ATE412641T1 - Iodierte triglycerid-derivate - Google Patents

Iodierte triglycerid-derivate

Info

Publication number
ATE412641T1
ATE412641T1 AT03715494T AT03715494T ATE412641T1 AT E412641 T1 ATE412641 T1 AT E412641T1 AT 03715494 T AT03715494 T AT 03715494T AT 03715494 T AT03715494 T AT 03715494T AT E412641 T1 ATE412641 T1 AT E412641T1
Authority
AT
Austria
Prior art keywords
sup
group
liposomes
substituent
carbon atoms
Prior art date
Application number
AT03715494T
Other languages
English (en)
Inventor
Kazunobu Takahashi
Hiroshi Kitaguchi
Kazuhiro Aikawa
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Application granted granted Critical
Publication of ATE412641T1 publication Critical patent/ATE412641T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461Dispersions, colloids, emulsions or suspensions
    • A61K49/0466Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234Liposomes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers
    • C07C69/712Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/117Esters of phosphoric acids with cycloaliphatic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03715494T 2002-03-27 2003-03-27 Iodierte triglycerid-derivate ATE412641T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002088694 2002-03-27
JP2002088695 2002-03-27

Publications (1)

Publication Number Publication Date
ATE412641T1 true ATE412641T1 (de) 2008-11-15

Family

ID=28456284

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03715494T ATE412641T1 (de) 2002-03-27 2003-03-27 Iodierte triglycerid-derivate

Country Status (7)

Country Link
US (1) US7371877B2 (de)
EP (1) EP1492776B1 (de)
JP (1) JP4464687B2 (de)
AT (1) ATE412641T1 (de)
AU (1) AU2003219554A1 (de)
DE (1) DE60324401D1 (de)
WO (1) WO2003080554A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5340281B2 (ja) 2007-07-12 2013-11-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
JP2011500533A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
CN101820924A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 造影剂
EP2200655B1 (de) 2007-10-12 2012-07-18 GE Healthcare AS Kontrastmittel
US20100209356A1 (en) 2007-10-12 2010-08-19 Duncan George Wynn Contrast agents
CN101891696A (zh) * 2009-05-22 2010-11-24 史命锋 一种多碘苯环化合物及其制备方法和应用
CN107249570B (zh) 2014-11-21 2022-08-09 丹麦技术大学 用于局部药物释放的凝胶制剂
AU2017266410B2 (en) 2016-05-20 2022-07-14 Nanovi Radiotherapy Aps Palpable marker composition
CA3143104A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63064C (fi) 1980-04-09 1983-04-11 Ksv Chemicals Oy Foerfarande foer fluorometrisk bestaemning av aktiviteten av fettspjaelkande enzymer och medel foer att genomfoera foerfarandet
US4873075A (en) * 1985-09-10 1989-10-10 The University Of Michigan Polyiodinated triglyceride analogs as radiologic agents
US5851510A (en) * 1994-05-16 1998-12-22 The Board Of Regents Of The University Of Michigan Hepatocyte-selective oil-in-water emulsion

Also Published As

Publication number Publication date
EP1492776B1 (de) 2008-10-29
AU2003219554A1 (en) 2003-10-08
WO2003080554A2 (en) 2003-10-02
US20060062726A1 (en) 2006-03-23
AU2003219554A8 (en) 2003-10-08
EP1492776A2 (de) 2005-01-05
JP4464687B2 (ja) 2010-05-19
JP2005529858A (ja) 2005-10-06
DE60324401D1 (de) 2008-12-11
WO2003080554A3 (en) 2004-04-15
US7371877B2 (en) 2008-05-13

Similar Documents

Publication Publication Date Title
EA200601830A1 (ru) Ортозамещённые арильные или гетероарильные амидные соединения
MX2010001240A (es) Derivado de oxopirazina y herbicida.
DE69512797D1 (en) Prostaglandin-synthase hemmer
TW200731013A (en) Salt suitable for an acid generator and a chemically amplified resist composition containing the same
MXPA04004164A (es) Analogos de omega-cicloalquil 17-heteroaril prostaglandina e2 como agonistas del receptor ep2.
WO2003082798A8 (es) Compuestos naturales y derivados de éstos para la prevención y el tratamiento de enfermedades cardiovasculares, hepáticas, renales y para aplicaciones cosméticas
ATE412641T1 (de) Iodierte triglycerid-derivate
NO20062617L (no) Anvendelse av glukosidase inhibitorer for terapi av mucovisidose
TW200612920A (en) Novel imidazolidine derivatives
ATE354622T1 (de) Flüssigkristallines medium
AU2006325931A8 (en) Amine compound and use thereof for medical purposes
NO923798L (no) Fremgangsmaate for fremstilling og anvendelse av nye acylaler av imidazol-5-karboksylsyrederivater
TW200706694A (en) Water-soluble preflux and use thereof
BRPI0411664A (pt) composição oral antiplaca aquosa estável
ATE145888T1 (de) Cyclohexanderivate und diese enthaltende flüssigkristalline zusammensetzung
WO2008149701A1 (ja) 感放射線性樹脂組成物
EP1568697A4 (de) 1,3-benzothiazinonderivate, deren herstellungsverfahren und verwendung
GEP20074256B (en) Novel benzothiadiazine, process for their preparation and pharmaceutical compositions containing
EA200900068A1 (ru) Способ получения формы i кандесартана цилексетила
ES464150A1 (es) Procedimiento para la preparacion de compuestos derivados defenil-amino-2-imidazolina
AP2001002314A0 (en) Substituted benzolactam compounds.
TW200616679A (en) Modified-release preparation
ES8504181A1 (es) Procedimiento para preparar nuevos derivados de piperidina
ATE375173T1 (de) Hydrophobe iodverbindung enthaltendes liposom und dieses enthaltendes röntgenkontrastmittel
EP1426353A4 (de) 1,3-glyceridverbindung mit zwei iodphenylgruppen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties