ATE411314T1 - Verfahren zur gewinnung der pharmazeutisch aktiven verbindung dolasetron, synthese- zwischenprodukte davon und verfahren zu deren gewinnung - Google Patents

Verfahren zur gewinnung der pharmazeutisch aktiven verbindung dolasetron, synthese- zwischenprodukte davon und verfahren zu deren gewinnung

Info

Publication number: ATE411314T1
Authority: AT; Austria
Prior art keywords: obtaining; dolasetron; give; active compound; pharmaceutically active
Prior art date: 2005-07-06

Application number

AT06763874T

Other languages

English (en)

Inventor

Andres Juan Antonio Perez

Barjoan Pere Dalmases

Original Assignee

Inke Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-06

Filing date

2006-06-26

Publication date

2008-10-15

2005-07-06 Priority claimed from ES200501704A external-priority patent/ES2264901B1/es

2006-06-26 Application filed by Inke Sa filed Critical Inke Sa

2008-10-15 Application granted granted Critical

2008-10-15 Publication of ATE411314T1 publication Critical patent/ATE411314T1/de

Links

238000000034 method Methods 0.000 title abstract 6
229960003413 dolasetron Drugs 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title 1
CGHRJBLSXVCYQF-YXSUXZIUSA-N dolasetron Chemical compound C1=CC=C[C]2C(C(O[C@@H]3C[C@@H]4C[C@@H]5C[C@@H](N4CC5=O)C3)=O)=CN=C21 CGHRJBLSXVCYQF-YXSUXZIUSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 4
UKTAZPQNNNJVKR-KJGYPYNMSA-N chembl2368925 Chemical compound C1=CC=C2C(C(O[C@@H]3C[C@@H]4C[C@H]5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 UKTAZPQNNNJVKR-KJGYPYNMSA-N 0.000 abstract 3
KMAKOBLIOCQGJP-UHFFFAOYSA-N indole-3-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CNC2=C1 KMAKOBLIOCQGJP-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
238000006228 Dieckmann condensation reaction Methods 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)

AT06763874T 2005-07-06 2006-06-26 Verfahren zur gewinnung der pharmazeutisch aktiven verbindung dolasetron, synthese- zwischenprodukte davon und verfahren zu deren gewinnung ATE411314T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200501704A ES2264901B1 (es)	2005-07-06	2005-07-06	Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
US70289405P	2005-07-27	2005-07-27

Publications (1)

Publication Number	Publication Date
ATE411314T1 true ATE411314T1 (de)	2008-10-15

Family

ID=37027823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06763874T ATE411314T1 (de)	2005-07-06	2006-06-26	Verfahren zur gewinnung der pharmazeutisch aktiven verbindung dolasetron, synthese- zwischenprodukte davon und verfahren zu deren gewinnung

Country Status (5)

Country	Link
EP (1)	EP1904492B1 (de)
AT (1)	ATE411314T1 (de)
DE (1)	DE602006003227D1 (de)
ES (1)	ES2314927T3 (de)
WO (1)	WO2007003522A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007081890A2 (en)	2006-01-05	2007-07-19	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Production of dolasetron
ES2389261T3 (es)	2007-11-13	2012-10-24	Inke, S.A.	Compuestos intermedios útiles para preparar dolasetrón
CN102180878B (zh) *	2010-07-02	2013-06-26	成都新恒创药业有限公司	一种多拉司琼异构体或其盐及其制备方法和其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU895334D0 (en) *	1986-07-30	1990-01-28	Sandoz Ag	Process for the preparation of nasal pharmaceutical compositions
ZA878096B (en) *	1986-11-03	1988-04-26	Merrell Dow Pharmaceuticals Inc.	Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
ZA893008B (en) *	1988-04-29	1989-12-27	Merrell Dow Pharma	Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one
EP1819705A1 (de) *	2004-11-25	2007-08-22	Cilag Ltd.	Verfahren zur herstellung von estern von hexahydro-8-hydroxy-2,6-methano-2h-chinolizin-3(4h)-on

2006
- 2006-06-26 EP EP06763874A patent/EP1904492B1/de active Active
- 2006-06-26 ES ES06763874T patent/ES2314927T3/es active Active
- 2006-06-26 AT AT06763874T patent/ATE411314T1/de not_active IP Right Cessation
- 2006-06-26 WO PCT/EP2006/063534 patent/WO2007003522A1/en not_active Ceased
- 2006-06-26 DE DE602006003227T patent/DE602006003227D1/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2314927T3 (es)	2009-03-16
WO2007003522A1 (en)	2007-01-11
EP1904492A1 (de)	2008-04-02
EP1904492B1 (de)	2008-10-15
DE602006003227D1 (de)	2008-11-27

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Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties