ATE413415T1 - Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate - Google Patents

Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate

Info

Publication number
ATE413415T1
ATE413415T1 AT97943460T AT97943460T ATE413415T1 AT E413415 T1 ATE413415 T1 AT E413415T1 AT 97943460 T AT97943460 T AT 97943460T AT 97943460 T AT97943460 T AT 97943460T AT E413415 T1 ATE413415 T1 AT E413415T1
Authority
AT
Austria
Prior art keywords
chains
modified
alginates
materials
polysaccharide
Prior art date
Application number
AT97943460T
Other languages
English (en)
Inventor
David Mooney
Kamal Bouhadir
Wai Wong
Jon Rowley
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Application granted granted Critical
Publication of ATE413415T1 publication Critical patent/ATE413415T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
AT97943460T 1996-09-19 1997-09-19 Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate ATE413415T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2646796P 1996-09-19 1996-09-19
US2636296P 1996-09-19 1996-09-19
US4156597P 1997-03-21 1997-03-21

Publications (1)

Publication Number Publication Date
ATE413415T1 true ATE413415T1 (de) 2008-11-15

Family

ID=27362748

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97943460T ATE413415T1 (de) 1996-09-19 1997-09-19 Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate

Country Status (9)

Country Link
US (1) US6642363B1 (de)
EP (1) EP0927196B1 (de)
JP (2) JP4335316B2 (de)
AT (1) ATE413415T1 (de)
AU (1) AU733716B2 (de)
CA (1) CA2266581C (de)
DE (1) DE69739085D1 (de)
ES (1) ES2317657T3 (de)
WO (1) WO1998012228A1 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112320B1 (en) 1995-06-07 2006-09-26 Andre Beaulieu Solid wound healing formulations containing fibronectin
DE69920198T2 (de) 1998-04-13 2005-09-22 Massachusetts Institute Of Technology, Cambridge Kamm-polymere zur regelung der zelloberflächenwechselwirkung
US7427602B1 (en) * 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
AU3898699A (en) * 1998-05-13 1999-11-29 Regents Of The University Of Michigan, The Sustained dna delivery from structural matrices
EP1109919A2 (de) 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Von heparinase i und ii abgeleitete heparinasen
US7241730B2 (en) 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
WO2000021572A2 (en) * 1998-10-09 2000-04-20 The University Of Michigan Hydrogels and water soluble polymeric carriers for drug delivery
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
DE60040648D1 (de) * 1999-01-21 2008-12-11 Adv Med Solutions Ltd Träger zum zellwachstum
JP4186294B2 (ja) * 1999-02-26 2008-11-26 セイコーエプソン株式会社 ポリグルロン酸の製造方法
MXPA01010692A (es) * 1999-04-22 2004-09-06 Univ Zuerich Matrices de proteina modificadas para ingenieria de tejidos o liberacion controlada.
US7412332B1 (en) 1999-04-23 2008-08-12 Massachusetts Institute Of Technology Method for analyzing polysaccharides
US6288043B1 (en) * 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
AU781865B2 (en) * 1999-08-20 2005-06-16 Andre Beaulieu Solid wound healing formulations containing fibronectin
ES2230318T3 (es) * 2000-05-31 2005-05-01 Mnemoscience Gmbh Materias termoplasticas con memoria de forma yredes polimeras para ingenieria de tejidos.
US6991652B2 (en) 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
US6748954B2 (en) * 2000-10-27 2004-06-15 The Regents Of The University Of Michigan Drug release from polymer matrices through mechanical stimulation
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
KR101180896B1 (ko) 2003-05-05 2012-09-07 벤-구리온 유니버시티 오브 더 네게브 리서치 앤드 디벨럽먼트 어쏘러티 주사용 가교결합된 폴리머 제제 및 그의 용도
US7008476B2 (en) * 2003-06-11 2006-03-07 Az Electronic Materials Usa Corp. Modified alginic acid of alginic acid derivatives and thermosetting anti-reflective compositions thereof
JP2007520259A (ja) * 2003-11-10 2007-07-26 シンフォニー メディカル， インコーポレイテッド 心房細動患者における心室速度を制御するための方法
EP1552818A1 (de) * 2004-01-07 2005-07-13 Shin-Etsu Chemical Co., Ltd. Zusammensetzung, die Freisetzung von Wirkstoffen verlängernd und Zubereitungen mit verlängerter Freisetzung
US20050220882A1 (en) * 2004-03-04 2005-10-06 Wilson Pritchard Materials for medical implants and occlusive devices
DE102004019241A1 (de) * 2004-04-16 2005-11-03 Cellmed Ag Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie
WO2006031388A2 (en) * 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
EP1799232B1 (de) 2004-10-12 2015-10-07 FMC Biopolymer AS Selbstgelierende alginatsysteme und verwendungsmöglichkeiten dafür
DE102004055729A1 (de) * 2004-11-18 2006-05-24 Cellmed Ag Herstellung von zwei-oder mehrschichtig aufgebauten Mikrokapseln
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
EP2385061A3 (de) 2005-05-10 2012-02-22 Neoloch Aps Neuritogene peptide
BRPI0610469A2 (pt) * 2005-05-27 2012-10-23 Royer Biomedical Inc composição bioerodìvel para a administração de um agente bioativo, kit para a formação de uma composição bioerodìvel, métodos de produção de uma composição bioerodìvel solidificada para a administração de um agente bioativo, de produção de uma fibra bioerodìvel para a administração de um agente bioativo e de formação de um filme bioerodìvel para a administração de um agente bioativo, dispositivo médico implantável, e, método de administração de um agente bioativo para um local do corpo necessitando do mesmo
WO2007008521A1 (en) * 2005-07-07 2007-01-18 Lonnie Shea Stage specific follicle maturation systems
CA2615173C (en) 2005-07-14 2012-01-03 Lipothera, Inc. Sustained release enhanced lipolytic formulation for regional adipose tissue treatment
KR100718329B1 (ko) * 2005-09-08 2007-05-14 광주과학기술원 다당류로 기능화된 수화젤막을 가지는 나노입자와 이를포함하는 서방형 약물전달시스템 및 그 제조방법
US20070248675A1 (en) * 2005-09-08 2007-10-25 Gwangju Institute Of Science And Technology Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof
WO2007070660A2 (en) 2005-12-13 2007-06-21 President And Fellows Of Harvard College Scaffolds for cell transplantation
JP5558002B2 (ja) * 2005-12-16 2014-07-23 オクセラ インコーポレイテッド シュウ酸塩低減化のための組成物および方法
CA2643083A1 (en) * 2006-03-01 2007-09-13 Fmc Biopolymer As Biodegradable foam
WO2007146319A2 (en) * 2006-06-13 2007-12-21 Symphony Medical, Inc. Methods and apparatus for using polymer-based beads and hydrogels for cardiac applications
ES2386123T3 (es) * 2006-06-16 2012-08-09 Fmc Biopolymer As Dispositivo celular con una matriz de colágeno revestida de alginato, proceso para su formación y utilizaciones
EP2046288B1 (de) * 2006-07-14 2013-07-03 FMC Biopolymer AS Hydrogele mit niedermolekularen alginaten und daraus hergestellte biostrukturen
EP2056106B1 (de) * 2006-08-09 2017-10-11 Sumitomo Bakelite Company, Ltd. Zuckerketten-einfangsubstanz und deren verwendung
JP2010506941A (ja) 2006-10-17 2010-03-04 リセラ，インク． 甲状腺眼症の治療のための方法、組成物及び製剤
WO2008098109A2 (en) * 2007-02-08 2008-08-14 Northwestern University Hydrogel compositions
WO2008098220A1 (en) * 2007-02-08 2008-08-14 University Of Washington Biocompatile amino acid anhydride polymers
EP2152860A4 (de) * 2007-06-13 2011-12-07 Fmc Corp Peptidgebundene zellmatrixmaterialien für stammzellen und ihre verwendung
US20100172953A1 (en) * 2007-06-13 2010-07-08 Fmc Corporation Biopolymer Based Implantable Degradable Devices
EP2155810A4 (de) * 2007-06-13 2013-07-03 Fmc Corp Alginatbeschichteter, polysaccharidgelhaltiger schaumverbundstoff, herstellungsverfahren und verwendungen davon
US9770535B2 (en) 2007-06-21 2017-09-26 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
ES2322637B1 (es) * 2007-06-26 2010-03-05 Universidad Del Pais Vasco Microparticulas de alginato modificado con rgd como sistema de liberacion de farmacos.
CN103463638A (zh) * 2007-08-28 2013-12-25 Fmc有限公司 延迟的自胶凝藻酸盐体系及其应用
WO2009057802A1 (ja) * 2007-11-01 2009-05-07 Osaka City University β-1,3-グルカン由来ポリアルデヒド／ポリアミンハイドロゲル
IL187707A0 (en) * 2007-11-27 2008-11-03 Univ Ben Gurion Alginate scaffold in hepatectomy
EP2082755A1 (de) * 2008-01-16 2009-07-29 CellMed AG Monolithische in-situ vernetzte Alginatimplantate
CN102006891B (zh) 2008-02-13 2017-04-26 哈佛学院董事会 连续的细胞程序化装置
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
WO2009108760A2 (en) 2008-02-26 2009-09-03 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
US8790701B2 (en) * 2008-04-28 2014-07-29 Surmodics, Inc. Poly-α(1→4)glucopyranose-based matrices with hydrazide crosslinking
WO2009146456A1 (en) 2008-05-30 2009-12-03 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US8252317B2 (en) * 2009-02-26 2012-08-28 General Electric Company Metal alginate hydrogel and articles thereof
