ATE414080T1 - Synthese von antidiabetischen rosiglitazonderivaten - Google Patents
Synthese von antidiabetischen rosiglitazonderivatenInfo
- Publication number
- ATE414080T1 ATE414080T1 AT05740577T AT05740577T ATE414080T1 AT E414080 T1 ATE414080 T1 AT E414080T1 AT 05740577 T AT05740577 T AT 05740577T AT 05740577 T AT05740577 T AT 05740577T AT E414080 T1 ATE414080 T1 AT E414080T1
- Authority
- AT
- Austria
- Prior art keywords
- rosiglitazone
- antidiabetic
- synthesis
- derivatives
- pharmaceutically acceptable
- Prior art date
Links
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical class C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 title abstract 5
- 230000003178 anti-diabetic effect Effects 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 abstract 2
- 229960004586 rosiglitazone Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FRMKJZNBTRONBV-UHFFFAOYSA-N 4-[2-[methyl(pyridin-2-yl)amino]ethoxy]benzaldehyde Chemical compound C=1C=CC=NC=1N(C)CCOC1=CC=C(C=O)C=C1 FRMKJZNBTRONBV-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0410013A GB2413795A (en) | 2004-05-05 | 2004-05-05 | Process for the preparation of rosiglitazone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414080T1 true ATE414080T1 (de) | 2008-11-15 |
Family
ID=32482705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05740577T ATE414080T1 (de) | 2004-05-05 | 2005-05-03 | Synthese von antidiabetischen rosiglitazonderivaten |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7598387B2 (de) |
| EP (1) | EP1756099B1 (de) |
| JP (1) | JP2007536358A (de) |
| KR (1) | KR20070014191A (de) |
| AT (1) | ATE414080T1 (de) |
| AU (1) | AU2005238282A1 (de) |
| CA (1) | CA2565665A1 (de) |
| DE (1) | DE602005011004D1 (de) |
| ES (1) | ES2315867T3 (de) |
| GB (1) | GB2413795A (de) |
| NZ (1) | NZ551126A (de) |
| PT (1) | PT1756099E (de) |
| WO (1) | WO2005105794A1 (de) |
| ZA (1) | ZA200609147B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5732453B2 (ja) | 2009-06-25 | 2015-06-10 | アルカーメス ファーマ アイルランド リミテッド | Ｎｈ酸性化合物のプロドラッグ |
| NZ604423A (en) * | 2010-06-24 | 2015-01-30 | Alkermes Pharma Ireland Ltd | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| JP5546372B2 (ja) * | 2010-06-30 | 2014-07-09 | 積水メディカル株式会社 | ベンジルヒダントイン化合物の製造法 |
| ES2972387T3 (es) | 2011-03-18 | 2024-06-12 | Alkermes Pharma Ireland Ltd | Composiciones farmacéuticas que comprenden ésteres de sorbitán |
| WO2013088255A1 (en) | 2011-12-15 | 2013-06-20 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
| CA2867121C (en) | 2012-03-19 | 2021-05-25 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
| WO2013142202A1 (en) | 2012-03-19 | 2013-09-26 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising glycerol esters |
| US9999670B2 (en) | 2012-03-19 | 2018-06-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising benzyl alcohol |
| JP6654042B2 (ja) | 2012-09-19 | 2020-02-26 | アルカームス ファーマ アイルランド リミテッド | 貯蔵安定性が改善された医薬組成物 |
| AU2015231278B2 (en) | 2014-03-20 | 2020-01-23 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
| AU2019230014B2 (en) | 2018-03-05 | 2024-11-28 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE186724T1 (de) * | 1987-09-04 | 1999-12-15 | Beecham Group Plc | Substituierte thiazolidindionderivate |
| ES2007537A6 (es) | 1988-07-21 | 1989-06-16 | Cenavisa S A | Procedimiento para la preparacion de derivados neutronsolubles de la sulfametoxipiridazina y del sulfametoxazol a partir de aldehidos aromaticos. |
| HUP0101830A3 (en) * | 1998-05-05 | 2002-10-28 | Lilly Co Eli | Purification carboxaldehyde |
| HU225919B1 (en) * | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
| WO2002051823A1 (en) * | 2000-12-26 | 2002-07-04 | Torrent Pharmaceuticals Ltd | Process for the preparation of rosiglitazone maleate |
-
2004
- 2004-05-05 GB GB0410013A patent/GB2413795A/en not_active Withdrawn
-
2005
- 2005-05-03 KR KR1020067025470A patent/KR20070014191A/ko not_active Abandoned
- 2005-05-03 EP EP05740577A patent/EP1756099B1/de not_active Expired - Lifetime
- 2005-05-03 PT PT05740577T patent/PT1756099E/pt unknown
- 2005-05-03 DE DE602005011004T patent/DE602005011004D1/de not_active Expired - Lifetime
- 2005-05-03 JP JP2007512313A patent/JP2007536358A/ja active Pending
- 2005-05-03 CA CA002565665A patent/CA2565665A1/en not_active Abandoned
- 2005-05-03 US US11/568,610 patent/US7598387B2/en not_active Expired - Fee Related
- 2005-05-03 AU AU2005238282A patent/AU2005238282A1/en not_active Abandoned
- 2005-05-03 AT AT05740577T patent/ATE414080T1/de not_active IP Right Cessation
- 2005-05-03 ES ES05740577T patent/ES2315867T3/es not_active Expired - Lifetime
- 2005-05-03 WO PCT/GB2005/001671 patent/WO2005105794A1/en not_active Ceased
- 2005-05-03 NZ NZ551126A patent/NZ551126A/en unknown
-
2006
- 2006-11-02 ZA ZA200609147A patent/ZA200609147B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005105794A1 (en) | 2005-11-10 |
| US7598387B2 (en) | 2009-10-06 |
| GB2413795A (en) | 2005-11-09 |
| JP2007536358A (ja) | 2007-12-13 |
| US20070191611A1 (en) | 2007-08-16 |
| ZA200609147B (en) | 2007-06-27 |
| AU2005238282A1 (en) | 2005-11-10 |
| KR20070014191A (ko) | 2007-01-31 |
| EP1756099B1 (de) | 2008-11-12 |
| EP1756099A1 (de) | 2007-02-28 |
| PT1756099E (pt) | 2009-02-03 |
| CA2565665A1 (en) | 2005-11-10 |
| ES2315867T3 (es) | 2009-04-01 |
| DE602005011004D1 (de) | 2008-12-24 |
| GB0410013D0 (en) | 2004-06-09 |
| NZ551126A (en) | 2010-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |