ATE413173T1 - Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung - Google Patents

Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung

Info

Publication number: ATE413173T1
Authority: AT; Austria
Prior art keywords: inhibition; serotonin; reuppost; combination; phenylpiperazine derivatives
Prior art date: 2004-12-08

Application number

AT05816322T

Other languages

English (en)

Inventor

Roelof W Feenstra

Axel Stoit

Jan-Willem Terpstra

Maria L Pras-Raves

Andrew C Mccreary

Vliet Bernard Van

Mayke Hesselink

Cornelis Kruse

Scharrenburg G J M Van

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-08

Filing date

2005-12-06

Publication date

2008-11-15

2005-12-06 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE413173T1 publication Critical patent/ATE413173T1/de

Links

102000004980 Dopamine D2 Receptors Human genes 0.000 title abstract 2
108090001111 Dopamine D2 Receptors Proteins 0.000 title abstract 2
230000008484 agonism Effects 0.000 title abstract 2
230000005764 inhibitory process Effects 0.000 title abstract 2
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
229940076279 serotonin Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000009286 beneficial effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000009977 dual effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000000697 serotonin reuptake Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT05816322T 2004-12-08 2005-12-06 Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung ATE413173T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63407404P	2004-12-08	2004-12-08
EP04106394		2004-12-08

Publications (1)

Publication Number	Publication Date
ATE413173T1 true ATE413173T1 (de)	2008-11-15

Family

ID=35744728

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT05850037T ATE401883T1 (de)	2004-12-08	2005-12-06	Aryloxyethylaminderivate mit einer kombination aus partiellem dopamin-d2-rezeptoragonismus und serotonin-wiederaufnahmehemmung
AT05816322T ATE413173T1 (de)	2004-12-08	2005-12-06	Phenylpiperazin-derivate mit einer kombination aus teilweisem dopamin-d2-rezeptor-agonismus und serotonin-wiederaufnahmehemmung

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT05850037T ATE401883T1 (de)	2004-12-08	2005-12-06	Aryloxyethylaminderivate mit einer kombination aus partiellem dopamin-d2-rezeptoragonismus und serotonin-wiederaufnahmehemmung

Country Status (18)

Country	Link
EP (4)	EP1824480A1 (de)
JP (4)	JP2008523029A (de)
KR (4)	KR20070085916A (de)
AT (2)	ATE401883T1 (de)
AU (4)	AU2005313390A1 (de)
BR (1)	BRPI0518613A2 (de)
CA (4)	CA2587357A1 (de)
DE (2)	DE602005010902D1 (de)
DK (2)	DK1827427T3 (de)
ES (2)	ES2317335T3 (de)
HR (2)	HRP20080538T3 (de)
IL (4)	IL183061A0 (de)
NO (4)	NO20072977L (de)
PL (2)	PL1827427T3 (de)
PT (2)	PT1827427E (de)
RU (4)	RU2007125661A (de)
SI (2)	SI1824479T1 (de)
WO (4)	WO2006061377A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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EP1979323A1 (de) *	2006-01-30	2008-10-15	Speedel Experimenta AG	Verfahren zur stereoselektiven zubereitung von alkoholen aus alpha, beta-ungesättigten verbindungen
US8063062B2 (en)	2006-12-20	2011-11-22	Solvay Pharmaceuticals B.V.	Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
AU2008204456A1 (en) *	2007-01-10	2008-07-17	Solvay Pharmaceuticals B.V.	Compounds with a combination of cannabinoid-CB1 antagonism and serotonin reuptake inhibition
US8138174B2 (en)	2007-01-10	2012-03-20	Solvay Pharmaceuticals B.V.	Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
CA2683111A1 (en) *	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
JP2010525013A (ja) *	2007-04-23	2010-07-22	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
MX2009011416A (es) *	2007-04-23	2009-11-05	Janssen Pharmaceutica Nv	Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
CN103360342B (zh) *	2012-04-09	2015-12-16	江苏恩华药业股份有限公司	3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用
CN103570698B (zh) *	2012-08-01	2016-08-03	江苏恩华药业股份有限公司	用于制备维拉佐酮的化合物及其中间体和应用
ITMI20130392A1 (it) *	2013-03-15	2014-09-16	Dipharma Francis Srl	Sintesi di un inibitore della ricaptazione della serotonina
EP3010586A1 (de)	2013-06-21	2016-04-27	Lupin Limited	Substituierte heterocyclische verbindungen als crac-modulatoren
EP3013810A1 (de)	2013-06-24	2016-05-04	Lupin Limited	Chroman- und chromenderivate und deren verwendung als crac-modulatoren
WO2015014256A1 (en)	2013-07-29	2015-02-05	Sunshine Lake Pharma Co., Ltd.	Substituted heteroaryl compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2692264B1 (fr) *	1992-06-12	1994-08-05	Adir	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
EP0900792B1 (de) *	1997-09-02	2003-10-29	Duphar International Research B.V	Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
WO1999051575A1 (en) *	1998-04-08	1999-10-14	American Home Products Corporation	N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
HRP20000847A2 (en) *	1998-06-19	2001-12-31	Lundbeck & Co As H	4,5,6 i 7 - INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE
AR022303A1 (es) *	1999-01-22	2002-09-04	Lundbeck & Co As H	Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
ATE299142T1 (de) *	1999-08-23	2005-07-15	Solvay Pharm Bv	Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme
BR0317126A (pt) *	2002-12-10	2005-10-25	Merck Patent Gmbh	Derivados de indol e o uso dos mesmos como ligantes de 5-ht

2005
- 2005-12-06 JP JP2007544895A patent/JP2008523029A/ja not_active Withdrawn
- 2005-12-06 KR KR1020077012935A patent/KR20070085916A/ko not_active Withdrawn
- 2005-12-06 KR KR1020077013041A patent/KR20070085975A/ko not_active Withdrawn
- 2005-12-06 DE DE602005010902T patent/DE602005010902D1/de not_active Expired - Fee Related
- 2005-12-06 AU AU2005313390A patent/AU2005313390A1/en not_active Abandoned
- 2005-12-06 WO PCT/EP2005/056506 patent/WO2006061377A1/en not_active Ceased
- 2005-12-06 AT AT05850037T patent/ATE401883T1/de not_active IP Right Cessation
- 2005-12-06 AT AT05816322T patent/ATE413173T1/de not_active IP Right Cessation
- 2005-12-06 EP EP05816324A patent/EP1824480A1/de not_active Withdrawn
- 2005-12-06 SI SI200530566T patent/SI1824479T1/sl unknown
- 2005-12-06 PL PL05850037T patent/PL1827427T3/pl unknown
- 2005-12-06 WO PCT/EP2005/056508 patent/WO2006061379A1/en not_active Ceased
- 2005-12-06 WO PCT/EP2005/056505 patent/WO2006061376A1/en not_active Ceased
- 2005-12-06 RU RU2007125661/04A patent/RU2007125661A/ru not_active Application Discontinuation
- 2005-12-06 EP EP05850037A patent/EP1827427B1/de not_active Expired - Lifetime
- 2005-12-06 CA CA002587357A patent/CA2587357A1/en not_active Abandoned
- 2005-12-06 JP JP2007544896A patent/JP2008523030A/ja not_active Withdrawn
- 2005-12-06 DK DK05850037T patent/DK1827427T3/da active
- 2005-12-06 HR HR20080538T patent/HRP20080538T3/xx unknown
- 2005-12-06 WO PCT/EP2005/056507 patent/WO2006061378A1/en not_active Ceased
- 2005-12-06 KR KR1020077013015A patent/KR20070085959A/ko not_active Withdrawn
- 2005-12-06 CA CA002587202A patent/CA2587202A1/en not_active Abandoned
- 2005-12-06 SI SI200530416T patent/SI1827427T1/sl unknown
- 2005-12-06 DK DK05816322T patent/DK1824479T3/da active
- 2005-12-06 BR BRPI0518613-7A patent/BRPI0518613A2/pt not_active IP Right Cessation
- 2005-12-06 PL PL05816322T patent/PL1824479T3/pl unknown
- 2005-12-06 RU RU2007125660/04A patent/RU2007125660A/ru not_active Application Discontinuation
- 2005-12-06 AU AU2005313311A patent/AU2005313311A1/en not_active Abandoned
- 2005-12-06 JP JP2007544898A patent/JP2008537725A/ja not_active Withdrawn
- 2005-12-06 CA CA002587559A patent/CA2587559A1/en not_active Abandoned
- 2005-12-06 PT PT05850037T patent/PT1827427E/pt unknown
- 2005-12-06 AU AU2005313312A patent/AU2005313312A1/en not_active Abandoned
- 2005-12-06 KR KR1020077013063A patent/KR20070085988A/ko not_active Withdrawn
- 2005-12-06 ES ES05816322T patent/ES2317335T3/es not_active Expired - Lifetime
- 2005-12-06 DE DE602005008471T patent/DE602005008471D1/de not_active Expired - Fee Related
- 2005-12-06 AU AU2005313391A patent/AU2005313391A1/en not_active Abandoned
- 2005-12-06 ES ES05850037T patent/ES2311245T3/es not_active Expired - Lifetime
- 2005-12-06 CA CA002587381A patent/CA2587381A1/en not_active Abandoned
- 2005-12-06 PT PT05816322T patent/PT1824479E/pt unknown
- 2005-12-06 HR HR20090015T patent/HRP20090015T3/xx unknown
- 2005-12-06 JP JP2007544897A patent/JP2008523031A/ja not_active Withdrawn
- 2005-12-06 RU RU2007125659/04A patent/RU2007125659A/ru not_active Application Discontinuation
- 2005-12-06 EP EP05816322A patent/EP1824479B1/de not_active Expired - Lifetime
- 2005-12-06 EP EP05813645A patent/EP1827426A1/de not_active Withdrawn
- 2005-12-06 RU RU2007125658/04A patent/RU2007125658A/ru not_active Application Discontinuation
2007
- 2007-05-08 IL IL183061A patent/IL183061A0/en unknown
- 2007-05-08 IL IL183064A patent/IL183064A0/en unknown
- 2007-05-08 IL IL183062A patent/IL183062A0/en unknown
- 2007-05-08 IL IL183063A patent/IL183063A0/en unknown
- 2007-06-11 NO NO20072977A patent/NO20072977L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072969A patent/NO20072969L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072974A patent/NO20072974L/no not_active Application Discontinuation
- 2007-06-11 NO NO20072981A patent/NO20072981L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2008537725A (ja)	2008-09-25
AU2005313311A1 (en)	2006-06-15
JP2008523030A (ja)	2008-07-03
RU2007125661A (ru)	2009-01-20
IL183064A0 (en)	2007-09-20
ATE401883T1 (de)	2008-08-15
PL1824479T3 (pl)	2009-04-30
CA2587202A1 (en)	2006-06-15
IL183061A0 (en)	2007-09-20
WO2006061377A1 (en)	2006-06-15
DK1824479T3 (da)	2009-03-09
EP1827427B1 (de)	2008-07-23
RU2007125658A (ru)	2009-01-20
ES2311245T3 (es)	2009-02-01
SI1827427T1 (sl)	2008-12-31
BRPI0518613A2 (pt)	2008-11-25
RU2007125660A (ru)	2009-01-20
EP1827426A1 (de)	2007-09-05
WO2006061379A1 (en)	2006-06-15
ES2317335T3 (es)	2009-04-16
KR20070085916A (ko)	2007-08-27
DK1827427T3 (da)	2008-11-24
AU2005313391A1 (en)	2006-06-15
CA2587357A1 (en)	2006-06-15
IL183063A0 (en)	2007-09-20
DE602005010902D1 (de)	2008-12-18
WO2006061376A1 (en)	2006-06-15
KR20070085975A (ko)	2007-08-27
NO20072977L (no)	2007-09-05
NO20072981L (no)	2007-09-05
HRP20080538T3 (en)	2008-12-31
WO2006061378A1 (en)	2006-06-15
NO20072974L (no)	2007-08-23
SI1824479T1 (sl)	2009-04-30
EP1827427A1 (de)	2007-09-05
JP2008523029A (ja)	2008-07-03
CA2587381A1 (en)	2006-06-15
EP1824479B1 (de)	2008-11-05
JP2008523031A (ja)	2008-07-03
NO20072969L (no)	2007-08-31
DE602005008471D1 (de)	2008-09-04
PT1827427E (pt)	2008-11-03
EP1824479A1 (de)	2007-08-29
AU2005313390A1 (en)	2006-06-15
IL183062A0 (en)	2007-09-20
KR20070085959A (ko)	2007-08-27
CA2587559A1 (en)	2006-06-15
EP1824480A1 (de)	2007-08-29
RU2007125659A (ru)	2009-01-20
PL1827427T3 (pl)	2009-01-30
KR20070085988A (ko)	2007-08-27
AU2005313312A1 (en)	2006-06-15
PT1824479E (pt)	2009-01-30
HRP20090015T3 (en)	2009-02-28

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2009-06-15

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Publication	Publication Date	Title
IL183062A0 (en)	2007-09-20	Phenylpiperazine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake in inhibition
HRP20090235A2 (hr)	2009-08-31	Karbonilirani (aza) cikloheksani kao ligandi dopaminskog receptora d<sub>3</sub>
PE20081690A1 (es)	2008-11-28	Sal de tosilato de un compuesto terapeutico y composiciones farmaceuticas de la misma
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ATE522530T1 (de)	2011-09-15	2-piperazin-1-yl-3h-imidazoä4,5-bü- pyridinderivate
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