ATE415387T1 - Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten - Google Patents

Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten

Info

Publication number
ATE415387T1
ATE415387T1 AT03734040T AT03734040T ATE415387T1 AT E415387 T1 ATE415387 T1 AT E415387T1 AT 03734040 T AT03734040 T AT 03734040T AT 03734040 T AT03734040 T AT 03734040T AT E415387 T1 ATE415387 T1 AT E415387T1
Authority
AT
Austria
Prior art keywords
cysteine
benzimidoic
benzonitriles
producing
peptidal
Prior art date
Application number
AT03734040T
Other languages
English (en)
Inventor
Mukund S Chorghade
Mukund K Gurjar
Joseph Cherian
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE415387T1 publication Critical patent/ATE415387T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
    • C07C257/08—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT03734040T 2002-05-15 2003-05-15 Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten ATE415387T1 (de)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US38088002P 2002-05-15 2002-05-15
US38090302P 2002-05-15 2002-05-15
US38089402P 2002-05-15 2002-05-15
US38091002P 2002-05-15 2002-05-15
US38102102P 2002-05-15 2002-05-15
US38087802P 2002-05-15 2002-05-15
US38101202P 2002-05-15 2002-05-15
US38101702P 2002-05-15 2002-05-15
US38089502P 2002-05-15 2002-05-15
US38090902P 2002-05-15 2002-05-15
US38101302P 2002-05-15 2002-05-15
US39283302P 2002-06-27 2002-06-27

Publications (1)

Publication Number Publication Date
ATE415387T1 true ATE415387T1 (de) 2008-12-15

Family

ID=29554649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03734040T ATE415387T1 (de) 2002-05-15 2003-05-15 Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten

Country Status (6)

Country Link
US (17) US6846958B2 (de)
EP (2) EP1506162B1 (de)
JP (3) JP2005538950A (de)
AT (1) ATE415387T1 (de)
AU (2) AU2003239472A1 (de)
WO (2) WO2003097622A2 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT500490A1 (de) * 2001-10-16 2006-01-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte
US20080086494A1 (en) * 2006-09-11 2008-04-10 Apple Computer, Inc. Transfer and synchronization of media data
US6846958B2 (en) * 2002-05-15 2005-01-25 Genzyme Corporation Synthesis of benzimidate from benzoic acid
US7394410B1 (en) * 2004-02-13 2008-07-01 Samplify Systems, Inc. Enhanced data converters using compression and decompression
US7432086B2 (en) 2004-07-22 2008-10-07 Mitsubishi Gas Chemical Company, Inc. L-amino acid amide asymmetric hydrolase and DNA encoding the same
DE102005054362A1 (de) 2004-12-01 2006-06-08 Degussa Ag Verfahren zur Herstellung von Amino- oder Hydroxybenzonitrilen
US7790720B2 (en) * 2005-03-31 2010-09-07 Ucb Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
AU2006238933B2 (en) 2005-04-28 2011-12-01 Pfizer Limited Amino acid derivatives
JP2006312614A (ja) * 2005-05-09 2006-11-16 Ajinomoto Co Inc チアゾリン化合物および光学活性α−アルキルシステインの製造方法
US7947837B2 (en) * 2006-10-25 2011-05-24 Polyera Corporation Organic semiconductor materials and methods of preparing and use thereof
US7799934B2 (en) * 2007-06-29 2010-09-21 University Of South Florida Enantioselective ring-opening of aziridines
EP2334620B1 (de) * 2008-09-05 2018-09-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur enantioselektiven trennung chiraler systeme mit verbindungsbildung unter anwendung von zwei aufeinanderfolgenden kristallisationsschritten
US8349899B1 (en) 2008-12-03 2013-01-08 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
US8765817B1 (en) 2008-12-03 2014-07-01 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
PL3300717T3 (pl) * 2009-06-29 2021-04-19 Inolex Investment Corporation Kationowe emulgatory niepochodzące z procesów petrochemicznych, które są zobojętnionymi estrami aminokwasów oraz kompozycje i sposoby
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
KR20140020236A (ko) * 2010-10-20 2014-02-18 바이오포믹스, 인크. 열 전달제 존재하에서의 빠른 회수를 사용하는 메틸렌 말로네이트의 합성
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
EP3517523A1 (de) 2011-10-19 2019-07-31 Sirrus, Inc. Multifunktionsmonomere und verfahren zur deren herstellung
CN102775399A (zh) * 2011-12-27 2012-11-14 盛世泰科生物医药技术(苏州)有限公司 arylhydrocarbon受体(AHR)的内源性配体,2-(1’H3’-吲哚羰基)噻唑-4-羧酸甲酯的合成新方法
US9181365B2 (en) 2012-03-30 2015-11-10 Sirrus, Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
JP6345644B2 (ja) 2012-03-30 2018-06-20 シラス・インコーポレイテッド インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系
EP3153530B1 (de) 2012-03-30 2021-02-24 Sirrus, Inc. Zusammengesetzte und laminierte artikel sowie polymerisierbare systeme zur herstellung davon
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
WO2014078689A1 (en) 2012-11-16 2014-05-22 Bioformix Inc. Plastics bonding systems and methods
US10607910B2 (en) 2012-11-30 2020-03-31 Sirrus, Inc. Composite compositions for electronics applications
CN105008321A (zh) 2013-01-11 2015-10-28 瑟拉斯公司 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2062210A5 (de) 1969-09-17 1971-06-25 Godo Shusei Kk
DE2020866A1 (de) 1970-04-29 1971-11-18 Basf Ag Verfahren zur Herstellung von Hydroxy- und Aminobenzonitrilen
DE3002989A1 (de) 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
EP0045281B1 (de) 1980-07-28 1985-05-08 Ciba-Geigy Ag Thiazolinderivate und Verfahren zu ihrer Herstellung
GB9126832D0 (en) 1991-12-18 1992-02-19 Sandoz Ltd Separation process
AU5602594A (en) 1992-11-16 1994-06-08 University Of Florida Research Foundation, Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives
US5840739A (en) 1992-11-16 1998-11-24 University Of Florida Research Foundation, Inc. Thiazoline acid derivatives
JPH08512281A (ja) * 1993-02-26 1996-12-24 メレル ダウ ファーマス−ティカルズ インコーポレイテッド アデノシンａ▲下１▼受容体拮抗剤としてのキサンチン誘導体類
US5554753A (en) * 1993-08-25 1996-09-10 Indiana University Foundation Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
US6319914B1 (en) * 1993-11-05 2001-11-20 Apollo Biopharmaceuticals, Inc. Cytoprotective effect of polycyclic phenolic compounds
US6197833B1 (en) * 1995-07-24 2001-03-06 Apollo Biopharmaceutics, Inc. Neuroprotective effects of polycyclic phenolic compounds
US6350739B1 (en) * 1999-08-11 2002-02-26 University Of Florida Resarch Foundation, Inc. Methods of prevention and treatment of ischemic damage
US5877169A (en) * 1993-11-05 1999-03-02 University Of Florida Research Foundation, Inc. Methods of treatment of ischemic damage
US5554601A (en) * 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
US5859001A (en) * 1996-01-11 1999-01-12 University Of Florida Research Foundation, Inc. Neuroprotective effects of polycyclic phenolic compounds
US5665890A (en) 1995-03-14 1997-09-09 President And Fellows Of Harvard College Stereoselective ring opening reactions
ES2182025T3 (es) 1996-03-10 2003-03-01 Reuter Chemischer Appbau Kg Procedimiento de separacion.
DE69822806T2 (de) * 1997-01-16 2005-03-10 University of Florida Research Foundation, Inc., Gainesville Zusammensetzungen zur verstärkung zytoprotektiver wirkung von polycyclischer phenolverbindungen durch synergistiche wechselwirkung von antioxidationsmitteln
WO1999012623A1 (en) 1997-09-06 1999-03-18 Reuter Chemische Apparatebau Kg Separation process
AU747807B2 (en) * 1997-11-24 2002-05-23 Apollo Biopharmaceutics Inc. Testosterone inhibitors and use for the protection of neurons
EP1054000A4 (de) * 1998-01-13 2003-07-23 Kaneka Corp Verfahren zur herstellung optisch aktiver cysteinderivate
US5929252A (en) * 1998-06-15 1999-07-27 The Scripps Research Institute Aziridination of olefins
US6765109B1 (en) * 1998-06-29 2004-07-20 Roche Colorado Corporation Preparation of S-aryl-cysteine and its derivatives
AU4856199A (en) 1998-07-03 2000-01-24 Millennium Pharmaceuticals, Inc. Substituted nitrogen and sulfur alicyclic compounds, including methods for synthesis thereof
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
US6159983A (en) 1998-09-18 2000-12-12 University Of Florida Method and composition for treatment of inflammatory bowel disease
EP1143951A3 (de) 1998-09-21 2002-02-06 University Of Florida Research Foundation, Inc. Mittel gegen malaria
CN101332157B (zh) * 1998-10-09 2012-01-11 味之素株式会社 半胱氨酸衍生物
US6339078B1 (en) * 1999-07-20 2002-01-15 University Of Florida Research Foundation, Inc. Methods of prevention and treatment of ischemic damage
US6326365B1 (en) * 1999-07-20 2001-12-04 Apollo Biopharmaceutics, Inc. Methods of prevention and treatment of ischemic damage
DE20000122U1 (de) * 2000-01-05 2000-04-20 ABT Advanced Bioanalytical Technology GmbH & Co KG, 01454 Radeberg Mobiles Handgerät mit wiederverwendbarem Biosensor
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
AT500490A1 (de) * 2001-10-16 2006-01-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte
US6846958B2 (en) 2002-05-15 2005-01-25 Genzyme Corporation Synthesis of benzimidate from benzoic acid
ITVR20020062A1 (it) * 2002-06-03 2003-12-03 Andrea Pretto Preparazione estemporanea di periossiacidi organici stabili nel tempo

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US20060069265A1 (en) 2006-03-30
US20030236426A1 (en) 2003-12-25
US20030225287A1 (en) 2003-12-04
EP1506162A2 (de) 2005-02-16
WO2003097582A3 (en) 2004-02-12
US7115769B2 (en) 2006-10-03
EP1529037A2 (de) 2005-05-11
US6982335B2 (en) 2006-01-03
US20060167267A1 (en) 2006-07-27
US6846958B2 (en) 2005-01-25
US7285676B2 (en) 2007-10-23
JP2007001986A (ja) 2007-01-11
US20060217561A1 (en) 2006-09-28
US6875882B2 (en) 2005-04-05
EP1506162B1 (de) 2008-11-26
US7038073B2 (en) 2006-05-02
US6903220B2 (en) 2005-06-07
US20030236434A1 (en) 2003-12-25
US20040002613A1 (en) 2004-01-01
US20040024224A1 (en) 2004-02-05
AU2003247374A8 (en) 2003-12-02
JP2005538950A (ja) 2005-12-22
US20040082796A1 (en) 2004-04-29
US7294718B2 (en) 2007-11-13
US20040006224A1 (en) 2004-01-08
AU2003239472A1 (en) 2003-12-02
US20030236435A1 (en) 2003-12-25
WO2003097622A2 (en) 2003-11-27
US6875883B2 (en) 2005-04-05
US6861532B2 (en) 2005-03-01
US20050209462A1 (en) 2005-09-22
JP2005525427A (ja) 2005-08-25
US20060142586A1 (en) 2006-06-29
EP1529037B1 (de) 2009-07-15
US6794515B2 (en) 2004-09-21
US7002036B2 (en) 2006-02-21
US7576234B2 (en) 2009-08-18
US6878828B2 (en) 2005-04-12
WO2003097622A3 (en) 2004-04-08
US20030236404A1 (en) 2003-12-25
US20030229231A1 (en) 2003-12-11
AU2003247374A1 (en) 2003-12-02
WO2003097582A2 (en) 2003-11-27
US20030220504A1 (en) 2003-11-27
JP4414331B2 (ja) 2010-02-10
US7285670B2 (en) 2007-10-23
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