ATE413407T1 - Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür - Google Patents

Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Info

Publication number
ATE413407T1
ATE413407T1 AT03816507T AT03816507T ATE413407T1 AT E413407 T1 ATE413407 T1 AT E413407T1 AT 03816507 T AT03816507 T AT 03816507T AT 03816507 T AT03816507 T AT 03816507T AT E413407 T1 ATE413407 T1 AT E413407T1
Authority
AT
Austria
Prior art keywords
pyrrolo
tumor agents
benzodiazepine dimers
analogues
benzodiazepine
Prior art date
Application number
AT03816507T
Other languages
English (en)
Inventor
Ahmed Kamal
Peram Reddy
Depatla Reddy
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Application granted granted Critical
Publication of ATE413407T1 publication Critical patent/ATE413407T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03816507T 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür ATE413407T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/001164 WO2004087716A1 (en) 2003-03-31 2003-03-31 Pyrrolo[(2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof

Publications (1)

Publication Number Publication Date
ATE413407T1 true ATE413407T1 (de) 2008-11-15

Family

ID=33104923

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03816507T ATE413407T1 (de) 2003-03-31 2003-03-31 Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür

Country Status (6)

Country Link
EP (1) EP1608663B1 (de)
AT (1) ATE413407T1 (de)
AU (1) AU2003215810B2 (de)
CA (1) CA2520897C (de)
DE (1) DE60324607D1 (de)
WO (1) WO2004087716A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1813614T1 (sl) 2006-01-25 2012-01-31 Sanofi 174 Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
WO2007093873A1 (en) * 2006-02-13 2007-08-23 Council Of Scientific And Industrial Research Bis-pyrr0l0[2,l-c] [1, 4] benzodiazepine- anthraquinone conjugates as antitumour agents and a process for the preparation thereof
ES2435779T3 (es) * 2007-07-19 2013-12-23 Sanofi Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico
US8153627B2 (en) 2008-03-05 2012-04-10 Council Of Scientific & Industrial Research Quinazoline linked pyrrolo[2,1-C][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof
EP2271647B1 (de) * 2008-03-11 2012-12-05 Council Of Scientific & Industrial Research C2-fluor-substituierte piperazingebundene pyrrolo[2,1-c][1,4]benzodiazepindimere und verfahren zu deren herstellung
WO2009118749A1 (en) * 2008-03-26 2009-10-01 Council Of Scientific & Industrial Research Benzophenone-piperazine linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof
BRPI1008749B8 (pt) * 2009-02-05 2021-05-25 Immunogen Inc compostos derivados de benzodiazepina, seus conjugados, composição farmacêutica, seu uso e seus processos de preparação
JP5941058B2 (ja) * 2010-12-06 2016-06-29 カウンシル・オヴ・サイエンティフィック・アンド・インダストリアル・リサーチ 潜在的抗腫瘍剤としてのピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン結合型イミダゾ［１，５−ａ］ピリジン複合体およびその調製方法
UA120696C2 (uk) 2011-02-15 2020-01-27 Імуноген, Інк. Спосіб одержання кон'югатів
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
JP2018522018A (ja) 2015-07-21 2018-08-09 イミュノジェン・インコーポレーテッド 細胞毒性ベンゾジアゼピン誘導体の調製方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205051D0 (en) * 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Also Published As

Publication number Publication date
DE60324607D1 (de) 2008-12-18
AU2003215810A1 (en) 2004-10-25
CA2520897A1 (en) 2004-10-14
EP1608663A1 (de) 2005-12-28
WO2004087716A1 (en) 2004-10-14
CA2520897C (en) 2010-08-24
EP1608663B1 (de) 2008-11-05
AU2003215810B2 (en) 2009-06-18

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