-03-21 | 2022-09-02 | 凯莱英生命科学技术(天津)有限公司 | N-Boc-2,5-二氢吡咯连续合成的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59104667D1 (de) | 1990-08-23 | 1995-03-30 | Sulzer Chemtech Ag | Statische Laminar-Mischeinrichtung, Zumischvorrichtung, sowie Verwendung von Mischeinrichtung und Zumischvorrichtung. |
| EP0478497B1 (de) | 1990-09-19 | 1994-03-30 | Sulzer Chemtech AG | Statischer Mischer mit rohrartigem Gehäuse |
| JP2851454B2 (ja) | 1991-06-18 | 1999-01-27 | 三井化学株式会社 | フェノキシアミン類の製造方法 |
| DE59204349D1 (de) | 1991-12-10 | 1995-12-21 | Sulzer Chemtech Ag | Statisches Mischelement mit Leitflächen. |
| GB9320455D0 (en) | 1993-10-05 | 1993-11-24 | Atomic Energy Authority Uk | Vortex mixer |
| EP0655275B1 (de) | 1993-11-26 | 1999-10-06 | Sulzer Chemtech AG | Statische Mischvorrichtung |
| GB9401969D0 (en) | 1994-02-02 | 1994-03-30 | Smithkline Beecham Plc | Process |
| EP0678504B1 (de) | 1994-04-22 | 2000-06-21 | Mitsui Chemicals, Inc. | Verfahren zur Herstellung von substituierten Aminen und Verfahren zur Reinigung von ihren Zwischenprodukten |
| DE69509442T2 (de) * | 1994-06-16 | 1999-09-02 | Lg Chemical Ltd. | Chinolincarbonsäurederivate mit 7-(4-Amino-methyl-3-oxim)-pyrrolidin-Substituenten und Verfahren zu ihrer Herstellung |
| US5776944A (en) * | 1994-06-16 | 1998-07-07 | Lg Chemical Ltd. | 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof |
| IT234996Y1 (it) * | 1994-06-22 | 2000-03-31 | Bocchiotti Soc Ind Elettrotec | Imballaggio per profilati metallici. |
| EP0727249B1 (de) | 1995-02-02 | 1999-05-06 | Sulzer Chemtech AG | Statische Mischvorrichtung für hochviskose Medien |
| EP0749776B1 (de) | 1995-06-21 | 2001-01-24 | Sulzer Chemtech AG | In einem Rohr angeordneter Mischer |
| DE59505850D1 (de) | 1995-08-30 | 1999-06-10 | Sulzer Chemtech Ag | Statischer Mischer für zähe Fluide |
| ATE246036T1 (de) | 1996-04-12 | 2003-08-15 | Sulzer Chemtech Ag | Mischrohr für niedrigviskose fluide |
| ES2151650T3 (es) | 1996-07-05 | 2001-01-01 | Sulzer Chemtech Ag | Mezclador estatico. |
| MA24500A1 (fr) | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
| KR100286874B1 (ko) * | 1998-03-04 | 2001-04-16 | 성재갑 | 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법 |
| GB9820405D0 (en) | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
| GB9905512D0 (en) | 1999-03-10 | 1999-05-05 | Smithkline Beecham Plc | Process |
| JP2003531101A (ja) | 1999-06-29 | 2003-10-21 | スミスクライン・ビーチャム・コーポレイション | 細菌に対するフルオロキノロン化合物の使用法 |
| WO2001015695A1 (en) | 1999-09-01 | 2001-03-08 | Smithkline Beecham Corporation | Methods of use of fluoroquinolone compounds against bacteria |
| GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
| GB9920917D0 (en) * | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
| JP2001081071A (ja) | 1999-09-10 | 2001-03-27 | Nippon Soda Co Ltd | フェノキシアミン類の製造法 |
| WO2001021176A1 (en) | 1999-09-22 | 2001-03-29 | Smithkline Beecham Corporation | Methods of use of fluoroquinolone compounds against bacteria |
| GB9925934D0 (en) | 1999-11-03 | 1999-12-29 | Glaxo Group Ltd | Novel apparatus and process |
| KR100517638B1 (ko) * | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
-
2002
- 2002-08-02 KR KR1020047001612A patent/KR100892864B1/ko not_active Expired - Lifetime
- 2002-08-02 DE DE60229255T patent/DE60229255D1/de not_active Expired - Lifetime
- 2002-08-02 JP JP2003516675A patent/JP2005500350A/ja active Pending
- 2002-08-02 US US10/485,488 patent/US7199242B2/en not_active Expired - Lifetime
- 2002-08-02 AT AT02755123T patent/ATE410225T1/de active
- 2002-08-02 DK DK02755123T patent/DK1412078T3/da active
- 2002-08-02 EP EP02755123A patent/EP1412078B1/de not_active Expired - Lifetime
- 2002-08-02 PT PT02755123T patent/PT1412078E/pt unknown
- 2002-08-02 SI SI200230778T patent/SI1412078T1/sl unknown
- 2002-08-02 ES ES02755123T patent/ES2314082T3/es not_active Expired - Lifetime
- 2002-08-02 WO PCT/GB2002/003585 patent/WO2003011450A1/en not_active Ceased
-
2009
- 2009-01-08 CY CY20091100007T patent/CY1108812T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60229255D1 (de) | 2008-11-20 |
| US7199242B2 (en) | 2007-04-03 |
| EP1412078A1 (de) | 2004-04-28 |
| CY1108812T1 (el) | 2014-04-09 |
| US20050043546A1 (en) | 2005-02-24 |
| ES2314082T3 (es) | 2009-03-16 |
| DK1412078T3 (da) | 2009-02-02 |
| JP2005500350A (ja) | 2005-01-06 |
| EP1412078B1 (de) | 2008-10-08 |
| KR100892864B1 (ko) | 2009-04-15 |
| SI1412078T1 (sl) | 2009-04-30 |
| WO2003011450A1 (en) | 2003-02-13 |
| PT1412078E (pt) | 2009-01-08 |
| KR20040058170A (ko) | 2004-07-03 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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