ATE412628T1 - N- (1-dimethylaminocycloalkyl)methyl benzamid- derivate - Google Patents
N- (1-dimethylaminocycloalkyl)methyl benzamid- derivateInfo
- Publication number
- ATE412628T1 ATE412628T1 AT02767220T AT02767220T ATE412628T1 AT E412628 T1 ATE412628 T1 AT E412628T1 AT 02767220 T AT02767220 T AT 02767220T AT 02767220 T AT02767220 T AT 02767220T AT E412628 T1 ATE412628 T1 AT E412628T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- alkyl
- dimethylaminocycloalkyl
- benzamide derivatives
- methyl
- Prior art date
Links
- XXUNIGZDNWWYED-UHFFFAOYSA-N 2-methylbenzamide Chemical class CC1=CC=CC=C1C(N)=O XXUNIGZDNWWYED-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 208000002193 Pain Diseases 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000008238 Muscle Spasticity Diseases 0.000 abstract 1
- 101710083167 Sodium- and chloride-dependent glycine transporter 2 Proteins 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01117273 | 2001-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE412628T1 true ATE412628T1 (de) | 2008-11-15 |
Family
ID=8178058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02767220T ATE412628T1 (de) | 2001-07-17 | 2002-07-11 | N- (1-dimethylaminocycloalkyl)methyl benzamid- derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7126027B2 (de) |
| EP (1) | EP1419138B1 (de) |
| JP (1) | JP4176633B2 (de) |
| AT (1) | ATE412628T1 (de) |
| DE (1) | DE60229646D1 (de) |
| ES (1) | ES2314096T3 (de) |
| WO (1) | WO2003010132A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005094808A1 (en) * | 2004-03-02 | 2005-10-13 | Bayer Healthcare Ag | Regulation of human glycine transporter 2 |
| RU2395502C2 (ru) * | 2004-12-09 | 2010-07-27 | Ф.Хоффманн-Ля Рош Аг | Производные фенил-пиперазин метанона |
| JP2008525398A (ja) * | 2004-12-23 | 2008-07-17 | グラクソ グループ リミテッド | グリシン輸送阻害剤 |
| PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| PE20061330A1 (es) * | 2004-12-23 | 2006-12-27 | Glaxo Group Ltd | Compuestos derivados de benzamida como inhibidores del transportador de glicina |
| GB0428233D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| WO2006080477A1 (en) * | 2005-01-25 | 2006-08-03 | Tanabe Seiyaku Co., Ltd. | Norvaline derivative and method for preparation thereof |
| JP5165950B2 (ja) * | 2006-07-21 | 2013-03-21 | 田辺三菱製薬株式会社 | 医薬組成物 |
| WO2010020548A1 (en) * | 2008-08-20 | 2010-02-25 | F. Hoffmann-La Roche Ag | Glyt1 receptor antagonists |
| WO2013081400A2 (ko) * | 2011-11-29 | 2013-06-06 | 주식회사 비보존 | 신규한 벤즈아마이드 유도체 및 그 용도 |
| TW201427947A (zh) | 2012-10-12 | 2014-07-16 | Lundbeck & Co As H | 環狀胺 |
| US20160130278A1 (en) * | 2013-06-10 | 2016-05-12 | Taisho Pharmaceutical Co., Ltd | Glycine transporter inhibitor |
| WO2020256456A1 (en) * | 2019-06-20 | 2020-12-24 | Vivozon Inc. | Method of preventing or treating postoperative pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975443A (en) * | 1972-06-06 | 1976-08-17 | Allen & Hanburys Limited | 1-(3,4-dichlorobenzamidomethyl)-cyclohexyldimethylamine |
| US4049663A (en) * | 1972-06-06 | 1977-09-20 | Allen & Hanburys Limited | Ethylene diamine derivatives |
| US4346101A (en) | 1980-12-08 | 1982-08-24 | The Upjohn Company | Benzamide derivative analgesics |
-
2002
- 2002-07-11 US US10/484,410 patent/US7126027B2/en not_active Expired - Fee Related
- 2002-07-11 WO PCT/EP2002/007892 patent/WO2003010132A1/de not_active Ceased
- 2002-07-11 DE DE60229646T patent/DE60229646D1/de not_active Expired - Fee Related
- 2002-07-11 ES ES02767220T patent/ES2314096T3/es not_active Expired - Lifetime
- 2002-07-11 AT AT02767220T patent/ATE412628T1/de not_active IP Right Cessation
- 2002-07-11 JP JP2003515492A patent/JP4176633B2/ja not_active Expired - Fee Related
- 2002-07-11 EP EP02767220A patent/EP1419138B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1419138A1 (de) | 2004-05-19 |
| WO2003010132A1 (de) | 2003-02-06 |
| JP4176633B2 (ja) | 2008-11-05 |
| ES2314096T3 (es) | 2009-03-16 |
| US20040242685A1 (en) | 2004-12-02 |
| JP2005519859A (ja) | 2005-07-07 |
| DE60229646D1 (de) | 2008-12-11 |
| US7126027B2 (en) | 2006-10-24 |
| EP1419138B1 (de) | 2008-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |