ATE412647T1 - SUBSTITUTED N-ARYLPYRROLIDINE AS SELECTIVE MODULATORS OF THE ANDROGEN RECEPTOR - Google Patents

SUBSTITUTED N-ARYLPYRROLIDINE AS SELECTIVE MODULATORS OF THE ANDROGEN RECEPTOR

Info

Publication number
ATE412647T1
ATE412647T1 AT06759481T AT06759481T ATE412647T1 AT E412647 T1 ATE412647 T1 AT E412647T1 AT 06759481 T AT06759481 T AT 06759481T AT 06759481 T AT06759481 T AT 06759481T AT E412647 T1 ATE412647 T1 AT E412647T1
Authority
AT
Austria
Prior art keywords
arylpyrrolidine
substituted
compound
formula
androgen receptor
Prior art date
Application number
AT06759481T
Other languages
German (de)
Inventor
Konstantinos Gavardinas
Prabhakar Jadhav
Douglas Stack
Ian Roger Clemens
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE412647T1 publication Critical patent/ATE412647T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention provides a compound of the Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula (I).
AT06759481T 2005-05-13 2006-05-10 SUBSTITUTED N-ARYLPYRROLIDINE AS SELECTIVE MODULATORS OF THE ANDROGEN RECEPTOR ATE412647T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68091105P 2005-05-13 2005-05-13

Publications (1)

Publication Number Publication Date
ATE412647T1 true ATE412647T1 (en) 2008-11-15

Family

ID=37057376

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06759481T ATE412647T1 (en) 2005-05-13 2006-05-10 SUBSTITUTED N-ARYLPYRROLIDINE AS SELECTIVE MODULATORS OF THE ANDROGEN RECEPTOR

Country Status (17)

Country Link
US (1) US7807691B2 (en)
EP (1) EP1891038B1 (en)
JP (1) JP5089578B2 (en)
CN (1) CN101175747B (en)
AT (1) ATE412647T1 (en)
AU (1) AU2006247738A1 (en)
BR (1) BRPI0610183A2 (en)
CA (1) CA2608419A1 (en)
CY (1) CY1108690T1 (en)
DE (1) DE602006003432D1 (en)
DK (1) DK1891038T3 (en)
ES (1) ES2314922T3 (en)
MX (1) MX2007014053A (en)
PL (1) PL1891038T3 (en)
PT (1) PT1891038E (en)
SI (1) SI1891038T1 (en)
WO (1) WO2006124447A2 (en)

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CA2617256C (en) * 2005-08-01 2014-07-15 Takeda Pharmaceutical Company Limited Cyclic amine compound
CA2670976C (en) 2006-11-30 2015-01-27 Atsushi Hasuoka Cyclic amine compound
TW200831080A (en) * 2006-12-15 2008-08-01 Irm Llc Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
AU2008284662B2 (en) 2007-08-07 2013-07-25 Takeda Pharmaceutical Company Limited Pyrrolidin-2 -one derivatives as androgen receptor modulator
JP5539221B2 (en) 2007-12-21 2014-07-02 リガンド・ファーマシューティカルズ・インコーポレイテッド Selective androgen receptor modulator (SARM) and uses thereof
MX2010009162A (en) 2008-02-22 2010-12-21 Radius Health Inc Selective androgen receptor modulators.
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
WO2009131196A1 (en) * 2008-04-24 2009-10-29 武田薬品工業株式会社 Substituted pyrrolidine derivative and use thereof
WO2009133861A1 (en) * 2008-04-28 2009-11-05 武田薬品工業株式会社 Cyclic amine compound
CA2788907A1 (en) 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
PT2568806T (en) 2010-05-12 2016-08-05 Radius Health Inc Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
ES2550319T3 (en) 2010-09-28 2015-11-06 Radius Health, Inc Selective androgen receptor modulators
AU2012220572A1 (en) * 2011-02-25 2013-08-29 Irm Llc Compounds and compositions as trk inhibitors
AR088082A1 (en) 2011-10-13 2014-05-07 Lilly Co Eli ANDROGEN RECEIVER SELECTIVE MODULATORS
WO2014078778A2 (en) * 2012-11-16 2014-05-22 Biocryst Pharmaceuticals, Inc. Antiviral azasugar-containing nucleosides
RS67458B1 (en) 2014-03-28 2025-12-31 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
RS63311B1 (en) 2016-06-22 2022-07-29 Ellipses Pharma Ltd AR+ METHODS OF BREAST CANCER TREATMENT
KR102881465B1 (en) 2017-01-05 2025-11-04 래디어스 파마슈티컬스, 인코포레이티드 Polymorphic forms of rad1901-2hcl
SG11202001684PA (en) 2017-10-06 2020-03-30 Forma Therapeutics Inc Inhibiting ubiquitin specific peptidase 30
SG11202011135WA (en) 2018-05-14 2020-12-30 Nuvation Bio Inc Anti-cancer nuclear hormone receptor-targeting compounds
ES2988920T3 (en) 2018-05-17 2024-11-22 Forma Therapeutics Inc Fused bicyclic compounds useful as inhibitors of ubiquitin-specific peptidase 30
CN112423844B (en) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Polymorphic forms of RAD1901-2HCL
PL3860989T3 (en) 2018-10-05 2023-07-10 Forma Therapeutics, Inc. Fused pyrrolines which act as ubiquitin-specific protease 30 (usp30) inhibitors
JOP20210218A1 (en) 2019-02-12 2023-01-30 Radius Pharmaceuticals Inc operations and vehicles
KR20220003554A (en) 2019-04-19 2022-01-10 리간드 파마슈티칼스 인코포레이티드 Crystalline Forms of Compounds and Methods of Preparing Crystalline Forms
US11826430B2 (en) 2019-05-14 2023-11-28 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US11952349B2 (en) 2019-11-13 2024-04-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CN114746400A (en) * 2019-11-20 2022-07-12 南京明德新药研发有限公司 Compounds useful as selective androgen receptor modulators
KR20230160299A (en) 2021-03-23 2023-11-23 누베이션 바이오 인크. Anticancer nuclear hormone receptor targeting compounds
US12006314B2 (en) 2021-05-03 2024-06-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
WO2025160286A1 (en) * 2024-01-24 2025-07-31 Siteone Therapeutics, Inc. 2-aryl cycloalkyl and heterocycloalkyl inhibitors of nav1.8 for the treatment of pain

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JP2007500245A (en) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション Compound

Also Published As

Publication number Publication date
WO2006124447A2 (en) 2006-11-23
JP2008540554A (en) 2008-11-20
DE602006003432D1 (en) 2008-12-11
EP1891038B1 (en) 2008-10-29
SI1891038T1 (en) 2009-04-30
CN101175747B (en) 2011-06-22
CY1108690T1 (en) 2014-04-09
PL1891038T3 (en) 2009-04-30
CA2608419A1 (en) 2006-11-23
DK1891038T3 (en) 2009-01-19
BRPI0610183A2 (en) 2012-12-04
EP1891038A2 (en) 2008-02-27
AU2006247738A1 (en) 2006-11-23
ES2314922T3 (en) 2009-03-16
MX2007014053A (en) 2008-02-05
CN101175747A (en) 2008-05-07
PT1891038E (en) 2008-12-02
WO2006124447A3 (en) 2007-03-29
JP5089578B2 (en) 2012-12-05
US20080176864A1 (en) 2008-07-24
US7807691B2 (en) 2010-10-05

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