US9297005B2 (en) 2009-04-13 2016-03-29 President And Fellows Of Harvard College Harnessing cell dynamics to engineer materials
JP5248676B2 (ja) 2009-05-22 2013-07-31 サンヨー食品株式会社 不斉酸化反応を有する蛋白質複合体およびその製造方法
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
AU2010278702C1 (en) 2009-07-31 2016-07-14 Forsyth Dental Infirmary For Children Programming of cells for tolerogenic therapies
CN102695501A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 碎裂水凝胶
CN106913902A (zh) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
PT104879B (pt) 2009-12-10 2012-10-17 Univ Do Minho Hidrogel de dextrino para aplicações biomédicas
GB0922133D0 (en) 2009-12-17 2010-02-03 Glaxo Group Ltd Composition
US8197849B2 (en) * 2010-02-12 2012-06-12 National Health Research Institutes Cross-linked oxidated hyaluronic acid for use as a vitreous substitute
US9610328B2 (en) 2010-03-05 2017-04-04 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1
WO2011163669A2 (en) 2010-06-25 2011-12-29 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
TWI398275B (zh) * 2010-07-12 2013-06-11 行政院農業委員會農業試驗所 皮膚創傷敷料及其製備方法
US20120064097A1 (en) * 2010-07-20 2012-03-15 Washburn Newell R Enhanced Binding of Pro-Inflammatory Cytokines by Polysaccharide-Antibody Conjugates
CN107648668B (zh) 2010-10-06 2021-06-18 哈佛学院董事会 用于基于材料的细胞疗法的可注射的成孔水凝胶
WO2012048289A1 (en) 2010-10-08 2012-04-12 Board Of Regents, The University Of Texas System Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
WO2012048283A1 (en) 2010-10-08 2012-04-12 Board Of Regents, The University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
US9603894B2 (en) 2010-11-08 2017-03-28 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
UA111822C2 (uk) 2010-11-24 2016-06-24 Общєство С Огранічєнной Отвєтствєнностью "Новамедіка" Монотерапевтичий препарат селективного ліпофільного бета-агоніста тривалої дії і спосіб косметичного лікування ожиріння і контурного випинання
JP6120778B2 (ja) * 2011-02-03 2017-04-26 ノースイースタン ユニヴァーシティ 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物
US10647959B2 (en) 2011-04-27 2020-05-12 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US10045947B2 (en) * 2011-04-28 2018-08-14 President And Fellows Of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
EP2714073B1 (de) 2011-06-03 2021-03-10 President and Fellows of Harvard College Krebsimpfstoff zur in-situ-antigen-erzeugung
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
WO2013025763A2 (en) * 2011-08-15 2013-02-21 President And Fellows Of Harvard College Tissue engineering using injectable, oxidized alginate hydrogels
CN104411331B (zh) 2012-01-13 2018-08-21 哈佛学院董事会 在结构聚合装置中tlr激动剂的控制传递
US9480747B2 (en) 2012-01-24 2016-11-01 Bvw Holding Ag Class of anti-adhesion hydrogels with healing aspects
DK2838515T3 (da) 2012-04-16 2020-02-24 Harvard College Mesoporøse siliciumdioxidsammensætninger til modulering af immunresponser
US11565027B2 (en) 2012-12-11 2023-01-31 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
EP3505197B1 (de) 2012-12-11 2023-09-06 Board of Regents, The University of Texas System Hydrogelmembran zur anhaftungsverhinderung
US9993497B2 (en) 2012-12-30 2018-06-12 Hadasit Medical Research Services And Development Ltd. Use of alginate compositions in preventing or reducing liver damage caused by a hepatotoxic agent
MX2015014053A (es) 2013-04-05 2016-04-07 Claudia Zylberberg Metaloproteinasas de matriz y sus usos.
DE202013012287U1 (de) 2013-04-23 2016-01-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Gelbildendes System zum Entfernen von Nierensteinfragmenten
DE202013012275U1 (de) 2013-04-23 2015-12-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten
EP2796101B1 (de) 2013-04-23 2016-04-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten
ES2577102T3 (es) 2013-04-23 2016-07-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Sistema gelificante para eliminar fragmentos de cálculos renales
AU2013405882B2 (en) * 2013-11-25 2017-03-02 Halliburton Energy Services, Inc. Viscosity enhancer
WO2015115609A1 (ja) * 2014-01-31 2015-08-06 生化学工業株式会社 ジアミン架橋剤、酸性多糖架橋体、及び医用材料
WO2015148512A1 (en) 2014-03-24 2015-10-01 Qt Holdings Corp Shaped articles including hydrogels and methods of manufacture and use thereof
US20170119892A1 (en) 2014-04-04 2017-05-04 President And Fellows Of Harvard College Refillable drug delivery devices and methods of use thereof
EP3137105A4 (de) 2014-04-30 2017-12-27 President and Fellows of Harvard College Kombinationsimpfstoffvorrichtungen und -verfahren zur abtötung von krebszellen
US11065362B2 (en) 2014-06-12 2021-07-20 President And Fellows Of Harvard College Viscoelastic hydrogels with fast stress relaxation
US9687455B2 (en) 2014-08-14 2017-06-27 John Daniel Dobak Sodium tetradecyl sulfate formulations for treatment of adipose tissue
US11786457B2 (en) 2015-01-30 2023-10-17 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
US9351945B1 (en) 2015-02-27 2016-05-31 John Daniel Dobak, III Reduction of adipose tissue
WO2016164705A1 (en) 2015-04-10 2016-10-13 Omar Abdel-Rahman Ali Immune cell trapping devices and methods for making and using the same
WO2017004071A1 (en) * 2015-06-29 2017-01-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Stapled acid-sensitive endosome disrupting alginates
US9790467B2 (en) 2015-09-22 2017-10-17 Qt Holdings Corp Methods and compositions for activation or expansion of T lymphocytes
EP3821880A1 (de) 2015-10-26 2021-05-19 President and Fellows of Harvard College Oxidierte polysaccharide und verfahren zur verwendung davon
US11752238B2 (en) 2016-02-06 2023-09-12 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
MA44490A (fr) 2016-03-22 2019-01-30 Harvard College Adhésifs biocompatibles et leurs procédés d'utilisation
US11655343B2 (en) 2016-03-24 2023-05-23 Takeda Pharmaceutical Company Limited Alginate hydrogel compositions
TWI841843B (zh) 2016-05-03 2024-05-11 瑞士商Ｂｖｗ控股公司 多相凝膠
CN109789092A (zh) 2016-07-13 2019-05-21 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
IL264557B2 (en) 2016-08-02 2024-01-01 Harvard College Biological agents for regulating immune responses
EA201991452A1 (ru) 2016-12-13 2020-01-16 Милленниум Фармасьютикалз, Инк. Конформное покрытие биологических поверхностей
US11591564B2 (en) * 2016-12-16 2023-02-28 University of Pittsburgh—of the Commonwealth System of Higher Education Peptide conjugated hydrogel substrate for the maintenance and expansion of human pluripotent stem cells
CA3051142A1 (en) 2017-01-27 2018-08-02 Cornell University Zwitterionically modified polymers and hydrogels
US11980700B2 (en) 2017-03-08 2024-05-14 Alafair Biosciences, Inc. Hydrogel medium for the storage and preservation of tissue
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
KR102123508B1 (ko) * 2018-10-01 2020-06-16 한국원자력연구원 전기전도성 마이크로 니들 패치의 제조방법 및 이에 의해 제조된 전기전도성 마이크로 니들 패치
US20210393850A1 (en) * 2018-11-07 2021-12-23 Universiteit Maastricht Bioinks
EP3893933B1 (de) * 2018-12-10 2025-10-15 The Regents of The University of California Regenerierung von speicheldrüsen
CN110201234B (zh) * 2019-06-26 2021-09-03 山东百多安医疗器械股份有限公司 一种组织工程用前列腺细胞微囊及其制备方法
CN110401637B (zh) * 2019-06-28 2021-03-02 中南民族大学 一种命名数据网络中基于名字的信任方法
US12605480B2 (en) 2019-09-20 2026-04-21 President And Fellows Of Harvard College Tough gel-based drug delivery compositions and methods thereof
WO2021061837A1 (en) 2019-09-23 2021-04-01 President And Fellows Of Harvard College Biomaterial-based antigen free vaccine and the use thereof
NL2024820B1 (en) * 2020-02-03 2021-09-13 Mosa Meat B V Hydrogels for cultured meat production
US11678579B2 (en) * 2020-04-29 2023-06-13 The University Of Hong Kong Stretchable ionic hydrogel with high thermopower for low-grade heat harvesting
DE102020116108B4 (de) 2020-06-18 2024-12-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Verfahren zur Herstellung von Trägerpartikeln für die Kultivierung biologischer Zellen, Trägerpartikel und deren Anwendung
US20230330147A1 (en) 2020-08-31 2023-10-19 The Board Of Trustees Of The University Of Illinois Alginate-coated mesenchymal stromal and progenitor cells and methods for using the same
AU2022378579A1 (en) 2021-10-28 2024-05-02 Lyell Immunopharma, Inc. Methods of generating cells
WO2024210882A1 (en) * 2022-12-30 2024-10-10 Sigilon Therapeutics, Inc. Modified polysaccharide polymers and related compositions and methods thereof
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2025072416A1 (en) * 2023-09-29 2025-04-03 Nutrition & Biosciences USA 4, Inc. Polysaccharide derivatives
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium
WO2026006604A1 (en) 2024-06-26 2026-01-02 Lyell Immunopharma, Inc. Feeder cell replacement

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1550819A (en) 1975-06-04 1979-08-22 Nat Res Dev Polymeric support for biogically active materials
ATE25708T1 (de) 1983-06-15 1987-03-15 Gist Brocades Nv Biologisch aktive konjugate, ihre herstellung und ihre anwendung.
JPH03500244A (ja) * 1987-09-28 1991-01-24 ラ　ジョラ　キャンサー　リサーチ　ファウンデーション 細胞接着性が増大した細胞の選別
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
NO171069C (no) 1990-05-29 1993-01-20 Protan Biopolymer As Kovalent tverrbundne, sterkt svellende alkalimetall- og ammonium-alginatgeler, samt fremgangsmaate for fremstilling derav
US5227298A (en) 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5110605A (en) 1990-08-21 1992-05-05 Oramed, Inc. Calcium polycarbophil-alginate controlled release composition and method
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
JPH0581A (ja) * 1991-06-21 1993-01-08 Koken Co Ltd 細胞培養担体及び培養方法
EP0610441A4 (de) * 1991-10-29 1996-01-10 Clover Cons Ltd Vernetzbare polysacchariden, polykationen und lipiden verwendbar zum einkapseln und abgabe von arzneimitteln.
US6197346B1 (en) * 1992-04-24 2001-03-06 Brown Universtiy Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5429821A (en) 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
GB2270920B (en) * 1992-09-25 1997-04-02 Univ Keele Alginate-bioactive agent conjugates
ATE162397T1 (de) * 1993-02-12 1998-02-15 Mayo Foundation Zusammensetzung aus mikropartikeln in verdichteter phase und verfahren
IT1268955B1 (it) 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Esteri attivi di polisaccaridi carbossilici
US5658592A (en) * 1994-05-13 1997-08-19 Kuraray Co., Ltd. Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane
JP3107726B2 (ja) * 1994-05-13 2000-11-13 株式会社クラレ 水膨潤性高分子ゲル
US5863551A (en) * 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses

Also Published As

Publication number Publication date
EP0927196A1 (de) 1999-07-07
JP5111416B2 (ja) 2013-01-09
CA2266581A1 (en) 1998-03-26
JP2009120855A (ja) 2009-06-04
JP2001524136A (ja) 2001-11-27
WO1998012228A1 (en) 1998-03-26
AU4493097A (en) 1998-04-14
EP0927196A4 (de) 2000-12-13
ES2317657T3 (es) 2009-04-16
DE69739085D1 (de) 2008-12-18
EP0927196B1 (de) 2008-11-05
JP4335316B2 (ja) 2009-09-30
AU733716B2 (en) 2001-05-24
US6642363B1 (en) 2003-11-04
CA2266581C (en) 2007-03-13

Similar Documents

Publication Publication Date Title
ATE413415T1 (de) Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate
WO2005012364A3 (fr) Matrice complexe a usage biomedical
Almany et al. Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures
EP1806367A3 (de) Polysaccharide wie Alginate oder modifizierte Alginate enthaltende Polymere
ATE356638T1 (de) Hydrolytisch abbaubare carbamatderivate von polyethylenglykol
EP0894825A4 (de) Dienpolymerzusammensetzung, verfahren zu deren herstellung und kautschukzusammensetzung die dieselbe enthält
DK0910412T3 (da) Hydrolyserbare hydrogeler til kontrolleret frigørelse
MX2009002653A (es) Derivados de acido hialuronico obtenidos via reticulacion de "quimica modular".
AU5061999A (en) Slow release formulations comprising anionic polysaccharide
DE69836491D1 (de) Fibrinmikrokugeln und deren verwendungen
WO2000021572A3 (en) Hydrogels and water soluble polymeric carriers for drug delivery
RU2010125705A (ru) Гелевые полисахаридные композиции и способы длительной доставки лекарственных средств
DK0973819T3 (da) Ikke-antigene forgrenede polymerkonjugater
DE69708304D1 (de) Vernetzte copolymere auf der basis von polycarbonsäurepolymeren
ATE252639T1 (de) Modifizierter, das dorsalgewebe beeinflussender faktor
WO2007064772A3 (en) Implantable microbial cellulose materials for various medical applications
ATE469936T1 (de) Modifiziertes polymer und modifizierte polymermembran
WO2004029137A3 (en) Cross-linked polymer matrices, and methods of making and using same
DK1051158T3 (da) Farmaceutiske præparater i form af polymere mikropartikler fremstillet ved ekstrudering og sfæronisering
EP0234114A3 (de) Polymerketten mit Endgruppen, Propfkopolymere und Sternkopolymere sowie Verfahren zu deren Herstellung
DK0889957T3 (da) Subtilisindimer med forbedret aktivitet og fremgangsmåde til fremstilling deraf
DE602005005062D1 (de) Dhydrogele und deren biomedizinischen und pharmazeutischen anwendungen
GB2325234A (en) Highly functionalized polyethylene glycol grafted polystyrene supports
WO2000066732A3 (en) Laminin 8 and methods for its use
AU2003285286A1 (en) Conjugates of insulin-like growth factor binding protein-4 and poly (ethylene glycol)

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties